The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Toxicity of glyphosate-based pesticides to four North American frog species
Abstract
Gyphosate-basedherbicides are among the most widely used pesticides in the world. We compared the acute toxicity of the glyphosate end-use formulation Roundup Original® to four North American amphibian species (Rana clamitans, R. pipiens, R. sylvatica, and Bufo americanus) and the toxicity of glyphosate technical, the polyethoxylated tallowamine surfactant (POEA) commonly used in glyphosate-based herbicides, and five newer glyphosate formulations to R. clamitans. For R. clamitans, acute toxicity values in order of decreasing toxicity were POEA > Roundup Original > Roundup Transorb® > Glyfos AU®; no significant acute toxicity was observed with glyphosate technical material or the glyphosate formulations Roundup Biactive®, Touchdown®, or Glyfos BIO®. Comparisons between the four amphibian species showed that the toxicity of Roundup Original varied with species and developmental stage. Rana pipiens tadpoles chronically exposed to environmentally relevant concentrations of POEA or glyphosate formulations containing POEA showed decreased snout-vent length at metamorphosis and increased time to metamorphosis, tail damage, and gonadal abnormalities. These effects may be caused, in some part, by disruption of hormone signaling, because thyroid hormone receptor β mRNA transcript levels were elevated by exposure to formulations containing glyphosate and POEA. Taken together, the data suggest that surfactant composition must be considered in the evaluation of toxicity of glyphosate-based herbicides.
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Cites
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Cited by
Worldwide pesticide usage and its impacts on ecosystem
Sharma, A., Kumar, V., Shahzad, B., Tanveer, M., Sidhu, G. P. S., Handa, N., Kohli, S. K., Yadav, P., Bali, A. S., Parihar, R. D., et al. (2019) · SN Applied Sciences · doi:10.1007/s42452-019-1485-1 · Cited by 2,057
Five Potential Consequences of Climate Change for Invasive Species
HELLMANN, J. J., BYERS, J. E., BIERWAGEN, B. G., & DUKES, J. S. (2008) · Conservation Biology · doi:10.1111/j.1523-1739.2008.00951.x · Cited by 1,435
The cause of global amphibian declines: a developmental endocrinologist's perspective
Hayes, T. B., Falso, P., Gallipeau, S., & Stice, M. (2010) · Journal of Experimental Biology · doi:10.1242/jeb.040865 · Cited by 451
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Self-citationComparative effects of the Roundup and glyphosate on mitochondrial oxidative phosphorylation
Peixoto, F. (2005) · Chemosphere · doi:10.1016/j.chemosphere.2005.03.044 · Cited by 259
Metadata
- Authors
- Howe, C. M., Berrill, M., Pauli, B. D., Helbing, C. C., Werry, K., & Veldhoen, N.
- Venue
- Environmental Toxicology and Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-08-01
- Volume
- 23
- Issue
- 8
- Pages
- 1928-1938
- ISSN
- 0730-7268 (ISSN-L)
- 1552-8618
- OpenAlex
- W2033532463
- Cited by
- 468
- References
- 25
- FWCI
- 9.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Howe, C. M., Berrill, M., Pauli, B. D., Helbing, C. C., Werry, K., & Veldhoen, N. (2004). Toxicity of glyphosate-based pesticides to four North American frog species. Environmental Toxicology and Chemistry. https://doi.org/10.1897/03-71
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