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Cited by 14Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchGenetic Associations and Epidemiology

MEF2C rs190982 polymorphism with late-onset Alzheimer's disease in Han Chinese: A replication study and meta-analyses

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Tang, Shan-Shan, Wang, Hui-Fu, Zhang, Wei, Kong, Ling-Li, Zheng, Zhan-Jie, Tan, Meng-Shan, Tan, Chen-Chen, Wang, Zi-Xuan +4 more·2016·Oncotarget
DOI 10.18632/oncotarget.9819PMC PMC5129919
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Abstract

// Shan-Shan Tang 1,* , Hui-Fu Wang 1,* , Wei Zhang 2 , Ling-Li Kong 3 , Zhan-Jie Zheng 3 , Meng-Shan Tan 1 , Chen-Chen Tan 1 , Zi-Xuan Wang 1 , Lin Tan 4 , Teng Jiang 5 , Jin-Tai Yu 1 and Lan Tan 1 1 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China 2 Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China 3 Department of Geriatric, Qingdao Mental Health Center, Qingdao, PR China 4 College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, PR China 5 Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, PR China * These authors should be regarded as co-first authors Correspondence to: Lan Tan, email: // Wei Zhang, email: // Keywords : Alzheimer’s disease; MEF2C; rs190982; association study; meta-analysis; Gerotarget Received : March 22, 2016 Accepted : May 25, 2016 Published : June 03, 2016 Abstract The myocyte enhancer factor ( MEF2 ) family of transcription factors plays a vital role in memory and learning due to its functions in regulating synapse number and reducing dendritic spines. Myocyte enhancer factor 2 C ( MEF2C ) is regarded as modulator of amyloid-protein precursor (APP) proteolytic processing, in which amyloid-β (Aβ) is produced. A common single nucleotide polymorphism (SNP, rs190982) in MEF2C gene was identified to be related to late-onset Alzheimer’s disease (LOAD) in Caucasians in a large meta-analysis of genome-wide association studies (GWAS). Here, we recruited unrelated 984 LOAD patients and 1348 healthy controls matched for gender and age to ascertain whether the rs190982 polymorphism is related to LOAD in Han Chinese. No difference in the genotype and allele distributions of the MEF2C rs190982 polymorphism was found between LOAD cases and healthy controls (genotype: P = 0.861; allele: P = 0.862), even after stratification for APOE ε4 allele as well as statistical adjustment for age, gender and APOE ε4 status. Furthermore, the meta-analysis in 4089 Chinese individuals did not detect the association of rs190982 within MEF2C with the risk for LOAD (OR = 1.03, 95%CI = 0.90-1.18). Overall, the current evidence did not support the relation between rs190982 polymorphism within MEF2C and the LOAD risk in Northern Han Chinese.

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  • The SNP rs190982 within the MEF2C gene has been linked to Alzheimer's disease risk in Caucasian populations.

    “In addition to SPI1, the SNPs rs190982 and rs9293506 within the microglial transcription factor gene Myocyte Enhancer Factor 2C (MEF2C) have been linked to Alzheimer's disease risk and cognitive aging in Caucasian [25] and Taiwanese [27] populations, respectively.”

    From Targeting Microglial Transcriptional Reprogramming as a Therapy Strategy for Alzheimer's Disease (2026) · cites this paper as [25]

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Authors
Tang, S.-S., Wang, H.-F., Zhang, W., Kong, L.-L., Zheng, Z.-J., Tan, M.-S., Tan, C.-C., Wang, Z.-X., Tan, L., Jiang, T., Yu, J.-T., & Tan, L.
Affiliations
  • Qingdao University (CN)
  • Department of Geriatric, Qingdao Mental Health Center, Qingdao, PR China
  • Qingdao Mental Health Center (CN)
  • Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, PR China
  • Nanjing First Hospital (CN)
Corresponding author
  • Tang, Shan-Shan
  • Wang, Hui-Fu
ORCID
Venue
Oncotarget
Publisher
Impact Journals, LLC
Published
2016-06-03
Volume
7
Issue
26
Pages
39136-39142
ISSN
1949-2553 (ISSN-L)
DOI
10.18632/oncotarget.9819
PMC
PMC5129919
OpenAlex
W2409955980
Cited by
14
References
2
Citations by year
2026: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 4 · 2019: 4
FWCI
1.07
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Oncotarget (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Qingdao Key Health Discipline Development Fund
  • National Natural Science Foundation of China (81371406, 81501103, 81371406, 81571245, 81471309, 81371406, 81571245, and 81501103, 81471309, 81571245)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
MEF2C, late-onset Alzheimer's disease, single nucleotide polymorphisms, genetic association, Han Chinese, replication study, MEF2, amyloid-beta, APP proteolytic processing, transcription factors, genetic susceptibility, learning and memory, dendritic spines, synapse number, neurodegeneration, neuroinflammation
MeSH terms
Aged, Alleles, Alzheimer Disease, Animals, Apolipoproteins E, China, Female, Genotype, Humans, Male, Mutation, Regression Analysis, Reproducibility of Results, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Asian People, Mice, Genome-Wide Association Study, Genetic Association Studies, MEF2 Transcription Factors

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