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Wheat powdery mildew resistance gene Pm13 from Aegilops longissima encodes a unique mixed lineage kinase domain-like protein
Open accessPreprint — published as 10.1038/s41467-024-46814-7 · Paper page
Abstract
Wheat powdery mildew is one of the most destructive diseases threatening global wheat production. The wild relatives of wheat comprise rich sources of diversity for powdery mildew resistance. Here, we report map-based cloning of broad-spectrum powdery mildew resistance gene Pm13 from wild wheat species Aegilops longissima. Pm13 encodes a novel mixed lineage kinase domain-like (MLKL) protein which contains an N-terminal HeLo domain and a C-terminal authentic serine/threonine kinase (STK) domain, a unique domain architecture that has not been reported in plant disease-resistance genes. The resistance function of Pm13 was validated by loss-of-function mutants, gene silencing, transgenic assay, and allelic association analyses. Thus, Pm13 represents a special class of plant resistance genes revealing a novel aspect of host-pathogen interactions. Though introgressed into wheat ~30 years ago it was hardly exploited due to linkage drag. The new lines with small Ae. longissima Pm13 segment will lead to wide-scale deployment in wheat cultivars.
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Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764
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Metadata
- Authors
- Liu, W., Li, H., Men, W., Ma, C., Liu, Q., Dong, Z., Tian, X., Wang, C., Liu, C., Gill, H., Ma, P., Zhang, Z., Liu, B., Zhao, Y., & Sehgal, S.
- Affiliations
- Henan Agricultural University (CN)
- Nanjing Agricultural University (CN)
- Chinese Academy of Sciences (CN)
- Shandong Academy of Agricultural Sciences (CN)
- South Dakota State University (US)
- Yantai University (CN)
- Northeast Normal University (CN)
- Corresponding author
- Liu, Wenxuan
- Zhao, Yue
- Sehgal, Sunish
- ORCID
- Venue
- Nature Communications
- Published
- 2023-04-28
- Volume
- 15
- Issue
- 1
- Pages
- 2449-2449
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC10951266
- OpenAlex
- W4392956091
- Cited by
- 67
- References
- 1
- Citations by year
- 2026: 16 · 2025: 34 · 2024: 14 · 2023: 3
- FWCI
- 15.56
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (31971887, 32272070, 32372089)
- Henan Agricultural University
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Powdery Mildew Fungal Diseases
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Wheat and Barley Genetics and Pathology
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
- Keywords
- wheat powdery mildew, disease resistance genes, MLKL, serine/threonine kinase domain, Aegilops longissima, wild wheat relative, positional cloning, introgression lines, gene silencing, allelic association
- MeSH terms
- Aegilops, Ascomycota, Plant Diseases, Protein Kinases, Triticum, Genes, Plant, Disease Resistance
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