The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The receptor kinase SRF3 coordinates iron-level and flagellin dependent defense and growth responses in plants
Open accessPreprint — published as 10.1038/s41467-022-32167-6 · Paper page
Abstract
Iron is critical for host-pathogen interactions. While pathogens seek to scavenge iron to spread, the host aims at decreasing iron availability to reduce pathogen virulence. Thus, iron sensing and homeostasis are of particular importance to prevent host infection and part of nutritional immunity. While the link between iron homeostasis and immunity pathways is well established in plants, how iron levels are sensed and integrated with immune response pathways remain unknown. We identified a receptor kinase, SRF3 coordinating root growth, iron homeostasis and immunity pathways via regulation of callose synthase activity. These processes are modulated by iron levels and rely on SRF3 extracellular and kinase domain which tune its accumulation and partitioning at the cell surface. Mimicking bacterial elicitation with the flagellin peptide flg22 phenocopies SRF3 regulation upon low iron levels and subsequent SRF3-dependent responses. We propose that SRF3 is part of nutritional immunity responses involved in sensing external iron levels.
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Citations
Cites
Iron in infection and immunity
Cassat, J. E., & Skaar, E. P. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.04.010 · Cited by 1,214
Iron homeostasis in host defence and inflammation
Ganz, T., & Nemeth, E. (2015) · Nature Reviews Immunology · doi:10.1038/nri3863 · Cited by 843
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Metadata
- Authors
- Platre, M., Satbhai, S., Brent, L., Gleason, M., Grison, M., Glavier, M., Zhang, L., Cao, M., Gaillochet, C., Göschl, C., Giovannetti, M., Enugutti, B., von Reth, M., Alcázar, R., Parker, J., Vert, G., Bayer, E., & Busch, W.
- Affiliations
- Salk Institute for Biological Studies (US)
- Centre National de la Recherche Scientifique (FR)
- Gregor Mendel Institute of Molecular Plant Biology (AT)
- Max Planck Institute for Plant Breeding Research (DE)
- Cluster of Excellence on Plant Sciences (DE)
- Plant Science Research Laboratory (LRSV), UMR5546 CNRS/Université Toulouse 3
- Corresponding author
- Busch, Wolfgang
- ORCID
- Venue
- Nature Communications
- Published
- 2021-07-12
- Volume
- 13
- Issue
- 1
- Pages
- 4445-4445
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC9343624
- OpenAlex
- W4289313504
- Cited by
- 46
- References
- 2
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 13 · 2023: 7 · 2022: 3
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- HAL (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion, cc-by)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by)
- Funders
- European Commission (772103, HORIZON2020)
- Österreichischen Akademie der Wissenschaften
- Austrian Science Fund (I 2377)
- International Max Planck Research School for Advanced Methods in Process and Systems Engineering
- National Institutes of Health (390686111)
- National Institute of General Medical Sciences (R01GM127759)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- iron homeostasis, nutritional immunity, flagellin, flg22, callose synthase, plant immunity, root growth, iron sensing, kinase domain, extracellular domain, host-pathogen interaction
- MeSH terms
- Flagellin, Iron, Protein Kinases, Arabidopsis, Arabidopsis Proteins
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