The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Mesenchymal Stromal Cells Promote Tumor Growth through the Enhancement of Neovascularization
Open accessAbstract
Mesenchymal stromal cells (MSCs), also called mesenchymal stem cells, migrate and function as stromal cells in tumor tissues. The effects of MSCs on tumor growth are controversial. In this study, we showed that MSCs increase proliferation of tumor cells in vitro and promote tumor growth in vivo. We also further analyzed the mechanisms that underlie these effects. For use in in vitro and in vivo experiments, we established a bone marrow-derived mesenchymal stromal cell line from cells isolated in C57BL/6 mice. Effects of murine MSCs on tumor cell proliferation in vitro were analyzed in a coculture model with B16-LacZ cells. Both coculture with MSCs and treatment with MSC-conditioned media led to enhanced growth of B16-LacZ cells, although the magnitude of growth stimulation in cocultured cells was greater than that of cells treated with conditioned media. Co-injection of B16-LacZ cells and MSCs into syngeneic mice led to increased tumor size compared with injection of B16-LacZ cells alone. Identical experiments using Lewis lung carcinoma (LLC) cells instead of B16-LacZ cells yielded similar results. Consistent with a role for neovascularization in MSC-mediated tumor growth, tumor vessel area was greater in tumors resulting from co-injection of B16-LacZ cells or LLCs with MSCs than in tumors induced by injection of cancer cells alone. Co-injected MSCs directly supported the tumor vasculature by localizing close to vascular walls and by expressing an endothelial marker. Furthermore, secretion of leukemia inhibitory factor, macrophage colony-stimulating factor, macrophage inflammatory protein-2 and vascular endothelial growth factor was increased in cocultures of MSCs and B16-LacZ cells compared with B16-LacZ cells alone. Together, these results indicate that MSCs promote tumor growth both in vitro and in vivo and suggest that tumor promotion in vivo may be attributable in part to enhanced angiogenesis.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Moreover, newer studies have depicted that injection of MSC subcutaneously develops tumor growth and neovascularization in syngeneic mouse models by promoting tumor vasculature and secreting proangiogenic factors [110].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [110]
Citations
Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues
Prockop, D. J. (1997) · Science · doi:10.1126/science.276.5309.71 · Cited by 4,629
Tumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391 · cited 1×
“INTRODUCTION Growth of solid tumors requires formation of the tumor stroma, which supplies oxygen and nutrients to tumor cells (1).”
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
Karnoub, A. E., Dash, A. B., Vo, A. P., Sullivan, A., Brooks, M. W., Bell, G. W., Richardson, A. L., Polyak, K., Tubo, R., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06188 · Cited by 3,206
Bissell, M. J., & Radisky, D. (2001) · Nature Reviews Cancer · doi:10.1038/35094059 · Cited by 2,180
Ortiz, L. A., Gambelli, F., McBride, C., Gaupp, D., Baddoo, M., Kaminski, N., & Phinney, D. G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432929100 · Cited by 1,462
Mesenchymal Stem Cell Homing: The Devil Is in the Details
Karp, J. M., & Leng Teo, G. S. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.02.001 · Cited by 1,445
Campagnoli, C., Roberts, I. A. G., Kumar, S., Bennett, P. R., Bellantuono, I., & Fisk, N. M. (2001) · Blood · doi:10.1182/blood.v98.8.2396 · Cited by 1,347
Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals
Djouad, F., Plence, P., Bony, C., Tropel, P., Apparailly, F., Sany, J., Noël, D., & Jorgensen, C. (2003) · Blood · doi:10.1182/blood-2003-04-1193 · Cited by 1,166
Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression
Hwang, R. F., Moore, T. T., Arumugam, T., Ramachandran, V., Amos, K. D., Rivera, A. M., Ji, B., Evans, D. B., & Logsdon, C. D. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5714 · Cited by 1,117
Cited by
Sorted by citations
Items 101–200 of 244
Mesenchymal stem cell therapy in diabetic foot ulcer: An updated comprehensive review
Hetta, . F., Elsaghir, A., Sijercic, V. C., Akhtar, M. S., Gad, S. A., Moses, A., Zeleke, M. S., Alanazi, F. E., Ahmed, A. K., & Ramadan, Y. N. (2024) · Health Science Reports · doi:10.1002/hsr2.2036 · Cited by 36
Sağlam, Ö., HALBUTOĞULLARI, Z. S., Subaşı, C., Ulukaya, E., & Karaöz, E. (2015) · Tumor Biology · doi:10.1007/s13277-015-3241-5 · Cited by 29
Immune cell landscape in therapy-naïve squamous cell and adenocarcinomas of the lung
Brčić, L., Stanzer, S., Krenbek, D., Gruber-Moesenbacher, U., Absenger, G., Quehenberger, F., Valipour, A., Lindenmann, J., Stoeger, H., Effah, M. A., et al. (2018) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-018-2326-0 · Cited by 29
Tumor-driven Molecular Changes in Human Mesenchymal Stromal Cells
Kučerová, L., Zmajkovic, J., Toro, L., Miklikova, S., Demková, L., & Matúšková, M. (2014) · Cancer Microenvironment · doi:10.1007/s12307-014-0151-9 · Cited by 28
Kamrani, S., Naseramini, R., Khani, P., Razavi, Z. S., Afkhami, H., Atashzar, M. R., Nasri, F., Alavimanesh, S., Saeidi, F., & Ronaghi, H. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03741-x · Cited by 27
“Moreover, newer studies have depicted that injection of MSC subcutaneously develops tumor growth and neovascularization in syngeneic mouse models by promoting tumor vasculature and secreting proangiogenic factors [110].”
Jahangiri, B., Khalaj‐Kondori, M., Asadollahi, E., Saei, A. K., & Sadeghizadeh, M. (2023) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-023-00794-3 · Cited by 29
Lasso, J. M., Cano, R. P., Castro, Y. G. S. D., de Arenas, L. M. D. R., García, J., & Fernández‐Santos, M. E. (2015) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2015.07.005 · Cited by 27
Safety Considerations in 3D Bioprinting Using Mesenchymal Stromal Cells
Belk, L., Tellisi, N., Macdonald, H., Erdem, A., Ashammakhi, N. A., & Pountos, I. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00924 · Cited by 28
Fusion of cancer stem cells and mesenchymal stem cells contributes to glioma neovascularization
Sun, C., Zhao, D., Dai, X., CHEN, J., Rong, X., Wang, H., Wang, A., Li, M., Dong, J., Huang, Q., et al. (2015) · Oncology Reports · doi:10.3892/or.2015.4135 · Cited by 27
Sequential culture on biomimetic nanoclay scaffolds forms three‐dimensional tumoroids
Katti, K. S., Molla, M. S., Karandish, F., Haldar, M. K., Mallik, S., & Katti, D. R. (2016) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35685 · Cited by 27
Targeting the IL-17/IL-6 axis can alter growth of Chronic Lymphocytic Leukemia in vivo/in vitro
Zhu, F., McCaw, L., Spaner, D., & Gorczynski, R. M. (2018) · Leukemia Research · doi:10.1016/j.leukres.2018.01.006 · Cited by 26
Fathollahi, A., Hashemi, S. M., Hoseini, M. H. M., & Yeganeh, F. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.12.009 · Cited by 26
Carmi, Y. K., Mahmoud, H., Khamaisi, H., Adawi, R., Gopas, J., & Mahajna, J. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186533 · Cited by 26
Ramuta, T. Ž., & Kreft, M. E. (2022) · Cancers · doi:10.3390/cancers14153761 · Cited by 28
Liu, B., Chen, F., Wu, Y. C., Wang, X., Feng, M., Li, Z., Zhou, M., Wang, Y., Wu, L., Liu, X., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16584 · Cited by 26
Adult Stem Cell Functioning in the Tumor Micro-Environment
Jiang, Y., Wells, A. H., Sylakowski, K., Clark, A. M., & Ma, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102566 · Cited by 26
Therapeutic Application of Cell Secretomes in Cutaneous Wound Healing
Bormann, D., Gugerell, A., Ankersmit, H. J., & Mildner, M. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.02.019 · Cited by 28
Stem Cell Based Gene Therapy in Prostate Cancer
Kim, J. H., Lee, H. J., & Song, Y. S. (2014) · BioMed Research International · doi:10.1155/2014/549136 · Cited by 26
The dual role of mesenchymal stem cells in tumor progression
Gomes, C. M. F. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt189 · Cited by 25
Bidirectional and Opposite Effects of Naïve Mesenchymal Stem Cells Ontumor Growth and Progression
Rahmatizadeh, F., Aziz, S. G., Khodadadi, K., Ataei, M. L., Ebrahimie, E., Rad, J. S., & Pashaiasl, M. (2019) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2019.063 · Cited by 25
Engineering mesenchymal stem cells: a novel therapeutic approach in breast cancer
Heidari, R., Dehkordi, N. G., Mohseni, R., & Safaei, M. (2020) · Journal of drug targeting · doi:10.1080/1061186x.2020.1775842 · Cited by 24
Bruna, F., Arango-Rodríguez, M. L., Plaza, A., Espinoza, I., & Conget, P. A. (2016) · Stem Cell Research · doi:10.1016/j.scr.2016.11.016 · Cited by 26
Knight, R. J., Emma Board-Davies, Brown, H. L., Clayton, A., Davis, T., Karatas, B., Burston, J. J., Tabi, Z., Falcón‐Pérez, J. M., Paisey, S. J., et al. (2022) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szac037 · Cited by 24
RetractedHerrmann, M., Stanić, B., Hildebrand, M., Alini, M., & Verrier, S. (2019) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2902 · Cited by 23
Bone marrow-derived stromal cells are associated with gastric cancer progression
Kasashima, H., Yashiro, M., Nakamae, H., Masuda, G., Kinoshita, H., Morisaki, T., Fukuoka, T., Hasegawa, T., Sakurai, K., Toyokawa, T., et al. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.236 · Cited by 23
Fracchiolla, N. S., Fattizzo, B., & Cortelezzi, A. (2017) · Stem Cells International · doi:10.1155/2017/6720594 · Cited by 23
Kim, E., Kim, H., Yang, Y., Kim, J., Choi, M.-Y., Choi, C. S., Kim, K.-H., Lee, J.-H., Jang, W.-H., & Cheong, S.-H. (2013) · Journal of Pathology and Translational Medicine · doi:10.4132/koreanjpathol.2013.47.6.507 · Cited by 21
The Potential Role of Microvesicles in Mesenchymal Stem Cell-Based Therapy
Huang, Y., Parolini, O., & Deng, L. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0631 · Cited by 21
Immunomodulatory function of mesenchymal stem cells: regulation and application
Qu, G., Xie, X., Li, X., Chen, Y., de Isla, N., Huselstein, C., Stoltz, J., & Li, Y. (2018) · Journal of Cellular Immunotherapy · doi:10.1016/j.jocit.2018.09.001 · Cited by 20
Nadesh, R., Menon, K. N., Biswas, L., Mony, U., Iyer, K. S., Vijayaraghavan, S., Nambiar, A., & Nair, S. V. (2021) · Scientific Reports · doi:10.1038/s41598-021-01878-z · Cited by 21
Ho, Y. K., Loke, K. M., Woo, J. Y., Lee, Y. L., & Too, H. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03198-z · Cited by 19
Duś‐Szachniewicz, K., Gdesz-Birula, K., & Rymkiewicz, G. (2022) · OncoTargets and Therapy · doi:10.2147/ott.s363994 · Cited by 21
Advances in mesenchymal stromal cells and nanomaterials for diabetic wound healing
Hou, L., Zhang, X., & Du, H. (2023) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3638 · Cited by 19
Exosome-based advances in pancreatic cancer: The potential of mesenchymal stem cells
Rahimian, S., Mirkazemi, K., Nejad, A. K., & Doroudian, M. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104594 · Cited by 18
Jazedje, T., Ribeiro, A. L., Pelatti, M., Bueno, H. M. D. S., Nagata, G. Y., Trierveiler, M., Rodrigues, E. G., & Zatz, M. (2015) · Stem Cells International · doi:10.1155/2015/796215 · Cited by 18
Reduction of tumorigenicity by placental extracts.
Marleau, A. M., McDonald, G., Koropatnick, J. D., Chen, C.-S., & Koos, D. (2012) · PubMed · Cited by 18
Bruna, F., Plaza, A., Arango-Rodríguez, M. L., Espinoza, I., & Conget, P. A. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0878-1 · Cited by 18
Razmkhah, M., Abtahi, S., & Ghaderi, A. A. (2018) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x13666180816114809 · Cited by 18
Alhattab, D. M., Isaioglou, I., Alshehri, S., Khan, Z. N., Susapto, H. H., Li, Y., Marghani, Y., Alghuneim, A. A., Díaz‐Rúa, R., Abdelrahman, S., et al. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00457-9 · Cited by 21
Li, C., Ruan, J., Yang, M., Pan, F., Gao, G., Qu, S., Shen, Y.-L., Dang, Y., Wang, K., Jin, W., et al. (2015) · Europe PMC (PubMed Central) · doi:10.7497/j.issn.2095-3941.2015.0040 · Cited by 16
Carnet, O., Lecomte, J., Masset, A., Primac, I., Durré, T., Maertens, L., Detry, B., Blacher, S., Gilles, C., Péqueux, C., et al. (2015) · Neoplasia · doi:10.1016/j.neo.2015.07.002 · Cited by 16
Diverse roles of tumor-stromal PDGFB-to-PDGFRβ signaling in breast cancer growth and metastasis
Shah, S., & Sizemore, G. M. (2022) · Advances in cancer research · doi:10.1016/bs.acr.2022.01.003 · Cited by 15
Rajendran, R. L., Jogalekar, M. P., Gangadaran, P., & Ahn, B. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i12.1492 · Cited by 14
Assessment of the Number and Phenotype of Macrophages in the Human BMB Samples of CML
Jian-xin, S., Dian, Z.-J., Wen, Y., Mei, F., Li, R.-W., & Sa, Y.-L. (2016) · BioMed Research International · doi:10.1155/2016/8086398 · Cited by 13
Role of Mesenchymal Stem Cells in Cancer Development and Their Use in Cancer Therapy
Serakıncı, N., Tulay, P., & Kalkan, R. (2017) · Advances in experimental medicine and biology · doi:10.1007/5584_2017_64 · Cited by 13
Tunoğlu, E. N. Y., Genç, D., Farooqı, A. A., Tunoğlu, S., Zeybek, Ü., Akkoç, T., & Yaylım, İ. (2020) · Anticancer Research · doi:10.21873/anticanres.14577 · Cited by 13
Compton, S. L. E., Pyne, E. S., Liu, L., Guinan, J., Shea, A. A., Grieco, J. P., Frisard, M. I., & Schmelz, E. M. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112397 · Cited by 12
Li, S., Xiang, W., Tian, J., Wang, H., Hu, S., Wang, K., Chen, L., Huang, C., & Zhou, J. (2021) · BioMed Research International · doi:10.1155/2021/4952876 · Cited by 13
Ghollasi, M., Ghasembaglou, S., Rahban, D., Korani, M., Motallebnezhad, M., Asadi, M., Zarredar, H., & Salimi, A. (2021) · International Journal of Stem Cells · doi:10.15283/ijsc20146 · Cited by 13
Yoo, S., Jang, J., Yoo, C., & Lee, M. (2014) · Archives of Virology · doi:10.1007/s00705-014-2094-3 · Cited by 12
The Origin of Stroma Influences the Biological Characteristics of Oral Squamous Cell Carcinoma
Omori, H., Shan, Q., Takabatake, K., Nakano, K., Kawai, H., Sukegawa, S., Tsujigiwa, H., & Nagatsuka, H. (2021) · Cancers · doi:10.3390/cancers13143491 · Cited by 12
Autologous Fat Transfer for Facial Augmentation and Regeneration
Clauser, L. C., Lucchi, A., Tussardi, I. T., Gardin, C., & Zavan, B. (2018) · Atlas of the Oral and Maxillofacial Surgery Clinics · doi:10.1016/j.cxom.2017.10.002 · Cited by 12
Qian, H., Ding, X., Zhang, J., Mao, F., Sun, Z., Jia, H., Yin, L., Wang, M., Zhang, X., Zhang, B., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17133 · Cited by 12
Classes of Stem Cells: From Biology to Engineering
Shah, S., Ghosh, D., Otsuka, T., & Laurencin, C. T. (2023) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-023-00317-x · Cited by 12
Multipotent Mesenchymal Stromal Cells: Possible Culprits in Solid Tumors?
Johann, P. D., & Müller, I. (2015) · Stem Cells International · doi:10.1155/2015/914632 · Cited by 11
Mesenchymal Stem Cells: Pivotal Players in Hematopoietic Stem Cell Microenvironment
Marsafy, S. E. (2014) · Journal of Stem Cell Research & Therapy · doi:10.4172/2157-7633.1000225 · Cited by 12
Annabi, B., Zgheib, A., & Annabi, B. (2016) · International Journal of Stem Cells · doi:10.15283/ijsc16032 · Cited by 11
Inhibitory effect and mechanism of mesenchymal stem cells on melanoma cells
Zhang, J., Hou, L., Zhao, D., Pan, M., Wang, Z., Hu, H., & He, J. (2017) · Clinical & Translational Oncology · doi:10.1007/s12094-017-1677-3 · Cited by 11
Tian, Y., Yu, M., Sun, L., Liu, L., Huo, S., Shang, W., Sheng, S., Wang, J., Sun, J., Hu, Q., et al. (2019) · Oncology Reports · doi:10.3892/or.2019.7228 · Cited by 11
Zhang, T., Huang, T., Su, Y., & Gao, J. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202100030 · Cited by 12
Gentile, P. (2022) · Biomedicines · doi:10.3390/biomedicines10051179 · Cited by 12
Qin, Y., Zhuo, L., Cai, J., He, X., Liu, B., Feng, C., & Zhang, L. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7902 · Cited by 10
Najafabadi, M. M., Shamsasenjan, K., & Akbarzadehlaleh, P. (2018) · PubMed Central · doi:10.22074/cellj.2018.4924 · Cited by 9
The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma
Smith, H. L., Beers, S. A., Gray, J. C., & Kanczler, J. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155499 · Cited by 9
Modulatory effects of mesenchymal stem cells on leucocytes and leukemic cells: A double-edged sword?
Low, J. H., Ramdas, P., & Radhakrishnan, A. K. (2015) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2015.07.017 · Cited by 10
The role of orthobiologics in bone healing and joint and tendon degeneration in the upper limb
Shahri, N. B., Chong, A. K. S., & Karjalainen, T. (2025) · Journal of Hand Surgery (European Volume) · doi:10.1177/17531934251327034 · Cited by 8
Human lung cancer-derived mesenchymal stem cells promote tumor growth and immunosuppression
Gao, X., Ren, H., Zhang, Z., Cao, S., Zhang, B., Sun, Q., Melino, G., & Huang, H. (2024) · Biology Direct · doi:10.1186/s13062-024-00479-w · Cited by 8
Bozkurt, C., Karaöz, E., Aksoy, B. A., Aydoğdu, S., & Fışgın, T. (2019) · Turkish Journal of Hematology · doi:10.4274/tjh.galenos.2019.2019.0090 · Cited by 8
Kim, W., Park, A., Jang, H. H., Kim, S.-E., & Park, K. (2022) · Cancers · doi:10.3390/cancers14194711 · Cited by 8
Burns, J. S., Safwat, A., Grisendi, G., Kassem, M. S., & Dominici, M. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.05.027 · Cited by 8
Guerra‐Rebollo, M., de Moraes, C. N., Alcoholado, C., Soler‐Botija, C., Sánchez‐Cid, L., Vila, O. F., Meca‐Cortés, Ó., Ramos‐Romero, S., Rubio, N., Becerra, J., et al. (2018) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2018.09.002 · Cited by 7
The therapeutic role of endothelial progenitor cells in Type 1 diabetes mellitus.
Grapensparr, L., Olerud, J., Vasylovska, S., & Carlsson, P. (2011) · Regenerative medicine · doi:10.2217/rme.11.45 · Cited by 7
Li, L., Dou, X., Song, X., & Wang, F. (2025) · Current Pain and Headache Reports · doi:10.1007/s11916-025-01378-z · Cited by 6
Saba, E., Sandhu, M. A., & Pelagalli, A. (2024) · Veterinary Sciences · doi:10.3390/vetsci11050187 · Cited by 10
Mamchur, A., Leman, E., Salah, S., Avivi, A., Shams, I., & Manov, I. (2018) · Stem Cells · doi:10.1002/stem.2884 · Cited by 6
Stem Cell-Secreted Factors in the Tumor Microenvironment
Jiménez, G., de Andrés, J. L., & Marchal, J. A. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-50224-9_8 · Cited by 5
Advances in Understanding the Roles of Mesenchymal Stem Cells in Lung Cancer
Ding, W., Zhang, K., Li, Q., Xu, L., Ma, Y., Han, F., Zhu, L. W., & Sun, X. (2023) · Cellular Reprogramming · doi:10.1089/cell.2022.0133 · Cited by 5
Stepanov, Y. V., Golovynska, I., Ostrovska, G. V., Pylyp, L. Y., Dovbynchuk, T., Stepanova, L. I., Gorbach, O. I., Shablii, V., Xu, H., Garmanchuk, L., et al. (2023) · Cytometry Part A · doi:10.1002/cyto.a.24814 · Cited by 4
Popper, H. (2020) · Cancer Drug Resistance · doi:10.20517/cdr.2020.40 · Cited by 4
Aristizábal, J. A., Chandía, M., del Cañizo, M. C., & Sanchez-Guijo, F. M. (2014) · Revista médica de Chile · doi:10.4067/s0034-98872014000500008 · Cited by 4
Cordeiro, M. F., Marmitt, L. P., & Horn, A. P. (2018) · Archives of Dermatological Research · doi:10.1007/s00403-018-1819-7 · Cited by 4
Gao, X., Sun, L., Li, T., Li, P., Liu, C., Li, Q., & Zhu, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1647988 · Cited by 3
Mesenchymal Stem Cells in Myelodysplastic Syndromes and Leukaemia
Eroz, I., Lazar, R. A., Vadakekolathu, J. N., Rutella, S., & El‐Jawhari, J. J. (2024) · Biomedicines · doi:10.3390/biomedicines12081677 · Cited by 4
[Investigational Study of Mesenchymal Stem Cells on Lung Cancer Cell Proliferation and Invasion].
Li, M., Wu, Y., Liu, R., Guo, L., Xu, T., Chen, J., & Xu, S. (2015) · Europe PMC (PubMed Central) · doi:10.3779/j.issn.1009-3419.2015.11.03 · Cited by 3
Sirithammajak, S., Manochantr, S., Tantrawatpan, C., Tantikanlayaporn, D., & Kheolamai, P. (2022) · Stem Cells International · doi:10.1155/2022/4020845 · Cited by 3
Yang, Y., Li, S., Peng, Q., Guo, Y., Gao, Y., Gong, Y., Lu, J., Zhang, Y., & Shi, X. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09688-y · Cited by 3
Wang, Y., Pang, X., Li, R., Chen, J., Chen, W., Zhu, H., Long, T., Li, J., Zheng, L., Deng, Y., et al. (2025) · Research · doi:10.34133/research.0594 · Cited by 2
Radiosensitising effect of mesenchymal stem cells on sarcoma M-1 under local gamma-irradiation
Sevan’kaeva, L. E., Yuzhakov, V. V., Георгиевич, К. А., Romanko, Y. S., Бандурко, Л. Н., Fomina, N. K., Ингель, И. Э., Анатольевич, К. М., Russia, F. F. O., Yakovleva, N. D., et al. (2017) · Radiation and Risk Bulletin of the National Radiation and Epidemiological Registry · doi:10.21870/0131-3878-2017-26-3-100-115 · Cited by 3
Li, Y., Liu, M., Cui, J., Yang, K., Zhao, L., Gong, M., Wang, Y., He, Y., He, T., & Bi, Y. (2018) · Oncology Letters · doi:10.3892/ol.2018.8132 · Cited by 3
Umbilical Cord Matrix Stem Cells for Cytotherapy of Breast Cancer
Ohta, N., Kawabata, A., Uppalapati, D., Ishiguro, S., Troyer, D. L., & Tamura, M. (2013) · Wiley eBooks · doi:10.1002/9781118660423.ch9 · Cited by 3
Fath, M. K., Zadian, S. S., Torbati, S. M. B., Saqagandomabadi, V., Afshar, O. Y., Khalilzad, M., Abedi, S., Moliani, A., & Barati, G. (2024) · Current Molecular Medicine · doi:10.2174/0115665240274818231207054037 · Cited by 2
Role of mesenchymal stem cells in tumor microenvironment
Mir, M. A., Mir, A. Y., Jan, U., Dar, M. A., & Shah, M. Z. U. H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-443-18696-7.00004-x · Cited by 2
Mesenchymal stem cells in progression and treatment of cancers
Zhao, Q., & Liu, F. (2014) · Frontiers in Biology · doi:10.1007/s11515-014-1306-2 · Cited by 2
Chan, J. K. Y., & Lam, P. Y. P. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3584-0_28 · Cited by 3
Similarities and Differences in Stem Cells Between Cancer, Normal, and Injured Brain
Huang, L. H., & Huang, P. (2016) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-46733-7_5 · Cited by 2
Enhance therapeutic efficacy of BiTE (HER2/CD3) for HER2- positive tumors through in vivo expression
Zong, H., Li, X., Li, Y., Wang, L., Yue, Y., Chen, J., Ke, Y., Paerhati, P., Han, L., Li, Y., et al. (2025) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2025.100375 · Cited by 1
The impact of oxygen heterogeneity on epithelial-mesenchymal transitions: a numerical study
Sadhu, G., Byrne, H. M., & Dalal, D. C. (2025) · Journal of Mathematical Biology · doi:10.1007/s00285-025-02335-5 · Cited by 1
The influence of cell-cell fusion on cancer heterogeneity and its promise for targeted treatments
Liu, K., Shi, J., Liu, J., Zhang, Y., Liang, J., Xu, J., Chen, S., & Zhang, S. (2026) · Cellular Oncology · doi:10.1007/s13402-025-01153-7 · Cited by 1
Pan, Z., Wang, H., & Shao, Q. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27093751 · Cited by 1
Mesenchymal Stromal Cells and Tumor Angiogenesis
Hung, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803102-5.00012-4 · Cited by 1
Metadata
- Authors
- Suzuki, K., Sun, R., Origuchi, M., Kanehira, M., Takahata, T., Itoh, J., Umezawa, A., Kijima, H., Fukuda, S., & Saijo, Y.
- Affiliations
- Hirosaki University (JP)
- Tohoku University (JP)
- National Center For Child Health and Development (JP)
- Corresponding author
- Saijo, Yasuo
- Venue
- Molecular Medicine
- Published
- 2011-03-11
- Volume
- 17
- Issue
- 7-8
- Pages
- 579-587
- ISSN
- 1076-1551 (ISSN-L)
- 1528-3658
- PMC
- PMC3146617
- OpenAlex
- W2207758069
- Cited by
- 244
- References
- 38
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 11 · 2023: 10 · 2022: 12 · 2021: 17 · 2020: 24 · 2019: 19 · 2018: 25 · 2017: 14 · 2016: 25 · 2015: 16 · 2014: 21 · 2013: 12 · 2012: 17
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Molecular Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (16022206, 20390229, 23790895, 22659160)
- RIKEN
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- mesenchymal stem cells, tumor growth, tumor angiogenesis, angiogenesis, tumor cell proliferation, bone marrow-derived stromal cells, Lewis lung carcinoma, leukemia inhibitory factor, macrophage colony-stimulating factor, CXCL2, vascular endothelial growth factor, tumor vasculature
- MeSH terms
- Animals, Cells, Cultured, Female, Flow Cytometry, Mice, Transgenic, Neoplasm Transplantation, Neoplasms, Experimental, Neovascularization, Pathologic, Macrophage Colony-Stimulating Factor, Microscopy, Confocal, Coculture Techniques, Antigens, CD34, Vascular Endothelial Growth Factor A, Mesenchymal Stem Cell Transplantation, Cell Line, Tumor, Tumor Burden, Cell Proliferation, Green Fluorescent Proteins, Mice, Chemokine CXCL2, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
