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PreprintCited by 24Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and TreatmentsCancer-related cognitive impairment studies

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The Importance of Stroke as a Risk Factor of Cognitive Decline in Community Dwelling Older and Oldest peoples : The SONIC Study

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Srithum, Werayuth, Kabayama, Mai, Gondo, Yasuyuki, Masui, Yukie, Akagi, Yuya, Klinpudtan, Nonglak, Kiyoshige, Eri, Godai, Kayo, Sugimoto, Ken, Akasaka, Hiroshi, Takami, Yoichi, Takeya, Yasushi, Yamamoto, Koichi, Ikebe, Kazunori, Ogawa, Madoka, Inagaki, Hiroki, Ishizaki, Tatsuro, Arai, Yasumichi, Rakugi, Hiromi, Kamide, Kei·2020·BMC Geriatrics
DOI 10.21203/rs.2.15994/v3PMC PMC6977260

Preprint — published as 10.1186/s12877-020-1423-5

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Abstract

Background: Cognitive impairment is a major health concern among older and oldest people.Moreover, stroke is a relevant contributor for cognitive decline and development of dementia. The study of cognitive decline focused on stroke as the important risk factor by recruiting older and oldest is still lagging behind. Therefore, the aim of this study was to investigate the importance of stroke as a risk factor of cognitive decline during three years in community dwelling older and oldest people. Methods: This study was longitudinal study with a 3-year follow-up in Japan. The participants were 1,333community dwelling older and oldest people (70 years old = 675, 80 years old = 589, and 90 years old = 69). Data collected included basic data (age, sex, and history of stroke), vascular risk factors (hypertension, diabetes mellitus, dyslipidemia, atrial fibrillation, and current smoking), and social factors (educational level, frequency of going outdoors, long-term care (LTC) service used, and residential area). The Japanese version of the Montreal Cognitive Assessment (MoCA-J) was decline of ≥ 2 points was defined as cognitive decline. Multiple logistic regression analysis was used to investigate the association between stroke and other risk factors with cognitive decline during a 3-year follow-up. Results: The fit of the hypothesized model by multiple logistic regression showed that a history of stroke, advanced age, and greater MoCA-J score at the baseline were important risk factors, while the presence of dyslipidemia and a higher educational level were protective factors that were significantly correlated with cognitive decline during the 3-year follow-up. Conclusions: The cognitive decline after the 3-year follow-up was influenced by the history of stroke and advanced age, while greater MoCA-J score at the baseline was positively associated with subsequent 3 years cognitive decline. The protective factors were the presence of dyslipidemia and a higher educational level. Therefore, these factors are considered important and should be taken into consideration when searching for creative solutions to prevent cognitive decline after stroke in community dwelling older and oldest people.

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References 69 · Cited by 24

Research works printed but not linked: 50

  1. Toyoda K. Epidemiology and registry studies of stroke in Japan. J Stroke. 2013;15(1):21–6. · DOI
  2. Fujiwara Y, Suzuki H, Yasunaga M, et al. Brief screening tool for mild cognitive impairment in older Japanese: validation of the Japanese version of the Montreal Cognitive Assessment. Geriatr Gerontol Int. 2010;10(3):225–32. · DOI
  3. Lin HR, Otsubo T, Imanaka Y. The effects of dementia and long-term care services on the deterioration of care-needs levels of the elderly in Japan. Medicine. 2015;94(7):1–7.
  4. WHO MONICA Project Investigators. The World Health Orgnization MONICA project (Monitoring trends and determinants in cardiovascular disease). J Clin Epidemiol. 1998;41:105–14. · DOI
  5. Tang EY, Amiesimaka O, Harrison SL, et al. Longitudinal effect of stroke on cognition: A systematic review. J Am Heart Assoc. 2018;7(2):1–9.
  6. Mijajlović MD, Pavlović A, Brainin M, et al. Post-stroke dementia - a comprehensive review. BMC Med. 2017;15(1):11. · DOI
  7. Levine DA, Galecki AT, Langa KM, et al. Trajectory of cognitive decline after incident stroke. JAMA. 2015;314(1):41–51. · DOI · Paper page
  8. Levine DA, Wadley VG, Langa KM, et al. Risk factors for poststroke cognitive decline: The REGARDS study (Reasons for Geographic and Racial Differences in Stroke). Stroke. 2018;49(4):987–94. · DOI
  9. Pinzon RT, Sanyasi RDL, Totting S. The prevalence and determinant factors of post-stroke cognitive impairment. Asian Pacific J Heal Sci. 2018;5(1):78–83. · DOI
  10. Nurani RRS, Martini S. Risk factors for cognitive impairment after ischemic stroke. KnE Life Sci. 2018. DOI 10.18502/kls.v4i9.3567 (Epub ahead of print). · DOI
  11. Alexandrova ML, Danovska MP. Cognitive impairment one year after ischemic stroke: Predictors and dynamics of significant determinants. Turkish J Med Sci. 2016;46(5):1366–73. · DOI
  12. Baccaro A, Wang YP, Candido M, et al. Post-stroke depression and cognitive impairment: Study design and preliminary findings in a Brazilian prospective stroke cohort (EMMA study). J Affect Disord. 2019;245:72–81. · DOI
  13. Liman TG, Heuschmann PU, Endres M, Flöel A, Schwab S, Kolominsky-Rabas PL. Changes in cognitive function over 3 years after first-ever stroke and predictors of cognitive impairment and long-term cognitive stability: the Erlangen stroke project. Dement Geriatr Cogn Disord. 2011;31(4):291–9. · DOI
  14. Arba F, Quinn T, Hankey GJ, et al. Determinants of post-stroke cognitive impairment: analysis from VISTA. Acta Neurol Scand. 2017;135(6):603–7. · DOI
  15. Jacquin A, Binquet C, Rouaud O, et al. Post-stroke cognitive impairment: high prevalence and determining factors in a cohort of mild stroke. J Alzheimer’s Dis. 2014;40(4):1029–38. · DOI
  16. Lu D, Li P, Zhou Y, et al. Association between serum non-high-density lipoprotein cholesterol and cognitive impairment in patients with acute ischemic stroke. BMC Neurol. 2016;16(1):154. · DOI
  17. Khedr EM, Hamed SA, El-Shereef HK, et al. Cognitive impairment after cerebrovascular stroke: Relationship to vascular risk factors. Neuropsychiatr Dis Treat. 2009;5:103–16.
  18. Wang Q, Zhao K, Cai Y, Tu X, Liu Y, He J. Prediabetes is associated with post-stroke cognitive impairment in ischaemic stroke patients. Brain Res. 2018;1687:137–43. · DOI
  19. Mizrahi EH, Waitzman A, Blumstein T, Arad M, Adunsky A. Diabetes mellitus predicts cognitive impairment in patients with ischemic stroke. Am J Alzheimers Dis Other Demen. 2010;25(4):362–6. · DOI
  20. Tu Q, Ding B, Yang X, et al. The current situation on vascular cognitive impairment after ischemic stroke in Changsha. Arch Gerontol Geriatr. 2014;58(2):236–47. · DOI
  21. Chander RJ, Lam BYK, Lim L, et al. Risk factor profiles predicting delayed vascular cognitive impairment in young and old ischemic stroke survivors. Alzheimer’s Dement. 2017;13(7):P740-2.
  22. Tang W, Chan SS, Chiu HF, et al. Frequency and clinical determinants of poststroke cognitive impairment in nondemented stroke patients. J Geriatr Psychiatr Neurol. 2006;19(2):65–71. · DOI
  23. Mizrahi EH, Waitzman A, Arad M, Adunsky A. Atrial fibrillation predicts cognitive impairment in patients with ischemic stroke. Am J Alzheimers Dis Other Demen. 2011;26(8):623–6. · DOI
  24. Fujita K, Fujiwara Y, Chaves PH, Motohashi Y, Shinkai S. Frequency of going outdoors as a good predictors for incident disability of physical function as well as disability recovery in community-dwelling older adults in rural Japan. J Epidemiol. 2006;16(6):261–70. · DOI
  25. Kawate N, Kayaba K, Hara M, Kotani K, Ishikawa S. Body mass index and stroke incidence in Japanese community residents: The Jichi Medical School (JMS) cohort study. J Epidemiol. 2017;27(7):325–30. · DOI
  26. Ishizaki T, Yoshida H, Suzuki T, et al. Effects of cognitive function on functional decline among community-dwelling non-disabled older Japanese. Arch Gerontol Geriatr. 2006;42(1):47–58. · DOI
  27. Mukhopadhyay A, Sundar U, Adwani S, Pandit D. Prevalence of stroke and post-stroke cognitive impairment in the elderly in Dharavi, Mumbai. J Assoc Physicians India. 2012;60:29–32.
  28. Gondo Y, Masui Y, Kamide K, Ikebe K, Arai Y, Ishizaki T. SONIC study: A longitudinal cohort study of the older people as part of a centenarian study. In Pachana NA, editor, Encyclopedia of Geropsychology, Springer Science+Business Media Singapore, Singapore, 2016. Doi 10.1007/978-981-287-080-3$4182-1 (e-pub ahead of print). · DOI
  29. Umemura S, Arima H, Arima S, et al. The Japanese society of hypertension guidelines for the management of hypertension (JSH 2019). Hypertens Res. 2019;42:1235–481. · DOI · Paper page
  30. Haneda M, Noda M, Origasa H, et al. Japanese clinical practice guideline for diabetes 2016. J Diabetes Investig. 2018;9(3):657–97. · DOI
  31. Kinoshita M, Yokote K, Arai H, et al. Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017. J Atheroscler Thromb. 2018;25(9):846–984. · DOI · Paper page
  32. Suzuki H, Kawai H, Hirano H, et al. One-year change in the Japanese version of the Montreal Cognitive Assessment performance and related predictors in community-dwelling older adults. J Am Geriatr Soc. 2015;63(9):1874–79. · DOI
  33. Krishnan K, Rossetti H, Hynan LS, et al. Changes in Montreal Cognitive Assessment score over time. Assessment. 2017;24(6):772–7. · DOI
  34. Davydow DS, Levine DA, Zivin K, Katon WJ, Langa KM. The association of depression, cognitive impairment without dementia and dementia with risk of ischemic stroke: A cohort study. Psychosom Med. 2015;77(2):200–8. · DOI
  35. Jokinen H, Melkas S, Ylikoski R, et al. Post-stroke cognitive impairment is common even after successful clinical recovery. Eur J Neurol. 2015;22(9):1288–94. · DOI · Paper page
  36. Swardfager W, MacIntosh BJ. Depression, type 2 diabetes, and poststroke cognitive impairment. Neurorehabil Neural Repair. 2017;31(1):48–55. · DOI
  37. Gorelick PB, Scuteri A, Black SE, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke. 2011;42(9):2672–713. · DOI · Paper page
  38. Sun JH, Tan L, Yu JT. Post-stroke cognitive impairment: epidemiology, mechanisms and management. Ann Transl Med. 2014;2(8):80.
  39. Rengen PN, Gauba C, Chaudhari D. Cognitive impairment after stroke. Cureus. 2015;7(9):e335.
  40. Doré V, Villemagne VL, Bourgeat P, et al. Cross-sectional and longitudinal analysis of the relationship between Aβ deposition, cortical thickness, and memory in cognitively unimpaired individuals and in Alzheimer disease. JAMA Neurol. 2013;70(7):903–11. · DOI
  41. Wirth M, Villeneuve S, Haase CM, et al. Association between Alzheimer disease biomarkers, neurodegeneration, and cognition in cognitively normal older people. JAMA Neurol. 2013;70(12):1512–9.
  42. Lee MJ, Seo SW, Na DL, et al. Synergistic effects of ischemia and β-amyloid burden on cognitive decline in patients with subcortical vascular mild cognitive impairment. JAMA Psychiatry. 2014;71(4):412–22. · DOI
  43. Skoog I, Lithell H, Hansson L, et al. Effect of baseline cognitive function and antihypertensive treatment on cognitive and cardiovascular outcomes: Study on COgnition and Prognosis in the Elderly (SCOPE). Am J Hypertens. 2005;18(8):1052–9. · DOI
  44. Rist PM, Chalmers J, Arima H, Anderson C, MacMahon S, Woodward M, Kurth TTC. Baseline cognitive function, recurrent stroke, and risk of dementia in stroke patients. Stroke. 2014;44(7):1790–5. · DOI
  45. Elias PK, Elias MF, D’Agostino RB, Sullivan LM, Wolf PA. Serum cholesterol and cognitive performance in the Framingham Heart Study. Psychosom Med. 2005;67(1):24–30. · DOI
  46. Ma C, Yin Z, Zhu P, et al. Blood cholesterol in late-life and cognitive decline: A longitudinal study of the Chinese elderly. Mol Neurodegener. 2017;12:1–9.
  47. Wolozin B, Wang SW, Li NC, Lee A, Lee TA, Kazis LE. Simvastatin is associated with a reduced incidence of dementia and Parkinson’s disease. BMC Med. 2007;5(20):1–11.
  48. Heart Protection Study Colloborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet. 2002;360(9326):7–22. · DOI · Paper page
  49. Mirza SS, Portegies MLP, Wolters FJ, et al. Higher education is associated with a lower risk of dementia after a stroke or TIA. The Rotterdam study. Neuroepidemiology. 2016;46(2):120–7. · DOI
  50. Lenehan Me, Summers MJ, Saunders NL, Summers JJ, Vickers JC. Relationship between education and age-related cognitive decline: a review of recent research. Psychogeriatrics. 2015;15(2):154–62. · DOI · Paper page

Metadata

Authors
Srithum, W., Kabayama, M., Gondo, Y., Masui, Y., Akagi, Y., Klinpudtan, N., Kiyoshige, E., Godai, K., Sugimoto, K., Akasaka, H., Takami, Y., Takeya, Y., Yamamoto, K., Ikebe, K., Ogawa, M., Inagaki, H., Ishizaki, T., Arai, Y., Rakugi, H., & Kamide, K.
Affiliations
  • Osaka University
  • The University of Osaka (JP)
  • Tokyo Metropolitan Institute of Gerontology (JP)
  • Keio University (JP)
Corresponding author
Kamide, Kei
ORCID
Venue
BMC Geriatrics
Publisher
Research Square Platform LLC
Published
2020-01-13
Volume
20
Issue
1
Pages
24-24
ISSN
1471-2318 (ISSN-L)
DOI
10.21203/rs.2.15994/v3
PMC
PMC6977260
OpenAlex
W3005450537
Cited by
24
References
69
Citations by year
2026: 3 · 2025: 3 · 2024: 3 · 2023: 8 · 2022: 3 · 2021: 3 · 2020: 1
FWCI
2.74
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Geriatrics (publishedVersion, cc-by)
  • Research Square (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology (19K11138, 19K07888)
  • Japan Society for the Promotion of Science (17H02633, 19K07888, 18K18456, 19K11138)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords
stroke, cognitive decline, oldest old, community-dwelling older adults, dementia risk factors, dyslipidemia, educational attainment, vascular risk factors, Montreal Cognitive Assessment, cognitive impairment prevention
MeSH terms
Aged, Female, Humans, Japan, Longitudinal Studies, Male, Risk Factors, Stroke, Independent Living, Cognitive Dysfunction

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