The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
The role of reactive oxygen species in the pathophysiology of cardiovascular diseases and the clinical significance of myocardial redox
Open accessAbstract
Acute and chronic excessive intracellular increase of reactive oxygen species (ROS) is involved in the development and progression of cardiovascular diseases. ROS are by-products of various oxidative physiological and biochemical processes. Sources of ROS are mitochondrial respiration, NADH/NADPH oxidase, xanthine oxidoreductase or the uncoupling of nitric oxide synthase (NOS) in vascular cells. ROS mediate various signaling pathways that underlie cardiovascular pathophysiology. The delicate equilibrium between free-radical generation and antioxidant defense is altered in favor of the former, thus leading to redox imbalance, oxidative stress, and increased cellular injury. An understanding of the pathophysiological mechanisms mediated by oxidative stress is crucial to the prevention and treatment of cardiovascular diseases.
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Cited by
ROS and diseases: role in metabolism and energy supply
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Theranostic Fluorescent Probes
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Biocompatibility and toxicity challenges of nanomaterials
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Metadata
- Authors
- Moris, D., Spartalis, M., Spartalis, E., Karachaliou, G.-S., Karaolanis, G. I., Tsourouflis, G., Tsilimigras, D. I., Tzatzaki, E., & Theocharis, S.
- Venue
- Annals of Translational Medicine
- Publisher
- AME Publishing Company
- Published
- 2017-08
- Volume
- 5
- Issue
- 16
- Pages
- 326-326
- ISSN
- 2305-5839 (ISSN-L)
- 2305-5847
- OpenAlex
- W2744282338
- Cited by
- 308
- References
- 63
- FWCI
- 10.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Moris, D., Spartalis, M., Spartalis, E., Karachaliou, G.-S., Karaolanis, G. I., Tsourouflis, G., Tsilimigras, D. I., Tzatzaki, E., & Theocharis, S. (2017). The role of reactive oxygen species in the pathophysiology of cardiovascular diseases and the clinical significance of myocardial redox. Annals of Translational Medicine. https://doi.org/10.21037/atm.2017.06.27
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
