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Cited by 264Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsDendrimers and Hyperbranched Polymers

Recent advances in PEG–PLA block copolymer nanoparticles

Open access
Zeng, Zhaowu·2010·International Journal of Nanomedicine
DOI 10.2147/ijn.s14912PMC PMC3000205
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Abstract

Due to their small particle size and large and modifiable surface, nanoparticles have unique advantages compared with other drug carriers. As a research focus in recent years, polyethylene glycol-polylactic acid (PEG-PLA) block copolymer and its end-group derivative nanoparticles can enhance the drug loading of hydrophobic drugs, reduce the burst effect, avoid being engulfed by phagocytes, increase the circulation time of drugs in blood, and improve bioavailability. Additionally, due to their smaller particle size and modified surface, these nanoparticles can accumulate in inflammation or target locations to enhance drug efficacy and reduce toxicity. Recent advances in PEG-PLA block copolymer nanoparticles, including the synthesis of PEG-PLA and the preparation of PEG-PLA nanoparticles, were introduced in this study, in particular the drug release and modifiable characteristics of PEG-PLA nanoparticles and their application in pharmaceutical preparations.

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  • PCL, PDLLA, and PLGA are examples of polyesters used to solubilize hydrophobic drugs.

    “Examples of polyesters for solubilizing hydrophobic drugs are PCL, PDLLA and PLGA [106–108].”

    From Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval. (2020) · cites this paper as [108]

    The sustained- and controlled-release section (page unavailable) says hydrophobic drugs can be dissolved or dispersed in a PLA matrix. The References section mentions poly(D,L-lactic acid) in a study of hydrophobic-drug release, but it does not establish PCL or PLGA as polyesters used to solubilize such drugs. The cited paper therefore supports the claim only for the PLA-related example, not the full three-polyester list. (LLM, conf=0.84)

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Authors
Zeng, Z.
Affiliations
Zhejiang Chinese Medical University (CN)
Corresponding author
Zeng, Zhaowu
ORCID
Zeng, Zhaowu
Venue
International Journal of Nanomedicine
Publisher
Informa UK Limited
Published
2010-11
Volume
5
Pages
1057
ISSN
  • 1176-9114 (ISSN-L)
  • 1178-2013
DOI
10.2147/ijn.s14912
PMC
PMC3000205
OpenAlex
W2027048152
Cited by
264
References
2
Citations by year
2026: 5 · 2025: 9 · 2024: 15 · 2023: 16 · 2022: 11 · 2021: 21 · 2020: 24 · 2019: 20 · 2018: 21 · 2017: 29 · 2016: 23 · 2015: 23 · 2014: 12 · 2013: 12 · 2012: 17
FWCI
0.55
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Nanomedicine (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Funders
  • National Natural Science Foundation of China (20906016)
  • China Postdoctoral Science Foundation
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
Keywords
nanoparticles, drug carriers, hydrophobic drug loading, burst release, circulation time, bioavailability, targeted drug delivery, inflammation targeting, drug release, nanoparticle synthesis, surface modification, pharmaceutical preparations
MeSH terms
Animals, Humans, Polyethylene Glycols, Drug Delivery Systems, Nanoparticles

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