Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.
Open accessAbstract
Vascular cell adhesion molecule-1 (VCAM-1), an inducible cell-cell recognition protein on the endothelial cell surface (EC), has been associated with early stages of atherosclerosis. In view of the accelerated vascular disease observed in patients with diabetes, and the enhanced expression of VCAM-1 in diabetic rabbits, we examined whether irreversible advanced glycation endproducts (AGEs), could mediate VCAM-1 expression by interacting with their endothelial cell receptor (receptor for AGE, RAGE). Exposure of cultured human ECs to AGEs induced expression of VCAM-1, increased adhesivity of the monolayer for Molt-4 cells, and was associated with increased levels of VCAM-1 transcripts. The inhibitory effect of anti-RAGE IgG, a truncated form of the receptor (soluble RAGE) or N-acetylcysteine on VCAM-1 expression indicated that AGE-RAGE-induced oxidant stress was central to VCAM-1 induction. Electrophoretic mobility shift assays on nuclear extracts from AGE-treated ECs showed induction of specific DNA binding activity for NF-kB in the VCAM-1 promoter, which was blocked by anti-RAGE IgG or N-acetylcysteine. Soluble VCAM-1 antigen was elevated in human diabetic plasma. These data are consistent with the hypothesis that AGE-RAGE interaction induces expression of VCAM-1 which can prime diabetic vasculature for enhanced interaction with circulating monocytes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Excessive AGE formation is particularly associated with cross-linking of matrix proteins such as collagen, vitronectin, and laminin.
“Excessive AGE formation is particularly associated with cross-linking of matrix proteins such as collagen, vitronectin, and laminin.[2,10,11]”
From The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction (2021) · cites this paper as [11]
Binding of AGEs to RAGE enhances the expression of adhesion molecules on endothelial cells to promote the migration and differentiation of monocytes into macrophages.
“Binding of AGEs to the receptor for AGE (RAGE) enhances the expression of adhesion molecules on endothelial cells to promote the migration and differentiation of monocytes into macrophages.”
From The Vasculature in Prediabetes (2018) · cites this paper as [60]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,725 · see citing works
Jaffe, E. A., Nachman, R., Becker, C. G., & Minick, C. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107470 · Cited by 7,146 · see citing works
Schreiber, E. H., Matthias, P., Müller, M. M., & Schaffner, W. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.15.6419 · Cited by 4,179 · see citing works
Schreck, R., RIEBER, P., & Baeuerle, P. A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07761.x · Cited by 3,816 · see citing works
Role of Oxidative Stress in Development of Complications in Diabetes
Baynes, J. (1991) · Diabetes · doi:10.2337/diab.40.4.405 · Cited by 3,791 · see citing works
Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications
Flier, J. S., Underhill, L. H., Brownlee, M., Cerami, A., & Vlassara, H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805193182007 · Cited by 2,512 · see citing works
Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis
Cybulsky, M. I., & Gimbrone, M. A. (1991) · Science · doi:10.1126/science.1990440 · Cited by 1,710 · see citing works
Neeper, M. P., Schmidt, A. M., Brett, J., Yan, S. D., Wang, F., Pan, Y., Elliston, K. O., Stern, D., & SHAW, A. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42138-2 · Cited by 1,542 · see citing works
Self-citationYan, S. D., Schmidt, A. M., Anderson, G. M., Zhang, J., Brett, J., Zou, Y., Pinsky, D. J., & Stern, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36966-1 · Cited by 1,305 · see citing works
Self-citationCytokines and endothelial cell biology
Pober, J. S., & Cotran, R. S. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.427 · Cited by 1,251 · see citing works
Structure Elucidation of a Senescence Cross-Link from Human Extracellular Matrix
Sell, D. R., & Monnier, V. M. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)88225-8 · Cited by 1,082 · see citing works
Marui, N., Offermann, M. K., Swerlick, R., Kunsch, C., Rosen, C. A., Ahmad, M., Alexander, R. W., & Medford, R. M. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116778 · Cited by 1,072 · see citing works
Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils
Kodama, T., Freeman, M. W., Rohrer, L., Zabrecky, J. R., Matsudaira, P. T., & Krieger, M. (1990) · Nature · doi:10.1038/343531a0 · Cited by 1,039 · see citing works
Schmidt, A. M., Vianna, M., Gerlach, M. L., Brett, J., Ryan, J., Kao, J. J., Esposito, C., Hegarty, H. M., Hurley, W. L., & Clauss, M. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42137-0 · Cited by 833 · see citing works
Self-citationHuman Endothelial Cells: Use of Heparin in Cloning and Long-Term Serial Cultivation
Thornton, S. C., Mueller, S. N., & Levine, E. M. (1983) · Science · doi:10.1126/science.6635659 · Cited by 800 · see citing works
O’Brien, K. D., Allen, M. D., McDonald, T. O., Chait, A., Harlan, J. M., Fishbein, D., McCarty, J. M., Ferguson, M. S., Hudkins, K. L., & Benjamin, C. D. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116670 · Cited by 701 · see citing works
Mullarkey, C. J., Edelstein, D., & Brownlee, M. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80875-7 · Cited by 691 · see citing works
Li, H., Cybulsky, M. I., Gimbrone, M. A., & Libby, P. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.2.197 · Cited by 686 · see citing works
Schmidt, A. M., Hori, O., Brett, J., Yan, S. D., Wautier, J., & Stern, D. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.10.1521 · Cited by 636 · see citing works
Self-citationCachectin/TNF and IL-1 Induced by Glucose-Modified Proteins: Role in Normal Tissue Remodeling
Vlassara, H., Brownlee, M., Manogue, K. R., Dinarello, C. A., & Pasagian, A. (1988) · Science · doi:10.1126/science.3259727 · Cited by 597 · see citing works
Free radicals mediate endothelial cell dysfunction caused by elevated glucose
Tesfamariam, B., & Cohen, R. A. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.263.2.h321 · Cited by 558 · see citing works
Hunt, J. V., Smith, C. C., & Wolff, S. P. (1990) · Diabetes · doi:10.2337/diab.39.11.1420 · Cited by 553 · see citing works
Carlos, T., Schwartz, B., Kovach, N. L., Yee, E., Rosa, M., Osborn, L., Chi-Rosso, G., Newman, B., Lobb, R. R., & Rosa, M. R. M. C. T. (1990) · Blood · doi:10.1182/blood.v76.5.965.965 · Cited by 527 · see citing works
Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion.
Collins, T. (1993) · PubMed · Cited by 526 · see citing works
A role for oxygen radicals as second messengers
Schreck, R., & Baeuerle, P. A. (1991) · Trends in Cell Biology · doi:10.1016/0962-8924(91)90072-h · Cited by 496 · see citing works
Functional analysis of the human vascular cell adhesion molecule 1 promoter.
Neish, A. S., Williams, A. J., Palmer, H. J., Whitley, M. Z., & Collins, T. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.6.1583 · Cited by 416 · see citing works
Gearing, A. J. H., Hemingway, I., PIGOIT, R., Hughes, J., Rees, A. J., & Cashman, S. J. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb51633.x · Cited by 399 · see citing works
Esposito, C., Gerlach, H., Brett, J., Stern, D., & Vlassara, H. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.170.4.1387 · Cited by 380 · see citing works
Self-citationGlucose and diabetic vascular disease 1
Ruderman, N. B., Williamson, J. R., & Brownlee, M. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.11.1644256 · Cited by 375 · see citing works
Kirstein, M., Brett, J., Radoff, S., Ogawa, S., Stern, D., & Vlassara, H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.22.9010 · Cited by 364 · see citing works
Self-citationSchmidt, A. M., Hasu, M., Popov, D., Zhang, J. H., Chen, J., Yan, S. D., Brett, J., Cao, R. Y., Kuwabara, K., & Costache, G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8807 · Cited by 327 · see citing works
Self-citationSuperoxide production from nonenzymatically glycated protein
Sakurai, T., & Tsuchiya, S. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80066-8 · Cited by 304 · see citing works
Schmidt, A. M., Yan, S. D., Brett, J., Mora, R., Nowygrod, R., & Stern, D. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116442 · Cited by 297 · see citing works
Self-citationNakamura, Y., Horii, Y., Nishino, T., Shiiki, H., Sakaguchi, Y., Kagoshima, T., Dohi, K., Makita, Z., Vlassara, H., & Bucala, R. (1993) · PubMed Central · Cited by 283 · see citing works
Santisteban, P., Kohn, L. D., & Lauro, R. D. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61309-2 · Cited by 192 · see citing works
Yang, Z., Makita, Z., Horii, Y., Brunelle, S., Cerami, A., Sehajpal, P. K., Suthanthiran, M., & Vlassara, H. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.3.515 · Cited by 191 · see citing works
Richardson, M., Hadcock, S. J., Dereske, M., & Cybulsky, M. I. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.5.760 · Cited by 150 · see citing works
Evolving natural history of coronary artery disease in diabetes mellitus
Królewski, A. S., Warram, J. H., Valsania, P., Martin, B. C., Laffel, L. M., & Christlieb, A. R. (1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)90040-5 · Cited by 143 · see citing works
Sasseville, V. G., Newman, W., Lackner, A. A., Smith, M. O., Lausen, N., Beall, D., & Ringler, D. J. (1992) · PubMed Central · Cited by 126 · see citing works
Catalysis of lipid peroxidation by glucose and glycosylated collagen
Hicks, M., Delbridge, L., Yue, D. K., & Reeve, T. S. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80330-9 · Cited by 92 · see citing works
Iademarco, M. F., McQuillan, J. J., & Dean, D. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.3943 · Cited by 86 · see citing works
Diabetes and coronary artery disease
Factor, S. M., Segal, B. H., & van Hoeven, K. H. (1992) · Coronary Artery Disease · doi:10.1097/00019501-199201000-00002 · Cited by 18 · see citing works
Cellular Receptors for Advanced Glycation Endproducts
Schmidt, A. M., & Stern, D. (2005) · Elsevier eBooks · doi:10.1533/9781845698393.4.262 · Cited by 16 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works
Oxidative stress and diabetic complications
Giacco, F., & Brownlee, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.223545 · Cited by 5,461 · see citing works
The Pathobiology of Diabetic Complications
Brownlee, M. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1615 · Cited by 5,339 · see citing works
The Free Radical Theory of Aging Matures
BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879 · see citing works
Mechanisms of Diabetic Complications
Forbes, J. M., & Cooper, M. E. (2013) · Physiological Reviews · doi:10.1152/physrev.00045.2011 · Cited by 2,890 · see citing works
Advanced Glycation End Products: Sparking the Development of Diabetic Vascular Injury
Goldin, A., Beckman, J. A., Schmidt, A. M., & Creager, M. A. (2006) · Circulation · doi:10.1161/circulationaha.106.621854 · Cited by 2,261 · see citing works
Self-citationEndothelial cells in physiology and in the pathophysiology of vascular disorders.
Cines, D. B., Pollak, E. S., Buck, C. A., Loscalzo, J., Zimmerman, G. A., McEver, R. P., Pober, J. S., Wick, T. M., Konkle, B. A., Schwartz, B. S., et al. (1998) · PubMed · doi:10.1182/blood.v91.10.3527 · Cited by 2,244 · see citing works
Self-citationRAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012 · see citing works
Self-citationRAGE Mediates a Novel Proinflammatory Axis
Hofmann, M. A., Drury, S., Fu, C., Qu, W., Taguchi, A., Lu, Y., Avila, C., Kambham, N., Bierhaus, A., Nawroth, P., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80801-6 · Cited by 1,864 · see citing works
Self-citationPark, J. S., Svetkauskaite, D., He, Q., Kim, J., Strassheim, D., Ishizaka, A., & Abraham, E. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306793200 · Cited by 1,560 · see citing works
Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis
Förstermann, U., Xia, N., & Li, H. (2017) · Circulation Research · doi:10.1161/circresaha.116.309326 · Cited by 1,519 · see citing works
Advanced Glycation End Products and Diabetic Complications
Singh, V. P., Bali, A., Singh, N., & Jaggi, A. S. (2014) · The Korean Journal of Physiology & Pharmacology · doi:10.4196/kjpp.2014.18.1.1 · Cited by 1,518 · see citing works
Molecular mechanisms of N-acetylcysteine actions
Zafarullah, M., Li, W. Q., Sylvester, J., & Ahmad, M. (2003) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s000180300001 · Cited by 1,343 · see citing works
The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
Schmidt, A. M., Yan, S. D., Yan, S. F., & Stern, D. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14002 · Cited by 1,256 · see citing works
Self-citationOxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus
Tangvarasittichai, S. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i3.456 · Cited by 1,238 · see citing works
Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes
Forbes, J. M., Coughlan, M. T., & Cooper, M. E. (2008) · Diabetes · doi:10.2337/db08-0057 · Cited by 1,203 · see citing works
The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin
Hori, O., Brett, J., Slattery, T., Cao, R., Zhang, J., Chen, J. X., Nagashima, M., Lundh, E. R., Vijay, S., Nitecki, D., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.43.25752 · Cited by 1,151 · see citing works
Self-citationInflammation in diabetic retinopathy
Tang, J. C. O., & Kern, T. S. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.05.002 · Cited by 1,118 · see citing works
Park, L., Raman, K. G., Lee, K. J., Lu, Y., Ferran, L. J., Chow, W. S., Stern, D. M., & Schmidt, A. M. (1998) · Nature Medicine · doi:10.1038/2012 · Cited by 1,103 · see citing works
Self-citationAdvanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus
Nowotny, K., Jung, T., Höhn, A., Weber, D., & Grune, T. (2015) · Biomolecules · doi:10.3390/biom5010194 · Cited by 1,095 · see citing works
Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE
Wautier, M., Chappey, O., Corda, S., Stern, D. M., Schmidt, A. M., & Wautier, J. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.5.e685 · Cited by 1,076 · see citing works
Self-citationBasta, G. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.05.001 · Cited by 996 · see citing works
Kislinger, T., Fu, C., Huber, B., Qu, W., Taguchi, A., Yan, S. D., Hofmann, M. A., Yan, S. F., Pischetsrieder, M., Stern, D. M., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.44.31740 · Cited by 868 · see citing works
Self-citationRedox Regulation of NF-kappa B Activation
Flohé, L., Brigelius‐Flohé, R., Saliou, C., Traber, M. G., & Packer, L. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00501-1 · Cited by 859 · see citing works
Diabetes-Associated Sustained Activation of the Transcription Factor Nuclear Factor-κB
Bierhaus, A., Schiekofer, S., Schwaninger, M., Andrassy, M., Humpert, P. M., Chen, J., Hong, M., Luther, T., Henle, T., Klöting, I., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.12.2792 · Cited by 826 · see citing works
Self-citationLander, H. M., Tauras, J. M., Ogiste, J. S., Hori, O., Moss, R. A., & Schmidt, A. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17810 · Cited by 813 · see citing works
Self-citationOxidative Stress as a Regulator of Gene Expression in the Vasculature
KUNSCH, C. A., & Medford, R. M. (1999) · Circulation Research · doi:10.1161/01.res.85.8.753 · Cited by 795 · see citing works
Mitochondrial Dysfunction in Atherosclerosis
Madamanchi, N. R., & Runge, M. S. (2007) · Circulation Research · doi:10.1161/01.res.0000258450.44413.96 · Cited by 794 · see citing works
Activation of Receptor for Advanced Glycation End Products
Schmidt, A. M., Yan, S. D., Wautier, J., & Stern, D. M. (1999) · Circulation Research · doi:10.1161/01.res.84.5.489 · Cited by 792 · see citing works
Self-citationTissue Angiotensin and Pathobiology of Vascular Disease
Dzau, V. J. (2001) · Hypertension · doi:10.1161/01.hyp.37.4.1047 · Cited by 748 · see citing works
Ramasamy, R., Vannucci, S. J., Yan, S. S. D., Herold, K., Yan, S. F., & Schmidt, A. M. (2005) · Glycobiology · doi:10.1093/glycob/cwi053 · Cited by 834 · see citing works
Self-citationYONEKURA, H., YAMAMOTO, Y., SAKURAI, S., PETROVA, R. G., ABEDIN, M. J., LI, H., YASUI, K., TAKEUCHI, M., MAKITA, Z., TAKASAWA, S., et al. (2003) · Biochemical Journal · doi:10.1042/bj20021371 · Cited by 716 · see citing works
The biology of the receptor for advanced glycation end products and its ligands
Schmidt, A. M., Yan, S. D., Yan, S. F., & Stern, D. M. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(00)00087-2 · Cited by 687 · see citing works
Self-citationMechanisms of maturation and ageing of collagen
Bailey, A. J., Paul, R. G., & Knott, L. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00119-5 · Cited by 672 · see citing works
Para-Inflammation in the Aging Retina
Xu, H., Chen, M., & Forrester, J. V. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.06.001 · Cited by 659 · see citing works
Vlassara, H., Cai, W., Crandall, J., Goldberg, T., Oberstein, R., Dardaine, V., Peppa, M., & Rayfield, E. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242407999 · Cited by 668 · see citing works
Self-citationChaudhuri, J., Bains, Y., Guha, S., Kahn, A., Hall, D., Bose, N., Gugliucci, A., & Kapahi, P. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.014 · Cited by 669 · see citing works
Giri, B., Dey, S., Das, T., Sarkar, M., Banerjee, J., & Dash, S. K. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.07.157 · Cited by 674 · see citing works
Neuroprotection by the Metabolic Antioxidant α-Lipoic Acid
Packer, L., Tritschler, H. J., & Wessel, K. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00269-9 · Cited by 639 · see citing works
Lotze, M. T., Zeh, H. J., Rubartelli, A., Sparvero, L. J., Amoscato, A. A., Washburn, N. R., DeVera, M., Liang, X., Tör, M., & Billiar, T. R. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00579.x · Cited by 634 · see citing works
Byon, C. H., Javed, A., Dai, Q., Kappes, J. C., Clemens, T. L., Darley-Usmar, V. M., McDonald, J. M., & Chen, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800021200 · Cited by 639 · see citing works
Huttunen, H. J., Fages, C., & Rauvala, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19919 · Cited by 629 · see citing works
Wendt, T., Tanji, N., Guo, J., Kislinger, T., Qu, W., Lu, Y., Bucciarelli, L. G., Rong, L., Moser, B., Markowitz, G. S., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63909-0 · Cited by 599 · see citing works
Self-citationPeriodontal disease: associations with diabetes, glycemic control and complications
Taylor, G., & Borgnakke, W. S. (2008) · Oral Diseases · doi:10.1111/j.1601-0825.2008.01442.x · Cited by 591 · see citing works
Advanced glycation end products
Gkogkolou, P., & Böhm, M. (2012) · Dermato-Endocrinology · doi:10.4161/derm.22028 · Cited by 594 · see citing works
The Pattern Recognition Receptor (RAGE) Is a Counterreceptor for Leukocyte Integrins
Chavakis, T., Bierhaus, A., Al‐Fakhri, N., Schneider, D., Witte, S., Linn, T., Nagashima, M., Morser, J., Arnold, B., Preissner, K. T., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030800 · Cited by 583 · see citing works
Nuclear Factor κB Signaling in Atherogenesis
de Winther, M. P. J., Kanters, E., Kraal, G., & Hofker, M. H. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000160340.72641.87 · Cited by 586 · see citing works
Bierhaus, A. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00233-2 · Cited by 555 · see citing works
Advanced Glycation End Products Activate Endothelium Through Signal-Transduction Receptor RAGE
Basta, G., Lazzerini, G., Massaro, M., Simoncini, T., Tanganelli, P., Fu, C., Kislinger, T., Stern, D. M., Schmidt, A. M., & Caterina, R. D. (2002) · Circulation · doi:10.1161/hc0702.104183 · Cited by 544 · see citing works
Self-citationLi, J., & Schmidt, A. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.26.16498 · Cited by 525 · see citing works
Self-citationHow hyperglycemia promotes atherosclerosis: molecular mechanisms
Aronson, D., & Rayfield, E. J. (2002) · Cardiovascular Diabetology · doi:10.1186/1475-2840-1-1 · Cited by 504 · see citing works
Moldogazieva, N. T., Mokhosoev, I. M., Melnikova, T. I., Porozov, Y. B., & Terentiev, A. A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3085756 · Cited by 504 · see citing works
Binding of S100 proteins to RAGE: An update
Leclerc, E., Fritz, G., Vetter, S. W., & Heizmann, C. W. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.11.016 · Cited by 490 · see citing works
Tanji, N., Markowitz, G. S., Fu, C., Kislinger, T., Taguchi, A., Pischetsrieder, M., Stern, D. M., Schmidt, A. M., & D’Agati, V. D. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1191656 · Cited by 485 · see citing works
Self-citationDiabetes Mellitus Enhances Vascular Matrix Metalloproteinase Activity
Uemura, S., Matsushita, H., Li, W., Glassford, A. J., Asagami, T., Lee, K., Harrison, D. G., & Tsao, P. S. (2001) · Circulation Research · doi:10.1161/hh1201.092042 · Cited by 484 · see citing works
Receptor for AGE (RAGE): Signaling mechanisms in the pathogenesis of diabetes and its complications
Ramasamy, R., Yan, S. F., & Schmidt, A. M. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06320.x · Cited by 521 · see citing works
Self-citationPapachristoforou, E., Lambadiari, V., Maratou, E., & Makrilakis, K. (2020) · Journal of Diabetes Research · doi:10.1155/2020/7489795 · Cited by 497 · see citing works
Mechanism of Development of Atherosclerosis and Cardiovascular Disease in Diabetes Mellitus
Katakami, N. (2017) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.rv17014 · Cited by 473 · see citing works
Oxidative stress and diabetic cardiovascular complications
Jay, D., Hitomi, H., & Griendling, K. K. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.06.018 · Cited by 464 · see citing works
HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins
Bertheloot, D., & Latz, E. (2017) · Cellular & Molecular Immunology · doi:10.1038/cmi.2016.34 · Cited by 455 · see citing works
Glucose and reactive oxygen species
Bonnefont‐Rousselot, D. (2002) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200209000-00016 · Cited by 455 · see citing works
Endothelial dysfunction and pathogenesis of diabetic angiopathy
Stehouwer, C. D. A. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(96)00272-6 · Cited by 441 · see citing works
Morigi, M., Angioletti, S., Imberti, B., Donadelli, R., Micheletti, G., Figliuzzi, M., Remuzzi, A., Zoja, C., & Remuzzi, G. (1998) · Journal of Clinical Investigation · doi:10.1172/jci656 · Cited by 439 · see citing works
Yan, S. F., Ramasamy, R., & Schmidt, A. M. (2008) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0786 · Cited by 434 · see citing works
Self-citationGoova, M. T., Li, J., Kislinger, T., Qu, W., Lu, Y., Bucciarelli, L. G., Nowygrod, S., Wolf, B. M., Caliste, X. A., Yan, S. F., et al. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61723-3 · Cited by 432 · see citing works
Self-citationRAGE regulation and signaling in inflammation and beyond
Kierdorf, K., & Fritz, G. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1012519 · Cited by 434 · see citing works
Yan, S. D., Zhu, H., Fu, J., Yan, S. F., Roher, A. E., Tourtellotte, W. W., Rajavashisth, T. B., Chen, X., Godman, G. C., Stern, D. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5296 · Cited by 427 · see citing works
Self-citationTanaka, N., Yonekura, H., Yamagishi, S., Fujimori, H., Yamamoto, Y., & Yamamoto, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001235200 · Cited by 425 · see citing works
Cellular adhesion molecules and atherogenesis
Price, D. T., & Loscalzo, J. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00153-9 · Cited by 388 · see citing works
Circulating markers of inflammation and atherosclerosis
Lind, L. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00012-1 · Cited by 369 · see citing works
Mason, B. N., Starchenko, A., Williams, R. M., Bonassar, L. J., & Reinhart‐King, C. A. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.08.007 · Cited by 365 · see citing works
Vascular effects of advanced glycation endproducts: Clinical effects and molecular mechanisms
Stirban, A. O., Gawlowski, T., & Roden, M. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.11.006 · Cited by 365 · see citing works
Biochemical and Clinical Impact of Organic Uremic Retention Solutes: A Comprehensive Update
Vanholder, R. C., Pletinck, A., Schepers, E., & Glorieux, G. (2018) · Toxins · doi:10.3390/toxins10010033 · Cited by 359 · see citing works
Basta, G. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.07.025 · Cited by 357 · see citing works
Atherosclerosis and arteriosclerosis in chronic renal failure
London, G. M., & Drüeke, T. B. (1997) · Kidney International · doi:10.1038/ki.1997.233 · Cited by 349 · see citing works
Du, X., Edelstein, D., Obici, S., Higham, N., Zou, M., & Brownlee, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci23354 · Cited by 344 · see citing works
The role of oxidative stress and NF‐κB activation in late diabetic complications
Mohamed, A. K., Bierhaus, A., Schiekofer, S., Tritschler, H., Ziegler, R., & Nawroth, P. P. (1999) · BioFactors · doi:10.1002/biof.5520100211 · Cited by 337 · see citing works
Yeh, C.-H., Sturgis, L., Haidacher, J., Zhang, X.-N., Sherwood, S. J., Bjercke, R. J., Juhasz, O., Crow, M. T., Tilton, R. G., & Denner, L. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1495 · Cited by 326 · see citing works
Pericyte Loss in Diabetic Retinopathy: Mechanisms and Consequences
Beltramo, E., & Porta, M. (2013) · Current Medicinal Chemistry · doi:10.2174/09298673113209990022 · Cited by 321 · see citing works
Advanced Glycation End Product Interventions Reduce Diabetes-Accelerated Atherosclerosis
Forbes, J. M., Yee, L. T. L., Thallas, V., Lassila, M., Candido, R., Jandeleit-Dahm, K. A. M., Thomas, M. C., Burns, W. C., Deemer, E. K., Thorpe, S. R., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.7.1813 · Cited by 314 · see citing works
Münch, G. W., Keis, R., Weßels, A., Riederer, P. F., Bahner, U., Heidland, A., Niwa, T., Lemke, H., & Schinzel, R. (1997) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1997.35.9.669 · Cited by 313 · see citing works
Schmidt, A. M., Weidman, E., Lalla, E., Yan, S. D., Hori, O., Cao, R. Y., Brett, J. G., & Lamster, I. B. (1996) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1996.tb01417.x · Cited by 304 · see citing works
Self-citationRAGE (receptor for advanced glycation end products): a central player in the inflammatory response
Chavakis, T., Bierhaus, A., & Nawroth, P. P. (2004) · Microbes and Infection · doi:10.1016/j.micinf.2004.08.004 · Cited by 301 · see citing works
(2002) · PubMed · Cited by 292 · see citing works
Role of NF-κB in the pathogenesis of diabetes and its associated complications
Patel, S., & Santani, D. D. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70111-2 · Cited by 291 · see citing works
Negative consequences of glycation
Brownlee, M. (2000) · Metabolism · doi:10.1016/s0026-0495(00)80078-5 · Cited by 284 · see citing works
Miyata, T., Hori, O., Zhang, J., Yan, S. S., Ferran, L., Iida, Y., & Schmidt, A. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118889 · Cited by 278 · see citing works
Self-citationKislinger, T., Tanji, N., Wendt, T., Qu, W., Lu, Y., Ferran, L. J., Taguchi, A., Olson, K. E., Bucciarelli, L. G., Goova, M. T., et al. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.6.905 · Cited by 284 · see citing works
Self-citationQuehenberger, P., Bierhaus, A., Fasching, P., Muellner, C., Klevesath, M. S., Hong, M., Stier, G., Sattler, M., Schleicher, E., Speiser, W., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.9.1561 · Cited by 283 · see citing works
Schram, M. T., Chaturvedi, N., Schalkwijk, C., Fuller, J., Stehouwer, C. D. A., & EURODIAB Prospective Complications Study Group (2005) · Diabetologia · doi:10.1007/s00125-004-1628-8 · Cited by 282 · see citing works
Stern, D. M., Yan, S. D., Yan, S. F., & Schmidt, A. M. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00160-6 · Cited by 281 · see citing works
Self-citationUremic Toxicity: Present State of the Art
Vanholder, R. C., Argilés, À., Baurmeister, U., Brunet, P., Clark, W. R., Cohen, G., Dedeyn, P. P., Deppisch, R. M., Descamps‐Latscha, B., Henle, T., et al. (2001) · The International Journal of Artificial Organs · doi:10.1177/039139880102401004 · Cited by 279 · see citing works
Shipanova, I. N., Glomb, M. A., & Nagaraj, R. H. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0195 · Cited by 279 · see citing works
Diabetes-Induced Oxidative Stress and Low-Grade Inflammation in Porcine Coronary Arteries
Zhang, L., Zalewski, A. A., Liu, Y., Mazurek, T., Cowan, S., Martin, J. L., Hofmann, S. M., Vlassara, H., & Shi, Y. (2003) · Circulation · doi:10.1161/01.cir.0000080378.96063.23 · Cited by 277 · see citing works
Advanced glycation endproducts in ageing and Alzheimer's disease
Münch, G. W., Thome, J., Foley, P. B., Schinzel, R., & Riederer, P. F. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00016-1 · Cited by 275 · see citing works
Soluble Vascular Cell Adhesion Molecule-1 as a Biohumoral Correlate of Atherosclerosis
Caterina, R. D., Basta, G., Lazzerini, G., Dell’Omo, G., Petrucci, R., Morale, M., Carmassi, F., & Pedrinelli, R. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2646 · Cited by 268 · see citing works
Mechanisms of diabetic vasculopathy: an overview
Cooper, M. E. (2001) · American Journal of Hypertension · doi:10.1016/s0895-7061(00)01323-6 · Cited by 264 · see citing works
Advanced glycation End-products (AGEs): an emerging concern for processed food industries
Sharma, C., Kaur, A., Thind, S. S., Singh, B., & Raina, S. (2015) · Journal of Food Science and Technology · doi:10.1007/s13197-015-1851-y · Cited by 254 · see citing works
Demling, N., Ehrhardt, C., Kasper, M. E., Laue, M. M., Knels, L., & Rieber, E. P. (2005) · Cell and Tissue Research · doi:10.1007/s00441-005-0069-0 · Cited by 249 · see citing works
RAGE Control of Diabetic Nephropathy in a Mouse Model
Myint, K.-M., Yamamoto, Y., Doi, T., Kato, I., Harashima, A., Yonekura, H., Watanabe, T., Shinohara, H., Takeuchi, M., Tsuneyama, K., et al. (2006) · Diabetes · doi:10.2337/db06-0221 · Cited by 248 · see citing works
- Authors
- Schmidt, A. M., Hori, O., Chen, J. X., Li, J. F., Crandall, J., Zhang, J., Cao, R., Yan, S. D., Brett, J., & Stern, D.
- Affiliations
- Columbia University Irving Medical Center (US)
- Columbia University (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1995-09-01
- Volume
- 96
- Issue
- 3
- Pages
- 1395-1403
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC185762
- OpenAlex
- W2138928713
- Cited by
- 896
- References
- 43
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 15 · 2023: 16 · 2022: 13 · 2021: 21 · 2020: 16 · 2019: 23 · 2018: 16 · 2017: 26 · 2016: 17 · 2015: 34 · 2014: 32 · 2013: 35 · 2012: 36
- FWCI
- 17.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- KU ScholarWorks (University of Kansas) (submittedVersion, other-oa)
- Funders
- American Heart Association
- National Institutes of Health (5r01hl042833-10, 5p50hl021006-17)
- U.S. Public Health Service
- National Institute on Aging (AG00602)
- National Heart, Lung, and Blood Institute (HL-42833, HL 21006)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- advanced glycation end products, receptor for advanced glycation end products, VCAM-1, endothelial cells, diabetes mellitus, diabetic vascular disease, oxidative stress, NF-kB, soluble RAGE, N-acetylcysteine, monocyte adhesion, atherosclerosis, soluble VCAM-1
- MeSH terms
- Receptor for Advanced Glycation End Products, Animals, Base Sequence, Cell Adhesion, Cell Line, Cell Nucleus, Cells, Cultured, Diabetic Angiopathies, Endothelium, Vascular, Enzyme-Linked Immunosorbent Assay, Humans, Male, Models, Biological, Molecular Sequence Data, Receptors, Immunologic, Transcription, Genetic, Umbilical Veins, Cell Adhesion Molecules, Gene Expression, Polymerase Chain Reaction, Glycation End Products, Advanced, DNA Primers, Oxidative Stress, Vascular Cell Adhesion Molecule-1, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
