The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
Bispecific antibodies: design, therapy, perspectives
Open accessAbstract
Antibodies (Abs) containing two different antigen-binding sites in one molecule are called bispecific. Bispecific Abs (BsAbs) were first described in the 1960s, the first monoclonal BsAbs were generated in the 1980s by hybridoma technology, and the first article describing the therapeutic use of BsAbs was published in 1992, but the number of papers devoted to BsAbs has increased significantly in the last 10 years. Particular interest in BsAbs is due to their therapeutic use. In the last decade, two BsAbs - catumaxomab in 2009 and blinatumomab in 2014, were approved for therapeutic use. Papers published in recent years have been devoted to various methods of BsAb generation by genetic engineering and chemical conjugation, and describe preclinical and clinical trials of these drugs in a variety of diseases. This review considers diverse BsAb-production methods, describes features of therapeutic BsAbs approved for medical use, and summarizes the prospects of practical application of promising new BsAbs.
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Cites
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Cited by
Antibody–Drug Conjugates: A Comprehensive Review
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Therapies for rare diseases: therapeutic modalities, progress and challenges ahead
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The Dawn of a New Era: Targeting the “Undruggables” with Antibody-Based Therapeutics
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“An interesting application of the Ig domain swapping in scFv molecules is the development of bispecific diabodies, especially as antitumor biotherapeutics [22,23].”
Background
Metadata
- Authors
- Sedykh, S., Prinz, V., Buneva, V., & Nevinsky, G.
- Venue
- Drug Design, Development and Therapy
- Publisher
- Informa UK Limited
- Published
- 2018-01
- Volume
- Volume 12
- Pages
- 195-208
- ISSN
- 1177-8881 (ISSN-L)
- OpenAlex
- W2784605149
- Cited by
- 292
- References
- 127
- FWCI
- 24.10
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sedykh, S., Prinz, V., Buneva, V., & Nevinsky, G. (2018). Bispecific antibodies: design, therapy, perspectives. Drug Design, Development and Therapy. https://doi.org/10.2147/dddt.s151282
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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