Cited by 47Antifungal resistance and susceptibilityFungal Plant Pathogen ControlFungal Infections and Studies

Multiresistant Fusarium Pathogens on Plants and Humans: Solutions in (from) the Antifungal Pipeline?

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Al-Hatmi, Abdullah, de Hoog, G Sybren, Meis, Jacques F·2019·Infection and Drug Resistance

Abstract

Abstract: The fungal genus Fusarium contains numerous plant pathogens causing considerable economic losses. In addition, Fusarium species are emerging as opportunistic human pathogens causing both superficial and systemic infections. Appropriate treatment of Fusarium infections in a clinical setting of neutropenia is currently not available. ESCMID and ECMM joint guidelines, following the majority of published studies, suggest early therapy with amphotericin B and voriconazole, in conjunction with surgical debridement and reversal of immunosuppression. In this review, we elaborate on the trans-kingdom pathogenicity of Fusarium . Intrinsic resistance to several antifungal drugs and the evolution of antifungal resistance over the years are highlighted. Recent studies present novel compounds that are effective against some pathogenic fungi including Fusarium . We discuss the robust and dynamic antifungal pipeline, including results from clinical trials as well as preclinical data that might appear beneficial for patients with invasive fusariosis. Keywords: Fusarium , trans-kingdom, novel compounds, antifungal pipeline, E1210, SCY-078, ASP2397, MGCD290, olorofim, AR-12, isavuconazole, efinaconazole, luliconazole

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  1. [17]Edwards ET. Studies on the Gibberella fujikuroi var. subglutinans the hitherto undescribed ascigerous stage of Fusarium moniliforme var. subglutinans and its pathogenicity on maize in New South Wales. Dep Agric New South Wales Sci Bull. 1935; 49: 1– 68.
  2. [37]Booth C. The Genus Fusarium. Kew: Commonwealth Mycological Institute; 1971: 237.

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Authors
Al-Hatmi, A., de Hoog, G. S., & Meis, J. F.
Affiliations
Radboud University Medical Center (NL)
Venue
Infection and Drug Resistance
Published
2019-11
Volume
Volume 12
Pages
3727-3737
ISSN
1178-6973 (ISSN-L)
OpenAlex
W2990221972
Cited by
47
References
109
Citations by year
2026: 5 · 2025: 5 · 2024: 9 · 2023: 11 · 2022: 6 · 2021: 7 · 2020: 4
FWCI
0.60
Type
journal article
Language
en
Open access
Locations
  • Infection and Drug Resistance (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
  • KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
Fusarium, antifungal resistance, invasive fusariosis, plant pathogens, opportunistic fungal infection, amphotericin B, voriconazole, neutropenia, isavuconazole, efinaconazole, luliconazole, olorofim

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