Multiresistant Fusarium Pathogens on Plants and Humans: Solutions in (from) the Antifungal Pipeline?
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Abstract: The fungal genus Fusarium contains numerous plant pathogens causing considerable economic losses. In addition, Fusarium species are emerging as opportunistic human pathogens causing both superficial and systemic infections. Appropriate treatment of Fusarium infections in a clinical setting of neutropenia is currently not available. ESCMID and ECMM joint guidelines, following the majority of published studies, suggest early therapy with amphotericin B and voriconazole, in conjunction with surgical debridement and reversal of immunosuppression. In this review, we elaborate on the trans-kingdom pathogenicity of Fusarium . Intrinsic resistance to several antifungal drugs and the evolution of antifungal resistance over the years are highlighted. Recent studies present novel compounds that are effective against some pathogenic fungi including Fusarium . We discuss the robust and dynamic antifungal pipeline, including results from clinical trials as well as preclinical data that might appear beneficial for patients with invasive fusariosis. Keywords: Fusarium , trans-kingdom, novel compounds, antifungal pipeline, E1210, SCY-078, ASP2397, MGCD290, olorofim, AR-12, isavuconazole, efinaconazole, luliconazole
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Infections caused by Lomentospora and Scedosporium currently have few or no reliable treatment options.
“Currently, infections by these organisms have few, if any, reliable therapeutic options.”
From Investigational Agents for the Treatment of Resistant Yeasts and Molds (2021) · cites this paper as [15]
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Self-citationIsavuconazole for treatment of invasive fungal diseases caused by more than one fungal species
Marty, F. M., Cornely, O. A., Mullane, K. M., Ostrosky‐Zeichner, L., Maher, R., Croos‐Dabrera, R., Lu, Q., Lademacher, C., Oren, I., Schmitt-Hoffmann, A.-H., et al. (2018) · Mycoses · doi:10.1111/myc.12777 · Cited by 38 · see citing works
Fusarium spp. is able to grow and invade healthy human nails as a single source of nutrients
Galletti, J., Negri, M., Grassi, F. L., Kioshima, É. S., & Svidzinski, T. I. E. (2015) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-015-2410-1 · Cited by 37 · see citing works
dos Santos, C. O., Kolwijck, E., van der Lee, H. A., Tehupeiory-Kooreman, M. C., Al‐Hatmi, A. M. S., Matayan, E., Burton, M. J., Eggink, C. A., & Verweij, P. E. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02669-18 · Cited by 35 · see citing works
Self-citationNatamycin in the treatment of fungal keratitis : a systematic review and Meta-analysis
Sheng, S., Qiu, Gui-Qiu, Zhao, Jing, Lin, L., Xue, Wang, Li-Ting, Hu, et al. (2015) · Acta Scientiarum Naturalium Universitatis Sunyatseni · Cited by 35 · see citing works
Efficacy of Liposomal Amphotericin B in Treatment of Systemic Murine Fusariosis
Ortoneda, M., Capilla, J., Pastor, F., Pujol, I., & Guarro, J. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.7.2273-2275.2002 · Cited by 32 · see citing works
Mehl, H. L., & Epstein, L. (2007) · Environmental Microbiology · doi:10.1111/j.1462-2920.2007.01333.x · Cited by 32 · see citing works
Abastabar, M., Al‐Hatmi, A. M. S., Moghaddam, M. V., de Hoog, S., Haghani, I., Âghili, S. R., Shokohi, T., Hedayati, M. T., Ghazvini, R. D., Kachuei, R., et al. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00009-18 · Cited by 32 · see citing works
Self-citationGrundlagen einer Monographie der Gattung Fusarium (Link).
Appel, O., & Wollenweber, H. (1913) · OpenAgrar · Cited by 32 · see citing works
Schäfer, K., Pietro, A. D., Gow, N. A. R., & MacCallum, D. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089920 · Cited by 27 · see citing works
Tupaki‐Sreepurna, A., Jishnu, B. T., Thanneru, V., Sharma, S., Gopi, A., Sundaram, M., & Kindo, A. J. (2017) · Journal of Fungi · doi:10.3390/jof3020020 · Cited by 27 · see citing works
Nucci, M., Shoham, S., Abdala, E., Hamerschlak, N., Rico, J. C., Forghieri, F., Nouér, S. A., Cappellano, P., Solza, C., Gonzaga, Y. B. D. M., et al. (2019) · Mycoses · doi:10.1111/myc.12901 · Cited by 23 · see citing works
Fusarium volatile, a new potential pathogen from a human respiratory sample
Al‐Hatmi, A. M. S., Sandoval‐Denis, M., Nabet, C., Ahmed, S. A., Demar, M., Normand, A., & de Hoog, S. (2019) · Fungal Systematics and Evolution · doi:10.3114/fuse.2019.04.09 · Cited by 17 · see citing works
Self-citationMycotic Keratitis Caused by Fusarium solani sensu stricto (FSSC5): A Case Series
Boral, H., van Diepeningen, A., Erdem, E., Yağmur, M., de Hoog, S., İlkit, M., Meis, J. F. G. M., & Al‐Hatmi, A. M. S. (2018) · Mycopathologia · doi:10.1007/s11046-018-0280-7 · Cited by 16 · see citing works
Self-citationRees, C. A., Bao, R., Zegans, M. E., & Cramer, R. A. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02505-18 · Cited by 15 · see citing works
In Vitro Efficacy of Chlorhexidine and a riboflavin/UVA Combination on Fungal Agents of Keratitis
Kunt, Z., Yağmur, M., Kandemir, H., Harbiyeli, I., Erdem, E., Kalkancı, A., de Hoog, S., & İlkit, M. (2019) · Current Eye Research · doi:10.1080/02713683.2019.1652916 · Cited by 8 · see citing works
The Fusaria; their description, injurious effects, and control.
Wollenweber, H. W., & Recking, O. A. (1935) · Cited by 6 · see citing works
Cornely, O. A., Ostrosky-Zeichner, L., Rahav, G., Maher, R., Zeiher, B. G., Lee, M., & Perfect, J. R. (2015) · Kölner Universitäts PublikationsServer (Universität zu Köln) · Cited by 6 · see citing works
Azole resistance is related to overexpression of the CYP51 gene in Mycosphaerella fijiensis
Díaz-Trujillo, C., da Cunha, V. C., Chong, P., Kema, G. H. J., Arango-Isaza, R., Guzman, M. S., Stergiopoulos, I., & WIT, P. J. G. M. D. (2011) · Socio-Environmental Systems Modeling · Cited by 1 · see citing works
Flagged first, then by citations
4 of the 109 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- [17]Edwards ET. Studies on the Gibberella fujikuroi var. subglutinans the hitherto undescribed ascigerous stage of Fusarium moniliforme var. subglutinans and its pathogenicity on maize in New South Wales. Dep Agric New South Wales Sci Bull. 1935; 49: 1– 68.
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Cited by
Sorted by citations
Review of the Novel Investigational Antifungal Olorofim
Wiederhold, N. P. (2020) · Journal of Fungi · doi:10.3390/jof6030122 · Cited by 155 · see citing works
Microbial diversity in soils suppressive to Fusarium diseases
Todorović, I., Moënne-Loccoz, Y., Raičević, V., Jovičić-Petrović, J., & Muller, D. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1228749 · Cited by 105 · see citing works
FUSARIUM-ID v.3.0: An Updated, Downloadable Resource for Fusarium Species Identification
Torres-Cruz, T. J., Whitaker, B. K., Proctor, R. H., Broders, K. D., Laraba, I., Kim, H.-S., Brown, D. W., O’Donnell, K., Estrada-Rodríguez, T. L., Lee, Y.-H., et al. (2021) · Plant Disease · doi:10.1094/pdis-09-21-2105-sr · Cited by 112 · see citing works
O'Donnell, K. L., Al‐Hatmi, A. M. S., Aoki, T., Brankovics, B., Cano, J., Coleman, J. J., de Hoog, S., Pietro, A. D., Frandsen, R. J. N., Geiser, D. M., et al. (2020) · mSphere · doi:10.1128/msphere.00810-20 · Cited by 111 · see citing works
Self-citationA One Health Perspective to Recognize Fusarium as Important in Clinical Practice
Saenz, V., Álvarez, C., Pape, P. L., Restrepo, S., Guarro, J., & Ramírez, A. M. C. (2020) · Journal of Fungi · doi:10.3390/jof6040235 · Cited by 79 · see citing works
Ten decadal advances in fungal biology leading towards human well-being
Mapook, A., Hyde, K. D., Hassan, K., Kemkuignou, B. M., Čmoková, A., Surup, F., Kuhnert, E., Paomephan, P., Cheng, T., de Hoog, S., et al. (2022) · Fungal Diversity · doi:10.1007/s13225-022-00510-3 · Cited by 72 · see citing works
Self-citationNaqvi, S. A. H., Farhan, M., Ahmad, M., Kiran, R., Shahbaz, M., Abbas, A., Hakim, F., Shabbir, M., Tan, Y. S., & Sathiya Seelan, J. S. (2025) · Archives of Microbiology · doi:10.1007/s00203-024-04219-6 · Cited by 61 · see citing works
Review of the novel antifungal drug olorofim (F901318)
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Dry root rot disease, an emerging threat to citrus industry worldwide under climate change: A review
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Investigational Agents for the Treatment of Resistant Yeasts and Molds
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Emerging Diagnostics and Therapeutics for Invasive Fungal Infections
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Gisi, U. (2021) · Plant Pathology · doi:10.1111/ppa.13429 · Cited by 18 · see citing works
Ranauda, M. A., Zuzolo, D., Maisto, M., Tartaglia, M., Scarano, P., Prigioniero, A., Sciarrillo, R., & Guarino, C. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.123656 · Cited by 17 · see citing works
Jambhulkar, P. P., Bajpai, R., Harish, J., Tripathy, P. S., Rout, A. K., Varun, P., Behera, B. K., Lakshman, D. K., & Mallikarjuna, N. (2024) · Journal of Fungi · doi:10.3390/jof10080574 · Cited by 17 · see citing works
Silent invaders: the hidden threat of asymptomatic phytobiomes to forest biosecurity
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Fungal Genomics in Respiratory Medicine: What, How and When?
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de Queiroz, J. C. E., Leite, J. R. S. A., & Vasconcelos, A. G. (2023) · Antibiotics · doi:10.3390/antibiotics12030427 · Cited by 15 · see citing works
Cruz, F. D. P. N., de Paula, A. F., Nogueira, C. T., de Andrade, P. H. M., Borges, L. M., Lacava, P. T., Camargo, I. L. B. D. C., Aníbal, F. D. F., & de Sousa, C. P. (2021) · International Journal of Microbiology · doi:10.1155/2021/6618559 · Cited by 14 · see citing works
Nosratabadi, M., Akhtari, J., Faeli, L., Haghani, I., Âghili, S. R., Shokohi, T., Hedayati, M. T., Zarrinfar, H., Mohammadi, R., Najafzadeh, M. J., et al. (2022) · Journal of Fungi · doi:10.3390/jof8070709 · Cited by 14 · see citing works
Self-citationBiofilm Formation in Clinical Isolates of Fusarium
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Climate change: shifting boundaries of fungal disease in Europe and beyond
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Phylogenetic Analysis of Clinically Relevant Fusarium Species in Iran
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Stepanov, A. A., Shulaev, N. А., & Vasilchenko, A. S. (2024) · Journal of Basic Microbiology · doi:10.1002/jobm.202400334 · Cited by 7 · see citing works
Response in barley roots during interaction with Bacillus subtilis and Fusarium graminearum
Reyna, M., Macor, E. P., Vilchez, A. C., & Villasuso, A. L. (2022) · Biological Control · doi:10.1016/j.biocontrol.2022.105128 · Cited by 7 · see citing works
Nosratabadi, M., Faeli, L., Haghani, I., Mohammadi, R., Khodavaisy, S., Kachuei, R., Katiraee, F., Âghili, S. R., Shokohi, T., Hedayati, M. T., et al. (2022) · Mycoses · doi:10.1111/myc.13550 · Cited by 6 · see citing works
Self-citationThe Multifaceted Menace of Fusarium as a Plant, Animal, and Human Pathogen
Abeysinghe, K. C., Madhushan, A., Ismail, A. M., Ilyukhin, E., & Maharachchikumbura, S. S. N. (2026) · Biology · doi:10.3390/biology15060453 · Cited by 5 · see citing works
Kao, A. S., Cramer‐Bour, C., Kupsky, W. J., & Soubani, A. O. (2023) · Medical Mycology Case Reports · doi:10.1016/j.mmcr.2023.02.004 · Cited by 5 · see citing works
Antifungal activity of a novel synthetic polymer M451 against phytopathogens
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Fonseca-Guerra, I. R., Posada, A. M. V., Rozo, M. E. B., & Pineda, M. E. B. (2024) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.13993 · Cited by 3 · see citing works
Cely-Veloza, W., Quiroga, D., & Coy-Barrera, E. D. (2023) · Molbank · doi:10.3390/m1630 · Cited by 2 · see citing works
Hassan, A., Zaib, S., & Anjum, T. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107561 · Cited by 2 · see citing works
Fusarium spp. causing invasive disease in humans: A case series from north India
Gourav, S., Mishra, H., Xess, I., Bhalla, A. S., Chandola, S., Gupta, S., Appasami, K. P., Shukla, B. D., Bakhshi, S., Manhas, A., et al. (2024) · Medical Mycology · doi:10.1093/mmy/myae111 · Cited by 2 · see citing works
Medical Fusarium: novel species or uncertain identifications?
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Bioremediation for Global Environmental Conservation [Working Title]
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Saenz, V., Lizcano-Salas, A. F., Pape, P. L., & Ramírez, A. M. C. (2025) · Scientific Reports · doi:10.1038/s41598-025-32234-0 · Cited by 1 · see citing works
Banda, M. F., Munyengabe, A., & Augustyn, W. A. (2023) · Environmental sciences · doi:10.5772/intechopen.112214 · Cited by 1 · see citing works
Nosratabadi, M., Ebrahimzadeh, M. A., Alizadeh, S. R., Haghani, I., Faeli, L., Barough, R. E., Al‐Hatmi, A. M. S., & Abastabar, M. (2023) · PubMed Central · doi:10.22034/cmm.2024.345189.1504 · Cited by 1 · see citing works
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Control of malting barley Fusarium head blight by bioagents
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Черновецкий, М. А., & Кондаурова, С. Л. (2022) · Лабораторная диагностика Восточная Европа · doi:10.34883/pi.2022.11.4.004
Identification and antifungal sensitivity of Fusarium species isolated from piscine hosts
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Emerging Antifungal Resistance in Ocular Infections
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Santos, P. R. D. O., das Neves, M. R. M., & de Brito, D. F. (2026) · Research Society and Development · doi:10.33448/rsd-v15i7.51459
A Multifactorial Azole Response in Clinically Relevant Fusarium Species Complexes
Barião, P. H. G., Tonani, L., Alves, A. R., de Almeida, O. G. G., Santos, C., & Kress, M. R. V. Z. (2026) · Mycoses · doi:10.1111/myc.70220
- Authors
- Al-Hatmi, A., de Hoog, G. S., & Meis, J. F.
- Affiliations
- Radboud University Medical Center (NL)
- Venue
- Infection and Drug Resistance
- Publisher
- Informa UK Limited
- Published
- 2019-11
- Volume
- Volume 12
- Pages
- 3727-3737
- ISSN
- 1178-6973 (ISSN-L)
- PMC
- PMC6886543
- OpenAlex
- W2990221972
- Cited by
- 47
- References
- 109
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 9 · 2023: 11 · 2022: 6 · 2021: 7 · 2020: 4
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Infection and Drug Resistance (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- Fusarium, antifungal resistance, invasive fusariosis, plant pathogens, opportunistic fungal infection, amphotericin B, voriconazole, neutropenia, isavuconazole, efinaconazole, luliconazole, olorofim
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