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Brown Adipose Tissue Responds to Cold and Adrenergic Stimulation by Induction of FGF21
Open accessAbstract
Fibroblast growth factor-21 (FGF21) is a pleiotropic protein involved in glucose, lipid metabolism and energy homeostasis, with main tissues of expression being the liver and adipose tissue. Brown adipose tissue (BAT) is responsible for cold-induced thermogenesis in rodents. The role of FGF21 in BAT biology has not been investigated. In the present study, wild-type C57BL/6J mice as well as a brown adipocyte cell line were used to explore the potential role of cold exposure and β3-adrenergic stimulation in the expression of FGF21 in BAT. Our results demonstrate that short-term exposure to cold, as well as β3-adrenergic stimulation, causes a significant induction of FGF21 mRNA levels in BAT, without a concomitant increase in FGF21 plasma levels. This finding opens new routes for the potential use of pharmaceuticals that could induce FGF21 and, hence, activate BAT thermogenesis.
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“Fgf21 mRNA expression is upregulated in both WAT (36, 52) and BAT (15, 36, 49, 52) in response to cold.”
From Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis (2018) · cites this paper as [15]
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Metadata
- Authors
- Chartoumpekis, D. V., Habeos, I. G., Ziros, P. G., Psyrogiannis, A. I., Kyriazopoulou, V. E., & Papavassiliou, A. G.
- Affiliations
- University of Patras (GR)
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Papavassiliou, Athanasios G
- Venue
- Molecular Medicine
- Published
- 2011-02-25
- Volume
- 17
- Issue
- 7-8
- Pages
- 736-740
- ISSN
- 1076-1551 (ISSN-L)
- 1528-3658
- PMC
- PMC3146611
- OpenAlex
- W31735925
- Cited by
- 252
- References
- 32
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 11 · 2023: 12 · 2022: 19 · 2021: 14 · 2020: 23 · 2019: 21 · 2018: 21 · 2017: 23 · 2016: 16 · 2015: 26 · 2014: 20 · 2013: 16 · 2012: 18
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Molecular Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- brown adipose tissue, FGF21, cold exposure, thermogenesis, brown adipocytes, energy homeostasis
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Adrenergic beta-Agonists, Animals, Adipose Tissue, Brown, Cell Line, Transformed, Cold Temperature, Dioxoles, Fibroblast Growth Factors, Male, Mice, Inbred C57BL, Oxazoles, RNA, Messenger, Transcription Factors, Tyrosine, Transcriptional Activation, Trans-Activators, Adipocytes, Reverse Transcriptase Polymerase Chain Reaction, Receptors, Adrenergic, beta-3, Thermogenesis, PPAR alpha, Mice
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