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The Antidepressant Effect of Magnolol on Depression-like Behavior of CORT-treated Mice
Open accessPreprint — published as 10.1007/s12031-023-02185-0 · Paper page
Abstract
Although the antidepressant effect of magnolol has been revealed in previous reports, the mechanism remains unclear. In this study, the antidepressant effect of magnolol on corticosterone-induced (CORT-induced) depressed mice was investigated in vivo. After 21 days of CORT induction, the mice showed marked depressive-like behaviors, with a decrease in sucrose preference score and an increase in immobility time in tail suspension test (TST) and forced swimming test (FST). Pretreatment with either magnolol (50 mg/kg, i.p.) or the kappa opioid receptor (KOR) antagonist nor-BNI (10 mg/kg, i.p.) prevented CORT-induced depression-like behavior and reduced CORT-induced dynorphin (DYN A) elevation in the hippocampal DG. However, no depression-like behavior was observed in mice with KOR downregulation in the DG. We further found that upregulation of DYN A in the DG caused depression, which was blocked by intraperitoneal injection of nor-BNI and modulated by magnolol. The present study demonstrated that magnolol could ameliorate CORT-induced depression-like behaviors, by modulating the DYN A/KOR system in the DG of the hippocampus.
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Cites
Tartt, A. N., Mariani, M. B., Hen, R., Mann, J. J., & Boldrini, M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01520-y · Cited by 408
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Metadata
- Authors
- Xu, C., Ye, J., Sun, Y., Sun, X., & Liu, J.-G.
- Affiliations
- Zhejiang Chinese Medical University (CN)
- Corresponding author
- Xu, Chi
- Liu, Jing-gen
- Venue
- Journal of Molecular Neuroscience
- Publisher
- Research Square Platform LLC
- Published
- 2023-06-29
- Volume
- 74
- Issue
- 1
- Pages
- 3-3
- ISSN
- 0895-8696 (ISSN-L)
- OpenAlex
- W4390636677
- Cited by
- 8
- References
- 1
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 1
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- green
- dx.doi.org
- Locations
- Journal of Molecular Neuroscience (publishedVersion)
- Research Square (acceptedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (82030112)
- Zhejiang Chinese Medical University (2022FSYYZZ11)
- Natural Science Foundation of Zhejiang Province (LY22H270004)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Magnolia and Illicium research
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- magnolol, antidepressant effects, depression-like behavior, corticosterone, chronic stress, kappa opioid receptor, nor-binaltorphimine, dynorphin A, ventral dentate gyrus, hippocampus, sucrose preference, immobility time, tail suspension test, forced swim test
- MeSH terms
- Animals, Antidepressive Agents, Biphenyl Compounds, Corticosterone, Depression, Lignans, Mice
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