Rationalizing Polysaccharide Extraction with Deep Eutectic Solvents: From Supramolecular Architecture to Emerging AI-Guided Solvent Design
Open accessPreprint — published as 10.3390/polysaccharides6030082
Abstract
Deep eutectic solvents (DESs) have emerged as sustainable and tunable alternatives to conventional solvents for the extraction polysaccharides. This review presents a struc-ture-informed framework linking DES composition to polysaccharide solubility, em-phasizing the differential responsiveness of amorphous, interfacial, and crystalline domains. Amorphous polysaccharides are efficiently extracted under mild DES condi-tions, while crystalline polymers often require stronger hydrogen bond acceptors or thermal/mechanical activation. Beyond dissolution, DESs modulate key properties of the extracted polysaccharides, including molecular weight, monomer composition, and bioactivity. Comparative analysis highlights how acidic, basic, or metal-coordinating DESs selectively target distinct polymer classes. Emerging innovations, such as in situ DES formation, mechanochemical systems, and switchable solvents, enhance efficiency and reduce downstream processing demands. Furthermore, the integration of machine learning and COSMO-RS modeling enables predictive solvent design, reducing reliance on empirical screening. By combining mechanistic insight, compositional tailoring, and computational tools, this review provides a scientifically grounded perspective for ad-vancing DES-mediated extraction processes and enabling structure-preserving, appli-cation-oriented recovery of polysaccharides in food, pharmaceutical, and biorefinery domains.
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By applying predictive modeling, researchers can avoid time-consuming empirical screening and accelerate rational design of DESs tailored for specific analytical purposes.
“By applying predictive modeling, researchers can avoid time-consuming empirical screening and accelerate the rational design of DESs tailored for specific analytical purposes [138].”
From Eco-Friendly Deep Eutectic Solvent-Based Extraction Technologies: A Comprehensive Review of Principles, Applications, and Comparative Insights (2026) · cites this paper as [138]
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Ionic liquids and deep eutectic solvents in polysaccharide extraction
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- Authors
- Al-Akayleh, F., Ali Agha, A. S. A., Olaimat, A. R., & Qinna, N. A.
- Affiliations
- University of Modena and Reggio Emilia (IT)
- Petra University (JO)
- Venue
- Polysaccharides
- Publisher
- MDPI AG
- Published
- 2025-07-08
- Volume
- 6
- Issue
- 3
- Pages
- 82-82
- ISSN
- 2673-4176 (ISSN-L)
- OpenAlex
- W4414096675
- Cited by
- 41
- References
- 180
- Citations by year
- 2026: 38 · 2025: 3
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Polysaccharides (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Chemical Engineering › Catalysis › Ionic liquids properties and applications
- Physical Sciences › Engineering › Biomedical Engineering › Phase Equilibria and Thermodynamics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- deep eutectic solvents, polysaccharide extraction, solvent design, polysaccharide solubility, hydrogen bond acceptors, switchable solvents, machine learning, COSMO-RS, molecular weight distribution, polysaccharide bioactivity, biorefinery
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