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An Oral Whole-Cell Killed Nontypeable Haemophilus influenzae Immunotherapeutic For The Prevention Of Acute Exacerbations Of Chronic Airway Disease
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“Likewise, Haemophilus species are common respiratory pathogen, and oral whole-cell killing of non-typing Haemophilus influenzae have been shown to enhance respiratory tract protection [49].”
From Severity-dependent alterations in oral microbiota and antibiotic resistance in children with dental fluorosis (2026) · cites this paper as [49]
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The Microbiome and the Respiratory Tract
Dickson, R. P., Erb-Downward, J. R., Martinez, F. J., & Huffnagle, G. B. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105238 · Cited by 953
Efficacy of High-Dose versus Standard-Dose Influenza Vaccine in Older Adults
DiazGranados, C. A., Dunning, A. J., Kimmel, M., Kirby, D., Treanor, J., Collins, A., Pollak, R., Christoff, J., Earl, J., Landolfi, V., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1315727 · Cited by 876
The development and function of lung-resident macrophages and dendritic cells
Kopf, M., Schneider, C., & Nobs, S. P. (2015) · Nature Immunology · doi:10.1038/ni.3052 · Cited by 555
Research works printed but not linked: 25
- [1]Clancy RL, Murree-Allen K, Cripps AW, Yeung S, Engel M. Oral immunisation with killed haemophilus influenzae for protection against acute bronchitis in chronic obstructive lung disease. Lancet. 1985; 326: 1395– 1397. doi: 10.1016/S0140-6736(85)92559-0 2867396 · DOI
- [2]Craig SW, Cebra JJ. Peyer’s patches: an enriched source of precursors for IgA-producing immunocytes in the rabbit. J Exp Med. 1971; 134: 188– 200. doi: 10.1084/jem.134.1.188 4934147 PMC2139023 · DOI
- [3]Rudzik R, Clancy RL, Perey DYE, Day RP, Bienenstock J. Repopulation with IgA-containing cells of bronchial and intestinal lamina propria after transfer of homologous Peyer’s patch and bronchial lymphocytes. J Immunol. 1975; 114: 1599– 1604. 1091707
- [4]Brandtzaeg P, Kiyono H, Pabst R, Russell MW. Terminology: nomenclature of mucosa-associated lymphoid tissue. Mucosal Immunol. 2008; 1: 31– 37. doi: 10.1038/mi.2007.9 19079158 · DOI
- [5]Clancy RL, Bienenstock J. The proliferative response of bronchus-associated lymphoid tissue after local and systemic immunization. J Immunol. 1974; 112: 1997– 2001. 4133074
- [6]Wallace FJ, Clancy RL, Cripps AW. An animal model demonstration of enhanced clearance of nontypable haemophilus influenzae from the respiratory tract after antigen stimulation of gut-associated lymphoid tissue. Am Rev Respir Dis. 1989; 140: 311– 316. doi: 10.1164/ajrccm/140.2.311 2788377 · DOI
- [7]Husband AJ, Dunkley ML, Cripps AW, Clancy RL. Antigen-specific response among T lymphocytes following intestinal administration of alloantigens. Aust J Exp Biol Med Sci. 1984; 62: 687– 699. doi: 10.1038/icb.1984.65 6241823 · DOI
- [8]Scicchitano R, Husband AJ, Clancy RL. Contribution of intraperitoneal immunization to the local immune response in the respiratory tract of sheep. Immunology. 1984; 53: 375– 384. doi: 10.1164/arrd.1978.117.3.513 6490090 PMC1454821 · DOI
- [9]Clancy RL, Pucci A, Jelihovsky T, Bye P. Immunologic “memory” for microbial antigens in lymphocytes obtained from human bronchial mucosa 1–3. Am Rev Respir Dis. 1978; 117: 513– 518. doi: 10.1164/arrd.1978.117.3.513 204236 · DOI
- [10]Anthonisen NR. The British hypothesis revisited. Eur Respir J. 2004; 23: 657– 658. doi: 10.1183/09031936.04.00013004 15176673 · DOI
- [11]Calverley P, Pauwels R, Vestbo J, et al. Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial. Lancet. 2003; 361: 449– 456. doi: 10.1016/S0140-6736(03)12459-2 12583942 · DOI
- [12]Tandon MK, Gebski V. A controlled trial of a killed haemophilus influenzae vaccine for prevention of acute exacerbations of chronic bronchitis. Intern Med J. 1991; 21: 427– 432. 1953532
- [13]Lehmann D, Coakley KJ, Coakley CA, et al. Reduction in the incidence of acute bronchitis by an oral haemophilus influenzae vaccine in patients with chronic bronchitis in the highlands of Papua New Guinea. Am J Respir Crit Care Med. 1991; 144: 324– 330. 1859055
- [14]Clancy RL, Cripps AW, Pang G, Yeung S, Murree-Allen K. The paradox of immunization against haemophilus influenzae-related endobronchitis: protection restricted to ingestion of’non-adjuvenated’vaccine. Adv Exp Med Biol. 1986; 216: 1759– 1764. 3321940
- [15]Clancy RL, Cripps AW, Husband AJ, Buckley D. Specific immune response in the respiratory tract after administration of an oral polyvalent bacterial vaccine. Infect Immun. 1983; 39: 491– 496. 6339379 PMC347977
- [16]Otczyk DC, Clancy RL, Cripps AW. Haemophilus influenzae and smoking-related obstructive airways disease. Int J Chron Obstruct Pulmon Dis. 2011; 6: 345– 351. doi: 10.2147/COPD.S19359 21760721 PMC3133506 · DOI
- [17]Wallace FJ, Cripps AW, Clancy RL, Husband AJ, Witt CS. A role for intestinal T lymphocytes in bronchus mucosal immunity. Immunology. 1991; 74: 68– 73. 1937575 PMC1384673
- [18]Clancy RL, Dunkley ML. Acute exacerbations in COPD and their control with oral immunization with non-typeable haemophilus influenzae. Front Immunol. 2011; 2: 1– 6. doi: 10.3389/fimmu.2011.00007 22566798 PMC3341997 · DOI
- [19]Pang G, Ortega M, Zighang R, Reeves G, Clancy RL. Autocrine modulation of IL-8 production by sputum neutrophils in chronic bronchial sepsis. Am J Respir Crit Care Med. 1997; 155: 726– 731. doi: 10.1164/ajrccm.155.2.9032219 9032219 · DOI
- [20]Clancy RL, Dunkley ML. Oral non‐typable haemophilus influenzae enhances physiological mechanism of airways protection. Clin Exp Immunol. 2010; 161: 127– 133. doi: 10.1111/j.1365-2249.2010.04142.x 20408861 PMC2940157 · DOI
- [21]Dunkley ML, Husband AJ, Beagley KW, Clancy RL, Collins AM, Cripps AW, Emery DL,. A rodent model of concurrent respiratory infection with influenza virus and gram-negative bacteria: synergistic infection and protection by oral immunization In: Mucosal Solutions: Advances in Mucosal Immunology. Vol. 1 University of Sydney, Sydney Australia. 1997; 261– 268.
- [23]Clancy RL. Towards a vaccine for chronic obstructive pulmonary disease. Intern Med J. 2012; 42: 607– 613. doi: 10.1111/j.1445-5994.2012.02752.x 22372964 · DOI
- [24]Tandon MK, Phillips M, Waterer G, Dunkley ML, Comans P, Clancy RL. Oral immunotherapy with inactivated nontypeable haemophilus influenzae reduces severity of acute exacerbations in severe COPD. Chest. 2010; 137: 805– 811. doi: 10.1378/chest.09-1382 19952063 · DOI
- [25]Clancy RL, Dunkley ML, Sockler J, McDonald CF. Multi‐site placebo‐controlled randomised clinical trial to assess protection following oral immunisation with inactivated non‐typeable haemophilus influenzae in chronic obstructive pulmonary disease. Internal Medicine Journal. 2016; 46: 684– 693. doi: 10.1111/imj.13072 27009822 · DOI
- [28]Grimwood K, Kyd JM, Owen SJ, Massa HM, Cripps AW. Vaccination against respiratory pseudomonas aeruginosa infection. Hum Vaccin Immunother. 2015; 11: 14– 20. doi: 10.4161/hv.34296 25483510 PMC4514401 · DOI
Cited by
Sorted by citations
Xia, Y., Peng, S., Yu, J., Wang, Y., Ye, Y., Liu, M., Shang, L., Cui, X., Wang, P., & Ding, Z. (2026) · Journal of Oral Microbiology · doi:10.1080/20002297.2026.2714622
Metadata
- Authors
- Clancy, R. L., & Cripps, A. W.
- Venue
- International Journal of Chronic Obstructive Pulmonary Disease
- Publisher
- Informa UK Limited
- Published
- 2019-10
- Volume
- Volume 14
- Pages
- 2423-2431
- ISSN
- 1178-2005
- PMC
- PMC6821045
- Cited by
- 8
- References
- 3
- Language
- en
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