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Estimation of Extended Mixed Models Using Latent Classes and Latent Processes: The R Package lcmm

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Proust-Lima, Cécile, Philipps, Viviane, Liquet, Benoit·2017·Journal of Statistical Software

Abstract

The R package lcmm provides a series of functions to estimate statistical models based on linear mixed model theory. It includes the estimation of mixed models and latent class mixed models for Gaussian longitudinal outcomes (hlme), curvilinear and ordinal univariate longitudinal outcomes (lcmm) and curvilinear multivariate outcomes (multlcmm), as well as joint latent class mixed models (Jointlcmm) for a (Gaussian or curvilinear) longitudinal outcome and a time-to-event outcome that can be possibly left-truncated right-censored and defined in a competing setting. Maximum likelihood esimators are obtained using a modified Marquardt algorithm with strict convergence criteria based on the parameters and likelihood stability, and on the negativity of the second derivatives. The package also provides various post-fit functions including goodness-of-fit analyses, classification, plots, predicted trajectories, individual dynamic prediction of the event and predictive accuracy assessment. This paper constitutes a companion paper to the package by introducing each family of models, the estimation technique, some implementation details and giving examples through a dataset on cognitive aging.

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Metadata

Authors
Proust-Lima, C., Philipps, V., & Liquet, B.
Venue
Journal of Statistical Software
Published
2017
Volume
78
Issue
2
ISSN
1548-7660 (ISSN-L)
OpenAlex
W1480271113
Cited by
1,106
References
38
FWCI
38.26
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Estimation of Extended Mixed Models Using Latent Classes and Latent Processes: The R Package lcmm. https://app.cochat.ai/papers/10.18637/jss.v078.i02
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Proust-Lima, C., Philipps, V., & Liquet, B. (2017). Estimation of Extended Mixed Models Using Latent Classes and Latent Processes: The R Package lcmm. Journal of Statistical Software. https://doi.org/10.18637/jss.v078.i02

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