The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Serotonin is a Common Thread Linking Different Classes of Antidepressants
Open accessPreprint — published as 10.1016/j.chembiol.2023.10.009 · Paper page
Abstract
Depression pathology remains elusive. The monoamine hypothesis has placed much focus on serotonin, but due to the variable clinical efficacy of monoamine reuptake inhibitors, the community is looking for alternative therapies such as ketamine (synaptic plasticity and neurogenesis theory of antidepressant action). There is evidence that different classes of antidepressants may affect serotonin levels; a notion we test here. We measure hippocampal serotonin in mice with voltammetry and study the effects of acute challenges of antidepressants. We find that pseudo-equivalent doses of these drugs similarly raise ambient serotonin levels, despite their differing pharmacodynamics because of differences in Uptake 1 and 2, rapid SERT trafficking and modulation of serotonin by histamine. These antidepressants have different pharmacodynamics but have strikingly similar effects on extracellular serotonin. Our findings suggest that serotonin is a common thread that links clinically effective antidepressants, synergizing different theories of depression (synaptic plasticity, neurogenesis and the monoamine hypothesis).
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Cites
Matveychuk, D., Thomas, R. K., Swainson, J., Khullar, A., MacKay, M.-A., Baker, G. B., & Dursun, S. M. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320916657 · Cited by 209
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Metadata
- Authors
- Witt, C. E., Mena, S., Holmes, J., Hersey, M., Buchanan, A. M., Parke, B., Saylor, R., Honan, L. E., Berger, S. N., Lumbreras, S., Nijhout, F. H., Reed, M. C., Best, J., Fadel, J., Schloss, P., Lau, T., & Hashemi, P.
- Affiliations
- University of South Carolina (US)
- Imperial College London (GB)
- Heidelberg University (DE)
- Duke University (US)
- The Ohio State University (US)
- Corresponding author
- Hashemi, Parastoo
- ORCID
- Venue
- Cell chemical biology
- Publisher
- Research Square Platform LLC
- Published
- 2023-03-28
- Volume
- 30
- Issue
- 12
- Pages
- 1557-1570.e6
- ISSN
- 2451-9448 (ISSN-L)
- PMC
- PMC10081366
- OpenAlex
- W4388871305
- Cited by
- 18
- References
- 1
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 7 · 2023: 1
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell chemical biology (publishedVersion)
- Research Square (acceptedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion, cc-by)
- Funders
- University of South Carolina (R01AG050518, R01MH106563)
- Chinese Academy of Medical Sciences
- National Institutes of Health
- National Institute on Aging (RF1AG050518, R01AG050518)
- National Institute of Mental Health (R01MH106563)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK062710, P30DK056336)
- Chinese American Medical Society
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- serotonin, antidepressants, depression, hippocampus, extracellular serotonin, monoamine hypothesis, monoamine reuptake inhibitors, escitalopram, fluoxetine, reboxetine, ketamine, serotonin transporter, neurogenesis, synaptic plasticity, voltammetry
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