Brown Adipose Tissue Responds to Cold and Adrenergic Stimulation by Induction of FGF21

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864

Cold-Activated Brown Adipose Tissue in Healthy Men

van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452

Role of leptin in the neuroendocrine response to fasting

Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125

Towards a molecular understanding of adaptive thermogenesis

Lowell, B. B., & Spiegelman, B. M. (2000) · Nature · doi:10.1038/35007527 · Cited by 1,630

Brown adipose tissue activity controls triglyceride clearance

Bartelt, A., Bruns, O. T., Reimer, R., Hohenberg, H., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Weller, H., Waurisch, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2297 · Cited by 1,608

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151

Fibroblast Growth Factor 21 Corrects Obesity in Mice

Coskun, T., Bina, H. A., Schneider, M. A., Dunbar, J. D., Hu, C. C., Chen, Y., Moller, D. E., & Kharitonenkov, A. (2008) · Endocrinology · doi:10.1210/en.2008-0816 · Cited by 1,031

Brown and beige fat: Development, function and therapeutic potential

Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478

Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

Choe, S. S., Huh, J. Y., Hwang, I. J., Kim, J. I., & Kim, J. B. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00030 · Cited by 1,206

Understanding the Physiology of FGF21

Fisher, F. M., & Maratos-Flier, E. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105339 · Cited by 912

Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

Lee, P., Linderman, J. D., Smith, S., Brychta, R. J., Wang, J., Idelson, C., Perron, R. M., Werner, C. D., Phan, G. Q., Kammula, U. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.017 · Cited by 802

Brown adipose tissue as a secretory organ

Villarroya, F., Cereijo, R., Villarroya, J., & Giralt, M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.136 · Cited by 697

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

Potthoff, M. J., Kliewer, S. A., & Mangelsdorf, D. J. (2012) · Genes & Development · doi:10.1101/gad.184788.111 · Cited by 442

βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism

Ding, X., Boney-Montoya, J., Owen, B. M., Bookout, A. L., Coate, K. C., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.002 · Cited by 403

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

Owen, B. M., Mangelsdorf, D. J., & Kliewer, S. A. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2014.10.002 · Cited by 286

Pharmacological and nutritional agents promoting browning of white adipose tissue

Bonet, M. L., Oliver, P., & Palou, A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.12.002 · Cited by 286

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21

Kliewer, S. A., & Mangelsdorf, D. J. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.004 · Cited by 273

Fibroblast Growth Factor 21—Metabolic Role in Mice and Men

Staiger, H., Keuper, M., Berti, L., Hrabě de Angelis, M., & Häring, H.-U. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00016 · Cited by 270

Direct Control of Brown Adipose Tissue Thermogenesis by Central Nervous System Glucagon-Like Peptide-1 Receptor Signaling

Lockie, S. H., Heppner, K. M., Chaudhary, N., Chabenne, J. R., Morgan, D. A., Veyrat‐Durebex, C., Ananthakrishnan, G., Rohner‐Jeanrenaud, F., Drucker, D. J., DiMarchi, R. D., et al. (2012) · Diabetes · doi:10.2337/db11-1556 · Cited by 240

Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders

Kim, S. H., & Plutzky, J. (2016) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2016.40.1.12 · Cited by 240

Brown adipose tissue and thermogenesis

Fenzl, A., & Kiefer, F. W. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0022 · Cited by 239

Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis

BonDurant, L. D., & Potthoff, M. J. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064800 · Cited by 222

Adipose tissue plasticity from WAT to BAT and in between

Lee, Y., Mottillo, E. P., & Granneman, J. G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.011 · Cited by 236

Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice

Douris, N., Stevanovic, D. M., Fisher, F. M., Cisu, T. I., Chee, M. J., Nguyen, N. L., Zarebidaki, E., Adams, A. C., Kharitonenkov, A., Flier, J. S., et al. (2015) · Endocrinology · doi:10.1210/en.2014-2001 · Cited by 215

Functional thermogenic beige adipogenesis is inducible in human neck fat

Lee, P., Werner, C., Kebebew, E., & Celi, F. S. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.82 · Cited by 213

Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications

Gómez‐Hernández, A., Beneit, N., Díaz-Castroverde, S., & Escribano, Ó. (2016) · International Journal of Endocrinology · doi:10.1155/2016/1216783 · Cited by 211

Crosstalk between adipokines and myokines in fat browning

Rodríguez, A., Becerril, S., Ezquerro, S., Méndez-Giménez, L., & Frühbeck, G. (2016) · Acta Physiologica · doi:10.1111/apha.12686 · Cited by 196

An endocrine role for brown adipose tissue?

Villarroya, J., Cereijo, R., & Villarroya, F. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00250.2013 · Cited by 193

Fibroblast Growth Factor 21 Induces Glucose Transporter-1 Expression through Activation of the Serum Response Factor/Ets-Like Protein-1 in Adipocytes

Ge, X., Chen, C., Hui, X. H., Wang, Y., Lam, K. S. L., & Xu, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.248591 · Cited by 181

FGF21 Requires βklotho to Act In Vivo

Adams, A. C., Cheng, C. C., Coskun, T., & Kharitonenkov, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049977 · Cited by 181

Adipose Tissue-Derived Signatures for Obesity and Type 2 Diabetes: Adipokines, Batokines and MicroRNAs

Lee, M.-W., Lee, M., & Oh, K. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060854 · Cited by 192

Brown adipose tissue

Townsend, K. L., & Tseng, Y. (2012) · Adipocyte · doi:10.4161/adip.18951 · Cited by 182

Brown adipose tissue: Development, metabolism and beyond

Schulz, T. J., & Tseng, Y.-H. (2013) · Biochemical Journal · doi:10.1042/bj20130457 · Cited by 173

Brown adipose tissue and its therapeutic potential

Lidell, M. E., Betz, M. J., & Enerbäck, S. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12255 · Cited by 168

Insulin Resistance and Mitochondrial Dysfunction

González-Franquesa, A., & Patti, M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_25 · Cited by 160

Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1

Samms, R. J., Smith, D. P., Cheng, C. C., Antonellis, P. P., Perfield, J. W., Kharitonenkov, A., Gimeno, R. E., & Adams, A. C. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.046 · Cited by 154

FGF21: A Novel Regulator of Glucose and Lipid Metabolism and Whole-Body Energy Balance

Szczepańska, E., & Gietka‐Czernel, M. (2022) · Hormone and Metabolic Research · doi:10.1055/a-1778-4159 · Cited by 155

Fibroblast growth factor 21 and browning of white adipose tissue

Cuevas-Ramos, D., Mehta, R., & Aguilar-Salinas, C. A. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00037 · Cited by 149

Fibroblast growth factor-21, energy balance and obesity

Giralt, M., Gavaldà‐Navarro, A., & Villarroya, F. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.09.018 · Cited by 150

Mild Cold Exposure Modulates Fibroblast Growth Factor 21 (FGF21) Diurnal Rhythm in Humans: Relationship between FGF21 Levels, Lipolysis, and Cold-Induced Thermogenesis

Lee, P., Brychta, R. J., Linderman, J. D., Smith, S., Chen, K. Y., & Celi, F. S. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3107 · Cited by 142

Fibroblast Growth Factor Signaling in Metabolic Regulation

Nies, V. J. M., Sancar, G., Liu, W., van Zutphen, T., Struik, D., Yu, R. T., Atkins, A. R., Evans, R. M., Jonker, J. W., & Downes, M. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00193 · Cited by 137

Serum FGF21 levels are associated with brown adipose tissue activity in humans

Hanssen, M. J. W., Broeders, E. P. M., Samms, R. J., Vosselman, M. J., van der Lans, A. A. J. J., Cheng, C., Adams, A. C., Lichtenbelt, W. D. V. M., & Schrauwen, P. (2015) · Scientific Reports · doi:10.1038/srep10275 · Cited by 136

FGF21 Is Increased by Inflammatory Stimuli and Protects Leptin-Deficient ob/ob Mice from the Toxicity of Sepsis

Feingold, K. R., Grünfeld, C., Heuer, J. G., Gupta, A., Cramer, M. S., Zhang, T., Shigenaga, J. K., Patzek, S. M., Chan, Z. W., Moser, A. H., et al. (2012) · Endocrinology · doi:10.1210/en.2011-1496 · Cited by 130

Long-Term Cold Adaptation Does Not Require FGF21 or UCP1

Keipert, S., Kutschke, M., Ost, M., Schwarzmayr, T., van Schothorst, E. M., Lamp, D., Brachthäuser, L., Hamp, I., Mazibuko, S. E., Hartwig, S., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.016 · Cited by 122

Development of a Novel Long-Acting Antidiabetic FGF21 Mimetic by Targeted Conjugation to a Scaffold Antibody

Huang, J., Ishino, T., Chen, G., Rolzin, P., Osothprarop, T. F., Retting, K., Li, L., Jin, P., Matin, M. J., Huyghe, B., et al. (2013) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.204420 · Cited by 121

Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet

Tanaka, N., Takahashi, S., Zhang, Y., Krausz, K. W., Smith, P. B. W., Patterson, A. D., & Gonzalez, F. J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.02.012 · Cited by 120

Angiotensin-(1-7), Adipokines and Inflammation

Lelis, D. D. F., de Freitas, D. F., Machado, A. S., Crespo, T. S., & Santos, S. H. S. (2019) · Metabolism · doi:10.1016/j.metabol.2019.03.006 · Cited by 124

The beneficial effects of brown adipose tissue transplantation

White, J. D., Dewal, R. S., & Stanford, K. I. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.06.004 · Cited by 124

FGF21 Revolutions: Recent Advances Illuminating FGF21 Biology and Medicinal Properties

Kharitonenkov, A., & DiMarchi, R. D. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.09.007 · Cited by 114

Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas

Singhal, G., Fisher, F. M., Chee, M. J. S., Tan, T. G., Ouaamari, A. E., Adams, A. C., Najarían, R. M., Kulkarni, R., Benoist, C. O., Flier, J. S., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148252 · Cited by 112

Inflammatory Signaling and Brown Fat Activity

Omran, F., & Christian, M. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00156 · Cited by 111

Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues

Singh, R., Barrios, A., Dirakvand, G., & Pervin, S. (2021) · Cells · doi:10.3390/cells10113030 · Cited by 114

FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes

Abu-Odeh, M., Zhang, Y., Reilly, S. M., Ebadat, N., Keinan, O., Valentine, J. M., Hafezi-Bakhtiari, M., Ashayer, H., Mamoun, L., Zhou, X., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109331 · Cited by 106

Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis

Markan, K. R., & Potthoff, M. J. (2016) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2015.09.021 · Cited by 103

RNA-Seq and Mass-Spectrometry-Based Lipidomics Reveal Extensive Changes of Glycerolipid Pathways in Brown Adipose Tissue in Response to Cold

Marcher, A.-B., Loft, A., Nielsen, R., Vihervaara, T., Madsen, J. G. S., Sysi‐Aho, M., Ekroos, K., & Mandrup, S. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.069 · Cited by 102

Low protein-induced increases in FGF21 drive UCP1-dependent metabolic but not thermoregulatory endpoints

Hill, C. M., Laeger, T., Albarado, D. C., McDougal, D. H., Berthoud, H.-R., Münzberg, H., & Morrison, C. D. (2017) · Scientific Reports · doi:10.1038/s41598-017-07498-w · Cited by 97

Understanding the brown adipocyte as a contributor to energy homeostasis

Chechi, K., Carpentier, A. C., & Richard, D. (2013) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.04.002 · Cited by 99

Cold and Exercise: Therapeutic Tools to Activate Brown Adipose Tissue and Combat Obesity

da Silva, C. P. V., Hernández‐Saavedra, D., White, J. D., & Stanford, K. (2019) · Biology · doi:10.3390/biology8010009 · Cited by 102

miRNA-32 Drives Brown Fat Thermogenesis and Trans-activates Subcutaneous White Fat Browning in Mice

Ng, R., Hussain, N. A., Zhang, Q., Chang, C. T., Li, H., Fu, Y., Cao, L., Han, W., Stünkel, W., & Xu, F. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.035 · Cited by 93

Activation and recruitment of brown adipose tissue as anti-obesity regimens in humans

Yoneshiro, T., & Saito, M. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.911595 · Cited by 94

The Lives and Times of Brown Adipokines

Villarroya, F., Gavaldà‐Navarro, A., Peyrou, M., Villarroya, J., & Giralt, M. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.10.005 · Cited by 92

Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes Mellitus

So, W. Y., & Leung, P. S. (2016) · Medicinal Research Reviews · doi:10.1002/med.21390 · Cited by 85

Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion

Keipert, S., Kutschke, M., Lamp, D., Brachthäuser, L., Neff, F., Meyer, C. W., Oelkrug, R., Kharitonenkov, A., & Jastroch, M. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.04.006 · Cited by 85

Adipokines in the Crosstalk between Adipose Tissues and Other Organs: Implications in Cardiometabolic Diseases

Jouy, S. H., Mohan, S., Scichilone, G., Mostafa, A., & Mahmoud, A. M. (2024) · Biomedicines · doi:10.3390/biomedicines12092129 · Cited by 96

Circulating FGF21 Levels in Human Health and Metabolic Disease

Keuper, M., Häring, H., & Staiger, H. (2019) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-0879-2968 · Cited by 83

Brown adipose tissue: a potential target in the fight against obesity and the metabolic syndrome

Poekes, L., Lanthier, N., & Leclercq, I. A. (2015) · Clinical Science · doi:10.1042/cs20150339 · Cited by 83

Brown Adipose Tissue Heterogeneity, Energy Metabolism, and Beyond

Shinde, A. B., Song, A., & Wang, Q. A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.651763 · Cited by 82

A New Vision for Therapeutic Hypothermia in the Era of Targeted Temperature Management: A Speculative Synthesis

Jackson, T. C., & Kochanek, P. M. (2019) · Therapeutic Hypothermia and Temperature Management · doi:10.1089/ther.2019.0001 · Cited by 77

Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones

Adams, A. C., Coşkun, T., Cheng, C., O’Farrell, L. S., DuBois, S. L., & Kharitonenkov, A. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.05.005 · Cited by 75

The potential function and clinical application of FGF21 in metabolic diseases

Chen, Z., Yang, L., Liu, Y., Huang, P., Song, H., & Zheng, P. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1089214 · Cited by 73

An Overview of FGF19 and FGF21: The Therapeutic Role in the Treatment of the Metabolic Disorders and Obesity

Babaknejad, N., Nayeri, H., Hemmati, R., Bahrami, S., & Esmaillzadeh, A. (2018) · Hormone and Metabolic Research · doi:10.1055/a-0623-2909 · Cited by 70

The Nuanced Metabolic Functions of Endogenous FGF21 Depend on the Nature of the Stimulus, Tissue Source, and Experimental Model

Spann, R. A., Morrison, C. D., & den Hartigh, L. J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.802541 · Cited by 76

Fibroblast Growth Factor 21 Analogs for Treating Metabolic Disorders

Zhang, J., & Li, Y. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00168 · Cited by 70

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Li, H., Zhang, J., & Jia, W. (2013) · Frontiers of Medicine · doi:10.1007/s11684-013-0244-8 · Cited by 67

Glucagon Is Essential for Adaptive Thermogenesis in Brown Adipose Tissue

Kinoshita, K., Ozaki, N., Takagi, Y., Murata, Y., Oshida, Y., & Hayashi, Y. (2014) · Endocrinology · doi:10.1210/en.2014-1175 · Cited by 67

The Saga of Endocrine FGFs

Phan, P., Saikia, B. B., Sonnaila, S., Agrawal, S., Alraawi, Z., Kumar, T. K. S., & Iyer, S. (2021) · Cells · doi:10.3390/cells10092418 · Cited by 70

Fatty liver and FGF21 physiology

Maratos–Flier, E. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.05.006 · Cited by 66

Adipokines from white adipose tissue in regulation of whole body energy homeostasis

Sahu, B., & Bal, N. C. (2022) · Biochimie · doi:10.1016/j.biochi.2022.09.003 · Cited by 73

Metabolic role of fibroblast growth factor 21 in liver, adipose and nervous system tissues

Lin, X., Liu, Y. B., & Hu, H. (2017) · Biomedical Reports · doi:10.3892/br.2017.890 · Cited by 61

Many Ways to Rome: Exercise, Cold Exposure and Diet—Do They All Affect BAT Activation and WAT Browning in the Same Manner?

Scheel, A. K., Espelage, L., & Chadt, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094759 · Cited by 68

High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice

Wall, C. E., Whyte, J., Suh, J. M., Fan, W., Collins, B. L., Liddle, C., Yu, R. T., Atkins, A. R., Naviaux, J. C., Li, K., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1509930112 · Cited by 61

Fibroblast growth factors in control of lipid metabolism: from biological function to clinical application

Struik, D., Dommerholt, M. B., & Jonker, J. W. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000599 · Cited by 61

Regulators of Human White Adipose Browning: Evidence for Sympathetic Control and Sexual Dimorphic Responses to Sprint Interval Training

Scalzo, R. L., Peltonen, G. L., Giordano, G., Binns, S. E., Klochak, A. L., Paris, H. L. R., Schweder, M. M., Szallar, S. E., Wood, L. M., Larson, D. G., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090696 · Cited by 60

Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat

Suárez, J., Rivera, P., Arrabal, S., Crespillo, A., Serrano, A., Baixerás, E., Pavón, F. J., Cifuentes, M., Nogueiras, R., Ballesteros, J., et al. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.013110 · Cited by 63

Deletion of hepatic carbohydrate response element binding protein (ChREBP) impairs glucose homeostasis and hepatic insulin sensitivity in mice

Jois, T., Chen, W., HOWARD, V. G., Harvey, R. E., Youngs, K., Thalmann, C., Saha, P., Chan, L., Cowley, M. A., & Sleeman, M. W. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.07.006 · Cited by 66

Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis

Han, H.-S., Choi, B. H., Kim, J. S., Kang, G. W., & Koo, S. (2017) · Nature Communications · doi:10.1038/s41467-017-01878-6 · Cited by 58

The weight of nutrients: kynurenine metabolites in obesity and exercise

Dadvar, S., Ferreira, D. M. S., Červenka, I., & Ruas, J. L. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12830 · Cited by 59

A low-protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic fibroblast growth factor 21 (FGF21)

Pérez‐Martí, A., Garcia‐Guasch, M., Tresserra‐Rimbau, A., Carrilho‐Do‐Rosário, A., Estruch, R., Salas‐Salvadó, J., Martínez‐González, M. Á., Lamuela‐Raventós, R., Marrero, P. F., Haro, D., et al. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600725 · Cited by 56

Research Perspectives on the Regulation and Physiological Functions of FGF21 and its Association with NAFLD

Inagaki, T. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00147 · Cited by 55

Neural Control of Energy Expenditure

Münzberg, H., Qualls‐Creekmore, E., Berthoud, H., Morrison, C. D., & Yu, S. (2015) · Handbook of experimental pharmacology · doi:10.1007/164_2015_33 · Cited by 53

MicroRNAs in brown and beige fat

Goody, D., & Pfeifer, A. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.05.003 · Cited by 54

Circulating α-klotho regulates metabolism via distinct central and peripheral mechanisms

Landry, T., Shookster, D., & Hu, H. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154819 · Cited by 55

Recent advance in brown adipose physiology and its therapeutic potential

Lee, Y., Jung, Y.-S., & Choi, D. (2014) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.163 · Cited by 56

Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis

Merlin, J., Evans, B. A., Dehvari, N., Sato, M., Bengtsson, T., & Hutchinson, D. S. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500251 · Cited by 56

Rapid increase in fibroblast growth factor 21 in protein malnutrition and its impact on growth and lipid metabolism

Ozaki, Y., Saito, K., Nakazawa, K., Konishi, M., Itoh, N., Hakuno, F., Takahashi, S.-I., Kato, H., & Takenaka, A. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515002846 · Cited by 51

Fibroblast Growth Factor 21 Protects against Atherosclerosis via Fine-Tuning the Multiorgan Crosstalk

Jin, L., Lin, Z., & Xu, A. (2016) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2016.40.1.22 · Cited by 52

Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis

Okamatsu‐Ogura, Y., & Saito, M. (2021) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2020.0291 · Cited by 55

Unlock the Thermogenic Potential of Adipose Tissue: Pharmacological Modulation and Implications for Treatment of Diabetes and Obesity

Peng, X., Gennemark, P., O’Mahony, G., & Bartesaghi, S. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00174 · Cited by 49

Multi-organ FGF21-FGFR1 signaling in metabolic health and disease

Kaur, N., Gare, S. R., Shen, J., Raja, R., Fonseka, O., & Liu, W. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.962561 · Cited by 49

Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism

Okun, E., Griffioen, K. J. S., Rothman, S. M., Wan, R., Cong, W.-N., de Cabo, R., Martín‐Montalvo, A., Levette, A., Maudsley, S. R., Martin, B., et al. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.10.013 · Cited by 53

FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance

Bernardo, B. L., Lu, M. M., Bandyopadhyay, G. K., Li, P., Zhou, Y., Huang, J. S., Levin, N., Tomás, E., Calle, R. A., Erion, D. M., et al. (2015) · Scientific Reports · doi:10.1038/srep11382 · Cited by 49

Adipokines in glucose and lipid metabolism

Wang, X., Zhang, S., & Li, Z. (2023) · Adipocyte · doi:10.1080/21623945.2023.2202976 · Cited by 51

Hydrodynamic delivery of FGF21 gene alleviates obesity and fatty liver in mice fed a high-fat diet

Gao, M., Ma, Y., Cui, R., & Liu, D. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.03.047 · Cited by 48

Erythropoietin (EPO) ameliorates obesity and glucose homeostasis by promoting thermogenesis and endocrine function of classical brown adipose tissue (BAT) in diet-induced obese mice

Kodo, K., Sugimoto, S., Nakajima, H., Mori, J., Itoh, I., Fukuhara, S., Shigehara, K., Nishikawa, T., Kosaka, K., & Hosoi, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173661 · Cited by 48

Time‐restricted feeding improves the reproductive function of female mice via liver fibroblast growth factor 21

Hua, L., Feng, B., Huang, L., Li, J., Luo, T. F., Jiang, X., Han, X., Che, L., Xu, S., Lin, Y., et al. (2020) · Clinical and Translational Medicine · doi:10.1002/ctm2.195 · Cited by 43

A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21

Han, M. S., Perry, R. J., Camporez, J.-P., Scherer, P. E., Shulman, G. I., Gao, G., & Davis, R. J. (2021) · Genes & Development · doi:10.1101/gad.344556.120 · Cited by 43

Serum FGF21 levels are associated with brown adipose tissue activity in humans

Hanssen, M. J. W., Broeders, E. P. M., Samms, R. J., Vosselman, M. J., van der Lans, A. A. J. J., Cheng, C., Adams, A. C., Lichtenbelt, W. D. V. M., & Schrauwen, P. (2015) · Scientific Reports · doi:10.1038/srep10275 · Cited by 136

Investigating the Involvement of Fibroblast Growth Factors in Adipose Tissue Thermogenesis

Kır, S. (2024) · European Journal of Biology · doi:10.26650/eurjbiol.2024.1415673

Circulating fibroblast growth factor 21 is reduced, whereas its production is increased in a fat depot-specific manner in cold-acclimated rats

Sepa-Kishi, D. M., & Ceddia, R. B. (2018) · Adipocyte · doi:10.1080/21623945.2018.1504591 · Cited by 10

FGF21 Promotes Thermogenesis by Browning Thermogenic Adipose Tissue during Cold Exposure

Li, C.-X., Tan, C.-F., Zhang, Q.-M., Qin, L., Cao, C., & Huang, X.-F. (2025) · Annals of Nutrition and Metabolism · doi:10.1159/000548868 · Cited by 3

Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

Hondares, E., Iglesias, R., Giralt, A., Gonzalez, F. J., Giralt, M., Mampel, T., & Villarroya, F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.215889 · Cited by 623