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Cited by 697

The DOI matches its Crossref record; 153 of the 153 references it cites were found in a registry or an index.

Demineralization–remineralization dynamics in teeth and bone

Open access
Abou Neel, Ensanya, Aljabo, Anas, Strange, Adam, Ibrahim, Salwa, Coathup, Melanie, Young, Anne, Bozec, Laurent, Mudera, Vivek·2016·International Journal of Nanomedicine

Abstract

Biomineralization is a dynamic, complex, lifelong process by which living organisms control precipitations of inorganic nanocrystals within organic matrices to form unique hybrid biological tissues, for example, enamel, dentin, cementum, and bone. Understanding the process of mineral deposition is important for the development of treatments for mineralization-related diseases and also for the innovation and development of scaffolds. This review provides a thorough overview of the up-to-date information on the theories describing the possible mechanisms and the factors implicated as agonists and antagonists of mineralization. Then, the role of calcium and phosphate ions in the maintenance of teeth and bone health is described. Throughout the life, teeth and bone are at risk of demineralization, with particular emphasis on teeth, due to their anatomical arrangement and location. Teeth are exposed to food, drink, and the microbiota of the mouth; therefore, they have developed a high resistance to localized demineralization that is unmatched by bone. The mechanisms by which demineralization-remineralization process occurs in both teeth and bone and the new therapies/technologies that reverse demineralization or boost remineralization are also scrupulously discussed. Technologies discussed include composites with nano- and micron-sized inorganic minerals that can mimic mechanical properties of the tooth and bone in addition to promoting more natural repair of surrounding tissues. Turning these new technologies to products and practices would improve health care worldwide.

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Crossref · 10.2147/ijn.s107624

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Metadata

Authors
Abou Neel, E., Aljabo, A., Strange, A., Ibrahim, S., Coathup, M., Young, A., Bozec, L., & Mudera, V.
Venue
International Journal of Nanomedicine
Published
2016-09
Volume
Volume 11
Pages
4743-4763
ISSN
  • 1176-9114 (ISSN-L)
  • 1178-2013
OpenAlex
W2523687761
Cited by
697
References
153
FWCI
11.70
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Demineralization–remineralization dynamics in teeth and bone. https://app.cochat.ai/papers/10.2147/ijn.s107624
The paper
Abou Neel, E., Aljabo, A., Strange, A., Ibrahim, S., Coathup, M., Young, A., Bozec, L., & Mudera, V. (2016). Demineralization–remineralization dynamics in teeth and bone. International Journal of Nanomedicine. https://doi.org/10.2147/ijn.s107624

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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