The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Receptor for Advanced Glycation End Products, Inflammation, and Accelerated Periodontal Disease in Diabetes: Mechanisms and Insights Into Therapeutic Modalities
Abstract
In hyperglycemic states found in diabetics, a nonenzymatic glycation and oxidation of proteins and lipids occurs. As a result, advanced glycation end products (AGEs), particularly N ∊ ‐(carboxymethyl) lysine, accumulate in the plasma and tissues of diabetic subjects. This accumulation has been linked to the development of pathogenic complications of diabetes. Many of the effects of AGEs are receptor‐dependent and involve a multi‐ligand member of the immunoglobulin superfamily of cell surface molecules. The best characterized of these is the receptor for advanced glycation end products (RAGE), which is expressed by multiple cell types including endothelium and mononuclear phagocytes. Based on data from a variety of sources, including studies of RAGE‐deficient mice, it appears that RAGE plays a central role in oral infection, exaggerated inflammatory host responses, and destruction of alveolar bone in diabetes. It is possible that antagonists of RAGE might have a valuable adjunctive therapeutic role for the management of periodontal disease found in diabetics. Ann Periodontol 2001;6:113‐118.
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Schmidt, A. M., Hori, O., Chen, J. X., Li, J. F., Crandall, J., Zhang, J., Cao, R., Yan, S. D., Brett, J., & Stern, D. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118175 · Cited by 896
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Cited by
Understanding RAGE, the receptor for advanced glycation end products
Bierhaus, A., Humpert, P. M., Morcos, M., Wendt, T., Chavakis, T., Arnold, B., Stern, D. M., & Nawroth, P. P. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0688-7 · Cited by 1,297
Self-citationA prospective study of social support, anger expression and risk of periodontitis in men
MERCHANT, A. T., PITIPHAT, W., AHMED, B., KAWACHI, I., & JOSHIPURA, K. (2003) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2003.0104 · Cited by 114
Metadata
- Authors
- Lalla, E., Lamster, I. B., Stern, D. M., & Schmidt, A. M.
- Venue
- Annals of Periodontology
- Publisher
- Wiley
- Published
- 2001-12
- Volume
- 6
- Issue
- 1
- Pages
- 113-118
- ISSN
- 1553-0841 (ISSN-L)
- 2162-5131
- OpenAlex
- W2160339712
- Cited by
- 178
- References
- 1
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lalla, E., Lamster, I. B., Stern, D. M., & Schmidt, A. M. (2001). Receptor for Advanced Glycation End Products, Inflammation, and Accelerated Periodontal Disease in Diabetes: Mechanisms and Insights Into Therapeutic Modalities. Annals of Periodontology. https://doi.org/10.1902/annals.2001.6.1.113
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
