Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction
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Abstract
Mood disorders and substance use disorder (SUD) are of immense medical and social concern. Although significant progress on neuronal involvement in mood and reward circuitries has been achieved, it is only relatively recently that the role of glia in these disorders has attracted attention. Detailed understanding of the glial functions in these devastating diseases could offer novel interventions. Here, following a brief review of circuitries involved in mood regulation and reward perception, the specific contributions of neurotrophic factors, neuroinflammation, and gut microbiota to these diseases are highlighted. In this context, the role of specific glial cells (e.g., microglia, astroglia, oligodendrocytes, and synantocytes) on phenotypic manifestation of mood disorders or SUD are emphasized. In addition, use of this knowledge in the potential development of novel therapeutics is touched upon.
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Cites
The biology <b>,</b> function <b>,</b> and biomedical applications of exosomes
Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770 · see citing works
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 3,949 · see citing works
The role of inflammation in depression: from evolutionary imperative to modern treatment target
Miller, A. H., & Raison, C. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.5 · Cited by 3,942 · cited 2× · see citing works
“Thus, when neuroin-flammation ensues, it may further exacerbate SUD or induce MDD [4,98].”
BackgroundMechanisms underlying inflammation in neurodegeneration
Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580 · see citing works
THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE
Schildkraut, J. J. (1965) · American Journal of Psychiatry · doi:10.1176/ajp.122.5.509 · Cited by 3,499 · see citing works
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
Goldstein, R. Z., & Volkow, N. D. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3119 · Cited by 2,749 · see citing works
Sokoloff, P., Bruno Giros, A., Martres, M., Bouthenet, M.-L., & Schwartz, J. (1990) · Nature · doi:10.1038/347146a0 · Cited by 2,608 · see citing works
Tripartite synapses: glia, the unacknowledged partner
Araque, A., Parpura, V., Sanzgiri, R. P., & Haydon, P. G. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01349-6 · Cited by 2,529 · see citing works
The human hippocampus and spatial and episodic memory
Burgess, N., Maguire, E. A., & O'Keefe, J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00830-9 · Cited by 2,401 · see citing works
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
The human brain in numbers: a linearly scaled-up primate brain
Herculano-Houzel, S. (2009) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.031.2009 · Cited by 1,778 · see citing works
Neurotrophins as synaptic modulators
Poo, M.-M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35049004 · Cited by 1,775 · see citing works
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678 · see citing works
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
Gao, C., Jiang, J., Tan, Y., & Chen, S. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01588-0 · Cited by 1,616 · see citing works
Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease.
Iyer, S. S., & Cheng, G. (2012) · Critical Reviews™ in Immunology · doi:10.1615/critrevimmunol.v32.i1.30 · Cited by 1,611 · see citing works
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
Rothstein, J. D., Patel, S., Regan, M. R., Haenggeli, C., Huang, Y. H., Bergles, D. E., Jin, L., Dykes Hoberg, M., Vidensky, S., Chung, D. S., et al. (2005) · Nature · doi:10.1038/nature03180 · Cited by 1,518 · see citing works
Depression Is the Leading Cause of Disability Around the World
Friedrich, M. J. (2017) · JAMA · doi:10.1001/jama.2017.3826 · Cited by 1,459 · see citing works
Brain-derived neurotrophic factor and its clinical Implications
Bathina, S., & Das, U. N. (2015) · Archives of Medical Science · doi:10.5114/aoms.2015.56342 · Cited by 1,381 · see citing works
The cellular neurobiology of depression
Manji, H. K., Drevets, W. C., & Charney, D. S. (2001) · Nature Medicine · doi:10.1038/87865 · Cited by 1,182 · see citing works
von Bartheld, C. S., Bahney, J., & Herculano‐Houzel, S. (2016) · Journal of Comparative Neurology · doi:10.1002/cne.24040 · Cited by 1,063 · see citing works
Sodium butyrate inhibits histone deacetylation in cultured cells
Candido, E. (1978) · Cell · doi:10.1016/0092-8674(78)90305-7 · Cited by 1,036 · see citing works
Cell Biology of Astrocyte-Synapse Interactions
Allen, N. J., & Eroğlu, Ç. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.056 · Cited by 1,031 · see citing works
The Role of Microglia in the Healthy Brain: Figure 1.
Tremblay, M.-È., Stevens, B., Sierra, A., Wake, H., Bessis, A., & Nimmerjahn, A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4158-11.2011 · Cited by 992 · see citing works
Colucci-D’Amato, L., Speranza, L., & Volpicelli, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207777 · Cited by 991 · see citing works
Lee, J., Duan, W., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01085.x · Cited by 975 · see citing works
Depression as a Microglial Disease
Yirmiya, R., Rimmerman, N., & Reshef, R. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.08.001 · Cited by 944 · see citing works
The Economic Burden of Adults with Major Depressive Disorder in the United States (2010 and 2018)
Greenberg, P. E., Fournier, A.-A., Sisitsky, T., Simes, M., Berman, R., Koenigsberg, S. H., & Kessler, R. C. (2021) · PharmacoEconomics · doi:10.1007/s40273-021-01019-4 · Cited by 838 · see citing works
Neurogenesis in the Adult Brain
Gage, F. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00612.2002 · Cited by 796 · see citing works
Interaction between BDNF and Serotonin: Role in Mood Disorders
Martinowich, K., & Lu, B. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301571 · Cited by 793 · see citing works
Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity
Ioannou, M. S., Jackson, J., Sheu, S.-H., Chang, C.-L., Weigel, A. V., Liu, H., Pasolli, H. A., Xu, C. S., Pang, S., Matthies, D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.04.001 · Cited by 760 · see citing works
Clinical applications of stem cell-derived exosomes
Tan, F., Li, X., Wang, Z., Li, J., Shahzad, K., & Zheng, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01704-0 · Cited by 708 · see citing works
The effect of sodium butyrate on histone modification
Sealy, L. J. (1978) · Cell · doi:10.1016/0092-8674(78)90306-9 · Cited by 691 · see citing works
The Role of Astrocytes in CNS Inflammation
Giovannoni, F., & Quintana, F. J. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.07.007 · Cited by 651 · see citing works
A brief history of the development of antidepressant drugs: From monoamines to glutamate.
Hillhouse, T. M., & Porter, J. H. (2015) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0038550 · Cited by 618 · see citing works
Gliogenesis and Glial Pathology in Depression
Rajkowska, G., & Miguel-Hidalgo, J. J. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707780619326 · Cited by 612 · see citing works
Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue
Rajkowska, G., & Stockmeier, C. (2013) · Current Drug Targets · doi:10.2174/13894501113149990156 · Cited by 603 · see citing works
Brites, D., & Fernandes, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00476 · Cited by 599 · cited 1× · see citing works
“Stress does this by disrupting homeostasis via its effects on microglia [160,161].”
BackgroundAstrocyte-neuron metabolic cooperation shapes brain activity
Bonvento, G., & Bolaños, J. P. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.006 · Cited by 580 · see citing works
BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization
Guillin, O., Díaz, J., Carroll, P., Griffon, N., Schwartz, J.-C., & Sokoloff, P. (2001) · Nature · doi:10.1038/35075076 · Cited by 573 · see citing works
Antidepressant-Like Effects of the Histone Deacetylase Inhibitor, Sodium Butyrate, in the Mouse
Schroeder, F. A., Lin, C. L., Crusio, W. E., & Akbarian, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.036 · Cited by 541 · see citing works
Microglial subtypes: diversity within the microglial community
Stratoulias, V., Venero, J. L., Tremblay, M., & Joseph, B. (2019) · The EMBO Journal · doi:10.15252/embj.2019101997 · Cited by 536 · see citing works
Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration
Patani, R., Hardingham, G. E., & Liddelow, S. A. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00822-1 · Cited by 531 · see citing works
Short-Chain Fatty Acids Regulate the Enteric Neurons and Control Gastrointestinal Motility in Rats
Soret, R., Chevalier, J., De Coppet, P., Poupeau, G., Derkinderen, P., Segain, J. P., & Neunlist, M. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.01.053 · Cited by 530 · see citing works
BDNF as a Promising Therapeutic Agent in Parkinson’s Disease
Palasz, E., Wysocka, A., Gasiorowska, A., Chalimoniuk, M., Niewiadomski, W., & Niewiadomska, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031170 · Cited by 504 · see citing works
Glial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation
Jäkel, S., & Dimou, L. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00024 · Cited by 501 · see citing works
Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity
Calabrese, F., Rossetti, A. C., Racagni, G., Gass, P., Riva, M. A., & Molteni, R. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00430 · Cited by 482 · see citing works
Astrocytes and microglia: In sickness and in health
Vainchtein, I. D., & Molofsky, A. V. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.01.003 · Cited by 450 · see citing works
Gut microbiome-wide association study of depressive symptoms
Radjabzadeh, D., Bosch, J. A., Uitterlinden, A. G., Zwinderman, A. H., Ikram, M. A., van Meurs, J. B. J., Luik, A. I., Nieuwdorp, M., Lok, A., van Duijn, C. M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34502-3 · Cited by 446 · see citing works
Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders
Brandebura, A. N., Paumier, A., Onur, T. S., & Allen, N. J. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-022-00641-1 · Cited by 427 · see citing works
Glutamate transmission in addiction
Kalivas, P. W., LaLumiere, R. T., Knackstedt, L. A., & Shen, H. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.011 · Cited by 389 · see citing works
Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes
Hamidi, M., Drevets, W. C., & Price, J. L. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.11.006 · Cited by 369 · see citing works
Microbial Infections, Immunomodulation, and Drugs of Abuse
Friedman, H. P., Newton, C. A., & Klein, T. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.2.209-219.2003 · Cited by 337 · see citing works
Toll-like receptors in the pathogenesis of neuroinflammation
Kumar, V. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.03.012 · Cited by 331 · see citing works
The Molecular Basis of Drug Addiction: Linking Epigenetic to Synaptic and Circuit Mechanisms
Nestler, E. J., & Lüscher, C. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.016 · Cited by 331 · see citing works
Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis
Wu, A., & Zhang, J. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02964-x · Cited by 327 · see citing works
(2008) · PubMed · Cited by 325 · see citing works
Gliotransmission: Beyond Black-and-White
Savtchouk, I., & Volterra, A. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.0017-17.2017 · Cited by 325 · see citing works
Duman, R. S., Deyama, S., & Fogaça, M. V. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14630 · Cited by 321 · see citing works
Beyond the GFAP-Astrocyte Protein Markers in the Brain
Jurga, A. M., Paleczna, M., Kadluczka, J., & Kuter, K. Z. (2021) · Biomolecules · doi:10.3390/biom11091361 · Cited by 319 · see citing works
Salim, S., Chugh, G., & Asghar, M. (2012) · Advances in protein chemistry and structural biology · doi:10.1016/b978-0-12-398314-5.00001-5 · Cited by 315 · see citing works
Adaptive Increase in D3Dopamine Receptors in the Brain Reward Circuits of Human Cocaine Fatalities
Staley, J. K., & Mash, D. C. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-19-06100.1996 · Cited by 308 · see citing works
Emerging roles of innate and adaptive immunity in Alzheimer’s disease
Chen, X., & Holtzman, D. M. (2022) · Immunity · doi:10.1016/j.immuni.2022.10.016 · Cited by 297 · see citing works
Kierdorf, K., & Prinz, M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90602 · Cited by 283 · see citing works
Li, L., Acioglu, C., Heary, R. F., & Elkabes, S. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.10.007 · Cited by 283 · see citing works
The role of Toll-like receptors and neuroinflammation in Parkinson’s disease
Heidari, A., Yazdanpanah, N., & Rezaei, N. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02496-w · Cited by 275 · see citing works
Neurotrophic factors and structural plasticity in addiction
Russo, S. J., Mazei‐Robison, M. S., Ables, J. L., & Nestler, E. J. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.059 · Cited by 271 · see citing works
Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse
Lacagnina, M. J., Rivera, P. D., & Bilbo, S. D. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.121 · Cited by 271 · see citing works
Neuroinflammation, Neurodegeneration, and Depression
Hurley, L. L., & Tizabi, Y. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9348-1 · Cited by 260 · see citing works
Self-citationNG 2‐glia and their functions in the central nervous system
Dimou, L., & Gallo, V. (2015) · Glia · doi:10.1002/glia.22859 · Cited by 258 · see citing works
Hatoum, A. S., Colbert, S. M. C., Johnson, E. C., Huggett, S. B., Deak, J. D., Pathak, G. A., Jennings, M. V., Paul, S. E., Karcher, N. R., Hansen, I., et al. (2023) · Nature Mental Health · doi:10.1038/s44220-023-00034-y · Cited by 241 · see citing works
Oligodendrocyte lineage cells and depression
Zhou, B., Zhu, Z., Ransom, B. R., & Tong, X. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00930-0 · Cited by 239 · see citing works
Quesseveur, G., David, D. J., Gaillard, M. C., Pla, P., Wu, M. V., Nguyen, H. T., Nicolas, V, Auregan, G., David, I., Dranovsky, A., et al. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.30 · Cited by 235 · see citing works
Kouba, B. R., Borba, L. A., de Souza, P. B., Gil‐Mohapel, J., & Rodrigues, A. L. S. (2024) · Cells · doi:10.3390/cells13050423 · Cited by 232 · see citing works
Dhabhar, F. S., Burke, H. M., Epel, E. S., Mellon, S. H., Rosser, R., Reus, V. I., & Wolkowitz, O. M. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.05.010 · Cited by 225 · see citing works
Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia
Bernier, L.-P., Bohlen, C. J., York, E. M., Choi, H. B., Kamyabi, A., Dissing-Olesen, L., Hefendehl, J. K., Collins, H. Y., Stevens, B., Barres, B. A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.010 · Cited by 211 · see citing works
Matveychuk, D., Thomas, R. K., Swainson, J., Khullar, A., MacKay, M.-A., Baker, G. B., & Dursun, S. M. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320916657 · Cited by 209 · cited 1× · see citing works
“More recently (March 2019), ketamine, a glutamate N-methyl-D-aspartate (NMDA)-receptor antagonist, was approved for use in treatment-resistant depression [11,12].”
BackgroundBrain-derived neurotrophic factor and cocaine addiction
McGinty, J. F., Whitfield, T. W., & Berglind, W. J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.08.078 · Cited by 204 · see citing works
Assessment of Annual Cost of Substance Use Disorder in US Hospitals
Peterson, C., Li, M., Xu, L., Mikosz, C. A., & Luo, F. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.0242 · Cited by 200 · cited 1× · see citing works
“Moreover, substance use disorder (SUD) is co-morbid with other psychiatric disorders such as anxiety, major depressive disorder (MDD), bipolar disorder, conduct disorder, and schizophrenia, and can result in unemployment, domestic violence, loss of productivity, and even suicide [3–6].”
BackgroundUpregulation of Glt1 Attenuates Cue-Induced Reinstatement of Cocaine-Seeking Behavior in Rats
Sari, Y., Smith, K. D., Ali, P. K., & Rebec, G. V. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1746-09.2009 · Cited by 200 · see citing works
Manu, D. R., SLEVIN, M. A., Bărcuţean, L., Forró, T., Boghițoiu, T., & Bălașa, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417146 · Cited by 195 · see citing works
Astrocytic Dysfunction and Addiction
Scofield, M. D., & Kalivas, P. W. (2014) · The Neuroscientist · doi:10.1177/1073858413520347 · Cited by 193 · see citing works
Adult Neurogenesis and Psychiatric DisordersPreprint
Kang, E., Wen, Z., Song, H., Christian, K. M., & Ming, G. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019026 · Cited by 187 · see citing works
Ziebell, J. M., Taylor, S. E., Cao, T., Harrison, J., & Lifshitz, J. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-247 · Cited by 185 · see citing works
Glutathione-Dependent Detoxification Processes in Astrocytes
Dringen, R., Brandmann, M., Hohnholt, M. C., & Blumrich, E. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1481-1 · Cited by 184 · see citing works
Classification of Microglial Morphological Phenotypes Using Machine Learning
Leyh, J., Paeschke, S., Mages, B., Michalski, D., Nowicki, M., Bechmann, I., & Winter, K. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.701673 · Cited by 182 · see citing works
Zhang, J.-C., Yao, W., Dong, C., Yang, C., Ren, Q., Ma, M., & Hashimoto, K. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.112 · Cited by 182 · see citing works
Epigenetic mechanisms of major depression: Targeting neuronal plasticity
Uchida, S., Yamagata, H., Seki, T., & Watanabe, Y. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12621 · Cited by 181 · see citing works
Chamberlain, K. A., Huang, N., Xie, Y., Licausi, F., Li, S., Li, Y., & Sheng, Z. (2021) · Neuron · doi:10.1016/j.neuron.2021.08.011 · Cited by 181 · see citing works
Mechanisms underlying gut microbiota–host interactions in insects
Schmidt, K., & Engel, P. (2021) · Journal of Experimental Biology · doi:10.1242/jeb.207696 · Cited by 176 · see citing works
C-Reactive protein as a biomarker for major depressive disorder?
Orsolini, L., Pompili, S., Tempia Valenta, S., Salvi, V., & Volpe, U. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031616 · Cited by 171 · see citing works
Depression research: where are we now?
Lee, S., Jeong, J., Kwak, Y., & Park, S. K. (2010) · Molecular Brain · doi:10.1186/1756-6606-3-8 · Cited by 170 · see citing works
Neuroinflammation in addiction: A review of neuroimaging studies and potential immunotherapies
Kohno, M., Link, J., Dennis, L. E., McCready, H. D., Huckans, M. S., Hoffman, W. F., & Loftis, J. M. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.01.007 · Cited by 168 · see citing works
Brain-derived neurotrophic factor and inflammation in depression: Pathogenic partners in crime?
Porter, G., & O'Connor, J. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i1.77 · Cited by 167 · see citing works
Microglia and Astrocyte Function and Communication: What Do We Know in Humans?
Garland, E. F., Hartnell, I. J., & Boche, D. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.824888 · Cited by 165 · see citing works
Akinfiresoye, L. R., & Tizabi, Y. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3153-2 · Cited by 149 · see citing works
Self-citationChapter 14 S100β as a neurotrophic factor
Marshak, D. R. (1990) · Progress in brain research · doi:10.1016/s0079-6123(08)63175-1 · Cited by 145 · see citing works
The Role of Glial Cells in Drug Abuse
Miguel-Hidalgo, J. J. (2009) · Current Drug Abuse Reviews · doi:10.2174/1874473710902010076 · Cited by 143 · see citing works
Rod Microglia: A Morphological Definition
Taylor, S. E., Morganti-Kossmann, M. C., Lifshitz, J., & Ziebell, J. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097096 · Cited by 138 · see citing works
NG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis
Zhang, S.-Z., Wang, Q., Yang, Q., Gu, H., Yin, Y., Li, Y., Hou, J., Chen, R., Sun, Q., Sun, Y., et al. (2019) · BMC Medicine · doi:10.1186/s12916-019-1439-x · Cited by 138 · see citing works
Berglind, W. J., Whitfield, T. W., LaLumiere, R. T., Kalivas, P. W., & McGinty, J. F. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5457-08.2009 · Cited by 131 · see citing works
Antidepressants act directly on astrocytes: Evidences and functional consequences
Czéh, B., & Benedetto, B. D. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.04.017 · Cited by 129 · see citing works
Cattaneo, A., Ferrari, C., Uher, R., Bocchio‐Chiavetto, L., Riva, M. A., & Pariante, C. M. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw045 · Cited by 129 · see citing works
Novakovic, M. M., Korshunov, K. S., Grant, R. A., Martin, M. E., Abdala‐Valencia, H., Budinger, G. R. S., Radulović, J., & Prakriya, M. (2023) · Nature Communications · doi:10.1038/s41467-023-40968-6 · Cited by 128 · see citing works
Das, S. C., Yamamoto, B. K., Hristov, A. M., & Sari, Y. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.05.009 · Cited by 125 · see citing works
O’Leary, L. A., & Mechawar, N. (2021) · Glia · doi:10.1002/glia.23994 · Cited by 122 · see citing works
Dysfunctional serotonergic neuron-astrocyte signaling in depressive-like states
González-Arias, C., Sánchez-Ruiz, A., Esparza, J., Sánchez‐Puelles, C., Arancibia, L., Ramírez‐Franco, J., Gobbo, D., Kirchhoff, F., & Perea, G. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02269-8 · Cited by 122 · see citing works
Astrocyte, a Promising Target for Mood Disorder Interventions
Zhou, X., Xiao, Q., Xie, L., Yang, F., Wang, L., & Tu, J. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00136 · Cited by 120 · see citing works
Microglia: A Central Player in Depression
Deng, S.-L., Chen, J.-G., & Wang, F. (2020) · Current Medical Science · doi:10.1007/s11596-020-2193-1 · Cited by 119 · see citing works
NG2 cells (polydendrocytes): Listeners to the neural network with diverse properties
Hill, R., & Nishiyama, A. (2014) · Glia · doi:10.1002/glia.22664 · Cited by 117 · see citing works
Oligodendrocytes in a Nutshell
Michalski, J., & Kothary, R. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00340 · Cited by 117 · see citing works
Kofler, J., & Wiley, C. A. (2010) · Toxicologic Pathology · doi:10.1177/0192623310387619 · Cited by 116 · see citing works
Neuroinflammation: a potential therapeutic target
Craft, J. M., Watterson, D. M., & Van Eldik, L. J. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.5.887 · Cited by 116 · see citing works
Salamone, J. D., & Correa, M. (2023) · Annual Review of Psychology · doi:10.1146/annurev-psych-020223-012208 · Cited by 113 · see citing works
Darwish, S. F., Elbadry, A. M. M., Elbokhomy, A. S., Salama, G. A., & Salama, R. M. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1231706 · Cited by 106 · see citing works
Küppers, E., & Beyer, C. (2001) · Neuroreport · doi:10.1097/00001756-200105080-00025 · Cited by 101 · see citing works
Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics
Fang, S., Wu, Z., Guo, Y., Zhu, W., Wan, C., Yuan, N., Chen, J., Hao, W., Mo, X., Guo, X., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1193053 · Cited by 101 · see citing works
From Neurotransmitters to Neurotrophic Factors to Neurogenesis
Hagg, T. (2008) · The Neuroscientist · doi:10.1177/1073858408324789 · Cited by 94 · see citing works
Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism
Lindholm, P., & Saarma, M. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01394-6 · Cited by 92 · see citing works
Cocaine abuse and effects in the serum levels of cytokines IL-6 and IL-10
Moreira, F. P., Medeiros, J. R. C., Lhullier, A. C., Souza, L. D. D. M., Jansen, K., Portela, L. V., Lara, D. R., Silva, R. A. D., Wiener, C. D., & Oses, J. P. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.11.024 · Cited by 92 · see citing works
Böttcher, C., Fernández‐Zapata, C., Snijders, G. J. L., Schlickeiser, S., Sneeboer, M. A. M., Kunkel, D., de Witte, L. D., & Priller, J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00992-2 · Cited by 91 · see citing works
Noteworthy perspectives on microglia in neuropsychiatric disorders
Zhu, H., Guan, A., Liu, J., Li, P., Zhang, Z., & Wang, S. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02901-y · Cited by 90 · see citing works
Anhedonia, Hyperkatifeia, and Negative Reinforcement in Substance Use Disorders
Koob, G. F. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2021_288 · Cited by 89 · see citing works
Numakawa, T., & Kajihara, R. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1247422 · Cited by 88 · see citing works
The Regulation of Exosome Generation and Function in Physiological and Pathological Processes
Wang, Y., Xiao, T., Zhao, C., & Li, G.-Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010255 · Cited by 87 · see citing works
Barker, J. M., Taylor, J. R., Vries, T. J. D., & Peters, J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.058 · Cited by 86 · see citing works
Valvassori, S. S., Varela, R. B., Arent, C. O., Dal-Pont, G. C., Bobsin, T. S., Budni, J., Réus, G. Z., & Quevedo, J. (2014) · Current Neurovascular Research · doi:10.2174/1567202611666140829162158 · Cited by 86 · see citing works
The tripartite glutamatergic synapse
Lalo, U., Koh, W., Lee, C. J., & Pankratov, Y. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108758 · Cited by 86 · see citing works
Microbiome epidemiology and association studies in human health
VanEvery, H., Franzosa, E. A., Nguyen, L. H., & Huttenhower, C. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00529-x · Cited by 85 · see citing works
Implications of Systemic Inflammation and Periodontitis for Major Depression
Hashioka, S., Inoue, K., Hayashida, M., Wake, R., Oh‐Nishi, A., & Miyaoka, T. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00483 · Cited by 84 · see citing works
Bsibsi, M., Nomden, A., van Noort, J. M., & Baron, W. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22767 · Cited by 79 · see citing works
Sarkar, D. K., Jung, M. K., & Wang, H. J. (2015) · Europe PMC (PubMed Central) · Cited by 78 · see citing works
Potential of Glial Cell Modulators in the Management of Substance Use Disorders
Jones, J. D. (2020) · CNS Drugs · doi:10.1007/s40263-020-00721-9 · Cited by 78 · see citing works
NEURONAL SUBSTRATES OF RELAPSE TO COCAINE-SEEKING BEHAVIOR: ROLE OF PREFRONTAL CORTEX
Rebec, G. V., & Sun, W. (2005) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.2005.105-04 · Cited by 76 · see citing works
Astrocytes and major depression: The purinergic avenue
Zhao, Y. F., Verkhratsky, A., Tang, Y. C., & Illés, P. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109252 · Cited by 73 · see citing works
Tanycytes and hypothalamic control of energy metabolism
Ebling, F. J. P., & Lewis, J. E. (2018) · Glia · doi:10.1002/glia.23303 · Cited by 71 · see citing works
Neuron-astrocyte omnidirectional signaling in neurological health and disease
Pathak, D., & Sriram, K. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1169320 · Cited by 71 · see citing works
Glutamate transport: a new bench to bedside mechanism for treating drug abuse
Spencer, S., & Kalivas, P. W. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx050 · Cited by 71 · see citing works
Kokkosis, A. G., Madeira, M. M., Mullahy, M., & Tsirka, S. E. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01512-y · Cited by 70 · see citing works
Zou, Y., Zhang, Y., Tu, M., Ye, Y., Li, M., Ran, R., & Zou, Z. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.110954 · Cited by 70 · see citing works
Molecular Mechanisms Underlying Neuroinflammation Elicited by Occupational Injuries and Toxicants
Pathak, D., & Sriram, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032272 · Cited by 69 · see citing works
Krystal, J., Kaye, A. P., Jefferson, S., Girgenti, M., Wilkinson, S. T., Sanacora, G., & Esterlis, I. (2023) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2305772120 · Cited by 69 · see citing works
Astrocytes in cocaine addiction and beyond
Wang, J., Holt, L. M., Huang, H. H., Sesack, S. R., Nestler, E. J., & Dong, Y. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01080-7 · Cited by 68 · see citing works
Taurine and Astrocytes: A Homeostatic and Neuroprotective Relationship
Ramírez-Guerrero, S., Guardo-Maya, S., Medina-Rincón, G. J., Orrego-González, E., Cabezas-Pérez, R., & González-Reyes, R. E. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.937789 · Cited by 68 · see citing works
Modulation of Glial Function in Health, Aging, and Neurodegenerative Disease
Hanslik, K. L., Marino, K. M., & Ulland, T. K. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.718324 · Cited by 68 · see citing works
Functional α7‐containing nicotinic receptors of NG2‐expressing cells in the hippocampus
Vélez‐Fort, M., Audinat, É., & Angulo, M. C. (2009) · Glia · doi:10.1002/glia.20834 · Cited by 67 · see citing works
The role of microglia in the development of neurodegeneration
Saitgareeva, A. R., Bulygin, K. V., Фанилевич, Г. И., Beylerli, O., & Ахмадеева, Л. Р. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04468-5 · Cited by 67 · see citing works
Xie, Z., Huang, J., Sun, G., He, S., Luo, Z., Zhang, L., Li, L., Yao, M., Du, C., Yu, W., et al. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115804 · Cited by 65 · see citing works
Update of neurotrophic factors in neurobiology of addiction and future directions
Koskela, M., Bäck, S., Võikar, V., Richie, C. T., Domanskyi, A., Harvey, B. K., & Airavaara, M. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.05.010 · Cited by 64 · see citing works
Nebeling, F. C., Poll, S., Justus, L. C., Mittag, M., Steffen, J., Keppler, K., & Fuhrmann, M. (2023) · eLife · doi:10.7554/elife.83176 · Cited by 64 · see citing works
Glial mechanisms underlying substance use disorders
Linker, K. E., Cross, S. J., & Leslie, F. M. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14163 · Cited by 64 · see citing works
de Souza, D. G., Almeida, R. F., Souza, D. O., & Zimmer, E. R. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.04.002 · Cited by 63 · see citing works
Tsai, S., Hsu, P., Chen, Y., Hossain, M. S., Chen, P., Tzeng, S., Chen, P. S., & Kuo, Y. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01787-1 · Cited by 63 · see citing works
Gut microbiome predicts cognitive function and depressive symptoms in late life
Kolobaric, A., Andreescu, C., Jašarević, E., Hong, C. H., Roh, H., Cheong, J. Y., Kim, Y., Shin, T. S., Kang, C. S., Kwon, C. O., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02551-3 · Cited by 62 · see citing works
Brain-derived neurotrophic factor in substance use disorders: A systematic review and meta-analysis
Ornell, F. R., Hansen, F., Schuch, F. B., Rebelatto, F. P., Tavares, A. L. J., Scherer, J. N., Valério, A. G., Pechansky, F., Kessler, F. H. P., & DIEMEN, L. V. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.08.036 · Cited by 61 · see citing works
Inflammatory Pathogenesis of Post-stroke Depression
Feng, X., Ma, X., Li, J., Zhou, Q., Liu, Y., Song, J., Liu, J., Situ, Q., Wang, L., Zhang, J., et al. (2024) · Aging and Disease · doi:10.14336/ad.2024.0203 · Cited by 61 · see citing works
Zelada, M. I., Garrido, V., Liberona, A., Jones, N., Zúñiga, K., Silva, H., & Nieto, R. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914810 · Cited by 60 · see citing works
Cytokine variations and mood disorders: influence of social stressors and social support
Audet, M., McQuaid, R. J., Merali, Z., & Anisman, H. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00416 · Cited by 58 · see citing works
Scheepstra, K. W. F., Mizee, M. R., van Scheppingen, J., Adelia, A., Wever, D. D., Mason, M. R. J., Dubbelaar, M. L., Hsiao, C., Eggen, B. J. L., Hamann, J., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.04.020 · Cited by 58 · see citing works
Szebeni, A., Szebeni, K., DiPeri, T. P., Johnson, L. A., Stockmeier, C. A., Crawford, J. D., Chandley, M. J., Hernandez, L. J., Burgess, K. C., Brown, R. W., et al. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw114 · Cited by 57 · see citing works
Du, J., Yi, M., Zhou, F., He, W., Yang, A., Qiu, M., & Huang, H. (2021) · Molecular Brain · doi:10.1186/s13041-021-00865-9 · Cited by 57 · see citing works
Microglia as therapeutic target in central nervous system disorders
Fatoba, O., Itokazu, T., & Yamashita, T. (2020) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2020.07.004 · Cited by 56 · see citing works
Cuitavi, J., Torres-Pérez, J. V., Lorente, J. D., Campos‐Jurado, Y., Andrés‐Herrera, P., Polache, A., Agustín‐Pavón, C., & Hipólito, L. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.105011 · Cited by 55 · see citing works
Pałasz, E., Wilkaniec, A., Stanaszek, L., Andrzejewska, A., & Adamczyk, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076321 · Cited by 54 · see citing works
Astrocytic modulation of neuronal signalling
Purushotham, S. S., & Buskila, Y. (2023) · Frontiers in Network Physiology · doi:10.3389/fnetp.2023.1205544 · Cited by 54 · see citing works
Glial cells: old cells with new twists.
Ndubaku, U., & de Bellard, M. D. (2008) · Acta Histochemica · doi:10.1016/j.acthis.2007.10.003 · Cited by 52 · see citing works
Astrocytes Are the Source of TNF Mediating Homeostatic Synaptic Plasticity
Heir, R., Abbasi, Z., Komal, P., Altimimi, H. F., Franquin, M., Moschou, D., Chambon, J., & Stellwagen, D. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.2278-22.2024 · Cited by 52 · see citing works
Inflammatory Markers in Substance Use and Mood Disorders: A Neuroimaging Perspective
Agarwal, K., Manza, P., Chapman, M., Nawal, N., Biesecker, E., McPherson, K. L., Dennis, E., Johnson, A., Volkow, N. D., & Joseph, P. V. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.863734 · Cited by 51 · see citing works
The History of the Intestinal Microbiota and the Gut-Brain Axis
Lewandowska, Z., Figlerowicz, M., & Mazur‐Melewska, K. (2022) · Pathogens · doi:10.3390/pathogens11121540 · Cited by 51 · see citing works
Dopamine D1-like receptor activation induces brain-derived neurotrophic factor protein expression
Williams, S. N., & Undieh, A. S. (2009) · Neuroreport · doi:10.1097/wnr.0b013e32832a0a98 · Cited by 47 · see citing works
Malik, A., Szydłowska, K., Nizińska, K., Asaro, A., van Vliet, E., Popp, O., Dittmar, G., Fritsche-Guenther, R., Kirwan, J., Nykjaer, A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.027 · Cited by 46 · see citing works
Liu, J., Fang, Y., Cui, L.-X., Wang, Z., Luo, Y., Gao, C., Ge, W., Huang, T., Wen, J., & Zhou, T. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112861 · Cited by 46 · see citing works
The role of neurotrophic factors in novel, rapid psychiatric treatments
Kim, J., He, M. J., Widmann, A. K., & Lee, F. S. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01717-x · Cited by 46 · see citing works
Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders
Marchi, F. D., Munitić, I., Vidatic, L., Papić, E., Rački, V., Nimac, J., Jurak, I., Novotni, G., Rogelj, B., Vuletić, V., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11102793 · Cited by 46 · see citing works
Revisiting the Monoamine Hypothesis of Depression: A New Perspective
Goldberg, J. S., Bell, C. E., & Pollard, D. A. (2014) · Perspectives in Medicinal Chemistry · doi:10.4137/pmc.s11375 · Cited by 45 · see citing works
Astrocytes as cellular mediators of cue reactivity in addiction
Kruyer, A., & Kalivas, P. W. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.07.009 · Cited by 44 · see citing works
Ferrara, G. B., Errede, M., Girolamo, F., Morando, S., Ivaldi, F., Panini, N., Bendotti, C., Perris, R., Furlan, R., Virgintino, D., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1563-z · Cited by 43 · see citing works
Microbiome and substances of abuse
Salavrakos, M., Leclercq, S., de Timary, P., & Dom, G. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110113 · Cited by 43 · see citing works
Котлярова, А. А., & Sidorova, Y. A. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.679034 · Cited by 43 · see citing works
Inflammatory pathophysiological mechanisms implicated in postpartum depression
Zhu, J., Jin, J., & Tang, J. Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.955672 · Cited by 42 · see citing works
Costa, T., Fernández‐Villalba, E., Izura, V., Lucas-Ochoa, A.-M., Menezes-Filho, N. J., Santana, R., de Oliveira, M., Araújo, F., Estrada, C. M., Silva, V., et al. (2020) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-020-09925-8 · Cited by 41 · see citing works
Dadkhah, M., Baziar, M., & Rezaei, N. (2023) · Cytokine · doi:10.1016/j.cyto.2023.156477 · Cited by 41 · see citing works
Microglia in neuroimmunopharmacology and drug addiction
Li, H., Watkins, L. R., & Wang, X. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02443-6 · Cited by 41 · see citing works
Two-Photon Imaging of Microglia in the Mouse Cortex In Vivo
Nimmerjahn, A. (2012) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot069294 · Cited by 38 · see citing works
Chandley, M., Szebeni, A., Szebeni, K., Wang‐Heaton, H., Garst, J., Stockmeier, C. A., Lewis, N. H., & Ordway, G. A. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110559 · Cited by 38 · see citing works
Astrocytes: The Stars in Neurodegeneration?
Dittlau, K. S., & Freude, K. (2024) · Biomolecules · doi:10.3390/biom14030289 · Cited by 38 · see citing works
Mood and microbes: a comprehensive review of intestinal microbiota’s impact on depression
Luqman, A., He, M., Hassan, A., Ullah, M., Zhang, L., Khan, M. R., Din, A. U., Ullah, K., Wang, W. J., & Wang, G. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1295766 · Cited by 38 · see citing works
Glial-neuronal ensembles: partners in drug addiction-associated synaptic plasticity
Cadet, J. L., & Bisagno, V. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00204 · Cited by 37 · see citing works
NG2 cells and their neurogenic potential
Kirdajová, D., & Anděrová, M. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.11.005 · Cited by 37 · see citing works
Glial mechanisms underlying major depressive disorder: Potential therapeutic opportunities
Rahman, S., & Alzarea, S. I. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.06.010 · Cited by 36 · see citing works
Ethanol-mediated alterations in oligodendrocyte differentiation in the developing brain
Darbinian, N., Darbinyan, A., Merabova, N., Bajwa, A., Tatevosian, G., Martirosyan, D., Zhao, H., Selzer, M. E., & Goetzl, L. M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105181 · Cited by 36 · see citing works
Velasco, B., Mohamed, E., & Sato‐Bigbee, C. (2021) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2021.107002 · Cited by 36 · see citing works
Zhou, Y., & Zhang, J. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1221890 · Cited by 36 · see citing works
Gál, Z., Török, D., Gonda, X., Eszlári, N., Anderson, I. M., Deakin, J. F. W., Juhász, G., Bagdy, G., & Petschner, P. (2022) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyac079 · Cited by 35 · see citing works
Niciu, M. J., Henter, I. D., Sanacora, G., & Zarate, C. A. (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.829585 · Cited by 34 · see citing works
Interaction of Heavy Metal Lead with Gut Microbiota: Implications for Autism Spectrum Disorder
Tizabi, Y., Bennani, S., Kouhen, N. E., Getachew, B., & Aschner, M. (2023) · Biomolecules · doi:10.3390/biom13101549 · Cited by 34 · see citing works
Self-citationInsights into optimizing exosome therapies for acute skin wound healing and other tissue repair
Sun, T., Li, M., Liu, Q., Yu, A., Cheng, K., Ma, J., Murphy, S. V., McNutt, P. M., & Zhang, Y. (2024) · Frontiers of Medicine · doi:10.1007/s11684-023-1031-9 · Cited by 32 · see citing works
Channels and Transporters in Astrocyte Volume Regulation in Health and Disease
Reed, M., & Blazer‐Yost, B. L. (2022) · Cellular Physiology and Biochemistry · doi:10.33594/000000495 · Cited by 31 · see citing works
Substance use disorder and lifetime suicidal behaviour: A scoping review
Leza, L., Haro, B., López-Goñi, J. J., & Fernández‐Montalvo, J. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115830 · Cited by 31 · see citing works
Formánek, T., Krupchanka, D., Mladá, K., Winkler, P., & Jones, P. B. (2022) · The Lancet Psychiatry · doi:10.1016/s2215-0366(22)00335-2 · Cited by 30 · see citing works
Dysfunction of NG2 glial cells affects neuronal plasticity and behavior
Timmermann, A., Tascio, D., Jabs, R., Boehlen, A., Domingos, C., Skubal, M., Huang, W., Kirchhoff, F., Henneberger, C., Bilkei‐Gorzó, A., et al. (2023) · Glia · doi:10.1002/glia.24352 · Cited by 30 · see citing works
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The Gut Microbiome-Neuroglia Axis: Implications for Brain Health, Inflammation, and Disease
Camberos-Barraza, J., Guadrón‐Llanos, A. M., & la Herrán-Arita, A. K. D. (2024) · Neuroglia · doi:10.3390/neuroglia5030018 · Cited by 34 · see citing works
Miller, M. R., Landis, H. E., Miller, R. E., & Tizabi, Y. (2024) · Cells · doi:10.3390/cells13181554 · Cited by 24 · see citing works
Self-citationHeavy Metal Interactions with Neuroglia and Gut Microbiota: Implications for Huntington’s Disease
Tizabi, Y., Bennani, S., Kouhen, N. E., Getachew, B., & Aschner, M. (2024) · Cells · doi:10.3390/cells13131144 · Cited by 17 · see citing works
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- Authors
- Tizabi, Y., Getachew, B., Hauser, S. R., Tsytsarev, V., Manhães, A. C., & da Silva, V. D. A.
- Affiliations
- Howard University (US)
- Indiana University School of Medicine (US)
- University of Maryland, Baltimore (US)
- Universidade do Estado do Rio de Janeiro (BR)
- Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador 40110-100, BA, Brazil
- Corresponding author
- Tizabi, Yousef
- ORCID
- Venue
- Brain Sciences
- Publisher
- MDPI AG
- Published
- 2024-05-30
- Volume
- 14
- Issue
- 6
- Pages
- 558
- ISSN
- 2076-3425 (ISSN-L)
- PMC
- PMC11201416
- OpenAlex
- W4399175317
- Cited by
- 27
- References
- 269
- Citations by year
- 2026: 4 · 2025: 16 · 2024: 7
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brain Sciences (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IUScholarWorks (Indiana University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- NIH/NIAAA (R03AA022479, 2 SO6 GM08016-39)
- NIH/NIGMS (R03AA022479, 2 SO6 GM08016-39)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- glial cells, mood disorders, substance use disorders, drug addiction, microglia, astrocytes, oligodendrocytes, neurotrophic factors, neuroinflammation, gut microbiota, reward systems, mood regulation, new drugs
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