MEF2: a central regulator of diverse developmental programs

MicroRNAs: small RNAs with a big role in gene regulation

He, L., & Hannon, G. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1379 · Cited by 5,910 · see citing works

Histone deacetylases (HDACs): characterization of the classical HDAC family

RUIJTER, A. J. M. D., GENNIP, A. H. V., CARON, H. N., KEMP, S., & KUILENBURG, A. B. P. V. (2003) · Biochemical Journal · doi:10.1042/bj20021321 · Cited by 3,114 · see citing works

The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation

Chen, J., Mandel, E. M., Thomson, J. M., Wu, Q., Callis, T. E., Hammond, S. M., Conlon, F. L., & Wang, D.-Z. (2005) · Nature Genetics · doi:10.1038/ng1725 · Cited by 2,763 · see citing works

Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

Vortkamp, A., Lee, K., Lanske, B., Segre, G. V., Kronenberg, H. M., & Tabin, C. J. (1996) · Science · doi:10.1126/science.273.5275.613 · Cited by 1,999 · see citing works

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formationPreprint

St‐Jacques, B., Hammerschmidt, M., & McMahon, A. P. (1999) · Genes & Development · doi:10.1101/gad.13.16.2072 · Cited by 1,742 · see citing works

Isl1 Identifies a Cardiac Progenitor Population that Proliferates Prior to Differentiation and Contributes a Majority of Cells to the Heart

Cai, C., Liang, X., Shi, Y., Chu, P.-H., Pfaff, S. L., Chen, J., & Evans, S. Μ. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00363-0 · Cited by 1,611 · see citing works

Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis

Zhao, Y. B., Samal, E., & Srivastava, D. P. (2005) · Nature · doi:10.1038/nature03817 · Cited by 1,556 · see citing works

PTH/PTHrP Receptor in Early Development and Indian Hedgehog—Regulated Bone Growth

Lanske, B., Karaplis, A. C., Lee, K., Luz, A., Vortkamp, A., Pirro, A. E., Karperien, M., Defize, L. H. K., Ho, C., Mulligan, R. C., et al. (1996) · Science · doi:10.1126/science.273.5275.663 · Cited by 1,325 · see citing works

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.Preprint

Karaplis, A. C., Luz, A., Glowacki, J., Bronson, R. T., Tybulewicz, V. L. J., Kronenberg, H. M., & Mulligan, R. C. (1994) · Genes & Development · doi:10.1101/gad.8.3.277 · Cited by 1,151 · see citing works

Control of Mouse Cardiac Morphogenesis and Myogenesis by Transcription Factor MEF2C

Lin, Q. F., Schwarz, J. J., Bucana, C. D., & Olson, E. N. (1997) · Science · doi:10.1126/science.276.5317.1404 · Cited by 1,055 · see citing works

TRANSCRIPTIONAL CONTROL OF MUSCLE DEVELOPMENT BY MYOCYTE ENHANCER FACTOR-2 (MEF2) PROTEINS

Black, B. L., & Olson, E. N. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.167 · Cited by 1,037 · see citing works

Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1

Kurihara, Y., Kurihara, H., Suzuki, H. I., Kodama, T., Maemura, K., Nagai, R., Oda, H., Kuwaki, T., Cao, W.-H., Kamada, N., et al. (1994) · Nature · doi:10.1038/368703a0 · Cited by 981 · see citing works

Class II Histone Deacetylases Act as Signal-Responsive Repressors of Cardiac Hypertrophy

Zhang, C. L., McKinsey, T. A., Chang, S., Antos, C. L., Hill, J. A., & Olson, E. N. (2002) · Cell · doi:10.1016/s0092-8674(02)00861-9 · Cited by 973 · see citing works

The MADS-Box Family of Transcription Factors

Shore, P., & Sharrocks, A. D. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.0001l.x · Cited by 898 · see citing works

Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins

Molkentin, J. D., Black, B. L., Martin, J. F., & Olson, E. N. (1995) · Cell · doi:10.1016/0092-8674(95)90139-6 · Cited by 819 · see citing works

Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis

Vega, R. B., Matsuda, K., Oh, J., Barbosa, A. C. C., Yang, X., Meadows, E., McAnally, J., Pomajzl, C., Shelton, J. M., Richardson, J. A., et al. (2004) · Cell · doi:10.1016/j.cell.2004.10.024 · Cited by 805 · see citing works

The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription

Tapscott, S. J. (2005) · Development · doi:10.1242/dev.01874 · Cited by 766 · see citing works

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

Han, J., Jiang, Y., Li, Z., Kravchenko, V. V., & Ulevitch, R. J. (1997) · Nature · doi:10.1038/386296a0 · Cited by 766 · see citing works

Muscle-specific microRNA miR-206 promotes muscle differentiation

Kim, H. K., Lee, Y. S., Sivaprasad, U., Malhotra, A., & Dutta, A. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200603008 · Cited by 762 · see citing works

MEF2: a calcium-dependent regulator of cell division, differentiation and death

McKinsey, T. A., Zhang, C. L., & Olson, E. N. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)02031-x · Cited by 691 · see citing works

Myogenic factors that regulate expression of muscle-specific microRNAs

Rao, P. K., Kumar, R., Farkhondeh, M., Baskerville, S., & Lodish, H. F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602831103 · Cited by 685 · see citing works

Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice

Clouthier, D. E., Hosoda, K., Richardson, J. A., Williams, S. C., Yanagisawa, H., Kuwaki, T., Kumada, M., Hammer, R. E., & Yanagisawa, M. (1998) · Development · doi:10.1242/dev.125.5.813 · Cited by 651 · see citing works

Histone Deacetylases 5 and 9 Govern Responsiveness of the Heart to a Subset of Stress Signals and Play Redundant Roles in Heart Development

Chang, S., McKinsey, T. A., Zhang, C. L., Richardson, J. A., Hill, J. A., & Olson, E. N. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.19.8467-8476.2004 · Cited by 612 · see citing works

A New Myocyte-Specific Enhancer-Binding Factor That Recognizes a Conserved Element Associated with Multiple Muscle-Specific Genes

Gossett, L. A., Kelvin, D. J., Sternberg, E. A., & Olson, E. N. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.11.5022 · Cited by 600 · see citing works

BMK1/ERK5 regulates serum‐induced early gene expression through transcription factor MEF2C

Kato, Y., Kravchenko, V. V., Tapping, R. I., Han, J., Ulevitch, R. J., & Lee, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.23.7054 · Cited by 582 · see citing works

Activity-Dependent Regulation of MEF2 Transcription Factors Suppresses Excitatory Synapse Number

Flavell, S. W., Cowan, C. W., Kim, T.-K., Greer, P. L., Lin, Y., Paradis, S., Griffith, E. C., Hu, L. S., Chen, C., & Greenberg, M. E. (2006) · Science · doi:10.1126/science.1122511 · Cited by 573 · see citing works

Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis

Edmondson, D. G., Lyons, G. E., Martin, J. F., & Olson, E. N. (1994) · Development · doi:10.1242/dev.120.5.1251 · Cited by 564 · see citing works

Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression

Wang, Z., Wang, D.-Z., Hockemeyer, D. F., McAnally, J., Nordheim, A., & Olson, E. N. (2004) · Nature · doi:10.1038/nature02382 · Cited by 562 · see citing works

Regulation of Skeletal Myogenesis by Association of the MEF2 Transcription Factor with Class II Histone Deacetylases

Lu, J., McKinsey, T. A., Zhang, C., & Olson, E. N. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00025-3 · Cited by 547 · see citing works

Myocardin is a master regulator of smooth muscle gene expression

Wang, Z., Wang, D.-Z., Pipes, G. C. T., & Olson, E. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1232341100 · Cited by 538 · see citing works

Neuronal Activity-Dependent Cell Survival Mediated by Transcription Factor MEF2

Mao, Z., Bonni, A., Xia, F., Nadal-Vicens, M. F., & Greenberg, M. E. (1999) · Science · doi:10.1126/science.286.5440.785 · Cited by 505 · see citing works

Requirement of MADS Domain Transcription Factor D-MEF2 for Muscle Formation in Drosophila

Lilly, B., Zhao, B., Ranganayakulu, G., Paterson, B. M., Schulz, R. A., & Olson, E. N. (1995) · Science · doi:10.1126/science.7839146 · Cited by 491 · see citing works

Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation.

Weir, E. C., Philbrick, W. M., Amling, M., Neff, L., Baron, R., & Broadus, A. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10240 · Cited by 480 · see citing works

Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors.Preprint

Yu, Y. T., Breitbart, R. E., Smoot, L. B., Lee, Y., Mahdavi, V., & Nadal‐Ginard, B. (1992) · Genes & Development · doi:10.1101/gad.6.9.1783 · Cited by 472 · see citing works

A Calcium-Regulated MEF2 Sumoylation Switch Controls Postsynaptic Differentiation

Shalizi, A., Gaudilliere, B. L., Yuan, Z., Stegmüller, J., Shirogane, T., Ge, Q., Tan, Y. L., Schulman, B. A., Harper, J. W., & Bonni, A. (2006) · Science · doi:10.1126/science.1122513 · Cited by 456 · see citing works

MEF2C Transcription Factor Controls Chondrocyte Hypertrophy and Bone Development

Arnold, M., Kim, Y., Czubryt, M. P., Phan, D., McAnally, J., Qi, X., Shelton, J. M., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.02.004 · Cited by 456 · see citing works

Histone Deacetylase 7 Maintains Vascular Integrity by Repressing Matrix Metalloproteinase 10

Chang, S., Young, B. D., Li, S., Qi, X., Richardson, J. A., & Olson, E. N. (2006) · Cell · doi:10.1016/j.cell.2006.05.040 · Cited by 454 · see citing works

Human SRF-related proteins: DNA-binding properties and potential regulatory targets.Preprint

Pollock, R. M., & Treisman, R. (1991) · Genes & Development · doi:10.1101/gad.5.12a.2327 · Cited by 426 · see citing works

The regulation of myogenin gene expression during the embryonic development of the mouse.Preprint

Yee, S., & Rigby, P. W. J. (1993) · Genes & Development · doi:10.1101/gad.7.7a.1277 · Cited by 423 · see citing works

Drosophila MEF2, a transcription factor that is essential for myogenesis.Preprint

Bour, B. A., O’Brien, M. A., Lockwood, W., Goldstein, E. S., Bodmer, R., Taghert, P. H., Abmayr, S. M., & Nguyen, H. T. (1995) · Genes & Development · doi:10.1101/gad.9.6.730 · Cited by 423 · see citing works

Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors.

Molkentin, J. D., & Olson, E. N. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9366 · Cited by 420 · see citing works

Histone deacetylase degradation andMEF2 activation promote the formation of slow-twitch myofibers

Potthoff, M. J., Wu, H., Arnold, M., Shelton, J. M., Backs, J., McAnally, J., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31960 · Cited by 416 · see citing works

Control of muscle development by dueling HATs and HDACs

McKinsey, T. A., Zhang, C. L., & Olson, E. N. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00224-0 · Cited by 414 · see citing works

Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growthPreprint

Sokol, N. S., & Ambros, V. (2005) · Genes & Development · doi:10.1101/gad.1356105 · Cited by 395 · see citing works

Divide, accumulate, differentiate: cell condensation in skeletal development revisited

Hall, B. K., & Miyake, T. (1995) · The International Journal of Developmental Biology · doi:10.1387/ijdb.8901191 · Cited by 385 · see citing works

Vasculogenesis and Angiogenesis as Mechanisms of Vascular Network Formation, Growth and Remodeling

Patan, S. (2000) · Journal of Neuro-Oncology · doi:10.1023/a:1006493130855 · Cited by 382 · see citing works

Mef2cis a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development

Dodou, E., Verzi, M. P., Anderson, J. P., Xu, S.-M., & Black, B. L. (2004) · Development · doi:10.1242/dev.01256 · Cited by 365 · see citing works

Induction of the neural crest: a multigene process

Knecht, A. K., & Bronner-Fraser, M. E. (2002) · Nature Reviews Genetics · doi:10.1038/nrg819 · Cited by 361 · see citing works

MATERNAL-ZYGOTIC GENE INTERACTIONS DURING FORMATION OF THE DORSOVENTRAL PATTERN IN DROSOPHILA EMBRYOS

Simpson, P. (1983) · Genetics · doi:10.1093/genetics/105.3.615 · Cited by 349 · see citing works

Yeast and apoptosis

Jin, C., & Reed, J. C. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm832 · Cited by 340 · see citing works

Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor

Naya, F. J., Black, B. L., Wu, H., Bassel‐Duby, R., Richardson, J. A., Hill, J. A., & Olson, E. N. (2002) · Nature Medicine · doi:10.1038/nm789 · Cited by 325 · see citing works

Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis

Gottlieb, P. D., Pierce, S. A., Sims, R. J., Yamagishi, H., Weihe, E., Harriss, J. V., Maika, S. D., Kuziel, W. A., King, H. L., Olson, E. N., et al. (2002) · Nature Genetics · doi:10.1038/ng866 · Cited by 320 · see citing works

Requirement of the MADS-box transcription factor MEF2C for vascular development

Lin, Q., Lu, J., Yanagisawa, H., Webb, R. C., Lyons, G. E., Richardson, J. A., & Olson, E. N. (1998) · Development · doi:10.1242/dev.125.22.4565 · Cited by 309 · see citing works

MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development

Boutz, P. L., Chawla, G., Stoilov, P., & Black, D. L. (2007) · Genes & Development · doi:10.1101/gad.1500707 · Cited by 304 · see citing works

Analysis of the Myogenin Promoter Reveals an Indirect Pathway for Positive Autoregulation Mediated by the Muscle-Specific Enhancer Factor MEF-2

Edmondson, D. G., Cheng, T. C., Cserjesi, P., Chakraborty, T., & Olson, E. N. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.9.3665 · Cited by 301 · see citing works

Toward transcriptional therapies for the failing heart: chemical screens to modulate genes

McKinsey, T. A., & Olson, E. N. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24144 · Cited by 288 · see citing works

A core transcriptional network for early mesoderm development in <i>Drosophila melanogaster</i>

Sandmann, T., Girardot, C., Brehme, M., Tongprasit, W., Stolc, V., & Furlong, E. E. M. (2007) · Genes &amp; Development · doi:10.1101/gad.1509007 · Cited by 286 · see citing works

Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure

Hayashi, M., Kim, S.-W., Imanaka‐Yoshida, K., Yoshida, T., Abel, E. D., Eliceiri, B. P., Yang, Y. C., Ulevitch, R. J., & Lee, J.-D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19890 · Cited by 279 · see citing works

Class II histone deacetylases: Structure, function, and regulation

Bertos, N., Wang, A. H., & Yang, X.-J. (2001) · Biochemistry and Cell Biology · doi:10.1139/o01-032 · Cited by 278 · see citing works

Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors.

Martin, J. F., Schwarz, J. J., & Olson, E. N. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.5282 · Cited by 272 · see citing works

Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation

Lyons, G., Micales, B. K., Schwarz, J. J., Martin, J., & Olson, E. N. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-08-05727.1995 · Cited by 271 · see citing works

Small changes in expression affect predisposition to tumorigenesis

Yan, H., Dobbie, Z., Gruber, S. B., Markowitz, S. D., Romans, K., Giardiello, F. M., Kinzler, K. W., & Vogelstein, B. (2001) · Nature Genetics · doi:10.1038/ng799 · Cited by 268 · see citing works

SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes

Berdeaux, R., Goebel, N., Banaszynski, L. A., Takemori, H., Wandless, T. J., Shelton, G. D., & Montminy, M. (2007) · Nature Medicine · doi:10.1038/nm1573 · Cited by 266 · see citing works

A signaling cascade involving endothelin-1, dHAND and Msx1 regulates development of neural-crest-derived branchial arch mesenchyme

Thomas, T., Kurihara, H., Yamagishi, H., Kurihara, Y., Yazaki, Y., Olson, E. N., & Srivastava, D. (1998) · Development · doi:10.1242/dev.125.16.3005 · Cited by 264 · see citing works

Apoptosis of T Cells Mediated by Ca 2+ -Induced Release of the Transcription Factor MEF2

Youn, H., Sun, L., Prywes, R., & Liu, J. O. (1999) · Science · doi:10.1126/science.286.5440.790 · Cited by 258 · see citing works

Separable Regulatory Elements Governing myogenin Transcription in Mouse Embryogenesis

Cheng, T.-C., Wallace, M., Merlie, J. P., & Olson, E. N. (1993) · Science · doi:10.1126/science.8392225 · Cited by 254 · see citing works

Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure

Hayashi, M., Kim, S.-W., Imanaka‐Yoshida, K., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419890 · Cited by 241 · see citing works

A Temporal Map of Transcription Factor Activity: Mef2 Directly Regulates Target Genes at All Stages of Muscle Development

Sandmann, T., Jensen, L. J., Jakobsen, J. S., Karzynski, M., Eichenlaub, M., Peer Bork, B., & Furlong, E. E. M. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.04.009 · Cited by 233 · see citing works

hMEF2C Gene Encodes Skeletal Muscle- and Brain-Specific Transcription Factors

McDermott, J. C., Cardoso, M. C., Yu, Y. T., Andrés, V., Leifer, D., Krainc, D., Lipton, S. A., & Nadal‐Ginard, B. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.4.2564 · Cited by 230 · see citing works

MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex.

Leifer, D., Krainc, D., Yu, Y. T., McDermott, J. C., Breitbart, R. E., Heng, J., Neve, R. L., Kosofsky, B. E., Nadal‐Ginard, B., & Lipton, S. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.4.1546 · Cited by 225 · see citing works

A Series of Mutations in the D-MEF2 Transcription Factor Reveal Multiple Functions in Larval and Adult Myogenesis in Drosophila

Ranganayakulu, G., Zhao, B., Dokidis, A., Molkentin, J. D., Olson, E. N., & Schulz, R. A. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1269 · Cited by 218 · see citing works

Regulation of Skeletal Muscle Sarcomere Integrity and Postnatal Muscle Function by Mef2c

Potthoff, M. J., Arnold, M., McAnally, J., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01187-07 · Cited by 218 · see citing works

A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing.

Martin, J. F., Miano, J. M., Hustad, C. M., Copeland, N. G., Jenkins, N. A., & Olson, E. N. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1647 · Cited by 216 · see citing works

HDAC7, a Thymus-Specific Class II Histone Deacetylase, Regulates Nur77 Transcription and TCR-Mediated Apoptosis

Dequiedt, F., Kasler, H. G., Fischle, W., Kiermer, V., Weinstein, M., HERNDIER, B. G., & Verdin, E. M. (2003) · Immunity · doi:10.1016/s1074-7613(03)00109-2 · Cited by 212 · see citing works

Regulation of the Nur77 Orphan Steroid Receptor in Activation-Induced Apoptosis

Woronicz, J. D., DeYoung, A. L., Calnan, B. J., Szychowski, S., Cheng, L. E., & Winoto, A. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.11.6364 · Cited by 210 · see citing works

Signaling Pathways Crucial for Craniofacial Development Revealed by Endothelin-A Receptor-Deficient Mice

Clouthier, D. E., Williams, S. C., Yanagisawa, H., Wieduwilt, M. J., Richardson, J. A., & Yanagisawa, M. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9527 · Cited by 208 · see citing works

SynGAP regulates spine formation

Vazquez, L. E., Chen, H.-J., Sokolova, I., Knuesel, I., & Kennedy, M. B. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3213-04.2004 · Cited by 203 · see citing works

Signaling chromatin to make muscle

McKinsey, T. A., Zhang, C. L., & Olson, E. N. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00389-7 · Cited by 198 · see citing works

The Saccharomyces cerevisiae MADS-Box Transcription Factor Rlm1 Is a Target for the Mpk1 Mitogen-Activated Protein Kinase Pathway

Dodou, E., & Treisman, R. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.1848 · Cited by 196 · see citing works

Foxh1 Is Essential for Development of the Anterior Heart Field

von Both, I., Silvestri, C., Erdemir, T., Lickert, H., Walls, J. R., Henkelman, R. M., Rossant, J., Harvey, R. P., Attisano, L., & Wrana, J. L. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.07.023 · Cited by 195 · see citing works

Antiapoptotic role of the p38 mitogen-activated protein kinase–myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation

Okamoto, S.-I., Krainc, D., Sherman, K., & Lipton, S. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.130502697 · Cited by 188 · see citing works

TheMef2cgene is a direct transcriptional target of myogenic bHLH and MEF2 proteins during skeletal muscle development

Wang, D., Valdez, M. R., McAnally, J., Richardson, J. A., & Olson, E. N. (2001) · Development · doi:10.1242/dev.128.22.4623 · Cited by 162 · see citing works

Cabin1 Represses MEF2-Dependent Nur77 Expression and T Cell Apoptosis by Controlling Association of Histone Deacetylases and Acetylases with MEF2

Youn, H., & Liu, J. O. (2000) · Immunity · doi:10.1016/s1074-7613(00)00010-8 · Cited by 161 · see citing works

Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1

Yang, C.-H., Ornatsky, O., McDermott, J. C., Cruz, T. F., & Prody, C. A. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.20.4771 · Cited by 161 · see citing works

Big Mitogen-Activated Protein Kinase (BMK1)/ERK5 Protects Endothelial Cells From Apoptosis

Pi, X., Chen, Y., & Berk, B. C. (2003) · Circulation Research · doi:10.1161/01.res.0000112406.27800.6f · Cited by 157 · see citing works

The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesisPreprint

Shen, H., McElhinny, A., Cao, Y., Gao, P., Liu, J., Bronson, R. T., Griffin, J. D., & Wu, L. (2006) · Genes & Development · doi:10.1101/gad.1383706 · Cited by 155 · see citing works

Transcriptional pathways in second heart field development

Black, B. L. (2007) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2007.01.001 · Cited by 155 · see citing works

The myogenic regulatory gene Mef2 is a direct target for transcriptional activation by Twist during Drosophila myogenesisPreprint

Cripps, R. M., Black, B. L., Zhao, B., Lien, C., Schulz, R. A., & Olson, E. N. (1998) · Genes & Development · doi:10.1101/gad.12.3.422 · Cited by 154 · see citing works

Calcineurin Enhances MEF2 DNA Binding Activity in Calcium-dependent Survival of Cerebellar Granule Neurons

Mao, Z., & Wiedmann, M. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.31102 · Cited by 150 · see citing works

Regulation of HDAC9 Gene Expression by MEF2 Establishes a Negative-Feedback Loop in the Transcriptional Circuitry of Muscle Differentiation

Haberland, M., Arnold, M., McAnally, J., Phan, D., Kim, Y., & Olson, E. N. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01415-06 · Cited by 149 · see citing works

D‐mef2 is a target for Tinman activation during Drosophila heart development

Gajewski, K. M., Kim, Y., Lee, Y. M., Olson, E. N., & Schulz, R. A. (1997) · The EMBO Journal · doi:10.1093/emboj/16.3.515 · Cited by 147 · see citing works

Myocardin is a direct transcriptional target of Mef2, Tead and Foxo proteins during cardiovascular development

Creemers, E. E., Sutherland, L. B., McAnally, J., Richardson, J. A., & Olson, E. N. (2006) · Development · doi:10.1242/dev.02610 · Cited by 146 · see citing works

Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancerPreprint

Charité, J., McFadden, D. G., Merlo, G. R., Levi, G., Clouthier, D. E., Yanagisawa, M., Richardson, J. A., & Olson, E. N. (2001) · Genes & Development · doi:10.1101/gad.931701 · Cited by 144 · see citing works

Specification of neural crest cell formation and migration in mouse embryos

Trainor, P. A. (2005) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2005.06.007 · Cited by 142 · see citing works

Protein Kinase D1 Phosphorylates HDAC7 and Induces Its Nuclear Export after T-cell Receptor Activation

Parra, M., Kasler, H. G., McKinsey, T. A., Olson, E. N., & Verdin, E. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m413396200 · Cited by 138 · see citing works

Presynaptic Development at the Drosophila Neuromuscular Junction: Assembly and Localization of Presynaptic Active Zones

Prokop, A., Landgraf, M., Rushton, E., Broadie, K., & Bate, M. (1996) · Neuron · doi:10.1016/s0896-6273(00)80195-6 · Cited by 138 · see citing works

Mef2s are required for thick filament formation in nascent muscle fibres

Hinits, Y., & Hughes, S. M. (2007) · Development · doi:10.1242/dev.007088 · Cited by 133 · see citing works

The Transcription Factor MEF2C Is Required for Craniofacial Development

Verzi, M. P., Agarwal, P., Brown, C., McCulley, D. J., Schwarz, J. J., & Black, B. L. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.03.007 · Cited by 129 · see citing works

BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart

Phan, D., Rasmussen, T. L., Nakagawa, O., McAnally, J., Gottlieb, P. D., Tucker, P. W., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2005) · Development · doi:10.1242/dev.01849 · Cited by 123 · see citing works

DrosophilaLame duck, a novel member of the Gli superfamily, acts as a key regulator of myogenesis by controlling fusion-competent myoblast development

Duan, H., Skeath, J. B., & Nguyen, H. T. (2001) · Development · doi:10.1242/dev.128.22.4489 · Cited by 119 · see citing works

Determination of the Consensus Binding Site for MEF2 Expressed in Muscle and Brain Reveals Tissue-specific Sequence Constraints

Andrés, V., Cervera, M., & Mahdavi, V. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.40.23246 · Cited by 116 · see citing works

Quantitative Discrimination of MEF2 Sites

Fickett, J. W. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.1.437 · Cited by 112 · see citing works

Myocyte Enhancer Binding Factor-2 Expression and Activity in Vascular Smooth Muscle Cells

Firulli, A. B., Miano, J. M., Bi, W., Johnson, A. D., Casscells, W., Olson, E. N., & Schwarz, J. J. (1996) · Circulation Research · doi:10.1161/01.res.78.2.196 · Cited by 105 · see citing works

The expression of MEF2 genes is implicated in CNS neuronal differentiation

Lin, X., Shah, S., & Bulleit, R. F. (1996) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00135-0 · Cited by 95 · see citing works

mef2ca is required in cranial neural crest to effect Endothelin1 signaling in zebrafish

Miller, C. T., Swartz, M. E., Khuu, P. A., Walker, M. B., Eberhart, J. K., & Kimmel, C. B. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.05.018 · Cited by 94 · see citing works

Mef2c is activated directly by Ets transcription factors through an evolutionarily conserved endothelial cell-specific enhancer

Val, S. D., Anderson, J. P., Heidt, A. B., Khiem, D., Xu, S.-M., & Black, B. L. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.08.016 · Cited by 83 · see citing works

Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytesPreprint

Parra, M., Mahmoudi, T., & Verdin, E. M. (2007) · Genes & Development · doi:10.1101/gad.1513107 · Cited by 78 · see citing works

Drosophila mef2Expression during Mesoderm Development Is Controlled by a Complex Array ofcis-Acting Regulatory Modules

Nguyen, H. T., & Xu, X. (1998) · Developmental Biology · doi:10.1006/dbio.1998.9081 · Cited by 75 · see citing works

A 40-Kilodalton Protein Binds Specifically to an Upstream Sequence Element Essential for Muscle-Specific Transcription of the Human Myoglobin Promoter

Bassel‐Duby, R., Hernandez, M. D., Gonzalez, M. A., Krueger, J. K., & Williams, R. S. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.11.5024 · Cited by 73 · see citing works

myoblasts incompetentencodes a zinc finger transcription factor required to specify fusion-competent myoblasts inDrosophila

Ruiz‐Gómez, M., Coutts, N., Suster, M. L., Landgraf, M., & Bate, M. (2002) · Development · doi:10.1242/dev.129.1.133 · Cited by 71 · see citing works

Disruption of MEF2 activity in cardiomyoblasts inhibits cardiomyogenesis

Karamboulas, C., Dakubo, G. D., Liu, J., Repentigny, Y. D., Yutzey, K. E., Wallace, V. A., Kothary, R., & Skerjanc, I. S. (2006) · Journal of Cell Science · doi:10.1242/jcs.03186 · Cited by 64 · see citing works

Generation of conditionalMef2cloxP/loxP mice for temporal- and tissue-specific analyses

Vong, L., Ragusa, M. J., & Schwarz, J. J. (2005) · genesis · doi:10.1002/gene.20152 · Cited by 63 · see citing works

Histone Deacetylase 7 Functions as a Key Regulator of Genes Involved in both Positive and Negative Selection of Thymocytes

Kasler, H. G., & Verdin, E. M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02091-06 · Cited by 63 · see citing works

The MEF2A 3′ Untranslated Region Functions as a cis -Acting Translational Repressor

Black, B. L., Lu, J., & Olson, E. N. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.5.2756 · Cited by 58 · see citing works

Positive autoregulation of the Myocyte enhancer factor-2 myogenic control gene during somatic muscle development in Drosophila

Cripps, R. M., Lovato, T. L., & Olson, E. N. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2003.12.004 · Cited by 57 · see citing works

PDP1, a novel Drosophila PAR domain bZIP transcription factor expressed in developing mesoderm, endoderm and ectoderm, is a transcriptional regulator of somatic muscle genes

Lin, S., Lin, M., Horváth, P., Reddy, K. L., & Storti, R. V. (1997) · Development · doi:10.1242/dev.124.22.4685 · Cited by 55 · see citing works

Sumoylation in neurons: nuclear and synaptic roles?

Scheschonka, A., Tang, Z., & Betz, H. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.01.003 · Cited by 53 · see citing works

Cellular and Molecular Events During Embryonic Bone Development

Bruder, S. P., & Caplan, A. I. (1989) · Connective Tissue Research · doi:10.3109/03008208909023875 · Cited by 50 · see citing works

Twist Is Required for Muscle Template Splitting during AdultDrosophilaMyogenesis

Cripps, R. M., & Olson, E. N. (1998) · Developmental Biology · doi:10.1006/dbio.1998.9040 · Cited by 49 · see citing works

Combinatorial control of Drosophila mef2 gene expression in cardiac and somatic muscle cell lineages

Gajewski, K. M., Kim, Y., Choi, C. Y., & Schulz, R. A. (1998) · Development Genes and Evolution · doi:10.1007/s004270050194 · Cited by 45 · see citing works

Expression of a MADS box gene, MEF2D, in neurons of the mouse central nervous system: implication of its binary function in myogenic and neurogenic cell lineages

Ikeshimaa, H., Imai, S., Shimoda, K., Hata, J.-I., & Takano, T. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12092-i · Cited by 44 · see citing works

Ectopic Expression of MEF2 in the Epidermis Induces Epidermal Expression of Muscle Genes and Abnormal Muscle Development inDrosophila

Lin, M., Bour, B. A., Abmayr, S. M., & Storti, R. V. (1997) · Developmental Biology · doi:10.1006/dbio.1996.8484 · Cited by 43 · see citing works

Mapping Dmef2-binding regulatory modules by using a ChIP-enriched in silico targets approach

Junion, G., Jagla, T., Duplant, S., Tapin, R., Ponte, J. P. D., & Jagla, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507030102 · Cited by 36 · see citing works

Undermining the endothelium by ablation of MAPK-MEF2 signaling

Olson, E. N. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21497 · Cited by 33 · see citing works

Undermining the endothelium by ablation of MAPK-MEF2 signaling

Olson, E. N. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421497 · Cited by 32 · see citing works

The Role of the CANNTG Promoter Element (E box) and the Myocyte‐enhancer‐binding‐factor‐2 (MEF‐2) Site in the Transcriptional Regulation of the Chick Myogenin Gene

Malik, S., Huang, C., & Schmidt, J. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.0088i.x · Cited by 30 · see citing works

A Novel Drosophila, mef2-Regulated Muscle Gene Isolated in a Subtractive Hybridisation-Based Molecular Screen Using Small Amounts of Zygotic Mutant RNA

Taylor, M. V. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9608 · Cited by 28 · see citing works

The MADS-box family of transcription factors

Shore, P., & Sharrocks, A. D. (1995) · Springer eBooks · doi:10.1007/978-3-642-85252-7_7 · Cited by 21 · see citing works

Pathogenesis of Liver Fibrosis

Hernandez-Gea, V., & Friedman, S. L. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130246 · Cited by 1,809 · see citing works

Building Muscle: Molecular Regulation of MyogenesisPreprint

Bentzinger, C. F., Wang, Y. X., & Rudnicki, M. A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008342 · Cited by 1,198 · see citing works

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

Bouhaddou, M., Memon, D., Meyer, B., White, K. M., Rezelj, V. V., Marrero, M. C., Polacco, B. J., Melnyk, J. E., Ulferts, S., Kaake, R. M., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.034 · Cited by 998 · see citing works

The oxytocin receptor: from intracellular signaling to behavior

Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works

Analysis of the coding genome of diffuse large B-cell lymphoma

Pasqualucci, L., Trifonov, V. A., Fabbri, G., Ma, J., Rossi, D., Chiarenza, A., Wells, V. A., Grunn, A., Messina, M., Elliott, O., et al. (2011) · Nature Genetics · doi:10.1038/ng.892 · Cited by 971 · see citing works

Regulation of energy metabolism by long-chain fatty acids

Nakamura, M., Yudell, B. E., & Loor, J. J. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.12.001 · Cited by 829 · see citing works

microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heartPreprint

Liu, N., Bezprozvannaya, S., Williams, A. H., Qi, X., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2008) · Genes & Development · doi:10.1101/gad.1738708 · Cited by 792 · see citing works

Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis

Vu, T., & Datta, P. K. (2017) · Cancers · doi:10.3390/cancers9120171 · Cited by 496 · see citing works

MicroRNA Regulatory Networks in Cardiovascular Development

Liu, N., & Olson, E. N. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.03.010 · Cited by 488 · see citing works

Genome-Wide Analysis of MEF2 Transcriptional Program Reveals Synaptic Target Genes and Neuronal Activity-Dependent Polyadenylation Site Selection

Flavell, S. W., Kim, T.-K., Gray, J. M., Harmin, D. A., Hemberg, M., Hong, E. J., Markenscoff-Papadimitriou, E., Bear, D. M., & Greenberg, M. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.029 · Cited by 440 · see citing works

Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia

Eze, U. C., Bhaduri, A., Haeussler, M., Nowakowski, T. J., & Kriegstein, A. R. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00794-1 · Cited by 427 · see citing works

An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133

Liu, N., Williams, A. H., Kim, Y., McAnally, J., Bezprozvannaya, S., Sutherland, L. B., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710558105 · Cited by 426 · see citing works

miR-206 and -486 Induce Myoblast Differentiation by Downregulating Pax7

Dey, B. K., Gagan, J. R., & Dutta, A. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01009-10 · Cited by 380 · see citing works

MicroRNA-133a Protects Against Myocardial Fibrosis and Modulates Electrical Repolarization Without Affecting Hypertrophy in Pressure-Overloaded Adult Hearts

Matkovich, S. J., Wang, W., Tu, Y., Eschenbacher, W. H., Dorn, L. E., Condorelli, G., Diwan, A., Nerbonne, J. M., & Dorn, G. W. (2009) · Circulation Research · doi:10.1161/circresaha.109.202176 · Cited by 381 · see citing works

MicroRNA control of muscle development and disease

Williams, A. H., Liu, N., van Rooij, E., & Olson, E. N. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.01.029 · Cited by 347 · see citing works

MicroRNAs flex their muscles

van Rooij, E., Liu, N., & Olson, E. N. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.01.007 · Cited by 334 · see citing works

Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis

Singh, A., Happel, C., Manna, S. K., Acquaah-Mensah, G., Carrerero, J., Kumar, S., Nasipuri, P., Krausz, K. W., Wakabayashi, N., Dewi, R., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66353 · Cited by 333 · see citing works

Long non-coding RNAs as emerging regulators of differentiation, development, and disease

Dey, B. K., Mueller, A. C., & Dutta, A. (2014) · Transcription · doi:10.4161/21541272.2014.944014 · Cited by 324 · see citing works

MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function

Barbosa, A. C., Kim, M.-S., Ertunc, M., Adachi, M., Nelson, E. D., McAnally, J., Richardson, J. A., Kavalali, E. T., Monteggia, L. M., Bassel-Duby, R., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802679105 · Cited by 303 · see citing works

Oxidative and nitrosative stress in Parkinson's disease

Tsang, A. H. K., & Chung, K. K. K. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.12.006 · Cited by 300 · see citing works

Cardiac-specific miRNA in cardiogenesis, heart function, and cardiac pathology (with focus on myocardial infarction)

Chistiakov, D. A., Orekhov, A. N., & Bobryshev, Y. V. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.03.015 · Cited by 275 · see citing works

Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7

Wang, S., Li, X.-M., Parra, M., Verdin, E. M., Bassel‐Duby, R., & Olson, E. N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802857105 · Cited by 268 · see citing works

NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

Yamamoto, H., Williams, E. G., Mouchiroud, L., Cantó, C., Fan, W., Downes, M., Héligon, C., Barish, G. D., Desvergne, B., Evans, R. M., et al. (2011) · Cell · doi:10.1016/j.cell.2011.10.017 · Cited by 261 · see citing works

An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training

Lindholm, M. E., Marabita, F., Gómez-Cabrero, D., Rundqvist, H., Ekström, T. J., Tegner, J. N., & Sundberg, C. J. (2014) · Epigenetics · doi:10.4161/15592294.2014.982445 · Cited by 250 · see citing works

Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers

Dos Santos, M., Backer, S., Saintpierre, B., Izac, B., Andrieu, M., Letourneur, F., Relaix, F., Sotiropoulos, A., & Maire, P. (2020) · Nature Communications · doi:10.1038/s41467-020-18789-8 · Cited by 259 · see citing works

Excitation‐transcription coupling in skeletal muscle: the molecular pathways of exercise

Gundersen, K. (2010) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2010.00161.x · Cited by 254 · see citing works

MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A

Urbich, C., Kaluza, D., Frömel, T., Knau, A., Bennewitz, K., Boon, R. A., Bonauer, A., Doebele, C., Boeckel, J., Hergenreider, E., et al. (2011) · Blood · doi:10.1182/blood-2011-08-373886 · Cited by 231 · see citing works

MiR-206, a Key Modulator of Skeletal Muscle Development and Disease

Ma, G., Wang, Y., Li, Y., Cui, L., Zhao, Y., Zhao, B., & Li, K. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.10921 · Cited by 231 · see citing works

Requirement of MEF2A, C, and D for skeletal muscle regeneration

Liu, N., Nelson, B. R., Bezprozvannaya, S., Shelton, J. M., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401732111 · Cited by 227 · see citing works

Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement

Jia, G., Preussner, J., Chen, X., Guenther, S., Yuan, X.-J., Yekelchyk, M., Kuenne, C., Looso, M., Zhou, Y., Teichmann, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07307-6 · Cited by 197 · see citing works

Regulation of Skeletal Muscle Sarcomere Integrity and Postnatal Muscle Function by Mef2c

Potthoff, M. J., Arnold, M., McAnally, J., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01187-07 · Cited by 218 · see citing works

miR-26a is required for skeletal muscle differentiation and regeneration in micePreprint

Dey, B. K., Gagan, J., Yan, Z., & Dutta, A. (2012) · Genes & Development · doi:10.1101/gad.198085.112 · Cited by 218 · see citing works

Unexpected repertoire of metazoan transcription factors in the unicellular holozoan Capsaspora owczarzaki

Sebe-Pedros, A., de Mendoza, A., Lang, B. F., Degnan, B. M., & Ruiz-Trillo, I. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msq309 · Cited by 195 · see citing works

The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe?

Vervoort, S. J., van Boxtel, R., & Coffer, P. J. (2012) · Oncogene · doi:10.1038/onc.2012.506 · Cited by 199 · see citing works

Microglial immune checkpoint mechanisms

Deczkowska, A., Amit, I., & Schwartz, M. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0145-x · Cited by 185 · see citing works

MEF2 transcription factors: developmental regulators and emerging cancer genes

Pon, J., & Marra, M. (2015) · OncoTarget · doi:10.18632/oncotarget.6223 · Cited by 182 · see citing works

Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS

Wang, W., Ha, C. H., Jhun, B. S., Wong, C. N., Jain, M. K., & Jin, Z. (2009) · Blood · doi:10.1182/blood-2009-05-224824 · Cited by 191 · see citing works

Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove

Garai, Á., Zeke, A., Gógl, G., Törő, I., Fördős, F., Blankenburg, H., Bárkai, T., Varga, J., Alexa, A., Emig, D., et al. (2012) · Science Signaling · doi:10.1126/scisignal.2003004 · Cited by 177 · see citing works

MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma

Ying, C. Y., Dominguez-Sola, D., Fabi, M., Lorenz, I. C., Hussein, S., Bansal, M., Califano, A., Pasqualucci, L., Basso, K., & Dalla‐Favera, R. (2013) · Nature Immunology · doi:10.1038/ni.2688 · Cited by 187 · see citing works

Coping with Endoplasmic Reticulum Stress in the Cardiovascular System

Groenendyk, J., Agellon, L. B., & Michalak, M. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183707 · Cited by 187 · see citing works

Mef2 and the skeletal muscle differentiation program

Taylor, M. V., & Hughes, S. M. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.11.020 · Cited by 181 · see citing works

Mutations in MEF2C from the 5q14.3q15 microdeletion syndrome region are a frequent cause of severe mental retardation and diminish MECP2 and CDKL5 expression

Zweier, M., Gregor, A., Zweier, C., Engels, H., Sticht, H., Wohlleber, E., Bijlsma, E. K., Holder, S., Zenker, M., Rossier, E., et al. (2010) · Human Mutation · doi:10.1002/humu.21253 · Cited by 180 · see citing works

Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation

Wilker, P. R., Kohyama, M., Sandau, M. M., Albring, J. C., Nakagawa, O., Schwarz, J. J., & MURPHY, K. M. M. (2008) · Nature Immunology · doi:10.1038/ni.1609 · Cited by 176 · see citing works

Diabetes impairs the angiogenic potential of adipose-derived stem cells by selectively depleting cellular subpopulations

Rennert, R. C., Sorkin, M., Januszyk, M., Duscher, D., Kosaraju, R. S., Chung, M. T., Lennon, J., Radiya-Dixit, A., Raghvendra, S., Maan, Z. N., et al. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt468 · Cited by 175 · see citing works

Aging disrupts cell subpopulation dynamics and diminishes the function of mesenchymal stem cells

Duscher, D., Rennert, R. C., Januszyk, M., Anghel, E. L., Maan, Z. N., Whittam, A. J., Perez, M. G., Kosaraju, R. S., Hu, M. S.-M., Walmsley, G. G., et al. (2014) · Scientific Reports · doi:10.1038/srep07144 · Cited by 169 · see citing works

Molecular Mechanisms of Skeletal Muscle Hypertrophy

Schiaffino, S., Reggiani, C., Akimoto, T., & Blaauw, B. (2020) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-200568 · Cited by 169 · see citing works

Transcriptional control of chondrocyte specification and differentiation

Liu, C.-F., Samsa, W. E., Zhou, G. D., & Lefèbvre, V. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.10.004 · Cited by 167 · see citing works

Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases

Nakamura, T., Prikhodko, O. A., Pirie, E., Nagar, S., Akhtar, M. W., Oh, C.-K., McKercher, S. R., Ambasudhan, R., Okamoto, S.-I., & Lipton, S. A. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.03.017 · Cited by 165 · see citing works

Atrial Identity Is Determined by a COUP-TFII Regulatory Network

Wu, S., Cheng, C.-M., Lanz, R. B., Wang, T., Respress, J. L., Ather, S., Chen, W., Tsai, S., Wehrens, X. H. T., Tsai, M., et al. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.04.017 · Cited by 164 · see citing works

microRNAs and muscle disorders

Chen, J., Callis, T. E., & Wang, D. (2008) · Journal of Cell Science · doi:10.1242/jcs.041723 · Cited by 158 · see citing works

Direct regulation of complex I by mitochondrial MEF2D is disrupted in a mouse model of Parkinson disease and in human patients

She, H., Yang, Q., Shepherd, K. R., Smith, Y., Miller, G. W., Testa, C. M., & Mao, Z. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43871 · Cited by 156 · see citing works

Evolution of Osteocrin as an activity-regulated factor in the primate brain

Ataman, B., Boulting, G. L., Harmin, D. A., Yang, M. G., Baker-Salisbury, M., Yap, E.-L., Malik, A. N., Mei, K., Rubin, A. A., Spiegel, I., et al. (2016) · Nature · doi:10.1038/nature20111 · Cited by 149 · see citing works

Specific Control of Pancreatic Endocrine β- and δ-Cell Mass by Class IIa Histone Deacetylases HDAC4, HDAC5, and HDAC9

Lenoir, O., Flosseau, K., Ma, F. X., Blondeau, B., Mai, A., Bassel‐Duby, R., Ravassard, P., Olson, E. N., Haumaître, C., & Scharfmann, R. (2011) · Diabetes · doi:10.2337/db11-0440 · Cited by 149 · see citing works

Nrf2 for cardiac protection: pharmacological options against oxidative stress

Chen, Q. M. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.06.005 · Cited by 145 · see citing works

MEF2C promotes M1 macrophage polarization and Th1 responses

Zhao, X., Di, Q., Liu, H., Quan, J., Jing, L., Zhao, Z., Xiao, Y., Wu, H. J., Wu, Z., Song, W., et al. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00841-w · Cited by 144 · see citing works

MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determination

Fazi, F., & Nervi, C. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn151 · Cited by 137 · see citing works

Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function

Shen, T., Aneas, I., Sakabe, N. J., Dirschinger, R. J., Wang, G., Smemo, S., Westlund, J. M., Cheng, H., Dalton, N., Gu, Y., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci59472 · Cited by 136 · see citing works

PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy

Ha, C. H., Kim, J., Zhao, J., Wang, W., Jhun, B. S., Wong, C. N., & Jin, Z. G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000462107 · Cited by 134 · see citing works

Sirt1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuating function of miR-34a

Wang, G., Wang, Y., Xiong, Y., Chen, X., Ma, M.-L., Cai, R., Gao, Y., Sun, Y., Yang, G.-S., & Pang, W.-J. (2016) · Scientific Reports · doi:10.1038/srep21865 · Cited by 134 · see citing works

Targeted deletion of Sost distal enhancer increases bone formation and bone mass

Collette, N. M., Genetos, D. C., Economides, A. N., Xie, L., Shahnazari, M., Yao, W., Lane, N. E., Harland, R. M., & Loots, G. G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207188109 · Cited by 132 · see citing works

Novel Small-Molecule PGC-1α Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice

Zhang, L., Zhou, H., Fu, Y., Li, Y., Wu, F., Gu, M., Wu, L., Xia, C.-M., Dong, T., Li, J.-Y., et al. (2012) · Diabetes · doi:10.2337/db12-0703 · Cited by 124 · see citing works

FoxO1: a novel insight into its molecular mechanisms in the regulation of skeletal muscle differentiation and fiber type specification

Xu, M., Chen, X., Chen, D., Yu, B., & Huang, Z. (2016) · Oncotarget · doi:10.18632/oncotarget.12891 · Cited by 119 · see citing works

Tissue-specific splicing of a ubiquitously expressed transcription factor is essential for muscle differentiationPreprint

Sebastian, S., Faralli, H., Yao, Z., Rakopoulos, P., Palii, C. G., Cao, Y., Singh, K., Liu, Q.-C., Chu, A., Aziz, A., et al. (2013) · Genes & Development · doi:10.1101/gad.215400.113 · Cited by 122 · see citing works

A p38 MAPK-MEF2C pathway regulates B-cell proliferation

Khiem, D., Cyster, J. G., Schwarz, J. J., & Black, B. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804868105 · Cited by 120 · see citing works

MEF2A regulates the Gtl2-Dio3 microRNA mega-cluster to modulate WNT signaling in skeletal muscle regeneration

Snyder, C. M., Rice, A., Estrella, N. L., Held, A., Kandarian, S. C., & Naya, F. J. (2012) · Development · doi:10.1242/dev.081851 · Cited by 119 · see citing works

Transcriptional regulation of hepatic stellate cells

Mann, J., & Mann, D. A. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.011 · Cited by 119 · see citing works

Does osteocytic SOST suppression mediate PTH bone anabolism?

Krämer, I., Keller, H., Leupin, O., & Kneissel, M. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.12.002 · Cited by 118 · see citing works

Neuronal MHC-I expression and its implications in synaptic function, axonal regeneration and Parkinson’s and other brain diseases

Cebrián, C., Loike, J. D., & Sulzer, D. L. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00114 · Cited by 119 · see citing works

Rbfox2-Coordinated Alternative Splicing of Mef2d and Rock2 Controls Myoblast Fusion during Myogenesis

Singh, R. K., Xia, Z., Bland, C. S., Kalsotra, A., Scavuzzo, M. A., Curk, T., Ule, J., Li, W., & Cooper, T. A. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.06.035 · Cited by 116 · see citing works

miRNAS in normal and diseased skeletal muscle

Eisenberg, I., Alexander, M. S., & Kunkel, L. M. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00524.x · Cited by 113 · see citing works

Fat body, fat pad and adipose tissues in invertebrates and vertebrates: the nexus

Azeez, O. I., Meintjes, R. A., & Chamunorwa, J. P. (2014) · Lipids in Health and Disease · doi:10.1186/1476-511x-13-71 · Cited by 115 · see citing works

Disruption of SIRT7 Increases the Efficacy of Checkpoint Inhibitor via MEF2D Regulation of Programmed Cell Death 1 Ligand 1 in Hepatocellular Carcinoma Cells

Xiang, J., Zhang, N., Sun, H., Su, L., Zhang, C., Xu, H., Feng, J., Wang, M., Chen, J., Liu, L., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.10.025 · Cited by 113 · see citing works

In Vivo Analysis of MEF2 Transcription Factors in Synapse Regulation and Neuronal Survival

Akhtar, M. W., Kim, M.-S., Adachi, M., Morris, M. J., Qi, X., Richardson, J. A., Bassel‐Duby, R., Olson, E. N., Kavalali, E. T., & Monteggia, L. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034863 · Cited by 113 · see citing works

Histone Methyltransferase G9a Is Required for Cardiomyocyte Homeostasis and Hypertrophy

Papait, R., Serio, S., Pagiatakis, C., Rusconi, F., Carullo, P., Mazzola, M., Salvarani, N., Miragoli, M., & Condorelli, G. (2017) · Circulation · doi:10.1161/circulationaha.117.028561 · Cited by 110 · see citing works

MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury

Calvente, C. J., Pilar, H. D., Tameda, M., Johnson, C. D., & Feldstein, A. E. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.09.013 · Cited by 111 · see citing works

MEF2C Haploinsufficiency features consistent hyperkinesis, variable epilepsy, and has a role in dorsal and ventral neuronal developmental pathways

Paciorkowski, A. R., Traylor, R. N., Rosenfeld, J. A., Hoover, J. M., Harris, C. J., Winter, S., Lacassie, Y., Bialer, M., Lamb, A. N., Schultz, R. A., et al. (2013) · neurogenetics · doi:10.1007/s10048-013-0356-y · Cited by 109 · see citing works

Evidence for pleiotropic factors in genetics of the musculoskeletal system

Karasik, D., & Kiel, D. P. (2010) · Bone · doi:10.1016/j.bone.2010.01.382 · Cited by 109 · see citing works

Exposure to blue light stimulates the proangiogenic capability of exosomes derived from human umbilical cord mesenchymal stem cells

Yang, K., Li, D., Wang, M., Xu, Z., Chen, X., Liu, Q., Sun, W., Li, J., Gong, Y., Liu, D., et al. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1472-x · Cited by 111 · see citing works

Regulation of GATA4 Transcriptional Activity in Cardiovascular Development and Disease

Zhou, P., He, A., & Pu, W. T. (2012) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-387786-4.00005-1 · Cited by 106 · see citing works

MEF2B Instructs Germinal Center Development and Acts as an Oncogene in B Cell Lymphomagenesis

Brescia, P., Schneider, C., Holmes, A. B., Shen, Q. “., Hussein, S., Pasqualucci, L., Basso, K., & Dalla‐Favera, R. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.08.006 · Cited by 105 · see citing works

The exercise-inducible bile acid receptor Tgr5 improves skeletal muscle function in mice

Sasaki, T., Kuboyama, A., Mita, M., Murata, S., Shimizu, M., Inoue, J., Mori, K., & Sato, R. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002733 · Cited by 105 · see citing works

Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells

Gardiner, E. J., Cairns, M. J., Liu, B., Beveridge, N. J., Carr, V. J., Kelly, B. J., Scott, R. J., & Tooney, P. A. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.11.007 · Cited by 103 · see citing works

Histone Deacetylase Inhibitors as Novel Anticancer Therapeutics

Walkinshaw, D. R., & Yang, X. (2008) · Current Oncology · doi:10.3747/co.v15i5.371 · Cited by 102 · see citing works

Protein Kinase D1 Stimulates MEF2 Activity in Skeletal Muscle and Enhances Muscle Performance

Kim, M.-S., Fielitz, J., McAnally, J., Shelton, J. M., Lemon, D. D., McKinsey, T. A., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00189-08 · Cited by 102 · see citing works

Diversity of Cnidarian Muscles: Function, Anatomy, Development and Regeneration

Leclère, L., & Röttinger, É. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00157 · Cited by 100 · see citing works

The Ubiquitin-Like SUMO System and Heart Function

Mendler, L., Braun, T. W., & Müller, S. P. (2016) · Circulation Research · doi:10.1161/circresaha.115.307730 · Cited by 102 · see citing works

MEF2B-Nox1 Signaling Is Critical for Stretch-Induced Phenotypic Modulation of Vascular Smooth Muscle Cells

Rodríguez, A. I., Csányi, G., Ranayhossaini, D. J., Feck, D. M., Blose, K. J., Assatourian, L., Vorp, D. A., & Pagano, P. J. (2015) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.114.304936 · Cited by 100 · see citing works

MEF2 Transcription Factors Regulate Distinct Gene Programs in Mammalian Skeletal Muscle Differentiation

Estrella, N. L., Desjardins, C. A., Nocco, S. E., Clark, A. L., Maksimenko, Y. M., & Naya, F. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.589838 · Cited by 101 · see citing works

MicroRNA identity and abundance in porcine skeletal muscles determined by deep sequencing

Nielsen, M. M., Hansen, J., Hedegaard, J., Nielsen, R. O., Panitz, F., Bendixen, C., & Thomsen, B. (2009) · Animal Genetics · doi:10.1111/j.1365-2052.2009.01981.x · Cited by 97 · see citing works

The Function of the MEF2 Family of Transcription Factors in Cardiac Development, Cardiogenomics, and Direct Reprogramming

Desjardins, C. A., & Naya, F. J. (2016) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd3030026 · Cited by 99 · see citing works

The Tumor Suppressor Kinase LKB1 Activates the Downstream Kinases SIK2 and SIK3 to Stimulate Nuclear Export of Class IIa Histone Deacetylases

Walkinshaw, D. R., Weist, R., Kim, G.-W., You, L., Xiao, L., Nie, J., Li, C. S., Zhao, S., Xu, M., & Yang, X. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.456996 · Cited by 98 · see citing works

Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome

Tian, Y., Voineagu, I., Paşca, S. P., Won, H., Chandran, V., Horvath, S., Dolmetsch, R. E., & Geschwind, D. H. (2014) · Genome Medicine · doi:10.1186/s13073-014-0075-5 · Cited by 93 · see citing works

The Mef2 Transcription Network Is Disrupted in Myotonic Dystrophy Heart Tissue, Dramatically Altering miRNA and mRNA Expression

Kalsotra, A., Singh, R. K., Gurha, P., Ward, A. J., Creighton, C. J., & Cooper, T. A. (2014) · Cell Reports · doi:10.1016/j.celrep.2013.12.025 · Cited by 93 · see citing works

MicroRNAs in cardiomyocyte development

Malizia, A. P., & Wang, D. (2010) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.111 · Cited by 95 · see citing works

Intrinsic Sex Differences in the Early Growth Hormone Responsiveness of Sex-Specific Genes in Mouse Liver

Wauthier, V., Sugathan, A., Meyer, R., Dombkowski, A. A., & Waxman, D. J. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0454 · Cited by 88 · see citing works

MiR-135b-5p and MiR-499a-3p Promote Cell Proliferation and Migration in Atherosclerosis by Directly Targeting MEF2C

Xu, Z., Han, Y., Liu, J., Jiang, F., Hu, H., Wang, Y., Liu, Q., Gong, Y., & Li, X. (2015) · Scientific Reports · doi:10.1038/srep12276 · Cited by 94 · see citing works

Research Resource: The Androgen Receptor Modulates Expression of Genes with Critical Roles in Muscle Development and Function

Wyce, A., Bai, Y., Nagpal, S., & Thompson, C. C. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0138 · Cited by 94 · see citing works

MHCI Requires MEF2 Transcription Factors to Negatively Regulate Synapse Density during Development and in Disease

Elmer, B. M., Estes, M. L., Barrow, S. L., & McAllister, A. K. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2366-13.2013 · Cited by 88 · see citing works

Emerging roles for MEF2 in brain development and mental disorders

Assali, A., Harrington, A. J., & Cowan, C. W. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.04.008 · Cited by 92 · see citing works

Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart

Planavila, A., Domínguez, E., Navarro, M., Vinciguerra, M., Iglesias, R., Giralt, M., Lope‐Piedrafita, S., Ruberte, J., & Villarroya, F. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.07.019 · Cited by 92 · see citing works

Regulation and function of myocyte enhancer factor 2 (MEF2) in myogenic and neurogenic cells

Salma, J. (2013) · York University Digital Library (York University)

TRANSCRIPTIONAL CONTROL OF MUSCLE DEVELOPMENT BY MYOCYTE ENHANCER FACTOR-2 (MEF2) PROTEINS

Black, B. L., & Olson, E. N. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.167 · Cited by 1,037 · see citing works

Regulation of Transcriptional Factor MEF2 to Multiple Signal Conduction Pathways and Biological Functions

Wen, Z. Y. (2004) · Zhongguo shengwu huaxue yu fenzi shengwu xuebao

Role of human Myocyte Enhancer Factor 2 (MEF2) proteins in cancer: structural insights, functional diversity, and regulatory mechanisms

Khandelwal, A., Fathi, A. H., Shetty, S., Mukhopadhyay, A., Devi, V., & Kabekkodu, S. P. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03995-5 · Cited by 4 · see citing works

Myocyte Enhancer Factor 2A Is Transcriptionally Autoregulated

Ramachandran, B., Yu, G.-S., Li, S., Zhu, B., & Gulick, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707623200 · Cited by 34 · see citing works