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Frequently asked questions in hypoxia research

Wenger, Roland, Kurtcuoglu, Vartan, Scholz, Carsten, Marti, Hugo, Hoogewijs, David·2015·Hypoxia
DOI 10.2147/hp.s92198PMC PMC5045069
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Figure 1 Composition of the gas phase in a tissue culture incubator. Notes: Input room air (left) is mixed with gaseous water and CO2 to form the incubator’s gas mixture (right).
Figure 1 Composition of the gas phase in a tissue culture incubator. Notes: Input room air (left) is mixed with gaseous water and CO2 to form the incubator’s gas mixture (right).CC BY-NC · PubMed Central
Figure 2 O2 concentration gradients in cell culture medium. Notes: Normal 24-well tissue culture plates without (left) or with (right) confluent HeLa cell layers were removed from a normoxic 37°C incubator, and O2 concentration profiles were determined under room air conditions at 25°C using a needle-type O2 sensor (PreSens, Regensburg, Germany). Note that the change from incubator air to room air results in a higher pO2 (no gaseous water, no pCO2) and a better O2 solubility (temperature change from 37°C to 25°C).
Figure 2 O2 concentration gradients in cell culture medium. Notes: Normal 24-well tissue culture plates without (left) or with (right) confluent HeLa cell layers were removed from a normoxic 37°C incubator, and O2 concentration profiles were determined under room air conditions at 25°C using a needle-type O2 sensor (PreSens, Regensburg, Germany). Note that the change from incubator air to room air results in a higher pO2 (no gaseous water, no pCO2) and a better O2 solubility (temperature change from 37°C to 25°C).CC BY-NC · PubMed Central
Figure 3 Pericellular O2 concentration as a function of medium height and cell density. Notes: 24-Well SensorDish tissue culture plates were filled with different medium volumes and seeded with HeLa cells at various densities, resulting in 0%–100% confluency as indicated. The SensorDishes were removed from the 37°C incubator and the pericellular O2 concentration determined under room air conditions at 25°C (resulting in a higher pO2 and better O2 solubility than within the incubator) using a SensorDish Reader (PreSens, Regensburg, Germany).
Figure 3 Pericellular O2 concentration as a function of medium height and cell density. Notes: 24-Well SensorDish tissue culture plates were filled with different medium volumes and seeded with HeLa cells at various densities, resulting in 0%–100% confluency as indicated. The SensorDishes were removed from the 37°C incubator and the pericellular O2 concentration determined under room air conditions at 25°C (resulting in a higher pO2 and better O2 solubility than within the incubator) using a SensorDish Reader (PreSens, Regensburg, Germany).CC BY-NC · PubMed Central
Figure 4 Krogh’s tissue cylinder. Notes: Overlapping longitudinal (convective) and radial (diffusive) pO2 gradients form the physiological tissue O2 distribution (calculated isobaric pO2 profiles assuming constant tissue O2 consumption). All cells located within this pO2 profile are considered to be physiologically “normoxic”, despite the highly variable absolute pO2 levels.
Figure 4 Krogh’s tissue cylinder. Notes: Overlapping longitudinal (convective) and radial (diffusive) pO2 gradients form the physiological tissue O2 distribution (calculated isobaric pO2 profiles assuming constant tissue O2 consumption). All cells located within this pO2 profile are considered to be physiologically “normoxic”, despite the highly variable absolute pO2 levels.CC BY-NC · PubMed Central
Figure 5 Organotypic characteristics in tissue oxygenation and O2 metabolism. Notes: Combined spatial and temporal processes result in a broad spectrum of physiologically “normoxic” tissue pO2 values. For details see section: What is the pO2 in organs?
Figure 5 Organotypic characteristics in tissue oxygenation and O2 metabolism. Notes: Combined spatial and temporal processes result in a broad spectrum of physiologically “normoxic” tissue pO2 values. For details see section: What is the pO2 in organs?CC BY-NC · PubMed Central

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Research works printed but not linked: 33

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Metadata

Authors
Wenger, R., Kurtcuoglu, V., Scholz, C., Marti, H., & Hoogewijs, D.
Venue
Hypoxia
Publisher
Informa UK Limited
Published
2015-09
Pages
35
ISSN
2324-1128
DOI
10.2147/hp.s92198
PMC
PMC5045069
Cited by
223
References
2
Language
en
Licence
creativecommons.org/licenses/by-nc/3.0/ (vor)

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