The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Vaccination and Allergic Disease: A Birth Cohort Study
Open accessAbstract
OBJECTIVES: We examined the effect of vaccination for diphtheria; polio; pertussis and tetanus; or measles, mumps, and rubella on the incidence of physician-diagnosed asthma and eczema. METHODS: We used a previously established birth cohort in the West Midlands General Practice research database. RESULTS: We found an association between vaccination and the development of allergic disease; however, this association was present only among children with the fewest physician visits and can be explained by this factor. CONCLUSIONS: Our data suggest that currently recommended routine vaccinations are not a risk factor for asthma or eczema.
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“Significant association only for the group with lower GP consultation during the first 6 live months (hazard ratio 7.18; 95% CI from 2. 95 to 17. 49)”
From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as McKeever 2004
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In the citing paper
“Stratifying for GP consultation frequency in the first 18 months, HR estimates remain significant only for the subgroup with lower consulting frequency (zero to six times in the first 18 months) and not for the other subgroups (seven to 10 times, 11 to 16 times and more than 16 times): HR 7.18 (95% CI 2.95 to 17.49) for association between MMR vaccination and asthma; HR 10.4 (95% CI 4.61 to 23.29)”
From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as McKeever 2004
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“Estimates from McKeever 2004 (although significant) are strongly affected by ascertainment bias, as children who are not taken to the doctor are less likely to be vaccinated and also have fewer opportunities to have diagnoses of allergic diseases recorded.”
From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as McKeever 2004
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“Correspondent crude hazard ratios (HR) were 3.51 (95% CI 2.42 to 5.11) and 4.61 (95% CI 3.15 to 6.74) for asthma and eczema, respectively.”
From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as McKeever 2004
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Citations
Cites
Hay fever, hygiene, and household size.
Strachan, D. P. (1989) · BMJ · doi:10.1136/bmj.299.6710.1259 · Cited by 5,054
Atopy in children of families with an anthroposophic lifestyle
Alm, J. S., Swartz, J., Lilja, G., Scheynius, A., & Pershagen, G. (1999) · The Lancet · doi:10.1016/s0140-6736(98)09344-1 · Cited by 531
Early childhood infection and atopic disorder
Farooqi, I. S., & Hopkin, J. M. (1998) · Thorax · doi:10.1136/thx.53.11.927 · Cited by 377
Does a higher number of siblings protect against the development of allergy and asthma? A review
Karmaus, W., & Botezan, C. (2002) · Journal of Epidemiology and Community Health · doi:10.1136/jech.56.3.209 · Cited by 319
McKeever, T. M., Lewis, S., Smith, C., Collins, J. S., Heatlie, H., Frischer, M., & Hubbard, R. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.121016 · Cited by 276
Risk Factors for Delayed Immunization in a Random Sample of 1163 Children From Oregon and Washington
Bobo, J. K., Gale, J. L., Thapa, P. B., & Wassilak, S. G. F. (1993) · PEDIATRICS · doi:10.1542/peds.91.2.308 · Cited by 183
A Randomized Controlled Trial of the Effect of Pertussis Vaccines on Atopic Disease
Nilsson, L. J. (1998) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.152.8.734 · Cited by 142
McKeever, T. M. (2001) · Thorax · doi:10.1136/thorax.56.10.758 · Cited by 139
Is Infant Immunization a Risk Factor for Childhood Asthma or Allergy?
Kemp, T., Pearce, N. E., Fitzharris, P., Crane, J., Fergusson, D. M., George, I. S., Wickens, K. L., & Beasley, R. W. (1997) · Epidemiology · doi:10.1097/00001648-199710000-00011 · Cited by 126
ANDERSON, H. R., Poloniecki, J. D., Strachan, D. P., Beasley, R. W., Björkstén, B., & Asher, M. I. (2001) · American Journal of Public Health · doi:10.2105/ajph.91.7.1126 · Cited by 120
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Vaccines for measles, mumps and rubella in children
Demicheli, V., Rivetti, A., Debalini, M. G., & Di Pietrantonj, C. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004407.pub3 · Cited by 372
Vaccines for measles, mumps, rubella, and varicella in children
Pietrantonj, C. D., Rivetti, A., Marchione, P., Debalini, M. G., & Demicheli, V. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004407.pub4 · Cited by 202
Adhikari, U. K., Tayebi, M., & Rahman, M. (2018) · Journal of Immunology Research · doi:10.1155/2018/6718083 · Cited by 174
“Before vaccine design, the allergenicity prediction is a key step, because most vaccines transfer the immune response to the allergic reaction by initiating immunoglobulin E and Type II T-helper cells [53].”
BackgroundAtopic Dermatitis and the Hygiene Hypothesis Revisited
Flohr, C., & Yeo, L. (2011) · Current problems in dermatology · doi:10.1159/000323290 · Cited by 130
Oany, A. R., Pervin, T., & Emran, A. A. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s67861 · Cited by 103
“Today, most vaccines stimulate the immune system into an "allergic" reaction, 60 through induction of type 2 T helper T (Th2) cells and immunoglobulin E (IgE).”
Metadata
- Authors
- McKeever, T. M., Lewis, S. A., Smith, C., & Hubbard, R.
- Affiliations
- University of Nottingham (GB)
- Venue
- American Journal of Public Health
- Publisher
- American Public Health Association
- Published
- 2004-06
- Volume
- 94
- Issue
- 6
- Pages
- 985-989
- ISSN
- 0090-0036 (ISSN-L)
- 1541-0048
- PMC
- PMC1448377
- OpenAlex
- W1982817031
- Cited by
- 114
- References
- 29
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 14 · 2020: 13 · 2019: 7 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 5 · 2014: 2 · 2013: 3 · 2012: 5
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Public Health (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- vaccination, allergic diseases, asthma, atopic dermatitis, diphtheria, poliomyelitis, pertussis, tetanus, measles, mumps and rubella, routine childhood immunization, physician visits, birth cohort
- MeSH terms
- Asthma, Child, Child, Preschool, Eczema, England, Female, Humans, Infant, Infant, Newborn, Male, Physicians, Family, Vaccination, Cohort Studies
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