The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A multi-adenylate cyclase regulator at the flagellar tip controls African trypanosome transmission
Open accessPreprint — published as 10.1038/s41467-022-33108-z · Paper page
Abstract
Signaling from ciliary nanodomains controls developmental processes in metazoans. Trypanosome transmission requires development and migration in the tsetse vector alimentary tract. Flagellar cAMP signaling has been linked to parasite social motility (SoMo) in vitro, yet uncovering control of directed migration in fly organs is challenging. Here we show that the architecture of an adenylate cyclase (AC) complex in the flagellar tip nanodomain is essential for tsetse salivary gland (SG) colonization and SoMo. Cyclic AMP response protein 3 (CARP3) binds and regulates multiple AC isoforms. CARP3 tip localization depends on the scaffold FLAM8. Re-localization of CARP3 away from the tip nanodomain is sufficient to abolish SoMo and fly SG colonization. Since intrinsic development is normal in ∆carp3 and ∆flam8 mutant parasites, AC complex-mediated tip signaling specifically controls parasite migration and thereby transmission. Participation of several developmentally regulated receptor-type AC isoforms may indicate the complexity of the in vivo signals perceived.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764
Flagged first, then by citations
Metadata
- Authors
- Bachmaier, S., Giacomelli, G., Calvo-Alvarez, E., Vieira, L. R., Abbeele, J. V. D., Aristodemou, A., Lorentzen, E., Gould, M., Brennand, A., Dupuy, J.-W., Forné, I., imhof, A., Bramkamp, M., Salmon, D., Rotureau, B., & Boshart, M.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- Institut Pasteur, Université de Paris
- Universidade Federal do Rio de Janeiro (BR)
- Instituut voor Tropische Geneeskunde (BE)
- Aarhus University (DK)
- University of Bordeaux
- Inserm (FR)
- Corresponding author
- Bachmaier, Sabine
- Boshart, Michael
- ORCID
- Venue
- Nature Communications
- Published
- 2022-01-25
- Volume
- 13
- Issue
- 1
- Pages
- 5445-5445
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC9481589
- OpenAlex
- W4296041492
- Cited by
- 38
- References
- 1
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 10 · 2023: 17 · 2022: 1
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Open access LMU (Ludwid Maxmilian's Universitat Munchen) (acceptedVersion)
- HAL (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Deutsche Forschungsgemeinschaft (443931024, 268759902, ANR-10-LABX-62-IBEID)
- Agence Nationale de la Recherche (10-LABX-62-IBEID, ANR‐10‐LABX‐62‐IBEID, LABX-62-IBEID, ANR-14-CE14-0019, ANR18, ANR-18-CE15-0012, ANR-10, ANR-10-LABX, ANR-10-LABX-0062, ANR-10-LABX-62)
- Institut National de la Santé et de la Recherche Médicale (ANR-10-LABX-62-IBEID)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (ANR-10-LABX-62-IBEID, 422022/2016-0)
- Institut Pasteur
- Ludwig-Maximilians-Universität München
- Topics
- Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- African trypanosomes, Trypanosoma brucei, adenylate cyclase, cAMP signaling, social motility, parasite migration, trypanosome transmission, ciliary signaling
- MeSH terms
- Cyclic AMP, Adenylyl Cyclases, Animals, Trypanosoma, Trypanosoma brucei brucei, Tsetse Flies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
