The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Comparison of the sensitivities of pharmacotherapy-related and disease-specific quality of life measures in response to pharmacist-led pharmaceutical care for cancer outpatients: a randomised controlled trial
Open accessPreprint — published as 10.1007/s11096-023-01692-9 · Paper page
Abstract
Background No data was available regarding the sensitivities of pharmacotherapy-related and disease-specific quality of life measures to pharmacist-led pharmaceutical care (PC). Objective To compare the sensitivities of two health-related quality of life (HRQoL) measures, i.e. the Patient-Reported Outcomes Measure of Pharmaceutical Therapy for Quality of Life (PROMPT-QoL) vs. the Functional Assessment of Cancer Therapy-General (FACT-G), in response to pharmacist-led PC for cancer outpatients. Methods A randomised controlled trial was conducted on the cancer outpatients of a tertiary Thai hospital. Eligible patients were randomly allocated to a PC group receiving PC interventions or a usual care (UC) group acquiring pharmacist’s ordinary care. The HRQoL of both groups was assessed using the PROMPT-QoL and the FACT-G before and after a session. The data were gathered and the sensitivities of the two measures using standardised mean differences (SMDs) were analysed. Results A total of 237 patients in two arms (120 PC vs. 117 UC patients) completed the trial. With PC interventions, all eight PROMPT-QoL domains and 3 out of 4 FACT-G domains were significantly improved. The PROMPT-QoL yielded SMDs ranging from 0.24 to 1.68 that were considered a moderate-to-high sensitivity, whereas the FACT-G provided a moderate sensitivity with SMDs of 0.31–0.64. The average SMDs of four FACT-G domains was 0.50 and SMD of its total score was 0.80. Eight PROMPT-QoL domains had the average SMD of 0.60 and the total score SMD was 1.40. Conclusions The PROMPT-QoL is more sensitive to detect HRQoL when delivering pharmacist-led pharmaceutical care to cancer outpatients. Trial registration TCTR20210809008 on August 9, 2021.
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CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials
the CONSORT Group, Schulz, K. F., Altman, D. G., & Moher, D. (2010) · Trials · doi:10.1186/1745-6215-11-32 · Cited by 1,871
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Metadata
- Authors
- Sakthong, P., Soipitak, P., & Winit-Watjana, W.
- Affiliations
- Chulalongkorn University (TH)
- Samut Prakan Hospital (TH)
- Bangkokthonburi University (TH)
- Corresponding author
- Sakthong, Phantipa
- ORCID
- Sakthong, Phantipa
- Venue
- International Journal of Clinical Pharmacy
- Published
- 2023-08-10
- Volume
- 46
- Issue
- 2
- Pages
- 463-470
- ISSN
- 2210-7703 (ISSN-L)
- OpenAlex
- W4391034610
- Cited by
- 7
- References
- 1
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- green
- dx.doi.org
- Locations
- International Journal of Clinical Pharmacy (publishedVersion)
- Research Square (acceptedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › Pharmacy › Pharmacy and Medical Practices
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- health-related quality of life, FACT-G, sensitivity to change, cancer outpatients, oncology pharmacy
- MeSH terms
- Humans, Neoplasms, Outpatients, Pharmaceutical Services, Pharmacists, Quality of Life
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