Monocyte chemoattractant protein-1: a proinflammatory cytokine elevated in sarcopenic obesity
Open accessAbstract
OBJECTIVE: Sarcopenic obesity (SO) is associated with poorer physical outcomes and functional status in the older adult. A proinflammatory milieu associated with central obesity is postulated to enhance muscle catabolism. We set out to examine associations of the chemokine monocyte chemoattractant protein-1 (MCP-1) in groups of older adults, with sarcopenia, obesity, and the SO phenotypes. METHODS: A total of 143 community dwelling, well, older adults were recruited. Cross-sectional clinical data, physical performance, and muscle mass measurements were collected. Obesity and sarcopenia were defined using revised National Cholesterol Education Program (NCEP) obesity guidelines and those of the Asian Working Group for Sarcopenia. Serum levels of MCP-1 were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: In all, 25.2% of subjects were normal, 15.4% sarcopenic, 48.3% obese, and 11.2% were SO. The SO groups had the lowest appendicular lean mass, highest percentage body fat, and lowest performance scores on the Short Physical Performance Battery and grip strength. The MCP-1 levels were significantly different, with the highest levels found in SO participants (P<0.05). CONCLUSION: Significantly raised MCP-1 levels in obese and SO subjects support the theory of chronic inflammation due to excess adiposity. Longitudinal studies will reveal whether SO represents a continuum of obesity causing accelerated sarcopenia and cardiovascular events, or the coexistence of two separate conditions with synergistic effects affecting functional performance.
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The highest level of monocyte chemoattractant protein-1 (MCP-1) and the lowest level of appendicular lean mass are found in the sarcopenic obesity group.
“The study has found the highest level of monocyte chemoattractant protein-1 (MCP-1) and the lowest level of appendicular lean mass in SO group (27), which supports the theory that low-grade inflammation is linked to SO.”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [27]
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Cites
Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,769 · see citing works
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works
Guralnik, J. M., Simonsick, E. M., Ferrucci, L., Glynn, R. J., Berkman, L. F., Blazer, D. G., Scherr, P. A., & Wallace, R. B. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.2.m85 · Cited by 9,792 · see citing works
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works
Sarcopenia in Asia: Consensus Report of the Asian Working Group for Sarcopenia
Chen, L.-K., Liu, L.-K., Woo, J., Assantachai, P., Auyeung, T.-W., Bahyah, K. S., Chou, M.-Y., Chen, L.-Y., Hsu, P.-S., Krairit, O., et al. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.11.025 · Cited by 4,051 · see citing works
Sarcopenic Obesity Predicts Instrumental Activities of Daily Living Disability in the Elderly
Baumgartner, R. N., Wayne, S. J., Waters, D. L., Janssen, I., Gallagher, D., & Morley, J. E. (2004) · Obesity Research · doi:10.1038/oby.2004.250 · Cited by 937 · see citing works
de Lemos, J. A., Morrow, D. A., Sabatine, M. S., Murphy, S. A., Gibson, C. M., Antman, E. M., McCabe, C. H., Cannon, C. P., & D, E. B. M. (2003) · Circulation · doi:10.1161/01.cir.0000049742.68848.99 · Cited by 468 · see citing works
The Frenchay Activities Index. Assessment of functional status in stroke patients.
Schuling, J., de Haan, R. J., Limburg, M., & Groenier, K. H. (1993) · Stroke · doi:10.1161/01.str.24.8.1173 · Cited by 381 · see citing works
Roubenoff, R. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06515.x · Cited by 230 · see citing works
Adjuvant arthritis as a model of inflammatory cachexia
Roubenoff, R., Freeman, L. M., Smith, D. E., Abad, L. W., Dinarello, C. A., & Kehayias, J. J. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400320 · Cited by 163 · see citing works
The obesity paradox in chronic disease: facts and numbers
Lainščak, M., von Haehling, S., Doehner, W., & Anker, S. D. (2012) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-012-0059-5 · Cited by 136 · see citing works
Increase in Circulating Levels of Monocyte Chemoattractant Protein-1 with Aging
Inadera, H., Egashira, K., Takemoto, M., Ouchi, Y., & Matsushima, K. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099313127 · Cited by 120 · see citing works
Strandberg, T. E., Stenholm, S., Strandberg, A. Y., Salomaa, V. V., Pitkälä, K. H., & Tilvis, R. S. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kwt157 · Cited by 104 · see citing works
Chiao, Y. A., Dai, Q., Zhang, J., Lin, J., Lopez, E. F., Ahuja, S. S., Chou, Y.-M., Lindsey, M. L., & Jin, Y.-F. (2011) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.111.959981 · Cited by 90 · see citing works
Obesity paradox or inappropriate study designs? Time for life-course epidemiology
Ferreira, I., & Stehouwer, C. D. A. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e32835b4fe0 · Cited by 51 · see citing works
Paraoxonases and chemokine (C-C motif) ligand-2 in noncommunicable diseases.
Camps, J., Rodríguez-Gallego, E., García-Heredia, A., Triguero, I., Riera-Borrull, M., Hernández-Aguilera, A., Luciano-Mateo, F., Fernández-Arroyo, S., & Joven, J. (2014) · Advances in Clinical Chemistry · doi:10.1016/b978-0-12-800094-6.00007-8 · Cited by 41 · see citing works
Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis
Bonapace, L., Coissieux, M., Wyckoff, J. B., Mertz, K. D., Varga, Z., Junt, T., & Bentires‐Alj, M. (2014) · Zurich Open Repository and Archive (University of Zurich) · doi:10.1038/nature13862 · Cited by 15 · see citing works
Flagged first, then by citations
1 of the 19 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [15]Xu H Barnes GT Yang Q Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance J Clin Invest 2003 112 12 1821 1830 14679177 PMC296998
Cited by
Sorted by citations
Inflammation and sarcopenia: A systematic review and meta-analysis
Bano, G., Trevisan, C., Carraro, S., Solmi, M., Luchini, C., Stubbs, B., Manzato, E., Sergi, G., & Veronese, N. (2017) · Maturitas · doi:10.1016/j.maturitas.2016.11.006 · Cited by 801 · see citing works
Biomarkers shared by frailty and sarcopenia in older adults: A systematic review and meta-analysis
Picca, A., Coelho‐Júnior, H. J., Calvani, R., Marzetti, E., & Vetrano, D. L. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101530 · Cited by 372 · see citing works
Donini, L. M., Busetto, L., Bauer, J. M., Bischoff, S., Boirie, Y., Cederholm, T., Cruz-Jentoft, A. J., Dicker, D., Frühbeck, G., Giustina, A., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2019.11.024 · Cited by 326 · see citing works
Metabolic Syndrome and Sarcopenia
Nishikawa, H., Asai, A., Fukunishi, S., Nishiguchi, S., & Higuchi, K. (2021) · Nutrients · doi:10.3390/nu13103519 · Cited by 333 · see citing works
The Anti-Inflammatory Effects of Testosterone
Bianchi, V. E. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2018-00186 · Cited by 253 · see citing works
Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments
Wang, M., Tan, Y., Shi, Y., Wang, X., Liao, Z., & Wei, P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00568 · Cited by 231 · see citing works
Mechanisms Underlying Metabolic Syndrome-Related Sarcopenia and Possible Therapeutic Measures
Rubio-Ruiz, M. E., Guarner‐Lans, V., Pérez-Torres, I., & Soto, M. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030647 · Cited by 166 · see citing works
Chen, L.-H., Huang, S.-Y., Huang, K.-C., Hsu, C.-C., Yang, K.-C., Li, L.-A., Chan, C.-H., & Huang, H.-Y. (2019) · Aging · doi:10.18632/aging.101782 · Cited by 117 · see citing works
Sarcopenic obesity: An appraisal of the current status of knowledge and management in elderly people
Molino, S., Dossena, M., Buonocore, D., & Verri, M. (2016) · The Journal of nutrition, health and aging · doi:10.1007/s12603-015-0631-8 · Cited by 91 · see citing works
Olive Oil Nutraceuticals in the Prevention and Management of Diabetes: From Molecules to Lifestyle
AlKhatib, A. H., Tsang, C., & Tuomilehto, J. O. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19072024 · Cited by 79 · see citing works
Moreira, M. A., Zunzunegui, M. V., Vafaei, A., da Câmara, S. M. A., Oliveira, T. S., & Maciel, Á. C. C. (2015) · BMC Public Health · doi:10.1186/s12889-015-2667-4 · Cited by 78 · see citing works
Blanc, R. S., Kallenbach, J. G., Bachman, J. F., Mitchell, A., Paris, N. D., & Chakkalakal, J. V. (2020) · Nature Communications · doi:10.1038/s41467-020-17620-8 · Cited by 68 · see citing works
Effect of sarcopenic obesity on deterioration of physical function in the elderly
Kong, H. H., Won, C. W., & Kim, W. D. (2020) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2020.104065 · Cited by 63 · see citing works
Liu, H.-W., Chang, Y.-C., Chan, Y.-C., Hu, S.-H., Liu, M.-Y., & Chang, S.-J. (2020) · Biogerontology · doi:10.1007/s10522-020-09867-x · Cited by 60 · see citing works
Lim, J. P., Chong, M. S., Tay, L. B. G., Yang, Y. X., Leung, B. P. L., Yeo, A., Yew, S., Tan, C. H., & Lim, W. S. (2018) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2018.11.006 · Cited by 61 · see citing works
Self-citationAgeing of skeletal muscle extracellular matrix and mitochondria: finding a potential link
Cai, L., Shi, L., Peng, Z., Sun, Y., & Chen, J. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2240707 · Cited by 60 · see citing works
Collins, K. H., Hart, D. A., Reimer, R. A., Seerattan, R. A., Waters‐Banker, C., Sibole, S. C., & Herzog, W. (2016) · Journal of Orthopaedic Research® · doi:10.1002/jor.23230 · Cited by 50 · see citing works
Khor, E. Q.-E., Lim, J. P., Tay, L., Yeo, A., Yew, S., Ding, Y. Y., & Lim, W. S. (2020) · The Journal of Frailty & Aging · doi:10.14283/jfa.2019.28 · Cited by 50 · see citing works
Self-citationKaranth, S. D., Washington, C. J., Cheng, T. D., Zhou, D., Leeuwenburgh, C., Braithwaite, D., & Zhang, D. (2021) · Nutrients · doi:10.3390/nu13113957 · Cited by 49 · see citing works
Lean nonalcoholic fatty liver disease and sarcopenia
Chen, M., Cao, Y. Y., Ji, G., & Zhang, L. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1217249 · Cited by 45 · see citing works
Sitapara, R. A., Gauthier, A. G., Valdés‐Ferrer, S. I., Lin, M., Patel, V., Wang, M., Martino, A. T., Perron, J. C., Ashby, C. R., Tracey, K. J., et al. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00177-z · Cited by 46 · see citing works
Automated assessment of thigh composition using machine learning for Dixon magnetic resonance images
Yang, Y. X., Chong, M. S., Tay, L. B. G., Yew, S., Yeo, A., & Tan, C. H. (2016) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/s10334-016-0547-2 · Cited by 44 · see citing works
Self-citationSoci, Ú. P. R., Melo, S. F. S., Gomes, J. L. P., Silveira, A. C., Nóbrega, C., & de Oliveira, E. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4304-8_16 · Cited by 42 · see citing works
Sarcopenic Obesity in Heart Failure With Preserved Ejection Fraction
Kirkman, D. L., Bohmke, N. J., Billingsley, H., & Carbone, S. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.558271 · Cited by 40 · see citing works
Ovarian kisspeptin expression is related to age and to monocyte chemoattractant protein-1
Merhi, Z. O., Thornton, K. A., Bonney, E. A., Cipolla, M. J., Charron, M. J., & Büyük, E. (2016) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-016-0672-x · Cited by 34 · see citing works
Ahn, J., Son, H. J., Seo, H., Ha, T. Y., Ahn, J., Lee, H., Shin, S. H., Jung, C. H., & Jang, Y. J. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000652 · Cited by 28 · see citing works
The Ketogenic Diet: Is It an Answer for Sarcopenic Obesity?
Ilyas, Z., Perna, S., Alalwan, T. A., Zahid, M. N., Spadaccini, D., Gasparri, C., Peroni, G., Faragli, A., Alogna, A., Porta, E. L., et al. (2022) · Nutrients · doi:10.3390/nu14030620 · Cited by 22 · see citing works
Raghupathy, R., McLean, R. R., Kiel, D. P., Hannan, M. T., & Sahni, S. (2023) · Aging Clinical and Experimental Research · doi:10.1007/s40520-023-02427-6 · Cited by 21 · see citing works
Oliveira, C. L. P., Antunes, B. M., Gomes, A. C., Lira, F. S., Pimentel, G. D., Boulé, N. G., & Mota, J. F. (2020) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2020.05.024 · Cited by 19 · see citing works
Hernández-Lepe, M. A., Ortiz-Ortiz, M., Hernández-Ontiveros, D. A., & Mejía-Rangel, J. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20054111 · Cited by 18 · see citing works
Singh, A., Buckholz, A. P., Kumar, S. R., & Newberry, C. A. (2024) · Nutrients · doi:10.3390/nu16050658 · Cited by 15 · see citing works
Kim, Y., & Park, Y. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1119719 · Cited by 16 · see citing works
Yang, Q., Bae, G., Nadiradze, G., Castagna, A., Berezhnoy, G., Zizmare, L., Kulkarni, A., Singh, Y., Weinreich, F., Kommoss, S., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03763-3 · Cited by 14 · see citing works
Kawao, N., Ishida, M., & Kaji, H. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224403 · Cited by 13 · see citing works
Powell, M., Lara, J., Mocciaro, G., Prado, C. M. M., Battezzati, A., Leone, A., Tagliabue, A., Amicis, R. S. D., Vignati, L., Bertoli, S., et al. (2016) · Clinical Obesity · doi:10.1111/cob.12165 · Cited by 11 · see citing works
Longitudinal Analysis of Sweet Taste Preference Through Genetic and Phenotypic Data Integration
Bae, J. H., & Kang, H. (2024) · Foods · doi:10.3390/foods13213370 · Cited by 7 · see citing works
Octaviani, A. N., Lock, H. S., Tay, L., Yeo, A., Yew, S., Leung, B. P. L., & Lim, W. S. (2021) · Journal of Frailty Sarcopenia and Falls · doi:10.22540/jfsf-06-025 · Cited by 5 · see citing works
Self-citationLim, J. P., Chew, J. L., Ismail, N. H., & Lim, W. S. (2021) · The Journal of Frailty & Aging · doi:10.14283/jfa.2021.28 · Cited by 5 · see citing works
Self-citationRaoof, I. B., Mohsin, R. A., & Okhti, Z. A. (2021) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/jpbs.jpbs_746_20 · Cited by 4 · see citing works
Absence of 4-1BB reduces obesity-induced atrophic response in skeletal muscle
Ngoc, H. L., Kim, C.-S., Tu, T. H., Kim, B.-S., Park, T., Park, J. H. Y., Goto, T., Kawada, T., Ha, T. Y., & Yu, R. (2017) · Journal of Inflammation · doi:10.1186/s12950-017-0156-5 · Cited by 2 · see citing works
Clinical analysis for pre-treatment sarcopenia assessments in elderly head and neck cancer patients
Kitano, M., Fujiwara, R., Horiguchi, S., Nishihara, M., Shiraishi, K., Kobyashi, T., Morikawa, H., Satõ, M., Hayamizu, K., Kitamura, A., et al. (2020) · Toukeibu Gan · doi:10.5981/jjhnc.46.284
Islam, M. S., Bhowmik, D. R., Roy, S., Shuvo, M. S. R., Begum, R., Hasan, M., Amin, M. T., Daula, A. F. M. S. U., & Hossain, M. S. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e12737
Kitgo, M., Seino, S., Shinkai, S., Nofuji, Y., Yokoyama, Y., Abe, T., Taniguchi, Y., Amano, H., Murayama, H., Kitamura, A., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2945230/v1
- Authors
- Chong, M. S., Lim, J. P., Leung, B., Ding, Y. Y., Tay, L., Ismail, N. H., Yeo, A., & Yew, S.
- Affiliations
- Tan Tock Seng Hospital (SG)
- Corresponding author
- Chong, Mei Sian
- Venue
- Clinical Interventions in Aging
- Publisher
- Informa UK Limited
- Published
- 2015-03
- Volume
- 10
- Pages
- 605
- ISSN
- 1176-9092 (ISSN-L)
- 1178-1998
- PMC
- PMC4378871
- OpenAlex
- W2031636157
- Cited by
- 43
- References
- 19
- Citations by year
- 2024: 2 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 9 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 2
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical Interventions in Aging (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- Lee Foundation
- National Healthcare Group
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- MCP-1, sarcopenic obesity, sarcopenia, obesity, chronic inflammation, older adults, chemokines, appendicular lean mass, physical performance, grip strength, adiposity
- MeSH terms
- Aged, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Obesity, Physical Fitness, Hand Strength, Chemokine CCL2, Sarcopenia
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