Polynucleotides HPT for Asian Skin Regeneration and Rejuvenation
Open accessAbstract
Introduction: Even lightly compromised skin may impact self-esteem and social behaviour. After intradermal infiltration, natural-origin Polynucleotides High Purification Technology (PN HPT) promote new collagen and extracellular matrix production, translating into a physiological correction of the ageing skin. The study aimed to explore the benefits of intradermal PN HPT on the four perceptual skin quality categories "Skin Tone Evenness", "Skin Surface Evenness", "Skin Firmness", and "Skin Glow" in a representative sample of 30 Asian subjects (mean age 40.2± 11.4 years old). Methods: Study protocol: three intradermal injections of a PN HPT-based Class III CE-marked medical device at T0 (baseline assessment and first treatment session), T1 (four weeks after baseline), and T2 (eight weeks after baseline), with efficacy and safety evaluations at T1, T2, T3 (four months after baseline) and T4 (six months after baseline). Quantitative and qualitative assessments: 3D skin analysis system QuantifiCare and Global Aesthetic Improvement Scale (GAIS, Investigator and Patient subscales). Results: PN HPT treatment led to a meaningful and statistically significant improvement of the skin surface, firmness, pigmentation, and radiance, with no early- or late-onset adverse events and benefits persisting up to the sixth-month visit in all subjects. At T4, 33% and 43% of treated subjects felt "Much Improved" and "Very Much Improved" (optimal result); 56% and 44% of treated subjects felt "Satisfied" or "Very Satisfied". At T4, the mean Investigator GAIS scores were 3.33 out of 5.0 for the "Skin Tone Evenness" skin quality perceptual category, 3.46 for the "Skin Surface Evenness" category, 3.61 for "Skin Firmness", and 3.45 per for the radiance determinant of the "Skin Glow" category. Conclusion: Intradermal treatment with the PN HPT-based medical device led to a meaningful improvement of the skin surface, firmness, pigmentation, and radiance with complete safety. The aesthetic benefits persisted up to the sixth-month visit in all subjects.
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Use of PN extends beyond Korea to the European Union and other countries such as Malaysia, Thailand, and Australia.
“In particular, the use of PN extends beyond Korea to the European Union [155] as well as other countries such as Malaysia [156], Thailand [157], Australia [158], and so on.”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [155]
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- [1]Samson N, Fink B, Matts P. Interaction of skin color distribution and skin surface topography cues in the perception of female facial age and health: perception of skin color and topography. J Cosmet Dermatol. 2011; 10(1): 78– 84. doi: 10.1111/j.1473-2165.2010.00538.x 21332921 · DOI
- [2]Samson N, Fink B, Matts PJ. Visible skin condition and perception of human facial appearance. Int J Cosmet Sci. 2010; 32(3): 167– 184. doi: 10.1111/j.1468-2494.2009.00535.x 19889046 · DOI
- [3]Fink B, Neave N. The biology of facial beauty. Int J Cosmet Sci. 2005; 27(6): 317– 325. doi: 10.1111/j.1467-2494.2005.00286.x 18492169 · DOI
- [4]Goldie KM, Guillen Fabi S, Fabi SG, et al. Skin Quality – a holistic 360° view: consensus results. Clin Cosmet Invest Dermatol. 2021; Volume 14: 643– 654. doi: 10.2147/CCID.S309374 PMC8214518 34163203 · DOI
- [5]Cassuto D, Bellia G, Schiraldi C. An overview of soft tissue fillers for cosmetic dermatology: from filling to regenerative medicine. Clin Cosmet Invest Dermatol. 2021; Volume 14: 1857– 1866. doi: 10.2147/CCID.S276676 PMC8710524 34992400 · DOI
- [6]Cavallini M, Bartoletti E; on behalf of The Polynucleotides HPT Priming Board, Collegio Italiano delle Società Scientifiche di Medicina Estetica (Italian College of the Aesthetic Medicine Scientific Societies) — SIME, AGORÀ, SIES. Consensus report on the use of PN HPT (polynucleotides highly purified technology) in aesthetic medicine. J Cosmet Dermatol. 2021; 20(3): 922– 928. doi: 10.1111/jocd.13679 32799391 PMC7984045 · DOI · Paper page
- [7]Colangelo MT, Govoni P, Belletti S, et al. Polynucleotide biogel enhances tissue repair, matrix deposition and organization. J Biol Regul Homeost Agents. 2021; 35(1): 355– 362. doi: 10.23812/20-320-L 33480222 · DOI
- [8]Massirone A. Polynucleotides Highly Purified Technology and the face skin, a history of innovative skin priming. Aesthetic Med. 2021; 7: 35– 40.
- [9]Cavallini M, Papagni M. Long chain polynucleotides gel and skin biorevitalization. Int J Plast Dermatol. 2007; 3: 27– 32.
- [10]Narins RS, Brandt F, Leyden J, et al. A randomized, double-blind, multicenter comparison of the efficacy and tolerability of Restylane versus Zyplast for the correction of nasolabial folds. Dermatol Surg. 2003. doi: 10.1046/j.1524-4725.2003.29150.x 12786700 · DOI
- [11]Garratt AM, Helgeland J, Gulbrandsen P. Five-point scales outperform 10-point scales in a randomized comparison of item scaling for the Patient Experiences Questionnaire. J Clin Epidemiol. 2011; 64(2): 200– 207. doi: 10.1016/j.jclinepi.2010.02.016 20566267 · DOI
- [12]Mishra P, Singh U, Pandey CM, et al. Application of Student’s t-test, analysis of variance, and covariance. Ann Card Anaesth. 2019; 22(4): 407. doi: 10.4103/aca.ACA_94_19 31621677 PMC6813708 · DOI
- [13]Faul F, Erdfelder E, Buchner A, et al. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods. 2009; 41(4): 1149– 1160. doi: 10.3758/BRM.41.4.1149 19897823 · DOI · Paper page
- [14]Shin J-W, Kwon S-H, Choi J-Y, et al. Molecular mechanisms of dermal aging and antiaging approaches. Int J Mol Sci. 2019. doi: 10.3390/ijms20092126 PMC6540032 31036793 · DOI · Paper page
- [15]Pensato R, La Padula S. The use of Platelet-Rich Plasma in aesthetic and regenerative medicine: a comprehensive review. Aesthetic Plast Surg. 2023. doi: 10.1007/s00266-022-02781-2 35075505 · DOI
- [16]Xiao H, Xu D, Mao R, et al. Platelet-Rich Plasma in facial rejuvenation: a systematic appraisal of the available clinical evidence. Clin Cosmet Invest Dermatol. 2021: 1697– 724. doi: 10.2147/CCID.S340434 PMC8606573 34819739 · DOI
- [17]Nanda S, Chauhan K, Shetty V, et al. Platelet-Rich Plasma in aesthetics. Indian Dermatol Online J. 2021; 12(7): 41. doi: 10.4103/idoj.idoj_290_21 PMC8664171 34976880 · DOI
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Kim, S. T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17081024 · Cited by 18 · see citing works
- Authors
- Lim, T. S., Liew, S., Tee, X. J., Chong, I., Lo, F. J., Ho, M. J., Ong, K., & Cavallini, M.
- Affiliations
- Clique Clinic (MY)
- Centro Diagnostico Italiano (IT)
- Corresponding author
- Lim, Ting Song
- Venue
- Clinical, Cosmetic and Investigational Dermatology
- Publisher
- Informa UK Limited
- Published
- 2024-02
- Volume
- Volume 17
- Pages
- 417-431
- ISSN
- 1178-7015 (ISSN-L)
- PMC
- PMC10874187
- OpenAlex
- W4391787390
- Cited by
- 21
- References
- 0
- Citations by year
- 2026: 13 · 2025: 6 · 2024: 2
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical Cosmetic and Investigational Dermatology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (acceptedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- polynucleotides, intradermal injection, skin rejuvenation, skin aging, collagen, extracellular matrix, skin firmness, skin tone evenness, skin radiance, Asian skin, treatment efficacy
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