Cited by 27Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchTryptophan and brain disorders

Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction

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Tizabi, Yousef, Getachew, Bruk, Hauser, Sheketha R., Tsytsarev, Vassiliy, Manhães, Alex C., da Silva, Victor Diogenes Amaral·2024·Brain Sciences

Published version of a preprint

Abstract

Mood disorders and substance use disorder (SUD) are of immense medical and social concern. Although significant progress on neuronal involvement in mood and reward circuitries has been achieved, it is only relatively recently that the role of glia in these disorders has attracted attention. Detailed understanding of the glial functions in these devastating diseases could offer novel interventions. Here, following a brief review of circuitries involved in mood regulation and reward perception, the specific contributions of neurotrophic factors, neuroinflammation, and gut microbiota to these diseases are highlighted. In this context, the role of specific glial cells (e.g., microglia, astroglia, oligodendrocytes, and synantocytes) on phenotypic manifestation of mood disorders or SUD are emphasized. In addition, use of this knowledge in the potential development of novel therapeutics is touched upon.

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Crossref · 10.3390/brainsci14060558

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Authors
Tizabi, Y., Getachew, B., Hauser, S. R., Tsytsarev, V., Manhães, A. C., & da Silva, V. D. A.
Affiliations
  • Howard University (US)
  • Indiana University School of Medicine (US)
  • University of Maryland, Baltimore (US)
  • Universidade do Estado do Rio de Janeiro (BR)
  • Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador 40110-100, BA, Brazil
Corresponding author
Tizabi, Yousef
Venue
Brain Sciences
Publisher
MDPI AG
Published
2024-05-30
Volume
14
Issue
6
Pages
558
ISSN
2076-3425 (ISSN-L)
OpenAlex
W4399175317
Cited by
27
References
269
Citations by year
2026: 4 · 2025: 16 · 2024: 7
FWCI
1.38
Type
journal article
Language
en
Open access
Locations
  • Brain Sciences (publishedVersion, cc-by)
  • Preprints.org (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • IUScholarWorks (Indiana University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • NIH/NIAAA (R03AA022479, 2 SO6 GM08016-39)
  • NIH/NIGMS (R03AA022479, 2 SO6 GM08016-39)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
glial cells, mood disorders, substance use disorders, drug addiction, microglia, astrocytes, oligodendrocytes, neurotrophic factors, neuroinflammation, gut microbiota, reward systems, mood regulation, new drugs

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