Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery
Open accessPreprint — published as 10.3390/pharmaceutics10040218
Abstract
The similarities between exosomes and liposomes, together with the high organotropism of several types of exosomes, have recently prompted the development of engineered-exosomes or exosome-mimetics, which may be artificial (liposomal) or cell-derived vesicles, as advanced platforms for targeted drug delivery. Here, we provide the current state-of-the-art of using exosome or exosome-inspired systems for drug delivery. We review the various approaches investigated and the shortcomings of each approach. Finally the challenges which have been identified to date in this field are summarized.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
High biocompatibility and low immunogenicity of exosomes enhance their uptake profile, stability in systemic circulation, and in vitro and in vivo therapeutic efficacy.
“Furthermore, their high biocompatibility and low immunogenicity enhance their uptake profile, their stability in systemic circulation, and their in vitro and in vivo therapeutic efficacy [229,230].”
From Alzheimer's Disease: Treatment Strategies and Their Limitations. (2022) · cites this paper as [229]
Cited by
Sorted by citations
Alzheimer's Disease: Treatment Strategies and Their Limitations.
Passeri, E., Elkhoury, K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate, C., Yen, F. T., & Arab-Tehrany, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213954 · Cited by 592 · see citing works
Strategies for the use of Extracellular Vesicles for the Delivery of Therapeutics
Sil, S., Dagur, R. S., Liao, K., Peeples, E. S., Hu, G., Periyasamy, P., & Buch, S. (2020) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09873-y · Cited by 109 · see citing works
- Authors
- Antimisiaris, S. G., Mourtas, S., & Marazioti, A.
- Affiliations
- University of Patras (GR)
- Foundation for Research and Technology Hellas (GR)
- Corresponding author
- Antimisiaris, Sophia G.
- Mourtas, Spyridon
- Marazioti, Antonia
- Venue
- Pharmaceutics
- Publisher
- MDPI AG
- Published
- 2018-10-22
- Volume
- 10
- Issue
- 4
- Pages
- 218-218
- ISSN
- 1999-4923 (ISSN-L)
- PMC
- PMC6321407
- OpenAlex
- W2897132139
- Cited by
- 605
- References
- 0
- Citations by year
- 2026: 50 · 2025: 73 · 2024: 78 · 2023: 89 · 2022: 96 · 2021: 112 · 2020: 77 · 2019: 28 · 2018: 1 · 2017: 1
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Locations
- Pharmaceutics (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, cc-by-nc-nd)
- Funders
- European Commission (NSRF 2014-2020, 2014‐2020, MIS 5002469)
- Stavros Niarchos Foundation
- European Regional Development Fund (NSRF 2014–2020, 2014-2020’, MIS5002469)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- exosomes, engineered exosomes, exosome mimetics, targeted drug delivery, liposomes, organotropism, artificial vesicles, cell-derived vesicles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
