Saturated Fatty Acids and Cardiovascular Disease: Replacements for Saturated Fat to Reduce Cardiovascular Risk
Open accessPreprint — published as 10.3390/healthcare5020029
Abstract
Dietary recommendations to decrease the risk of cardiovascular disease (CVD) have focused on reducing intake of saturated fatty acids (SFA) for more than 50 years. While the 2015-2020 Dietary Guidelines for Americans advise substituting both monounsaturated and polyunsaturated fatty acids for SFA, evidence supports other nutrient substitutions that will also reduce CVD risk. For example, replacing SFA with whole grains, but not refined carbohydrates, reduces CVD risk. Replacing SFA with protein, especially plant protein may also reduce CVD risk. While dairy fat (milk, cheese) is associated with a slightly lower CVD risk compared to meat, dairy fat results in a significantly greater CVD risk relative to unsaturated fatty acids. As research continues, we will refine our understanding of dietary patterns associated with lower CVD risk.
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Aune, D., Keum, N., Giovannucci, E., Fadnes, L. T., Boffetta, P., Greenwood, D. C., Tonstad, S., Vatten, L. J., Riboli, E., & Norat, T. (2016) · BMJ · doi:10.1136/bmj.i2716 · Cited by 1,013 · see citing works
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Machate, D. J., Figueiredo, P. S., Marcelino, G., Guimarães, R. D. C. A., Hiane, P. A., Bogo, D., Pinheiro, V. A. Z., Oliveira, L. C. S. D., & Pott, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114093 · Cited by 243 · see citing works
Formisano, E., Pasta, A., Cremonini, A. L., Di Lorenzo, I., Sukkar, S. G., & Pisciotta, L. (2021) · Nutrients · doi:10.3390/nu13041161 · Cited by 19 · see citing works
- Authors
- Briggs, M. A., Petersen, K. S., & Kris-Etherton, P. M.
- Affiliations
- Lycoming College (US)
- Pennsylvania State University (US)
- Corresponding author
- Briggs, Michelle A.
- Venue
- Healthcare
- Publisher
- MDPI AG
- Published
- 2017-05-18
- Volume
- 5
- Issue
- 2
- Pages
- 29-29
- ISSN
- 2227-9032 (ISSN-L)
- PMC
- PMC5492032
- OpenAlex
- W2614280800
- Cited by
- 410
- References
- 1
- Citations by year
- 2026: 20 · 2025: 58 · 2024: 59 · 2023: 47 · 2022: 60 · 2021: 60 · 2020: 51 · 2019: 35 · 2018: 17 · 2017: 3
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Healthcare (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- saturated fatty acids, cardiovascular disease, fat replacement, monounsaturated fatty acids, polyunsaturated fatty acids, whole grains, refined carbohydrates, plant proteins, milk fat, meat, dietary guidelines, cardiovascular risk reduction
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