Heart transplantation in survivors of childhood cancer
Open accessAbstract
There are approximately 450,000 survivors of childhood cancer due, in large part, to successes of therapeutic regimens. With this success comes an increase in the number of patients developing cardiotoxicity as a result of cancer therapies. In certain cases, this includes heart failure recalcitrant to medical therapy, and consideration for heart transplantation may be necessary. However, this group of patients has unique comorbidities that may affect outcomes. Despite this, available data show that complications and overall survival are similar for patients transplanted for anthracycline-induced cardiomyopathy compared to those with other cardiomyopathies, demonstrating that this is a viable treatment option for this population. As other cancer therapies become more common, new cardiovascular toxicities are recognized. Whether heart transplantation will be appropriate for all patients with cancer-therapy related cardiotoxicity (CTRC) will require demonstration of similarly good outcomes to ensure proper allocation of organs.
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Allogeneic heart transplants may be indicated for severe cases of anthracycline-induced heart failure.
“Allogeneic heart transplants may be indicated for severe cases 165,166 .”
From Osteosarcoma (2022) · cites this paper as [166]
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- Authors
- Shugh, S. B., & Ryan, T. D.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Ryan, Thomas D.
- Venue
- Translational Pediatrics
- Publisher
- AME Publishing Company
- Published
- 2019-10
- Volume
- 8
- Issue
- 4
- Pages
- 314-321
- ISSN
- 2224-4336 (ISSN-L)
- 2224-4344
- PMC
- PMC6825967
- OpenAlex
- W2950189434
- Cited by
- 13
- References
- 51
- Citations by year
- 2026: 2 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 1
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Translational Pediatrics (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Chemotherapy-induced cardiotoxicity and mitigation
- Physical Sciences › Engineering › Biomedical Engineering › Mechanical Circulatory Support Devices
- Keywords
- heart transplantation, childhood cancer survivors, cancer therapy-related cardiotoxicity, anthracycline-induced cardiomyopathy, heart failure, transplant outcomes, organ allocation, cardiotoxicity
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