The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Role of Glial Cells in Depression and Drug Addiction
Open accessPreprint — published as 10.3390/brainsci14060558 · Paper page
Abstract
Major depressive disorder (MDD) and substance use disorder (SUD) are of immense medical and social concerns. Although significant progress on neuronal involvement in mood and reward circuitries has been achieved, only relatively recently the role of glia in these disorders have attracted attention. Detail understanding of the glial function in these devastating diseases could offer novel interventions. Here, following a brief review of circuitries involved in mood regulation and reward perception, specific contribution of the neurotrophic factors, neuroinflammation and gut microbiota to these diseases are highlighted. In this context, the role of specific glial cells (e.g., microglia, astroglia, oligodendrocytes and synantocytes) on phenotypic manifestation of MDD or SUD are emphasized. In addition, potential use of this knowledge in developing novel therapeutics is touched upon.
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Cites
Matveychuk, D., Thomas, R. K., Swainson, J., Khullar, A., MacKay, M.-A., Baker, G. B., & Dursun, S. M. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320916657 · Cited by 209
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Metadata
- Authors
- Tizabi, Y., Getachew, B., Hauser, S. R., Tsytsarev, V., Manhães, A. C., & da Silva, V. D. A.
- Affiliations
- Howard University (US)
- Indiana University School of Medicine (US)
- University of Maryland, Baltimore (US)
- Universidade do Estado do Rio de Janeiro (BR)
- Corresponding author
- Tizabi, Yousef
- ORCID
- Venue
- Brain Sciences
- Publisher
- MDPI AG
- Published
- 2024-05-03
- Volume
- 14
- Issue
- 6
- Pages
- 558-558
- ISSN
- 2076-3425 (ISSN-L)
- PMC
- PMC11201416
- OpenAlex
- W4399175317
- Cited by
- 27
- References
- 1
- Citations by year
- 2026: 4 · 2025: 16 · 2024: 7
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Brain Sciences (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IUScholarWorks (Indiana University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R03AA022479, R01AA029788)
- National Institute on Drug Abuse (R03DA054335)
- National Institute of General Medical Sciences (S06GM008016)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- glial cells, mood disorders, substance use disorders, drug addiction, microglia, astrocytes, oligodendrocytes, neurotrophic factors, neuroinflammation, gut microbiota, reward systems, mood regulation, new drugs
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