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Cited by 548Dysphagia Assessment and ManagementVoice and Speech DisordersNutrition and Health in Aging

Oropharyngeal dysphagia in older persons – from pathophysiology to adequate intervention: a review and summary of an international expert meeting

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Wirth, Rainer, Dziewas, Rainer, Beck, Anne Marie, Clave, Pere, Heppner, Hans Juergen, Langmore, Susan, Leischker, Andreas, Martino, Rosemary +7 more·2016·Clinical Interventions in Aging
DOI 10.2147/cia.s97481PMC PMC4770066
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Abstract

Oropharyngeal dysphagia (OD) is a highly prevalent and growing condition in the older population. Although OD may cause very severe complications, it is often not detected, explored, and treated. Older patients are frequently unaware of their swallowing dysfunction which is one of the reasons why the consequences of OD, ie, aspiration, dehydration, and malnutrition, are regularly not attributed to dysphagia. Older patients are particularly vulnerable to dysphagia because multiple age-related changes increase the risk of dysphagia. Physicians in charge of older patients should be aware that malnutrition, dehydration, and pneumonia are frequently caused by (unrecognized) dysphagia. The diagnosis is particularly difficult in the case of silent aspiration. In addition to numerous screening tools, videofluoroscopy was the traditional gold standard of diagnosing OD. Recently, the fiberoptic endoscopic evaluation of swallowing is increasingly utilized because it has several advantages. Besides making a diagnosis, fiberoptic endoscopic evaluation of swallowing is applied to evaluate the effectiveness of therapeutic maneuvers and texture modification of food and liquids. In addition to swallowing training and nutritional interventions, newer rehabilitation approaches of stimulation techniques are showing promise and may significantly impact future treatment strategies.

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  1. [1]Cabre M Serra-Prat M Palomera E Almirall J Pallares R Clave P Prevalence and prognostic implications of dysphagia in elderly patients with pneumonia Age and ageing 2010 39 1 39 45 19561160
  2. [2]Clave P Rofes L Carrion S Pathophysiology, relevance and natural history of oropharyngeal dysphagia among older people Nestle Nutr Inst Workshop Ser 2012 72 57 66 23052001
  3. [3]Clave P Shaker R Dysphagia: current reality and scope of the problem Nat Rev Gastroenterol Hepatol 2015 12 5 259 270 25850008
  4. [4]Butler SG Stuart A Leng X Rees C Williamson J Kritchevsky SB Factors influencing aspiration during swallowing in healthy older adults Laryngoscope 2010 120 11 2147 2152 20938951 PMC3780773
  5. [5]Butler SG Maslan J Stuart A Factors influencing bolus dwell times in healthy older adults assessed endoscopically Laryngoscope 2011 121 12 2526 2534 22081498 PMC3383802
  6. [6]Leopold NA Daniels SK Supranuclear control of swallowing Dysphagia 2010 25 3 250 257 19730940
  7. [7]Teismann IK Dziewas R Steinstraeter O Pantev C Time-dependent hemispheric shift of the cortical control of volitional swallowing Hum Brain Mapp 2009 30 1 92 100 17979116 PMC6870608
  8. [8]Suntrup S Kemmling A Warnecke T The impact of lesion location on dysphagia incidence, pattern and complications in acute stroke. Part 1: dysphagia incidence, severity and aspiration Eur J Neurol 2015 22 5 832 838 25677582
  9. [9]Lowell SY Poletto CJ Knorr-Chung BR Reynolds RC Simonyan K Ludlow CL Sensory stimulation activates both motor and sensory components of the swallowing system Neuroimage 2008 42 1 285 295 18515150 PMC2556067
  10. [10]Teismann IK Steinstraeter O Stoeckigt K Functional oropharyngeal sensory disruption interferes with the cortical control of swallowing BMC Neurosci 2007 8 62 17678546 PMC1950520
  11. [11]Li S Ma Z Tu S Altered resting-state functional and white matter tract connectivity in stroke patients with dysphagia Neurorehabil Neural Repair 2014 28 3 260 272 24297761
  12. [12]Teismann I Warnecke T Suntrup S Cortical processing of swallowing in ALS patients with progressive dysphagia – a magneto-encephalographic study PLoS One 2011 6 e19987 21625445 PMC3098861
  13. [13]Hamdy S Aziz Q Rothwell JC Explaining oropharyngeal dysphagia after unilateral hemispheric stroke Lancet 1997 350 9079 686 692 9291902
  14. [14]Hamdy S Aziz Q Rothwell JC Recovery of swallowing after dysphagic stroke relates to functional reorganization in the intact motor cortex Gastroenterology 1998 115 5 1104 1112 9797365
  15. [15]Li S Chen Q Yu B Structural and functional changes mapped in the brains of amyotrophic lateral sclerosis patients with/without dysphagia: a pilot study Amyotroph Lateral Scler 2009 10 5–6 280 287 19922114
  16. [16]Dziewas R Teismann I Suntrup S Cortical compensation associated with dysphagia caused by selective degeneration of bulbar motor neurons Hum Brain Mapp 2009 30 4 1352 1360 18548558 PMC6870969
  17. [17]Suntrup S Teismann I Bejer J Evidence for adaptive cortical changes in swallowing in Parkinson’s disease Brain 2013 136 Pt 3 726 738 23412935
  18. [18]Yang CJ Roh JL Choi KH Pretreatment Dysphagia Inventory and videofluorographic swallowing study as prognostic indicators of early survival outcomes in head and neck cancer Cancer 2015 121 10 1588 1598 25639759
  19. [19]Jiang N Zhang LJ Li LY Zhao Y Eisele DW Risk factors for late dysphagia after (chemo) radiotherapy for head and neck cancer: a systematic methodological review Head Neck Epub 2014 12 22 25532723
  20. [20]van den Berg MG Rutten H Rasmussen-Conrad EL Nutritional status, food intake, and dysphagia in long-term survivors with head and neck cancer treated with chemoradiotherapy: a cross-sectional study Head Neck 2014 36 1 60 65 23559543
  21. [21]Kern M Bardan E Arndorfer R Hofmann C Ren J Shaker R Comparison of upper esophageal sphincter opening in healthy asymptomatic young and elderly volunteers Ann Otol Rhinol Laryngol 1999 108 10 982 989 10526854
  22. [22]Shaker R Kern M Bardan E Augmentation of deglutitive upper esophageal sphincter opening in the elderly by exercise Am J Physiol 1997 272 6 Pt 1 G1518 G1522 9227489
  23. [23]Shaker R Easterling C Kern M Rehabilitation of swallowing by exercise in tube-fed patients with pharyngeal dysphagia secondary to abnormal UES opening Gastroenterology 2002 122 5 1314 1321 11984518
  24. [24]Massey B Manometry of the UES Including High-Resolution Manometry Shaker R Easterling C Belafsky PC Postma GN Manual of Diagnostic and Therapeutic Techniques for Disorders of Deglutition New York Springer Publishing 2012 129 149
  25. [25]Easterling C Shaker R UES opening muscle dysfunction Shaker R Belafsky PC Postma GN Easterling C Principles of Deglutition: A Multidisciplinary Text for Swallowing and its Disorders New York Springer Publishing 2013 529 535
  26. [26]Don Kim K Lee HJ Lee MH Ryu HJ Effects of neck exercises on swallowing function of patients with stroke J Phys Ther Sci 2015 27 4 1005 1008 25995543 PMC4433964
  27. [27]Kahrilas PJ Logemann JA Krugler C Flanagan E Volitional augmentation of upper esophageal sphincter opening during swallowing Am J Physiol 1991 260 3 Pt 1 G450 G456 2003609
  28. [28]Altman KW Yu GP Schaefer SD Consequence of dysphagia in the hospitalized patient: impact on prognosis and hospital resources Arch Otolaryngol Head Neck Surg 2010 136 8 784 789 20713754
  29. [29]Muhle P Wirth R Glahn J Dziewas R Schluckstörungen im Alter [Age-related changes in swallowing. Physiology and pathophysiology] Nervenarzt 2015 86 4 440 451 German 25833400
  30. [30]Rofes L Arreola V Romea M Pathophysiology of oropharyngeal dysphagia in the frail elderly Neurogastroenterol Motil 2010 22 8 851 858 e230 20529208
  31. [31]Tracy JF Logemann JA Kahrilas PJ Jacob P Kobara M Krugler C Preliminary observations on the effects of age on oropharyngeal deglutition Dysphagia 1989 4 2 90 94 2640185
  32. [32]Sonies BC Ship JA Baum BJ Relationship between saliva production and oropharyngeal swallow in healthy, different-aged adults Dysphagia 1989 4 2 85 89 2640184
  33. [34]Feng X Todd T Lintzenich CR Aging-related geniohyoid muscle atrophy is related to aspiration status in healthy older adults J Gerontol A Biol Sci Med Sci 2013 68 7 853 860 23112114 PMC3732109
  34. [35]Butler SG Stuart A Leng X The relationship of aspiration status with tongue and handgrip strength in healthy older adults J Gerontol A Biol Sci Med Sci 2011 66 4 452 458 21300744 PMC3107020
  35. [36]Cruz-Jentoft AJ Baeyens JP Bauer JM Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People Age Ageing 2010 39 4 412 423 20392703 PMC2886201
  36. [38]Sokoloff LG Pavlakovic R Neuroleptic-induced dysphagia Dysphagia 1997 12 4 177 179 9294935
  37. [39]Yang EJ Kim KW Lim JY Paik NJ Relationship between dysphagia and mild cognitive impairment in a community-based elderly cohort: the Korean longitudinal study on health and aging J Am Geriatr Soc 2014 62 1 40 46 25180377
  38. [40]Martino R Beaton D Diamant NE Using different perspectives to generate items for a new scale measuring medical outcomes of dysphagia (MOD) J Clin Epidemiol 2009 62 5 518 526 18722085
  39. [41]Simonetti A Viasus D Garcia-Vidal C Timing of antibiotic administration and outcomes of hospitalized patients with community-acquired and healthcare-associated pneumonia Clin Microbiol Infect 2012 18 11 1149 1155 22115052
  40. [42]Garcia-Vidal C Viasus D Roset A Low incidence of multidrug- resistant organisms in patients with healthcare-associated pneumonia requiring hospitalization Clin Microbiol Infect 2011 17 11 1659 1665 21463391
  41. [43]Komiya K Ishii H Umeki K Impact of aspiration pneumonia in patients with community-acquired pneumonia and healthcare-associated pneumonia: a multicenter retrospective cohort study Respirology 2013 18 3 514 521 23231701
  42. [44]Kwong JC Howden BP Charles PG New aspirations: the debate on aspiration pneumonia treatment guidelines Med J Aust 2011 195 7 380 381 21978335
  43. [45]Komiya K Ishii H Kadota J Healthcare-associated Pneumonia and Aspiration Pneumonia Aging Dis 2015 6 1 27 37 25657850 PMC4306471
  44. [46]Hibberd J Fraser J Chapman C McQueen H Wilson A Can we use influencing factors to predict aspiration pneumonia in the United Kingdom? Multidiscip Respir Med 2013 8 1 39 23758693 PMC3686575
  45. [47]Gomes GF Pisani JC Macedo ED Campos AC The nasogastric feeding tube as a risk factor for aspiration and aspiration pneumonia Curr Opin Clin Nutr Metab Care 2003 6 3 327 333 12690267
  46. [48]DeLegge MH Aspiration pneumonia: incidence, mortality, and at-risk populations JPEN J Parenter Enteral Nutr 2002 26 6 Suppl S19 S24 discussion S24–S15 12405619
  47. [49]Kalita M Majewska K Gradowska A Karwowska K Lawinski M Food, mechanic and septic complications in patients enterally nutritioned in home conditions Pol Przegl Chir 2014 86 10 466 472 25720105
  48. [50]Hu X Yi ES Ryu JH Aspiration-related deaths in 57 consecutive patients: autopsy study PloS One 2014 9 7 e103795 25076409 PMC4116222
  49. [51]Mier L Dreyfuss D Darchy B Is penicillin G an adequate initial treatment for aspiration pneumonia? A prospective evaluation using a protected specimen brush and quantitative cultures Intensive Care Med 1993 19 5 279 284 8408937
  50. [52]Mandell LA Wunderink RG Anzueto A Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults Clin Infect Dis 2007 44 Suppl 2 S27 S72 17278083 PMC7107997
  51. [53]O’Donoghue C Iversen C Duggan J Power D Fanning S Kyne L Polypharmacy is an independent risk factor for oropharyngeal isolation of gram-negative bacilli in older persons J Am Geriatr Soc 2012 60 1 182 183 22239314
  52. [54]El-Solh AA Pietrantoni C Bhat A Microbiology of severe aspiration pneumonia in institutionalized elderly Am J Respir Crit Care Med 2003 167 12 1650 1654 12689848
  53. [55]Lanspa MJ Jones BE Brown SM Dean NC Mortality, morbidity, and disease severity of patients with aspiration pneumonia J Hosp Med 2013 8 2 83 90 23184866 PMC3774007
  54. [56]Lanspa MJ Peyrani P Wiemken T Wilson EL Ramirez JA Dean NC Characteristics associated with clinician diagnosis of aspiration pneumonia: a descriptive study of afflicted patients and their outcomes J Hosp Med 2015 10 2 90 96 25363892 PMC4310822
  55. [57]Falcone M Blasi F Menichetti F Pea F Violi F Pneumonia in frail older patients: an up to date Intern Emerg Med 2012 7 5 415 424 22688530
  56. [58]Kaiser MJ Bauer JM Ramsch C Frequency of malnutrition in older adults: a multinational perspective using the mini nutritional assessment J Am Geriatr Soc 2010 58 9 1734 1738 20863332
  57. [59]Serra-Prat M Palomera M Gomez C Oropharyngeal dysphagia as a risk factor for malnutrition and lower respiratory tract infection in independently living older persons: a population-based prospective study Age Ageing 2012 41 3 376 381 22311895
  58. [60]Valentini L Schindler K Schlaffer R The first nutrition Day in nursing homes: participation may improve malnutrition awareness Clin Nutr 2009 28 2 109 116 19264381
  59. [62]Poisson P Laffond T Campos S Dupuis V Bourdel-Marchasson I Relationships between oral health, dysphagia and undernutrition in hospitalised elderly patients Gerodontology Epub 2014 3 11 24612262
  60. [63]Foley NC Salter KL Robertson J Teasell RW Woodbury MG Which reported estimate of the prevalence of malnutrition after stroke is valid? Stroke 2009 40 3 e66 e74 19164799
  61. [64]Davalos A Ricart W Gonzalez-Huix F Effect of malnutrition after acute stroke on clinical outcome Stroke 1996 27 6 1028 1032 8650709
  62. [65]Finestone HM Greene-Finestone LS Wilson ES Teasell RW Prolonged length of stay and reduced functional improvement rate in malnourished stroke rehabilitation patients Arch Phys Med Rehabil 1996 77 4 340 345 8607756
  63. [66]FOOD Trial Collaboration Poor nutritional status on admission predicts poor outcomes after stroke: observational data from the FOOD trial Stroke 2003 34 6 1450 1456 12750536
  64. [67]Davis JP Wong AA Schluter PJ Henderson RD O’Sullivan JD Read SJ Impact of premorbid undernutrition on outcome in stroke patients Stroke 2004 35 8 1930 1934 15218159
  65. [68]Gariballa SE Parker SG Taub N Castleden CM Influence of nutritional status on clinical outcome after acute stroke Am J Clin Nutr 1998 68 2 275 281 9701183
  66. [69]Martino R Foley N Bhogal S Diamant N Speechley M Teasell R Dysphagia after stroke: incidence, diagnosis, and pulmonary complications Stroke 2005 36 12 2756 2763 16269630
  67. [70]Yoo SH Kim JS Kwon SU Yun SC Koh JY Kang DW Undernutrition as a predictor of poor clinical outcomes in acute ischemic stroke patients Arch Neurol 2008 65 1 39 43 18195138
  68. [71]Rofes L Arreola V Almirall J Diagnosis and management of oropharyngeal Dysphagia and its nutritional and respiratory complications in the elderly Gastroenterol Res Pract 2011 2011 pii:818979 PMC2929516 20811545
  69. [72]Wright L Cotter D Hickson M Frost G Comparison of energy and protein intakes of older people consuming a texture modified diet with a normal hospital diet J Hum Nutr Diet 2005 18 3 213 219 15882384
  70. [73]Bannerman E McDermott K Dietary and fluid intakes of older adults in care homes requiring a texture modified diet: the role of snacks J Am Med Dir Assoc 2011 12 3 234 239 21333927
  71. [74]Volkert D Berner YN Berry E ESPEN Guidelines on Enteral Nutrition: Geriatrics Clin Nutr 2006 25 2 330 360 16735082
  72. [75]Wirth R Smoliner C Jager M Guideline clinical nutrition in patients with stroke Exp Transl Stroke Med 2013 5 1 14 24289189 PMC4176491
  73. [76]McCullough GH MR Clinical evaluation of patients with dysphagia: Importance of history taking and physical exam Manual of diagnostic and therapeutic techniques for disorders of deglutition New York Springer 2013 11 30
  74. [77]Martino R Silver F Teasell R The Toronto Bedside Swallowing Screening Test (TOR-BSST): development and validation of a dysphagia screening tool for patients with stroke Stroke 2009 40 2 555 561 19074483
  75. [78]Streiner DL Diagnosing tests: using and misusing diagnostic and screening tests J Pers Assess 2003 81 3 209 219 14638445
  76. [79]Martino R Pron G Diamant NE Oropharyngeal dysphagia: surveying practice patterns of the speech-language pathologist Dysphagia 2004 19 3 165 176 15383946
  77. [80]Hinchey JA Shephard T Furie K Formal dysphagia screening protocols prevent pneumonia Stroke 2005 36 9 1972 1976 16109909
  78. [81]Jauch EC Saver JL Adams HP Jr Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association Stroke 2013 44 3 870 947 23370205
  79. [82]No authors listed National clinical guidelines for stroke: a concise update Clin Med 2002 2 3 231 233 PMC4954038 12108473
  80. [85]Whiting PF Rutjes AW Westwood ME QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies Ann Intern Med 2011 155 8 529 536 22007046
  81. [86]Schepp SK Tirschwell DL Miller RM Longstreth WT Jr Swallowing screens after acute stroke: a systematic review Stroke 2012 43 3 869 871 22156697 PMC3288702
  82. [87]Edmiaston J Connor LT Loehr L Nassief A Validation of a dysphagia screening tool in acute stroke patients Am J Crit Care 2010 19 4 357 364 19875722 PMC2896456
  83. [88]Martino R Flowers HL Shaw SM Diamant NE A systematic review of current clinical and instrumental swallowing assessment methods Curr Phys Med Rehabil Rep 2013 1 267 279
  84. [89]Rosenbek JC Robbins JA Roecker EB Coyle JL Wood JL A penetration-aspiration scale Dysphagia 1996 11 2 93 98 8721066
  85. [90]Rofes L Arreola V Mukherjee R Swanson J Clave P The effects of a xanthan gum-based thickener on the swallowing function of patients with dysphagia Aliment Pharmacol Ther 2014 39 10 1169 1179 24628492
  86. [91]Langmore SE Schatz K Olsen N Fiberoptic endoscopic examination of swallowing safety: a new procedure Dysphagia 1988 2 4 216 219 3251697
  87. [92]Langmore SE Schatz K Olson N Endoscopic and videofluoroscopic evaluations of swallowing and aspiration Ann Otol Rhinol Laryngol 1991 100 8 678 681 1872520
  88. [93]Langmore SE Endoscopic Evaluation and Treatment of Swallowing Disorders New York Thieme 2001
  89. [94]Langmore SE Murray J Flexible Endoscopic Evaluation of Swallowing Shaker R Belafsky PC Postma GN Easterling C Principles of Deglutition: A Multidisciplinary Text for Swallowing and its Disorder New York Springer 2012 85 101
  90. [95]Langmore SE Flexible endoscopic evaluation of swallowing Johnson AF Jacobson BJ Medical Speech-Language Pathology New York Thieme 2015 148 157
  91. [96]Manor Y Mootanah R Freud D Giladi N Cohen JT Video-assisted swallowing therapy for patients with Parkinson’s disease Parkinsonism Relat Disord 2013 19 2 207 211 23131836
  92. [97]Butler SG Clark H Baginski SG Todd JT Lintzenich C Leng X Computed tomography pulmonary findings in healthy older adult aspirators versus nonaspirators Laryngoscope 2014 124 2 494 497 23832617 PMC3871987
  93. [98]Murray J Langmore SE Ginsberg S Dostie A The significance of accumulated oropharyngeal secretions and swallowing frequency in predicting aspiration Dysphagia 1996 11 2 99 103 8721067
  94. [99]Takahashi N Kikutani T Tamura F Groher M Kuboki T Videoen-doscopic assessment of swallowing function to predict the future incidence of pneumonia of the elderly J Oral Rehabil 2012 39 6 429 437 22329364
  95. [102]Titsworth WL Abram J Fullerton A Prospective quality initiative to maximize dysphagia screening reduces hospital-acquired pneumonia prevalence in patients with stroke Stroke 2013 44 11 3154 3160 23963330
  96. [103]Gandolfi M Smania N Bisoffi G Squaquara T Zuccher P Mazzucco S Improving post-stroke dysphagia outcomes through a standardized and multidisciplinary protocol: an exploratory cohort study Dysphagia 2014 29 6 704 712 25115857
  97. [104]Carnaby G Hankey GJ Pizzi J Behavioural intervention for dysphagia in acute stroke: a randomised controlled trial Lancet Neurol 2006 5 1 31 37 16361020
  98. [106]Cichero JA Steele C Duivestein J The Need for International Terminology and Definitions for Texture-Modified Foods and Thickened Liquids Used in Dysphagia Management: Foundations of a Global Initiative Curr Phys Med Rehabil Rep 2013 1 280 291 24392282 PMC3873065
  99. [107]Wheeler-Hegland K Ashford J Frymark T Evidence-based systematic review: oropharyngeal dysphagia behavioral treatments. Part II – impact of dysphagia treatment on normal swallow function J Rehabil Res Dev 2009 46 2 185 194 19533532
  100. [108]Drulia TC Ludlow CL Relative Efficacy of Swallowing versus Non-swallowing Tasks in Dysphagia Rehabilitation: Current Evidence and Future Directions Curr Phys Med Rehabil Rep 2013 1 4 242 256 24470988 PMC3901279
  101. [109]Langmore SE Pisegna JM Efficacy of exercises to rehabilitate dysphagia: a critique of the literature Int J Speech Lang Pathol 2015 17 3 222 229 25825989
  102. [110]Speyer R Baijens L Heijnen M Zwijnenberg I Effects of therapy in oropharyngeal dysphagia by speech and language therapists: a systematic review Dysphagia 2010 25 1 40 65 19760458 PMC2846331
  103. [111]McHorney CA Bricker DE Kramer AE The SWAL-QOL outcomes tool for oropharyngeal dysphagia in adults: I. Conceptual foundation and item development Dysphagia 2000 15 3 115 121 10839823
  104. [112]Cook IJ Kahrilas PJ AGA technical review on management of oropharyngeal dysphagia Gastroenterology 1999 116 2 455 478 9922328
  105. [114]Keller H Chambers L Niezgoda H Duizer L Issues associated with the use of modified texture foods J Nutr Health Aging 2012 16 3 195 200 22456772
  106. [115]Cichero JA Murdoch BE Dysphagia, foundation, theory and practice John Wiley & Sons 2006
  107. [116]Logemann JA Pauloski BR Colangelo L Lazarus C Fujiu M Kahrilas PJ Effects of a sour bolus on oropharyngeal swallowing measures in patients with neurogenic dysphagia J Speech Hear Res 1995 38 3 556 563 7674647
  108. [117]Rosenbek JC Roecker EB Wood JL Robbins J Thermal application reduces the duration of stage transition in dysphagia after stroke Dysphagia 1996 11 4 225 233 8870348
  109. [118]Kaatzke-McDonald MN Post E Davis PJ The effects of cold, touch, and chemical stimulation of the anterior faucial pillar on human swallowing Dysphagia 1996 11 3 198 206 8755466
  110. [120]Rosenbek JC Robbins J Willford WO Comparing treatment intensities of tactile-thermal application Dysphagia 1998 13 1 1 9 9391220
  111. [121]Power ML Fraser CH Hobson A Evaluating oral stimulation as a treatment for dysphagia after stroke Dysphagia 2006 21 1 49 55 16544087
  112. [122]Freed ML Freed L Chatburn RL Christian M Electrical stimulation for swallowing disorders caused by stroke Respir Care 2001 46 5 466 474 11309186
  113. [123]Rofes L Arreola V Martin A Clave P Natural capsaicinoids improve swallow response in older patients with oropharyngeal dysphagia Gut 2013 62 9 1280 1287 22722616
  114. [124]Fraser C Power M Hamdy S Driving plasticity in human adult motor cortex is associated with improved motor function after brain injury Neuron 2002 34 5 831 840 12062028
  115. [125]Jayasekeran V Singh S Tyrrell P Adjunctive functional pharyngeal electrical stimulation reverses swallowing disability after brain lesions Gastroenterology 2010 138 5 1737 1746 20138037
  116. [126]Michou E Hamdy S Cortical input in control of swallowing Curr Opin Otolaryngol Head Neck Surg 2009 17 3 166 171 19369872
  117. [127]Lisanby SH Kinnunen LH Crupain MJ Applications of TMS to therapy in psychiatry J Clin Neurophysiol 2002 19 4 344 360 12436089
  118. [128]Khedr EM Abo-Elfetoh N Rothwell JC Treatment of post-stroke dysphagia with repetitive transcranial magnetic stimulation Acta Neurol Scand 2009 119 3 155 161 18771521
  119. [129]Verin E Leroi AM Poststroke dysphagia rehabilitation by repetitive transcranial magnetic stimulation: a noncontrolled pilot study Dysphagia 2009 24 2 204 210 18956227
  120. [130]Khedr EM Abo-Elfetoh N Therapeutic role of rTMS on recovery of dysphagia in patients with lateral medullary syndrome and brainstem infarction J Neurol Neurosurg Psychiatry 2010 81 5 495 499 19828479
  121. [131]Adeyemo BO Simis M Macea DD Fregni F Systematic review of parameters of stimulation, clinical trial design characteristics, and motor outcomes in non-invasive brain stimulation in stroke Front Psychiatry 2012 3 88 23162477 PMC3495265
  122. [132]Jefferson S Mistry S Singh S Rothwell J Hamdy S Characterizing the application of transcranial direct current stimulation in human pharyngeal motor cortex Am J Physiol Gastrointest Liver Physiol 2009 297 6 G1035 G1040 19815630 PMC2850087
  123. [133]Shigematsu T Fujishima I Ohno K Transcranial direct current stimulation improves swallowing function in stroke patients Neurorehabil Neural Repair 2013 27 4 363 369 23392916
  124. [134]Kumar S Wagner CW Frayne C Noninvasive brain stimulation may improve stroke-related dysphagia: a pilot study Stroke 2011 42 4 1035 1040 21441148 PMC3116809
  125. [135]Yang EJ Baek SR Shin J Effects of transcranial direct current stimulation (tDCS) on post-stroke dysphagia Restor Neurol Neurosci 2012 30 4 303 311 22572022
  126. [137]Kudsk KA Croce MA Fabian TC Enteral versus parenteral feeding. Effects on septic morbidity after blunt and penetrating abdominal trauma Ann Surg 1992 215 5 503 511 discussion 511–513 1616387 PMC1242485
  127. [138]Moore FA Feliciano DV Andrassy RJ Early enteral feeding, compared with parenteral, reduces postoperative septic complications. The results of a meta-analysis Ann Surg 1992 216 2 172 183 1386982 PMC1242589
  128. [139]Gomes CA Jr Lustosa SA Matos D Andriolo RB Waisberg DR Waisberg J Percutaneous endoscopic gastrostomy versus nasogastric tube feeding for adults with swallowing disturbances Cochrane Database Syst Rev 2012 3 CD008096 22419328
  129. [140]Jaafar MH Mahadeva S Morgan K Tan MP Percutaneous endoscopic gastrostomy versus nasogastric feeding in older individuals with non-stroke dysphagia: a systematic review J Nutr Health Aging 2015 19 2 190 197 25651445
  130. [141]Wang J Liu M Liu C Ye Y Huang G Percutaneous endoscopic gastrostomy versus nasogastric tube feeding for patients with head and neck cancer: a systematic review J Radiat Res 2014 55 3 559 567 24453356 PMC4014167
  131. [142]Dennis MS Lewis SC Warlow C FOOD Trial Collaboration Effect of timing and method of enteral tube feeding for dysphagic stroke patients (FOOD): a multicentre randomised controlled trial Lancet 2005 365 9461 764 772 15733717
  132. [143]Dennis M Lewis S Cranswick G Forbes J FOOD Trial Collaboration FOOD: a multicentre randomised trial evaluating feeding policies in patients admitted to hospital with a recent stroke Health Technol Assess 2006 10 2 iii iv ix x 1 120 16409880
  133. [144]Geeganage C Beavan J Ellender S Bath PM Interventions for dysphagia and nutritional support in acute and subacute stroke Cochrane Database Syst Rev 2012 10 CD000323 23076886
  134. [145]Bechtold ML Nguyen DL Palmer LB Kiraly LN Martindale RG McClave SA Nasal bridles for securing nasoenteric tubes: a meta-analysis Nutr Clin Pract 2014 29 5 667 671 25606648 PMC4304091
  135. [146]Crisan D Shaban A Boehme A Predictors of recovery of functional swallow after gastrostomy tube placement for Dysphagia in stroke patients after inpatient rehabilitation: a pilot study Ann Rehabil Med 2014 38 4 467 475 25229025 PMC4163586
  136. [147]Sheard JM Ash S Silburn PA Kerr GK Prevalence of malnutrition in Parkinson’s disease: a systematic review Nutr Rev 2011 69 9 520 532 21884132
  137. [148]Sheard JM Ash S Mellick GD Silburn PA Kerr GK Markers of disease severity are associated with malnutrition in Parkinson’s disease PloS One 2013 8 3 e57986 23544041 PMC3609752
  138. [149]Livesay S Ruppert SD Pneumonia and encephalopathy in a patient with progressing Parkinson’s disease and dementia Crit Care Nurs Q 2012 35 2 160 172 22407372
  139. [150]Nyholm D Duodopa® treatment for advanced Parkinson’s disease: a review of efficacy and safety Parkinsonism Relat Disord 2012 18 8 916 929 22824056
  140. [151]Langmore SE Kasarskis EJ Manca ML Olney RK Enteral tube feeding for amyotrophic lateral sclerosis/motor neuron disease Cochrane Database Syst Rev 2006 4 CD004030 17054194
  141. [152]Priefer BA Robbins J Eating changes in mild-stage Alzheimer’s disease: a pilot study Dysphagia 1997 12 4 212 221 9294942
  142. [153]Humbert IA McLaren DG Kosmatka K Early deficits in cortical control of swallowing in Alzheimer’s disease J Alzheimers Dis 2010 19 4 1185 1197 20308785 PMC2891325
  143. [154]Suh MK Kim H Na DL Dysphagia in patients with dementia: Alzheimer versus vascular Alzheimer Dis Assoc Disord 2009 23 2 178 184 19474573
  144. [155]Levine R Robbins JA Maser A Periventricular white matter changes and oropharyngeal swallowing in normal individuals Dysphagia 1992 7 3 142 147 1499355
  145. [156]Londos E Hanxsson O Alm Hirsch I Janneskog A Bulow M Palmqvist S Dysphagia in Lewy body dementia – a clinical observational study of swallowing function by videofluoroscopic examination BMC Neurol 2013 13 140 24099488 PMC4126015
  146. [157]Langmore SE Olney RK Lomen-Hoerth C Miller BL Dysphagia in patients with frontotemporal lobar dementia Arch Neurol 2007 64 1 58 62 17210809
  147. [158]Bautmans I Demarteau J Cruts B Lemper JC Mets T Dysphagia in elderly nursing home residents with severe cognitive impairment can be attenuated by cervical spine mobilization J Rehabil Med 2008 40 9 755 760 18843429
  148. [159]Logemann JA Gensler G Robbins J A randomized study of three interventions for aspiration of thin liquids in patients with dementia or Parkinson’s disease J Speech Lang Hear Res 2008 51 1 173 183 18230864 PMC2894528
  149. [160]Robbins J Gensler G Hind J Comparison of 2 interventions for liquid aspiration on pneumonia incidence: a randomized trial Ann Intern Med 2008 148 7 509 518 18378947 PMC2364726
  150. [161]Rosler A Pfeil S Lessmann H Hoder J Befahr A Renteln-Kruse WV Dysphagia in Dementia: Influence of Dementia Severity and Food Texture on the Prevalence of Aspiration and Latency to Swallow in Hospitalized Geriatric Patients J Am Med Dir Assoc 2015 16 8 697 701 25933727
  151. [163]Coelho M Marti MJ Tolosa E Late-stage Parkinson’s disease: the Barcelona and Lisbon cohort J Neurol 2010 257 9 1524 1532 20411272
  152. [164]Manor Y Giladi N Cohen A Fliss DM Cohen JT Validation of a swallowing disturbance questionnaire for detecting dysphagia in patients with Parkinson’s disease Mov Disord 2007 22 13 1917 1921 17588237
  153. [165]Muller J Wenning GK Verny M Progression of dysarthria and dysphagia in postmortem-confirmed parkinsonian disorders Arch Neurol 2001 58 2 259 264 11176964
  154. [166]Lam K Lam FK Lau KK Simple clinical tests may predict severe oropharyngeal dysphagia in Parkinson’s disease Mov Disord 2007 22 5 640 644 17266075
  155. [167]Cereda E Cilia R Klersy C Swallowing disturbances in Parkinson’s disease: a multivariate analysis of contributing factors Parkinsonism Relat Disord 2014 20 12 1382 1387 25456827
  156. [168]Simons JA Fietzek UM Waldmann A Warnecke T Schuster T Ceballos-Baumann AO Development and validation of a new screening questionnaire for dysphagia in early stages of Parkinson’s disease Parkinsonism Relat Disord 2014 20 9 992 998 25012695
  157. [171]El Sharkawi A Ramig L Logemann JA Swallowing and voice effects of Lee Silverman Voice Treatment (LSVT): a pilot study J Neurol Neurosurg Psychiatry 2002 72 1 31 36 11784821 PMC1737706
  158. [172]Troche MS Okun MS Rosenbek JC Aspiration and swallowing in Parkinson disease and rehabilitation with EMST: a randomized trial Neurology 2010 75 21 1912 1919 21098406 PMC2995389
  159. [173]Warnecke T Oelenberg S Teismann I Endoscopic characteristics and levodopa responsiveness of swallowing function in progressive supranuclear palsy Mov Disord 2010 25 9 1239 1245 20629130
  160. [174]Warnecke T Hamacher C Oelenberg S Dziewas R Off and on state assessment of swallowing function in Parkinson’s disease Parkinsonism Relat Disord 2014 20 9 1033 1034 24997546

Cited by

Sorted by citations

Authors
Wirth, R., Dziewas, R., Beck, A. M., Clave, P., Heppner, H. J., Langmore, S., Leischker, A., Martino, R., Pluschinski, P., Rösler, A., Shaker, R., Warnecke, T., Sieber, C. C., Volkert, D., & Hamdy, S.
Affiliations
  • Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
  • University Hospital Münster (DE)
  • Metropolitan University College (DK)
  • Witten/Herdecke University (DE)
  • Boston University (US)
  • University of Toronto (CA)
  • Philipps University of Marburg (DE)
  • Medical College of Wisconsin (US)
Corresponding author
Wirth, Rainer
ORCID
Venue
Clinical Interventions in Aging
Publisher
Informa UK Limited
Published
2016-02
Volume
11
Pages
189
ISSN
  • 1176-9092 (ISSN-L)
  • 1178-1998
DOI
10.2147/cia.s97481
PMC
PMC4770066
OpenAlex
W2280675984
Cited by
548
References
5
Citations by year
2026: 52 · 2025: 67 · 2024: 63 · 2023: 65 · 2022: 71 · 2021: 58 · 2020: 50 · 2019: 45 · 2018: 41 · 2017: 30 · 2016: 4 · 2015: 1
FWCI
7.87
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Interventions in Aging (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc)
  • Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by-nc)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Funders
  • National Institute for Health and Care Research (PB-PG-0212-27024, PB-PG-0107-12076)
  • Friedrich-Alexander-Universität Erlangen-Nürnberg
  • Deutsche Forschungsgemeinschaft
Topics
  • Health Sciences › Health Professions › Speech and Hearing › Dysphagia Assessment and Management
  • Health Sciences › Medicine › Physiology › Voice and Speech Disorders
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
oropharyngeal dysphagia, older adults, dysphagia, aspiration, malnutrition, dehydration, pneumonia, silent aspiration, dysphagia screening, videofluoroscopy, fiberoptic endoscopic evaluation of swallowing, texture modification, swallowing rehabilitation, stimulation techniques, dietary intervention, age-related changes
MeSH terms
Aged, Deglutition, Deglutition Disorders, Dehydration, Dementia, Enteral Nutrition, Humans, Parkinson Disease, Pneumonia, Aspiration, Risk Factors, Randomized Controlled Trials as Topic, Endoscopy, Gastrointestinal, Malnutrition, Transcranial Magnetic Stimulation, Transcranial Direct Current Stimulation

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