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p16 in HPV-associated cancers

Munger, Karl, Gwin, Tyshia K., McLaughlin-Drubin, Margaret E.·2013·Oncotarget
DOI 10.18632/oncotarget.1523PMC PMC3875753
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Figure 1 The retinoblastoma (Rb) tumor suppressor pathway p16INK4A inhibits CDK4/6 This overrides growth signals and results in G1 growth arrest and senescence (upper panel). The high-risk HPV E7 proteins, which trigger p16INK4A expression, have evolved to overcome this response by targeting Rb for degradation. Under these conditions, p16INK4A expression and CDK4/6 inhibition is required for cell survival. Hence p16INK4A, which normally functions as a tumor suppressor (red) now has oncogenic activities (green) and similarly, CDK4/6, which normally are oncogenic (green) are now tumor suppressive (red), demonstrating the biological activities of key components of the retinoblastoma tumor suppressor pathway are dependent on the cellular context (see text for details).
Figure 1 The retinoblastoma (Rb) tumor suppressor pathway p16INK4A inhibits CDK4/6 This overrides growth signals and results in G1 growth arrest and senescence (upper panel). The high-risk HPV E7 proteins, which trigger p16INK4A expression, have evolved to overcome this response by targeting Rb for degradation. Under these conditions, p16INK4A expression and CDK4/6 inhibition is required for cell survival. Hence p16INK4A, which normally functions as a tumor suppressor (red) now has oncogenic activities (green) and similarly, CDK4/6, which normally are oncogenic (green) are now tumor suppressive (red), demonstrating the biological activities of key components of the retinoblastoma tumor suppressor pathway are dependent on the cellular context (see text for details).CC BY · PubMed Central

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Metadata

Authors
Munger, K., Gwin, T. K., & McLaughlin-Drubin, M. E.
Venue
Oncotarget
Publisher
Impact Journals, LLC
Published
2013-10-31
Volume
4
Issue
11
Pages
1864-1865
ISSN
1949-2553
DOI
10.18632/oncotarget.1523
PMC
PMC3875753
Cited by
30
References
0
Language
en

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CoChat. (2026). Citation check: p16 in HPV-associated cancers. https://app.cochat.ai/papers/10.18632/oncotarget.1523
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Munger, K., Gwin, T. K., & McLaughlin-Drubin, M. E. (2013). p16 in HPV-associated cancers. Oncotarget. https://doi.org/10.18632/oncotarget.1523