The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
Survival after liver resection in metastatic colorectal cancer: review and meta-analysis of prognostic factors
Open accessAbstract
BACKGROUND: Hepatic metastases develop in approximately 50% of colorectal cancer (CRC) cases. We performed a review and meta-analysis to evaluate survival after resection of CRC liver metastases (CLMs) and estimated the summary effect for seven prognostic factors. METHODS: Studies published between 1999 and 2010, indexed on Medline, that reported survival after resection of CLMs, were reviewed. Meta-relative risks for survival by prognostic factor were calculated, stratified by study size and annual clinic volume. Cumulative meta-analysis results by annual clinic volume were plotted. RESULTS: Five- and 10-year survival ranged from 16% to 74% (median 38%) and 9% to 69% (median 26%), respectively, based on 60 studies. The overall summary median survival time was 3.6 (range: 1.7-7.3) years. Meta-relative risks (95% confidence intervals) by prognostic factor were: node positive primary, 1.6 (1.5-1.7); carcinoembryonic antigen level, 1.9 (1.1-3.2); extrahepatic disease, 1.9 (1.5-2.4); poor tumor grade, 1.9 (1.3-2.7); positive margin, 2.0 (1.7-2.5); >1 liver metastases, 1.6 (1.4-1.8); and >3 cm tumor diameter, 1.5 (1.3-1.8). Cumulative meta-analyses by annual clinic volume suggested improved survival with increasing volume. CONCLUSION: The overall median survival following CLM liver resection was 3.6 years. All seven investigated prognostic factors showed a modest but significant predictive relationship with survival, and certain prognostic factors may prove useful in determining optimal therapeutic options. Due to the increasing complexity of surgical interventions for CLM and the inclusion of patients with higher disease burdens, future studies should consider the potential for selection and referral bias on survival.
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Bias in meta-analysis detected by a simple, graphical test
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Trends in Long-Term Survival Following Liver Resection for Hepatic Colorectal Metastases
Choti, M. A., Sitzmann, J. V., Tiburi, M. F., Sumetchotimetha, W., Rangsin, R., Schulick, R. D., Lillemoe, K. D., Yeo, C. J., & Cameron, J. L. (2002) · Annals of Surgery · doi:10.1097/00000658-200206000-00002 · Cited by 1,454
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Actual 10-Year Survival After Resection of Colorectal Liver Metastases Defines Cure
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Cited by
ESMO consensus guidelines for the management of patients with metastatic colorectal cancer
Van Cutsem, E., Cervantes, A., Adam, R., Sobrero, A., Van Krieken, J. H., Aderka, D., Aranda Aguilar, E., Bardelli, A., Benson, A., Bodoky, G., et al. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw235 · Cited by 3,421
Follow-up strategies for patients treated for non-metastatic colorectal cancer
Jeffery, M., Hickey, B. E., Hider, P. N., & See, A. M. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002200.pub3 · Cited by 640
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Self-citationSurvival improvement for patients with metastatic colorectal cancer over twenty years
Zeineddine, F. A., Zeineddine, M. A., Yousef, A., Gu, Y., Chowdhury, S., Dasari, A., Huey, R. W., Johnson, B., Kee, B., Lee, M. S., et al. (2023) · npj Precision Oncology · doi:10.1038/s41698-023-00353-4 · Cited by 192
Metadata
- Authors
- Taylor, A., Primrose, Langeberg, W., Kelsh, Mowat, F., Alexander, D., Choti, M., Poston, G., & Kanas, G.
- Venue
- Clinical Epidemiology
- Publisher
- Informa UK Limited
- Published
- 2012-11
- Volume
- 4
- Pages
- 283
- ISSN
- 1179-1349 (ISSN-L)
- OpenAlex
- W2080229397
- Cited by
- 657
- References
- 94
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- gold
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- Taylor, A., Primrose, Langeberg, W., Kelsh, Mowat, F., Alexander, D., Choti, M., Poston, G., & Kanas, G. (2012). Survival after liver resection in metastatic colorectal cancer: review and meta-analysis of prognostic factors. Clinical Epidemiology. https://doi.org/10.2147/clep.s34285
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