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Cited by 35Antifungal resistance and susceptibilityYeasts and Rust Fungi StudiesFungal Infections and Studies

Prevalence of Candida blood stream infections among children in tertiary care hospital: detection of species and antifungal susceptibility

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Khairat, Sahar Mohammed, Sayed, Amal Mohammed, Nabih, Mohammad, Soliman, Noha Salah, Hassan, Yosra Mohammed·2019·Infection and Drug Resistance
DOI 10.2147/idr.s196972PMC PMC6689130
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Abstract

Background: Of all blood stream infections (BSI), candidaemia poses the greatest threat with a high fatality rate among children. There has been an increase in the number of reports of non- C. albicans species and antifungal resistance has progressively emerge. Aim: The present study aimed to demonstrate the prevalence of candidaemia among children and to characterize the involved species and their susceptibility to antifungal agents. Methodology: Microbes were isolated from blood samples and identified via standard microbiological procedures. Chromogenic media was used to characterize the Candida species. The susceptibility of the isolates to the antifungal agents; caspofungin, amphotericin, itraconazole, and fluconazole was determined with the E-test. Statistical methods: The data were analysed with Statistical Package for the Social Science SPSS; SPSS Inc., Chicago, IL, USA) version 15 for Microsoft Windows. Comparisons between the study groups were performed using the Chi square (χ 2 ) test. p -values less than 0.05 were considered significant. Results: Candidaemia accounted for 17.3% of all BSIs. C. albicans and non- C. albicans species accounted for 36% and 64% of the cases of candidaemia, respectively. Caspofungin, amphotericin, itraconazole, and fluconazole antifungals had activities of 99%, 97%, 73% and 64%, respectively. In total, 64% of patients with candiaemia died. Conclusion: The prevalence of candidaemia was high, the fatality rate was alarming and non- C. albicans species were predominant. Fluconazole was the least effective of the tested antifungal agents owing to the high level of resistance. Keywords: candidaemia, chromogenic agar, antifungal

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Cited by

Sorted by citations

Authors
Khairat, S. M., Sayed, A. M., Nabih, M., Soliman, N. S., & Hassan, Y. M.
Affiliations
Cairo University (EG)
Corresponding author
Hassan, Yosra Mohammed
ORCID
Venue
Infection and Drug Resistance
Publisher
Informa UK Limited
Published
2019-08
Volume
Volume 12
Pages
2409-2416
ISSN
1178-6973 (ISSN-L)
DOI
10.2147/idr.s196972
PMC
PMC6689130
OpenAlex
W2964497754
Cited by
35
References
2
Citations by year
2026: 2 · 2025: 4 · 2024: 9 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 4
FWCI
2.88
Type
journal article
Language
en
Open access
Licence
Locations
  • Infection and Drug Resistance (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
candidemia, bloodstream infection, pediatric patients, non-albicans Candida, Candida albicans, antifungal susceptibility, caspofungin, amphotericin B, itraconazole, fluconazole, mortality

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