Biofilm formation is a risk factor for mortality in patients with Candida albicans bloodstream infection—Scotland, 2012–2013

Rajendran, R.; Sherry, L.; Nile, C.J.; Sherriff, A.; Johnson, E.M.; Hanson, M.F.; Williams, C.; Munro, C.A.; Jones, B.J.; Ramage, G.

doi:10.1016/j.cmi.2015.09.018

Cited by 228Antifungal resistance and susceptibilityFungal Infections and StudiesFungal and yeast genetics research

Biofilm formation is a risk factor for mortality in patients with Candida albicans bloodstream infection—Scotland, 2012–2013

Open access

Rajendran, R., Sherry, L., Nile, C.J., Sherriff, A., Johnson, E.M., Hanson, M.F., Williams, C., Munro, C.A. +2 more·2016·Clinical Microbiology and Infection

DOI 10.1016/j.cmi.2015.09.018PMC PMC4721535

Open this paper in CoChat — free account Open PDF

Abstract

Bloodstream infections caused by Candida species remain a significant cause of morbidity and mortality in hospitalized patients. Biofilm formation by Candida species is an important virulence factor for disease pathogenesis. A prospective analysis of patients with Candida bloodstream infection (n = 217) in Scotland (2012-2013) was performed to assess the risk factors associated with patient mortality, in particular the impact of biofilm formation. Candida bloodstream isolates (n = 280) and clinical records for 157 patients were collected through 11 different health boards across Scotland. Biofilm formation by clinical isolates was assessed in vitro with standard biomass assays. The role of biofilm phenotype on treatment efficacy was also evaluated in vitro by treating preformed biofilms with fixed concentrations of different classes of antifungal. Available mortality data for 134 patients showed that the 30-day candidaemia case mortality rate was 41%, with predisposing factors including patient age and catheter removal. Multivariate Cox regression survival analysis for 42 patients showed a significantly higher mortality rate for Candida albicans infection than for Candida glabrata infection. Biofilm-forming ability was significantly associated with C. albicans mortality (34 patients). Finally, in vitro antifungal sensitivity testing showed that low biofilm formers and high biofilm formers were differentially affected by azoles and echinocandins, but not by polyenes. This study provides further evidence that the biofilm phenotype represents a significant clinical entity, and that isolates with this phenotype differentially respond to antifungal therapy in vitro. Collectively, these findings show that greater clinical understanding is required with respect to Candida biofilm infections, and the implications of isolate heterogeneity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cmi.2015.09.018

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

C. albicans biofilms exhibit high tolerance to antifungal drugs, posing a substantial challenge in clinical treatment.
“Once established, these biofilms exhibit a high tolerance to antifungal drugs, posing a substantial challenge in clinical treatment [54,55,56,57].”
From Disruption of the UPC2 Gene Enhances Fluconazole Antifungal Activity by Inhibiting HAC1 mRNA Splicing in Candida albicans (2026) · cites this paper as [54]
The Results section (‘Biofilm sensitivity to antifungals’) reports that voriconazole was ineffective against mature C. albicans biofilms, supporting a treatment challenge for that drug. It also reports that caspofungin and amphotericin B were effective against both groups tested, so the source does not support high tolerance to antifungal drugs generally; these susceptibility findings were measured in vitro. (LLM, conf=0.86)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance Study
Wisplinghoff, H., Bischoff, T., Tallent, S. M., Seifert, H., Wenzel, R. P., & Edmond, M. B. (2004) · Clinical Infectious Diseases · doi:10.1086/421946 · Cited by 4,496 · see citing works
Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America.
Mermel, L. A., Allon, M., Bouza, E., Craven, D. E., Flynn, P., O'Grady, N. P., Raad, I. I., Rijnders, B. J. A., Sherertz, R. J., & Warren, D. K. (2009) · Clinical Infectious Diseases · doi:10.1086/599376 · Cited by 3,638 · see citing works
ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients
Cornely, O. A., Bassetti, M., Calandra, T., Garbino, J., Kullberg, B. J., Lortholary, O., Meersseman, W., Akova, M., Arendrup, M. C., Arikan-Akdagli, S., et al. (2012) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12039 · Cited by 1,217 · see citing works
Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options
Sardi, J. C. O., Scorzoni, L., Bernardi, T., Fusco-Almeida, A. M., & Mendes Giannini, M. J. S. (2013) · Journal of Medical Microbiology · doi:10.1099/jmm.0.045054-0 · Cited by 1,184 · see citing works
Candida Infections of Medical Devices
Kojic, E. M., & Darouiche, R. O. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.2.255-267.2004 · Cited by 1,055 · see citing works
A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing
Pierce, C. G., Uppuluri, P., Tristan, A. R., Wormley, F. L., Mowat, E., Ramage, G., & Lopez-Ribot, J. L. (2008) · Nature Protocols · doi:10.1038/nprot.2008.141 · Cited by 1,041 · see citing works
Self-citation
Impact of Treatment Strategy on Outcomes in Patients with Candidemia and Other Forms of Invasive Candidiasis: A Patient-Level Quantitative Review of Randomized Trials
Andes, D. R., Safdar, N., Baddley, J. W., Playford, G., Reboli, A. C., Rex, J. H., Sobel, J. D., Pappas, P. G., Kullberg, B. J., & for the Mycoses Study Group (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis021 · Cited by 793 · see citing works
Standardized Method for In Vitro Antifungal Susceptibility Testing of Candida albicans Biofilms
Ramage, G., Vande Walle, K., Wickes, B. L., & López-Ribot, J. L. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.9.2475-2479.2001 · Cited by 753 · see citing works
Self-citation
Bacterial and Fungal Biofilm Infections
Lynch, A. S., & Robertson, G. T. (2007) · Annual Review of Medicine · doi:10.1146/annurev.med.59.110106.132000 · Cited by 448 · see citing works
Biofilm Production by Candida Species and Inadequate Antifungal Therapy as Predictors of Mortality for Patients with Candidemia
Tumbarello, M., Posteraro, B., Trecarichi, E. M., Fiori, B., Rossi, M., Porta, R., de Gaetano Donati, K., La Sorda, M., Spanu, T., Fadda, G., et al. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.00131-07 · Cited by 343 · see citing works
Intravascular Catheter Exchange and Duration of Candidemia
Rex, J. H., Bennett, J. E., Sugar, A. M., Pappas, P. G., Serody, J., Edwards, J. E., Washburn, R. G., NIAID Mycoses Study Group, & Candidemia Study Group (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/21.4.994 · Cited by 252 · see citing works
Early removal of central venous catheter in patients with candidemia does not improve outcome: analysis of 842 patients from 2 randomized clinical trials
Nucci, M., Anaissie, E., Betts, R. F., Dupont, B. F., Wu, C., Buell, D. N., Kovanda, L., & Lortholary, O. (2010) · Clinical Infectious Diseases · doi:10.1086/653935 · Cited by 228 · see citing works
Epidemiological changes with potential implication for antifungal prescription recommendations for fungaemia: data from a nationwide fungaemia surveillance programme
Arendrup, M. C., Dzajic, E., Jensen, R. H., Johansen, H. K., Kjaldgaard, P., Knudsen, J. D., Kristensen, L., Leitz, C., Lemming, L. E., Nielsen, L., et al. (2013) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12212 · Cited by 206 · see citing works
Risk Factors and Outcomes of Candidemia Caused by Biofilm-Forming Isolates in a Tertiary Care Hospital
Tumbarello, M., Fiori, B., Trecarichi, E. M., Posteraro, P., Losito, A. R., Luca, A. D., Sanguinetti, M., Fadda, G., Cauda, R., & Posteraro, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033705 · Cited by 197 · see citing works
Candida albicans versus non-albicans intensive care unit-acquired bloodstream infections: differences in risk factors and outcome.
Dimopoulos, G., Ntziora, F., Rachiotis, G., Armaganidis, A., & Falagas, M. E. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181607262 · Cited by 189 · see citing works
One year prospective survey of Candida bloodstream infections in Scotland
Odds, F. C., Hanson, M. F., Davidson, A. D., Jacobsen, M. D., Wright, P., Whyte, J. A., Gow, N. A. R., & Jones, B. L. (2007) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47239-0 · Cited by 176 · see citing works
Self-citation
Epidemiology, clinical characteristics, and outcome of candidemia: experience in a tertiary referral center in the UK
Das, I., Nightingale, P., Patel, M., & Jumaa, P. (2011) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2011.06.006 · Cited by 136 · see citing works
Biofilms formed by Candida albicans bloodstream isolates display phenotypic and transcriptional heterogeneity that are associated with resistance and pathogenicity
Sherry, L., Rajendran, R., Lappin, D. F., Borghi, E., Perdoni, F., Falleni, M., Tosi, D., Smith, K., Williams, C., Jones, B., et al. (2014) · BMC Microbiology · doi:10.1186/1471-2180-14-182 · Cited by 134 · see citing works
Self-citation
Antifungal lock therapy
Walraven, C. J., & Lee, S. A. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01351-12 · Cited by 132 · see citing works
Comparison of three assays for the quantification of Candida biomass in suspension and CDC reactor grown biofilms
Honraet, K., Goetghebeur, E. J. T., & Nelis, H. J. C. F. (2005) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2005.03.014 · Cited by 114 · see citing works
Parenteral Lipid Emulsion Induces Germination of Candida albicans and Increases Biofilm Formation on Medical Catheter Surfaces
Swindell, K., Lattif, A. A., Chandra, J., Mukherjee, P. K., & Ghannoum, M. A. (2009) · The Journal of Infectious Diseases · doi:10.1086/600106 · Cited by 63 · see citing works
Candida albicansand non-Candida albicansfungemia in an institutional hospital during a decade
Parmeland, L., Gazon, M., Guérin, C., Argaud, L., Lehot, J.-J., Bastien, O. H., Allaouchiche, B., Michallet, M., Picot, S., Bienvenu, A., et al. (2012) · Medical Mycology · doi:10.3109/13693786.2012.686673 · Cited by 45 · see citing works
Our 2014 approach to candidaemia
Koehler, P. A., Tacke, D., & Cornely, O. A. (2014) · Mycoses · doi:10.1111/myc.12207 · Cited by 30 · see citing works
Treatment of critically ill patients with candidemia
Mensa, J., Pitart, C., & Marco, F. (2008) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(08)70007-4 · Cited by 23 · see citing works
Candida glabrata fungaemia in a tertiary centre in Taiwan: antifungal susceptibility and outcomes
Ruan, S., Huang, Y., Chu, C.-C., Yu, C., & Hsueh, P. (2009) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2009.02.021 · Cited by 21 · see citing works

Flagged first, then by citations

Sorted by citations

Biofilm-Forming Capability of Highly Virulent, Multidrug-Resistant Candida auris
Sherry, L., Ramage, G., Kean, R., Borman, A., Johnson, E. M., Richardson, M. D., & Rautemaa-Richardson, R. (2017) · Emerging Infectious Diseases · doi:10.3201/eid2302.161320 · Cited by 420 · see citing works
Self-citation
Biofilm of Candida albicans : formation, regulation and resistance
Pereira, R., Fontenelle, R. O. D. S., de Brito, É. H. S., & de Morais, S. M. (2020) · Journal of Applied Microbiology · doi:10.1111/jam.14949 · Cited by 388 · see citing works
The impact of the Fungus-Host-Microbiota interplay uponCandida albicansinfections: current knowledge and new perspectives
d’Enfert, C., Kaune, A.-K., Alaban, L. R., Chakraborty, S., Cole, N. L., Delavy, M., Kosmala, D., Marsaux, B., Fróis-Martins, R., Morelli, M., et al. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa060 · Cited by 351 · see citing works
Self-citation
Candida albicans biofilms and polymicrobial interactions
Ponde, N. O., Lortal, L., Ramage, G., Naglik, J. R., & Richardson, J. P. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2020.1843400 · Cited by 281 · see citing works
Self-citation
Virulence Factors in Candida species
Staniszewska, M. (2019) · Current Protein and Peptide Science · doi:10.2174/1389203720666190722152415 · Cited by 281 · see citing works
Candida albicans biofilm growth and dispersal: contributions to pathogenesis
Wall, G., Montelongo-Jauregui, D., Vidal Bonifacio, B., Lopez-Ribot, J. L., & Uppuluri, P. (2019) · Current Opinion in Microbiology · doi:10.1016/j.mib.2019.04.001 · Cited by 263 · see citing works
Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap
Daneshnia, F., de Almeida Júnior, J. N., Ilkit, M., Lombardi, L., Perry, A. M., Gao, M., Nobile, C. J., Egger, M., Perlin, D. S., Zhai, B., et al. (2023) · The Lancet Microbe · doi:10.1016/s2666-5247(23)00067-8 · Cited by 257 · see citing works
Transcriptome Assembly and Profiling of Candida auris Reveals Novel Insights into Biofilm-Mediated Resistance
Kean, R., Delaney, C., Sherry, L., Borman, A., Johnson, E. M., Richardson, M. D., Rautemaa-Richardson, R., Williams, C., & Ramage, G. (2018) · mSphere · doi:10.1128/msphere.00334-18 · Cited by 220 · see citing works
Self-citation
Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida Species
Czajka, K. M., Venkataraman, K., Brabant-Kirwan, D., Santi, S. A., Verschoor, C. P., Appanna, V. D., Singh, R. I., Saunders, D., & Tharmalingam, S. (2023) · Cells · doi:10.3390/cells12222655 · Cited by 196 · see citing works
Risk factors for chronic biofilm-related infection associated with implanted medical devices
Stewart, P. S., & Bjarnsholt, T. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.02.027 · Cited by 177 · see citing works
Candida albicans biofilms: antifungal resistance, immune evasion, and emerging therapeutic strategies
Fan, F., Liu, Y., Liu, Y., Lv, R., Sun, W., Ding, W., Cai, Y., Li, W., Liu, X., & Qu, W. (2022) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2022.106673 · Cited by 137 · see citing works
Update from a 12-Year Nationwide Fungemia Surveillance: Increasing Intrinsic and Acquired Resistance Causes Concern
Astvad, K. M. T., Johansen, H. K., Røder, B. L., Rosenvinge, F. S., Knudsen, J. D., Lemming, L., Schønheyder, H. C., Hare, R. K., Kristensen, L., Nielsen, L., et al. (2018) · Journal of Clinical Microbiology · doi:10.1128/jcm.01564-17 · Cited by 125 · see citing works
Molecular basis of antifungal drug resistance in yeasts
Morio, F., Jensen, R. H., Le Pape, P., & Arendrup, M. C. (2017) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2017.05.012 · Cited by 114 · see citing works
Antifungal and biofilm inhibitory effect of Cymbopogon citratus (lemongrass) essential oil on biofilm forming by Candida tropicalis isolates; an in vitro study
Şahal, G., Woerdenbag, H. J., Hinrichs, W. L. J., Visser, A., Tepper, P. G., Quax, W. J., van der Mei, H. C., & Bilkay, I. S. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112188 · Cited by 112 · see citing works
Prevalence of biofilms in Candida spp. bloodstream infections: A meta-analysis
Atiencia-Carrera, M. B., Cabezas-Mera, F. S., Tejera, E., & Machado, A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263522 · Cited by 112 · see citing works
Rosmarinic acid–Modes of antimicrobial and antibiofilm activities of a common plant polyphenol
Ivanov, M., Kostić, M., Stojković, D., & Soković, M. (2022) · South African Journal of Botany · doi:10.1016/j.sajb.2021.11.050 · Cited by 98 · see citing works
Community Development betweenPorphyromonas gingivalisandCandida albicansMediated by InlJ and Als3
Sztukowska, M. N., Dutton, L. C., Delaney, C., Ramsdale, M., Ramage, G., Jenkinson, H. F., Nobbs, A. H., & Lamont, R. J. (2018) · mBio · doi:10.1128/mbio.00202-18 · Cited by 96 · see citing works
Self-citation
Attack, Defend and Persist: How the Fungal Pathogen Candida auris was Able to Emerge Globally in Healthcare Environments
de Jong, A. W., & Hagen, F. (2019) · Mycopathologia · doi:10.1007/s11046-019-00351-w · Cited by 98 · see citing works
Antifungal Resistance, Metabolic Routes as Drug Targets, and New Antifungal Agents: An Overview about Endemic Dimorphic Fungi
Parente-Rocha, J. A., Bailão, A. M., Amaral, A. C., Taborda, C. P., Paccez, J. D., Borges, C. L., & Pereira, M. (2017) · Mediators of Inflammation · doi:10.1155/2017/9870679 · Cited by 93 · see citing works
Piperine Impedes Biofilm Formation and Hyphal Morphogenesis of Candida albicans
Priya, A., & Pandian, S. K. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00756 · Cited by 96 · see citing works
Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation
Chang, W., Liu, J., Zhang, M., Shi, H., Zheng, S., Jin, X., Gao, Y., Wang, S., Ji, A., & Lou, H. (2018) · Nature Communications · doi:10.1038/s41467-018-07633-9 · Cited by 91 · see citing works
Candida auris: A Decade of Understanding of an Enigmatic Pathogenic Yeast
Kean, R., Brown, J. L., Gülmez, D., Ware, A., & Ramage, G. (2020) · Journal of Fungi · doi:10.3390/jof6010030 · Cited by 86 · see citing works
Self-citation
Antibiofilm Activities of Biogenic Silver Nanoparticles Against Candida albicans
Ahamad, I., Bano, F., Anwer, R., Srivastava, P., Kumar, R., & Fatma, T. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.741493 · Cited by 86 · see citing works
A Prospective Surveillance Study of Candidaemia: Epidemiology, Risk Factors, Antifungal Treatment and Outcome in Hospitalized Patients
Rajendran, R., Sherry, L., Deshpande, A., Johnson, E. M., Hanson, M., Williams, C., Munro, C. A., Jones, B., & Ramage, G. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00915 · Cited by 82 · see citing works
Self-citation
Biofilm Specific Activity: A Measure to Quantify Microbial Biofilm
Corte, L., Pierantoni, D. C., Tascini, C., Roscini, L., & Cardinali, G. (2019) · Microorganisms · doi:10.3390/microorganisms7030073 · Cited by 80 · see citing works
Candida auris Phenotypic Heterogeneity Determines Pathogenicity In Vitro
Brown, J. L., Delaney, C., Short, B., Butcher, M. C., McKloud, E., Williams, C., Kean, R., & Ramage, G. (2020) · mSphere · doi:10.1128/msphere.00371-20 · Cited by 76 · see citing works
Self-citation
Candida glabrata Antifungal Resistance and Virulence Factors, a Perfect Pathogenic Combination
León, M. G. F.-D., Hernández‐Castro, R., Conde-Cuevas, E., García-Coronel, I. H., Vázquez-Aceituno, V. A., Soriano-Ursua, M. A., Farfán‐García, E. D., Ocharan-Hernández, M. E., Rodríguez‐Cerdeira, C., Arenas, R., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101529 · Cited by 78 · see citing works
Fungal biofilms in human health and disease
Ramage, G., Kean, R., Rautemaa-Richardson, R., Williams, C., & Lopez-Ribot, J. L. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01147-0 · Cited by 72 · see citing works
Self-citation
Candida biofilm production is associated with higher mortality in patients with candidaemia
Vitális, E., Nagy, F., Tóth, Z., Forgács, L., Bozó, A., Kardos, G., Majoros, L., & Kovács, R. (2020) · Mycoses · doi:10.1111/myc.13049 · Cited by 72 · see citing works
Antifungal Potential of Copper(II), Manganese(II) and Silver(I) 1,10-Phenanthroline Chelates Against Multidrug-Resistant Fungal Species Forming the Candida haemulonii Complex: Impact on the Planktonic and Biofilm Lifestyles
Gandra, R. M., Carron, P. M., Fernandes, M. F., Ramos, L. S., de Mello, T. P., Aor, A. C., Branquinha, M. H., McCann, M., Devereux, M. M., & dos Santos, A. L. S. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01257 · Cited by 71 · see citing works
Virus-Derived Peptides for Clinical Applications
Yang, M., Sunderland, K. S., & Mao, C. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00100 · Cited by 68 · see citing works
Candida auris: a comparison between planktonic and biofilm susceptibility to antifungal drugs
Romera, D., Aguilera-Correa, J. J., Gadea, I., Viñuela-Sandoval, L., García‐Rodríguez, J., & Esteban, J. (2019) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001036 · Cited by 68 · see citing works
Screening the Pathogen Box for Identification of Candida albicans Biofilm Inhibitors
Vila, T. V. M., & Lopez-Ribot, J. L. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02006-16 · Cited by 64 · see citing works
Relative Abundances of Candida albicans and Candida glabrata in In Vitro Coculture Biofilms Impact Biofilm Structure and Formation
Olson, M. L., Jayaraman, A., & Kao, K. C. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.02769-17 · Cited by 73 · see citing works
The Impact of Biofilm Formation on the Persistence of Candidemia
Li, W., Chen, Y., Kuo, S., Chen, F., & Lee, C. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01196 · Cited by 63 · see citing works
5-hydroxymethyl-2-furaldehyde from marine bacterium Bacillus subtilis inhibits biofilm and virulence of Candida albicans
Ganapathy, A. S., Swetha, T. K., Prasanth, M. I., Balamurugan, K., & Pandian, S. K. (2017) · Microbiological Research · doi:10.1016/j.micres.2017.11.002 · Cited by 60 · see citing works
Transcriptomic and Genomic Approaches for Unravelling Candida albicans Biofilm Formation and Drug Resistance—An Update
Chong, P. P., Chin, V. K., Wong, W. F., Madhavan, P., Yong, P. V. C., & Looi, C. Y. (2018) · Genes · doi:10.3390/genes9110540 · Cited by 56 · see citing works
Advances in Biomaterials for the Prevention and Disruption of Candida Biofilms
Vera‐González, N., & Shukla, A. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.538602 · Cited by 59 · see citing works
Microbiologic and clinical characteristics of biofilm-forming Candida parapsilosis isolates associated with fungaemia and their impact on mortality
Soldini, S., Posteraro, B., Vella, A., Carolis, E. D., Borghi, E., Falleni, M., Losito, A. R., Maiuro, G., Trecarichi, E. M., Sanguinetti, M., et al. (2017) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2017.11.005 · Cited by 56 · see citing works
Gaining Insights from Candida Biofilm Heterogeneity: One Size Does Not Fit All
Kean, R., Delaney, C., Rajendran, R., Sherry, L., Metcalfe, R., Thomas, R., McLean, W., Williams, C., & Ramage, G. (2018) · Journal of Fungi · doi:10.3390/jof4010012 · Cited by 53 · see citing works
Self-citation
Candida guilliermondii Complex Is Characterized by High Antifungal Resistance but Low Mortality in 22 Cases of Candidemia
Marcos-Zambrano, L. J., Puig‐Asensio, M., Pérez‐García, F., Escribano, P., Sánchez‐Carrillo, C., Zaragoza, Ó., Padilla, B., Cuenca‐Estrella, M., Almirante, B., Martín-Gómez, M. T., et al. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00099-17 · Cited by 54 · see citing works
Potential Strategies to Control the Risk of Antifungal Resistance in Humans: A Comprehensive Review
Rabaan, A. A., Sulaiman, T., Al-Ahmed, S. H., Buhaliqah, Z. A., Buhaliqah, A. A., AlYuosof, B., Alfaresi, M. S., Fares, M. A. A., Alwarthan, S. M., Alkathlan, M. S., et al. (2023) · Antibiotics · doi:10.3390/antibiotics12030608 · Cited by 53 · see citing works
Miltefosine inhibits Candida albicans and non-albicans Candida spp. biofilms and impairs the dispersion of infectious cells
Vila, T. V. M., Ishida, K., Seabra, S. H., & Rozental, S. (2016) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2016.07.022 · Cited by 52 · see citing works
Candida glabrata ( Nakaseomyces glabrata ): A systematic review of clinical and microbiological data from 2011 to 2021 to inform the World Health Organization Fungal Priority Pathogens List
Beardsley, J., Kim, H. Y., Dao, A., Kidd, S. E., Alastruey‐Izquierdo, A., Sorrell, T. C., Tacconelli, E., Chakrabarti, A., Harrison, T. S., Bongomin, F., et al. (2024) · Medical Mycology · doi:10.1093/mmy/myae041 · Cited by 51 · see citing works
Biofilm Formation by Pseudallescheria/Scedosporium Species: A Comparative Study
Rollin‐Pinheiro, R., de Meirelles, J. V., Vila, T. V. M., Fonseca, B. B., Alves, V., Frasés, S., Rozental, S., & Barreto‐Bergter, E. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01568 · Cited by 50 · see citing works
Integrating Candida albicans metabolism with biofilm heterogeneity by transcriptome mapping
Rajendran, R., May, A., Sherry, L., Kean, R., Williams, C., Jones, B., Burgess, K., Heringa, J., Abeln, S., Brandt, B. W., et al. (2016) · Scientific Reports · doi:10.1038/srep35436 · Cited by 48 · see citing works
Self-citation
Recent advances in the application of biofilm in bioremediation of industrial wastewater and organic pollutants
Maurya, A., & Raj, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819001-2.00005-x · Cited by 49 · see citing works
Clinical characteristics, risk factors and outcomes of mixed Candida albicans/bacterial bloodstream infections
Zhong, L., Zhang, S., Tang, K., Zhou, F., Zheng, C., Zhang, K., Cai, J., Zhou, H., Wang, Y., Tian, B., et al. (2020) · BMC Infectious Diseases · doi:10.1186/s12879-020-05536-z · Cited by 48 · see citing works
Determinants of fluconazole resistance and echinocandin tolerance in C. parapsilosis isolates causing a large clonal candidemia outbreak among COVID-19 patients in a Brazilian ICU
Daneshnia, F., de Almeida, J. N., Arastehfar, A. A., Lombardi, L., Shor, E., Moreno, L., Mendes, A. V. A., Barberino, M. G., Thomaz, D. Y., Butler, G., et al. (2022) · Emerging Microbes & Infections · doi:10.1080/22221751.2022.2117093 · Cited by 47 · see citing works
The antifungal and antibiofilm activity of Cymbopogon nardus essential oil and citronellal on clinical strains of Candida albicans
Trindade, L. A., Cordeiro, L. V., Silva, D., de Figueiredo, P. T. R., de Pontes, M. L. C., Lima, E. D. O., & Carvalho, A. D. A. T. (2022) · Brazilian Journal of Microbiology · doi:10.1007/s42770-022-00740-2 · Cited by 45 · see citing works
Our current clinical understanding of Candida biofilms: where are we two decades on?
Ramage, G., Borghi, E., Rodrigues, C. F., Kean, R., Williams, C., & Lopez-Ribot, J. L. (2023) · Apmis · doi:10.1111/apm.13310 · Cited by 45 · see citing works
Self-citation
Role of the extracellular matrix in Candida biofilm antifungal resistance
Massey, J., Żarnowski, R., & Andes, D. R. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad059 · Cited by 47 · see citing works
Prevalence and Impact of Biofilms on Bloodstream and Urinary Tract Infections: A Systematic Review and Meta-Analysis
Pinto, H., Simões, M. V., & Borges, A. D. S. (2021) · Antibiotics · doi:10.3390/antibiotics10070825 · Cited by 44 · see citing works
The role of biofilm forming on mortality in patients with candidemia: a study derived from real world data
Tascini, C., Sozio, E., Corte, L., Sbrana, F., Scarparo, C., Ripoli, A., Bertolino, G., Merelli, M., Tagliaferri, E., Corcione, A., et al. (2017) · Scandinavian Journal of Infectious Diseases · doi:10.1080/23744235.2017.1384956 · Cited by 45 · see citing works
Synergistic effect of nikkomycin Z with caspofungin and micafungin against Candida albicans and Candida parapsilosis biofilms
Kovács, R., Nagy, F., Tóth, Z., Bozó, A., Balázs, B., & Majoros, L. (2019) · Letters in Applied Microbiology · doi:10.1111/lam.13204 · Cited by 42 · see citing works
New N-(oxazolylmethyl)-thiazolidinedione Active against Candida albicans Biofilm: Potential Als Proteins Inhibitors
Marc, G., Araniciu, C., Oniga, S. D., Vlase, L., Pı̂rnău, A., Duma, M. N., Marutescu, L. G., Chifiriuc, M. C., & Oniga, O. (2018) · Molecules · doi:10.3390/molecules23102522 · Cited by 40 · see citing works
High-contrast Brillouin and Raman micro-spectroscopy for simultaneous mechanical and chemical investigation of microbial biofilms
Mattana, S., Cardinali, M. A., Caponi, S., Pierantoni, D. C., Corte, L., Roscini, L., Cardinali, G., & Fioretto, D. (2017) · Biophysical Chemistry · doi:10.1016/j.bpc.2017.06.008 · Cited by 36 · see citing works
Interkingdom interactions on the denture surface: Implications for oral hygiene
Delaney, C., O’Donnell, L. E., Kean, R., Sherry, L., Brown, J. L., Calvert, G., Nile, C. J., Cross, L. J., Bradshaw, D. J., Brandt, B. W., et al. (2019) · Biofilm · doi:10.1016/j.bioflm.2019.100002 · Cited by 36 · see citing works
Self-citation
Candida blood stream infections observed between 2011 and 2016 in a large Italian University Hospital: A time-based retrospective analysis on epidemiology, biofilm production, antifungal agents consumption and drug-susceptibility
Brunetti, G., Navazio, A. S., Giuliani, A., Giordano, A., Proli, E. M., Antonelli, G., & Raponi, G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224678 · Cited by 36 · see citing works
Prevalence of Candida blood stream infections among children in tertiary care hospital: detection of species and antifungal susceptibility
Khairat, S. M., Sayed, A. M., Nabih, M., Soliman, N. S., & Hassan, Y. M. (2019) · Infection and Drug Resistance · doi:10.2147/idr.s196972 · Cited by 35 · see citing works
Functional diversification accompanies gene family expansion of MED2 homologs in Candida albicans
Dunn, M. J., Kinney, G. M., Washington, P. M., Berman, J. G., & Anderson, M. Z. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007326 · Cited by 34 · see citing works
The Synergism of the Small Molecule ENOblock and Fluconazole Against Fluconazole-Resistant Candida albicans
Li, L., Zhang, T., Xu, J., Wu, J., Wang, Y., Qiu, X.-R., Zhang, Y., Hou, W.-T., Yan, L., An, M., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02071 · Cited by 34 · see citing works
Candida Pathogenicity and Interplay with the Immune System
Valand, N., & Girija, U. V. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-67452-6_11 · Cited by 36 · see citing works
Antibiofilm activities of ceragenins and antimicrobial peptides against fungal-bacterial mono and multispecies biofilms
Hacıoğlu, M., Oyardı, Ö., Guzel, C. B., & Savage, P. B. (2020) · The Journal of Antibiotics · doi:10.1038/s41429-020-0299-0 · Cited by 33 · see citing works
The relationship between biofilm formation and mortality in patients with Candida tropicalis candidemia
Sasani, E., Khodavaisy, S., Rezaie, S., Salehi, M., & Yadegari, M. H. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.104889 · Cited by 33 · see citing works
Fungal Metabolites for the Control of Biofilm Infections
Estrela, A. B., & Abraham, W. (2016) · Agriculture · doi:10.3390/agriculture6030037 · Cited by 33 · see citing works
The possible molecular mechanisms of farnesol on the antifungal resistance of C. albicans biofilms: the regulation of CYR1 and PDE2
Chen, S., Xia, J., Li, C., Zuo, L., & Wei, X. (2018) · BMC Microbiology · doi:10.1186/s12866-018-1344-z · Cited by 32 · see citing works
Potency of gastrointestinal colonization and virulence of Candida auris in a murine endogenous candidiasis
Abe, M., Katano, H., Nagi, M., Higashi, Y., Sato, Y., Kikuchi, K., Hasegawa, H., & Miyazaki, Y. (2020) · PLoS ONE · doi:10.1371/journal.pone.0243223 · Cited by 32 · see citing works
Macrophage Migration Is Impaired within Candida albicans Biofilms
Alonso, M., Gow, N. A. R., Erwig, L. P., & Bain, J. M. (2017) · Journal of Fungi · doi:10.3390/jof3030031 · Cited by 32 · see citing works
WMR Peptide as Antifungal and Antibiofilm against Albicans and Non-Albicans Candida Species: Shreds of Evidence on the Mechanism of Action
Maione, A., Bellavita, R., de Alteriis, E., Galdiero, S., Albarano, L., Pietra, A. L., Guida, M., Parrilli, E., D’Angelo, C., Galdiero, E., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042151 · Cited by 31 · see citing works
Clinical outcome of Escherichia coli bloodstream infection in cancer patients with/without biofilm formation: a single-center retrospective study
Zhang, Q., Gao, H.-Y., Ding, L., Li, Z., Qi, S., Zheng, S., Bai, C., & Zhang, S. (2019) · Infection and Drug Resistance · doi:10.2147/idr.s192072 · Cited by 30 · see citing works
Heme Competition Triggers an Increase in the Pathogenic Potential of Porphyromonas gingivalis in Porphyromonas gingivalis-Candida albicans Mixed Biofilm
Guo, Y., Wang, Y., Wang, Y., Jin, Y., & Wang, C. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.596459 · Cited by 30 · see citing works
Nanoscale Surface Roughness Influences Candida albicans Biofilm Formation
Le, P. H., Nguyen, H., Aburto‐Medina, A., Linklater, D. P., Crawford, R. J., MacLaughlin, S. A., & Ivanova, E. P. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00985 · Cited by 29 · see citing works
Ellagic Acid–Cyclodextrin Complexes for the Treatment of Oral Candidiasis
Sampaio, A. D. G., Gontijo, A. V. L., Lima, G. D. M. G., de Oliveira, M. A. C., Lepesqueur, L. S. S., & Koga‐Ito, C. Y. (2021) · Molecules · doi:10.3390/molecules26020505 · Cited by 29 · see citing works
Population genetics and microevolution of clinical Candida glabrata reveals recombinant sequence types and hyper-variation within mitochondrial genomes, virulence genes, and drug targets
Helmstetter, N., Chybowska, A. D., Delaney, C., Dantas, A. D. S., Gifford, H., Wacker, T., Munro, C. A., Warris, A., Jones, B. L., Cuomo, C. A., et al. (2022) · Genetics · doi:10.1093/genetics/iyac031 · Cited by 29 · see citing works
Self-citation
Microbiota-driven interleukin-17 production provides immune protection against invasive candidiasis
Li, M., Li, C., Wu, X., Chen, T., Ren, L., Xu, B., & Cao, J. (2020) · Critical Care · doi:10.1186/s13054-020-02977-5 · Cited by 28 · see citing works
Targeting pathogenic fungi, bacteria and fungal-bacterial biofilms by newly synthesized quaternary ammonium derivative of pyridoxine and terbinafine with dual action profile
Garipov, M. R., Sabirova, A. E., Pavelyev, R. S., Валерьевич, Ш. Н., Lisovskaya, S. А., Bondar, O. V., Laikov, A. V., Romanova, J. G., Bogachev, M. I., Kayumov, A. R., et al. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.104306 · Cited by 28 · see citing works
Anti-Biofilm Activity of Phenyllactic Acid against Clinical Isolates of Fluconazole-Resistant Candida albicans
Maione, A., Imparato, M., Buonanno, A., Carraturo, F., Schettino, A., Schettino, M. T., Galdiero, M., de Alteriis, E., Guida, M., & Galdiero, E. (2023) · Journal of Fungi · doi:10.3390/jof9030355 · Cited by 28 · see citing works
Identification of Virulence Factors in Isolates of Candida haemulonii, Candida albicans and Clavispora lusitaniae with Low Susceptibility and Resistance to Fluconazole and Amphotericin B
Angiolella, L., Rojas, F. D., Giammarino, A., Bellucci, N., & Giusiano, G. (2024) · Microorganisms · doi:10.3390/microorganisms12010212 · Cited by 27 · see citing works
Antimicrobial and Biofilm-Preventing Activity of l-Borneol Possessing 2(5H)-Furanone Derivative F131 against S. aureus—C. albicans Mixed Cultures
Sulaiman, R. K., Trizna, E. Y., Kolesnikova, A. I., Мунавировна, Х. А., Рафаэловна, К. А., Bogachev, M. I., & Kayumov, A. R. (2022) · Pathogens · doi:10.3390/pathogens12010026 · Cited by 28 · see citing works
Skin and hard surface disinfection against Candida auris – What we know today
Omardien, S., & Teska, P. J. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1312929 · Cited by 29 · see citing works
Inhibitory Effects of Photodynamic Inactivation on Planktonic Cells and Biofilms of Candida auris
Tan, J., Liu, Z., Sun, Y., Yang, L., & Gao, L. (2019) · Mycopathologia · doi:10.1007/s11046-019-00352-9 · Cited by 26 · see citing works
Candida albicans Biofilm Heterogeneity and Tolerance of Clinical Isolates: Implications for Secondary Endodontic Infections
Alshanta, O. A., Shaban, S. M. A., Nile, C. J., McLean, W., & Ramage, G. (2019) · Antibiotics · doi:10.3390/antibiotics8040204 · Cited by 26 · see citing works
Self-citation
Candida albicans cell wall as a target of action for the protein–carbohydrate fraction from coelomic fluid of Dendrobaena veneta
Fiołka, M. J., Wójcik-Mieszawska, S., Czaplewska, P., Szymańska, A., Stępnik, K. E., Sofińska-Chmiel, W., Buchwald, T., & Lewtak, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-73044-w · Cited by 27 · see citing works
Biofilm production is not associated with poor clinical outcome in 485 patients with Staphylococcus aureus bacteraemia
Guembe, M., Alonso, B., Lucio, J., Pérez-Granda, M. J., Cruces, R., Sánchez‐Carrillo, C., Fernández‐Cruz, A., & Bouza, E. (2017) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2017.10.018 · Cited by 26 · see citing works
Chlorpromazine-Impregnated Catheters as a Potential Strategy to Control Biofilm-Associated Urinary Tract Infections
Sidrim, J. J. C., Amando, B. R., Gomes, F. I. F., Amaral, M. S. M. G., de Sousa, P. C. P., Ocadaque, C. J., Brilhante, R. S., Cordeiro, R. D. A., Rocha, M. F. G., & de, S. C. M. C.-B. D. (2019) · Future Microbiology · doi:10.2217/fmb-2019-0092 · Cited by 27 · see citing works
Exploring ecological modelling to investigate factors governing the colonization success in nosocomial environment of Candida albicans and other pathogenic yeasts
Corte, L., Roscini, L., Colabella, C., Tascini, C., Leonildi, A., Sozio, E., Menichetti, F., Merelli, M., Scarparo, C., Meyer, W., et al. (2016) · Scientific Reports · doi:10.1038/srep26860 · Cited by 24 · see citing works
Candida albicans biofilm heterogeneity does not influence denture stomatitis but strongly influences denture cleansing capacity
O’Donnell, L. E., Alalwan, H. K. A., Kean, R., Calvert, G., Nile, C. J., Lappin, D. F., Robertson, D. P., Williams, C., Ramage, G., & Sherry, L. (2016) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000419 · Cited by 25 · see citing works
Self-citation
Clinical impact of Candida spp. biofilm production in a cohort of patients with candidemia
Monfredini, P. M., Souza, A. C. R., Cavalheiro, R. P., Siqueira, R. A., & Colombo, A. L. (2017) · Medical Mycology · doi:10.1093/mmy/myx133 · Cited by 25 · see citing works
Synthesis of novel proxyphylline derivatives with dual Anti-Candida albicans and anticancer activity
Borowiecki, P., Wińska, P., Bretner, M., Gizińska, M., Koronkiewicz, M., & Staniszewska, M. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.02.077 · Cited by 25 · see citing works
Candida isolates causing candidemia show different degrees of virulence in Galleria mellonella
Marcos-Zambrano, L. J., Bordallo-Cardona, M. Á., Borghi, E., Falleni, M., Tosi, D., Muñoz, P., Escribano, P., & Guinea, J. (2020) · Medical Mycology · doi:10.1093/mmy/myz027 · Cited by 25 · see citing works
Comparing apples and oranges: considerations for quantifying candidal biofilms with XTT [2,3-bis(2-methoxy-4-nitro-5-sulfo-phenyl)-2H-tetrazolium-5-carboxanilide] and the need for standardized testing
Ramage, G. (2016) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000237 · Cited by 24 · see citing works
Self-citation
Contact Active Antimicrobial Coatings Prepared by Polymer Blending
Cuervo‐Rodríguez, R., López, F., Gómez-Garcés, J. L., Muñoz‐Bonilla, A., & Fernández‐García, M. (2017) · Macromolecular Bioscience · doi:10.1002/mabi.201700258 · Cited by 24 · see citing works
Emergence of Trichosporon mycotoxinivorans (Apiotrichum mycotoxinivorans) invasive infections in Latin America
de Almeida, J. N., Francisco, E. C., Barberino, M. G., Filho, L. V. R. F. D. S., Brandão, O. M., Colombo, A. L., & Padovan, A. C. B. (2017) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760170011 · Cited by 23 · see citing works
Is biofilm production a prognostic marker in adults with candidaemia?
Muñóz, P., Agnelli, C., Guinea, J., Vena, A., Álvarez-Uría, A., Marcos-Zambrano, L. J., Escribano, P., Valerio, M., & Bouza, E. (2018) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2018.01.022 · Cited by 23 · see citing works
Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans
Jiang, Y. Y., Su, L., Liao, Y.-C., Shen, Y., Gao, H., Zhang, Y., Wang, R., & Mao, Z. (2022) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2022.128525 · Cited by 22 · see citing works
Mutant Prevention Concentration and Mutant Selection Window of Micafungin and Anidulafungin in Clinical Candida glabrata Isolates
Bordallo-Cardona, M. Á., Marcos-Zambrano, L. J., Sánchez‐Carrillo, C., de la Pedrosa, E. G. G., Cantón, R., Bouza, E., Escribano, P., & Guinea, J. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01982-17 · Cited by 21 · see citing works
Effect of Cold Atmospheric Plasma Jet Associated to Polyene Antifungals on Candida albicans Biofilms
Leite, L. D. P., de Oliveira, M. A. C., Vegian, M. R. D. C., Sampaio, A. D. G., Nishime, T. M. C., Kostov, K. G., & Koga‐Ito, C. Y. (2021) · Molecules · doi:10.3390/molecules26195815 · Cited by 21 · see citing works
Discovery of Novel 8-Hydroxyquinoline Derivatives with Potent In Vitro and In Vivo Antifungal Activity
Li, L., Wu, H., Wang, J., Ji, Z., Fang, T., Lu, H., Yan, L., Shen, F., Zhang, D., Jiang, Y., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c01771 · Cited by 21 · see citing works
Antifungal Resistance and Virulence Among Candida spp. from Captive Amazonian manatees and West Indian Manatees: Potential Impacts on Animal and Environmental Health
Sidrim, J. J. C., Carvalho, V. L., Castelo‐Branco, D. D. S. C. M., Brilhante, R. S. N., Guedes, G. M. D. M., Riello, G. B. C., Lazzarini, S. M., Oliveira, D. C. R., de Meirelles, A. C. O., Attademo, F. L. N., et al. (2016) · EcoHealth · doi:10.1007/s10393-015-1090-8 · Cited by 21 · see citing works

Biofilm Production by Candida Species and Inadequate Antifungal Therapy as Predictors of Mortality for Patients with Candidemia
Tumbarello, M., Posteraro, B., Trecarichi, E. M., Fiori, B., Rossi, M., Porta, R., de Gaetano Donati, K., La Sorda, M., Spanu, T., Fadda, G., et al. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.00131-07 · Cited by 343 · see citing works
Effects of biofilm formation and plethora of Candida species causing ailments: a mini review
Aliyu, A. (2022) · Gadau Journal of Pure and Allied Sciences · doi:10.54117/gjpas.v1i2.27 · Cited by 3 · see citing works
Association between Candida biofilm-forming bloodstream isolates and the clinical evolution in patients with candidemia: An observational nine-year single center study in Mexico
Treviño‐Rangel, R. D. J., Peña-López, C. D., Hernández-Rodríguez, P. A., Beltrán-Santiago, D., & González, G. M. (2017) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2017.01.005 · Cited by 20 · see citing works
Candida biofilm production is associated with higher mortality in patients with candidaemia
Vitális, E., Nagy, F., Tóth, Z., Forgács, L., Bozó, A., Kardos, G., Majoros, L., & Kovács, R. (2020) · Mycoses · doi:10.1111/myc.13049 · Cited by 72 · see citing works
Risk Factors and Outcomes of Candidemia Caused by Biofilm-Forming Isolates in a Tertiary Care Hospital
Tumbarello, M., Fiori, B., Trecarichi, E. M., Posteraro, P., Losito, A. R., Luca, A. D., Sanguinetti, M., Fadda, G., Cauda, R., & Posteraro, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033705 · Cited by 197 · see citing works

Authors: Rajendran, R., Sherry, L., Nile, C. J., Sherriff, A., Johnson, E. M., Hanson, M. F., Williams, C., Munro, C. A., Jones, B. J., & Ramage, G.
Affiliations: University of Glasgow (GB)
Public Health England (GB)
NHS Lothian (GB)
University of the West of Scotland (GB)
University of Aberdeen (GB)
Glasgow Royal Infirmary (GB)
Corresponding author: Ramage, G.
ORCID: Rajendran, R.
Sherry, L.
Nile, C.J.
Sherriff, A.
Johnson, E.M.
Williams, C.
Munro, C.A.
Ramage, G.
Venue: Clinical Microbiology and Infection
Publisher: Elsevier BV
Published: 2016-01
Volume: 22
Issue: 1
Pages: 87-93
ISSN: 1198-743X (ISSN-L)
DOI: 10.1016/j.cmi.2015.09.018
PMC: PMC4721535
OpenAlex: W1960109612
Cited by: 228
References: 25
Citations by year: 2026: 14 · 2025: 16 · 2024: 18 · 2023: 22 · 2022: 25 · 2021: 17 · 2020: 25 · 2019: 22 · 2018: 24 · 2017: 29 · 2016: 16
FWCI: 17.91
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Clinical Microbiology and Infection (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
The UWS Academic Portal (University of the West of Scotland) (submittedVersion, cc-by)
Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
Newcastle University ePrints (Newcastle Univesity) (cc-by)
Funders: Wellcome Trust (097377/Z/11/Z)
Pfizer
Gilead Sciences
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: Candida albicans, Candida glabrata, biofilm formation, candidemia, bloodstream infection, mortality risk factors, antifungal susceptibility, echinocandins, azoles, polyenes, virulence factors, catheter removal
MeSH terms: Adult, Aged, Aged, 80 and over, Antifungal Agents, Candida albicans, Female, Humans, Male, Middle Aged, Mortality, Retrospective Studies, Scotland, Incidence, Biofilms, Risk Assessment, Candida glabrata, Candidemia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Biofilm formation is a risk factor for mortality in patients with Candida albicans bloodstream infection—Scotland, 2012–2013

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks