The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages
Open accessAbstract
The topical route of administration has many advantages for the treatment of various skin disorders as well as cosmeceutical purposes. This route bypasses hepatic first-pass effect and systemic availability of many pharmaceuticals is limited to skin organelles such as hair follicles and so could avoid unwanted adverse reactions and increase the localized therapeutic effect. Despite such attributed advantages of the topical route, the most important challenge is skin barrier characteristics that should be overcome to obtain dermal or trans-dermal drug delivery. Different approaches have been recruited to overcome this barrier. In this review, different types of nanoparticles for skin permeation enhancement and targeted delivery to skin organelles are discussed. The potential mechanisms of each nanocarrier in permeation enhancement and dermal delivery are considered and finally, the most important advantages and disadvantages of each group are summarized.
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Cites
1 retracted
Negi, P., Aggarwal, M., Sharma, G., Rathore, C., Sharma, G., Singh, B., & Katare, O. P. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.01.083 · Cited by 104
RetractedMüller, R. H., Radtke, M., & Wissing, S. A. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00118-7 · Cited by 2,113
Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products
Pardeike, J., Hommoss, A., & Müller, R. H. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.10.003 · Cited by 1,478
Mohammadi-Samani, S., & Ghasemiyeh, P. (2018) · Research in Pharmaceutical Sciences · doi:10.4103/1735-5362.235156 · Cited by 970
Self-citationMüller, R. H., Gohla, S., & Keck, C. M. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2011.01.007 · Cited by 702
Nanostructured lipid carriers (NLC) in cosmetic dermal products☆
MULLER, R., PETERSEN, R., HOMMOSS, A., & PARDEIKE, J. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.04.012 · Cited by 700
Skin penetration and distribution of polymeric nanoparticles
Alvarez-Román, R., Naik, A., Kalia, Y. N., Guy, R. H., & Fessi, H. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.06.015 · Cited by 626
Challenges and Opportunities in dermal/transdermal Delivery
Paudel, K. S., Milewski, M., Swadley, C. L., Brogden, N. K., Ghosh, P., & Stinchcomb, A. L. (2010) · Therapeutic Delivery · doi:10.4155/tde.10.16 · Cited by 616
Liposomes and niosomes as topical drug carriers: dermal and transdermal drug delivery
Schreier, H., & Bouwstra, J. (1994) · Journal of Controlled Release · doi:10.1016/0168-3659(94)90039-6 · Cited by 532
Jenning, V., Gysler, A., Schäfer-Korting, M., & Gohla, S. H. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(99)00075-2 · Cited by 528
Cited by
Nanotechnology in Cosmetics and Cosmeceuticals—A Review of Latest Advancements
Gupta, V., Mohapatra, S., Mishra, H., Farooq, U., Kumar, K., Ansari, M., Aldawsari, M., Alalaiwe, A., Mirza, M., & Iqbal, Z. (2022) · Gels · doi:10.3390/gels8030173 · Cited by 370
Repurposing of atorvastatin emulsomes as a topical antifungal agent
Eita, A. S., M. A. Makky, A., Anter, A., & Khalil, I. A. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2149898 · Cited by 24
Pramoda, G., Verma, R. K., Kesharwani, P., & Shukla, R. (2025) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2025.127938 · Cited by 15
Metadata
- Authors
- Ghasemiyeh, P., & Mohammadi-Samani, S.
- Venue
- Drug Design, Development and Therapy
- Publisher
- Informa UK Limited
- Published
- 2020-08
- Volume
- Volume 14
- Pages
- 3271-3289
- ISSN
- 1177-8881 (ISSN-L)
- OpenAlex
- W3048581459
- Cited by
- 346
- References
- 79
- FWCI
- 12.39
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ghasemiyeh, P., & Mohammadi-Samani, S. (2020). Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages. Drug Design, Development and Therapy. https://doi.org/10.2147/dddt.s264648
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
