Title: Dust and Antimicrobial Resistance (AMR) in Ghanaian Homes: developing home cleaning intervention through community engagement to reduce infections and AMR.
Open accessPreprint — published as 10.1038/s41598-023-37317-4 · Paper page
Abstract
Background Globally Antimicrobial Resistance (AMR) constitutes a health crisis, particularly in developing countries, where infectious disease commonly leads to fatalities. Personal and environmental hygiene form the best ways of reducing home infections thus decreasing the need for antibiotics and consequently diminishing AMR. Despite this being an obvious step, our understanding of cleaning in the home and possible interventions on home cleaning are limited. Methods We combined design and microbiology methods in an innovative mixed-method approach. A traditional survey design (n = 240), a design ethnography (n = 12), a co-design workshop and a pre-intervention microbiological dust sample analysis was undertaken to provide insights for codesign workshops in which new cleaning practices might be developed to minimise any AMR bacteria present in the home environments located in the Greater Accra Region of Ghana. Results Microbiological analysis of household dust showed that 36.6% of bacterial isolates detected were found to carry at least one resistance to the panel of antibiotics tested. Four scenarios were generated from an economic segmentation of the survey data. 50 ethnographic insights were ‘presented’ and descriptions of 12 bacteria species that showed resistance to one or more antibiotics (representing 176 bacterial isolates that showed resistance to one or more antibiotics found in the dust samples) were presented to the participants in a codesign workshop. An intervention, a new regime of cleaning practices agreed through the co-design workshop and practiced for thirty days, was made in (n = 7) households. Conclusion The high prevalence of multidrug resistance observed in this study indicate the need for antibiotics surveillance program, not only in hospital settings but also in the home environment. There is, thus, an urgent need for targeting of interventions at the household level. Activating knowledge through community engagement in the research helps in increasing public perception and breaking down the scientist-public barrier.
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- Authors
- Tsekleves, E., De Souza, D., Pickup, R., Ahorlu, C., & Darby, A.
- Affiliations
- Lancaster University (GB)
- Noguchi Memorial Institute for Medical Research
- University of Ghana (GH)
- Corresponding author
- Tsekleves, Emmanuel
- Venue
- Scientific Reports
- Publisher
- Research Square Platform LLC
- Published
- 2022-12-15
- Volume
- 13
- Issue
- 1
- Pages
- 10505-10505
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC10307869
- OpenAlex
- W4382361565
- Cited by
- 10
- References
- 48
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 1
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Lancaster EPrints (Lancaster University) (submittedVersion)
- Funders
- Arts and Humanities Research Council (AH/R002177/1)
- Noguchi Memorial Institute for Medical Research, University of Ghana
- Topics
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Keywords
- antimicrobial resistance, house dust, multidrug resistance, community participation, co-design workshops, design ethnography, household infection, environmental hygiene, antibiotic surveillance, Greater Accra Region
- MeSH terms
- Anthropology, Cultural, Anti-Bacterial Agents, Dust, Ghana, Humans, Drug Resistance, Bacterial
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