Strategies for the use of Extracellular Vesicles for the Delivery of Therapeutics
Open accessAbstract
Extracellular vesicles (EVs) are nanosized, membrane-bound vesicles released from eukaryotic and prokaryotic cells that can transport cargo containing DNA, RNA, lipids and proteins, between cells as a means of intercellular communication. Although EVs were initially considered to be cellular debris deprived of any essential biological functions, emerging literature highlights the critical roles of EVs in the context of intercellular signaling, maintenance of tissue homeostasis, modulation of immune responses, inflammation, cancer progression, angiogenesis, and coagulation under both physiological and pathological states. Based on the ability of EVs to shuttle proteins, lipids, carbohydrates, mRNAs, long non-coding RNAs (lncRNAs), microRNAs, chromosomal DNA, and mitochondrial DNA into target cells, the presence and content of EVs in biofluids have been exploited for biomarker research in the context of diagnosis, prognosis and treatment strategies. Additionally, owing to the characteristics of EVs such as stability in circulation, biocompatibility as well as low immunogenicity and toxicity, these vesicles have become attractive systems for the delivery of therapeutics. More recently, EVs are increasingly being exploited as conduits for delivery of therapeutics for anticancer strategies, immunomodulation, targeted drug delivery, tissue regeneration, and vaccination. In this review, we highlight and discuss the multiple strategies that are employed for the use of EVs as delivery vehicles for therapeutic agents, including the potential advantages and challenges involved. Graphical abstract.
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Exosomes have gained particular interest in the field of mRNA delivery due to their unique ability to cross physiological barriers, favorable biocompatibility, low toxicity, cell-specific tropism, and ability to evade the mononuclear phagocytic system.
“Exosomes have gained particular interest in the field of mRNA delivery due to their unique ability to cross physiological barriers, favorable biocompatibility, low toxicity, cell-specific tropism, and ability to evade the mononuclear phagocytic system [16, 17].”
From Exosome for mRNA delivery: Strategies and therapeutic applications (2024) · cites this paper as [17]
Exosomes have gained growing attention in mRNA delivery because of their good biocompatibility, low immunogenicity, small size, unique capacity to traverse physiological barriers, and cell-specific tropism.
“Exosomes have gained growing attention in mRNA delivery because of their good biocompatibility, low immunogenicity, small size, unique capacity to traverse physiological barriers, and cell-specific tropism.”
From Exosome for mRNA delivery: Strategies and therapeutic applications (2024) · cites this paper as [17]
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Flagged first, then by citations
Research works printed but not linked: 1
- Vesicles Extracellular. Stem Cells Transl Med 6: 1730– 1739. PMC5689784 28714557
Cited by
Sorted by citations
Exosome for mRNA delivery: Strategies and therapeutic applications
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MiR-128-3p – a gray eminence of the human central nervous system
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- Authors
- Sil, S., Dagur, R. S., Liao, K., Peeples, E. S., Hu, G., Periyasamy, P., & Buch, S.
- Affiliations
- Nebraska Medical Center (US)
- University of Nebraska Medical Center (US)
- Corresponding author
- Hu, Guoku
- Periyasamy, Palsamy
- Buch, Shilpa
- ORCID
- Venue
- Journal of Neuroimmune Pharmacology
- Published
- 2019-08-27
- Volume
- 15
- Issue
- 3
- Pages
- 422-442
- ISSN
- 1557-1890 (ISSN-L)
- 1557-1904
- PMC
- PMC7044028
- OpenAlex
- W2970839635
- Cited by
- 109
- References
- 248
- Citations by year
- 2026: 9 · 2025: 19 · 2024: 21 · 2023: 15 · 2022: 12 · 2021: 15 · 2020: 13 · 2019: 5
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuroimmune Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (DA041751, DA043164, DA040397, MH112848, DA043138, DA042704, DA046831, DA044087)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- extracellular vesicles, treatment delivery, drug carriers, intercellular communication, biomarkers, cancer therapy, immunomodulation, targeted drug delivery, tissue regeneration, vaccination, microRNA, long non-coding RNA, biological fluids
- MeSH terms
- Extracellular Vesicles, Animals, Cell Communication, Drug Carriers, Humans, Biomarkers, Drug Delivery Systems, Immunomodulation, Bioengineering
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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