Cholesterol-conjugated poly(D, L-lactide)-based micelles as a nanocarrier system for effective delivery of curcumin in cancer therapy
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Polymeric micelles have been widely explored preclinically as suitable delivery systems for poorly soluble chemotherapeutic drugs in cancer therapy. The present study reported the development of cholesterol (Ch)-conjugated poly(D,L-Lactide) (PLA)-based polymeric micelles (mPEG–PLA-Ch) for effective encapsulation and delivery of curcumin (CUR) at the tumor site. Cholesterol conjugation dramatically affected the particle size and improved drug loading (DL) and encapsulation efficiency (EE). mPEG–PLA-Ch-CUR showed bigger hydrodynamic diameter (104.6 ± 2.1 nm, and 169.3 ± 1.52 nm for mPEG–PLA and mPEG–PLA-Ch, respectively) due to increased size of the hydrophobic core. The newly developed polymer exhibited low critical micelles concentration (CMC) (25 μg/mL) which is close to lipid-based polymer, PEG-phosphatidyl ethanolamine (12.5 μg/mL) compared to mPEG–PLA (50 μg/mL). mPEG–PLA-Ch micelles exhibited relatively higher EE (93.74 ± 1.6%) and DL (11.86 ± 0.8%) compared to mPEG–PLA micelles (EE 91.89 ± 1.2% and DL 11.06 ± 0.8%). mPEG–PLA-Ch micelles were internalized by the cancer cells effectively and exhibited higher cytotoxicity compared to free CUR in both, murine melanoma (B16F10) and human breast cancer (MDA-MB-231) cells. mPEG–PLA-Ch exhibited satisfactory hemocompatibility indicating their potential for systemic application. Further, mPEG–PLA-Ch-CUR demonstrated higher rate of reduction of tumor volume in B16F10-xenografted tumor-bearing mice compared to free CUR. At the end of 22 days, the tumor reduced to 1.87-fold (627.72 ± 0.9 mm3 versus 1174.68 ± 1.64 mm3) compared to the treatment with free CUR. In conclusion, the experimental data in vitro and in vivo indicated that the newly developed CUR-mPEG–PLA-Ch micelles may have promising applications in solid tumors.
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Curcumin-embedded mPEG-PLA-Ch micelles significantly reduced tumor volume in the B16-F10 xenograft tumor model compared to pure curcumin.
“Curcumin-embedded mPEG-PLA-Ch micelles significantly reduced the tumor volume in the B16-F10 xenograft tumor model compared to that obtained with pure curcumin.248”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [248]
Conjugation of cholesterol altered particle size and enhanced encapsulation efficiency.
“The conjugation of cholesterol altered the particle size and enhanced the encapsulation efficiency.”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [248]
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Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
OWENSIII, D., & PEPPAS, N. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.10.010 · Cited by 3,637 · see citing works
Biodegradable Long-Circulating Polymeric Nanospheres
Gref, R., Minamitake, Y., Peracchia, M. T., Trubetskoy, V. S., Torchilin, V. P., & Langer, R. (1994) · Science · doi:10.1126/science.8128245 · Cited by 2,924 · see citing works
Tumor delivery of macromolecular drugs based on the EPR effect
Torchilin, V. P. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.03.011 · Cited by 2,032 · see citing works
Gref, R., Lück, M., Quellec, P., Marchand, M., Dellacherie, E., Harnisch, S., Blunk, T., & Müller, R. H. (2000) · Colloids and Surfaces B Biointerfaces · doi:10.1016/s0927-7765(99)00156-3 · Cited by 1,725 · see citing works
Stability of curcumin in buffer solutions and characterization of its degradation products
Wang, Y., Pan, M., Cheng, A., Lin, L., Ho, Y., Hsieh, C., & Lin, J. (1997) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(96)02024-9 · Cited by 1,709 · see citing works
Cholesterol and the cell membrane
Yèagle, P. L. (1985) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(85)90011-5 · Cited by 1,492 · see citing works
Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer
Dhillon, N., Aggarwal, B. B., Newman, R. A., Wolff, R. A., Kunnumakkara, A. B., Abbruzzese, J. L., Ng, C. S., Badmaev, V., & Kurzrock, R. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0024 · Cited by 1,337 · see citing works
Role of cholesterol and lipid organization in disease
Maxfield, F. R., & Tabas, I. A. (2005) · Nature · doi:10.1038/nature04399 · Cited by 1,297 · see citing works
Curcumin and cancer: An “old-age” disease with an “age-old” solution
Anand, P., Sundaram, C., Jhurani, S., Kunnumakkara, A. B., & Aggarwal, B. B. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.025 · Cited by 1,134 · see citing works
Shaikh, J., Ankola, D. D., Beniwal, V., Singh, D., & Kumar, M. N. V. R. (2009) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2009.02.019 · Cited by 970 · see citing works
Biotransformation of Curcumin Through Reduction and Glucuronidation in Mice
Pan, M., Huang, T., & Lin, J. (1999) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(24)15211-7 · Cited by 950 · see citing works
Naksuriya, O., Okonogi, S., Schiffelers, R. M., & Hennink, W. E. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.12.090 · Cited by 844 · see citing works
Shuai, X., Ai, H., Nasongkla, N., Kim, S., & Gao, J. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.06.003 · Cited by 695 · see citing works
Nanocarriers for cancer-targeted drug delivery
Kumari, P., Ghosh, B., & Biswas, S. (2015) · Journal of drug targeting · doi:10.3109/1061186x.2015.1051049 · Cited by 612 · see citing works
Self-citationNovel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice.
Nishiyama, N., Okazaki, S., Cabral, H., Miyamoto, M., Kato, Y., Sugiyama, Y., Nishio, K., Matsumura, Y., & Kataoka, K. (2003) · PubMed · Cited by 602 · see citing works
Kawamori, T., Lubet, R., Steele, V. E., Kelloff, G. J., Kaskey, R. B., Rao, C. V., & Reddy, B. S. (1999) · PubMed · Cited by 589 · see citing works
Ireson, C. R., Orr, S., Jones, D. J. L., Verschoyle, R. D., Lim, C. K., Luo, J., Howells, L. M., Plummer, S. M., Jukes, R., Williams, M. L., et al. (2001) · PubMed · Cited by 588 · see citing works
Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine.
Ireson, C. R., Jones, D. J. L., Orr, S., Coughtrie, M. W. H., Boocock, D. J., Williams, M. L., Farmer, P. B., Steward, W. P., & Gescher, A. J. (2002) · PubMed · Cited by 561 · see citing works
Mittal, G., Sahana, D. K., Bhardwaj, V., & Kumar, M. N. V. R. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.01.016 · Cited by 549 · see citing works
Meng, H., Xue, M., Xia, T., Ji, Z., Tarn, D., Zink, J. I., & Nel, A. E. (2011) · ACS Nano · doi:10.1021/nn200809t · Cited by 509 · see citing works
Polymeric nanoparticulate system: A potential approach for ocular drug delivery
Nagarwal, R. C., Kant, S., Singh, P., Maiti, P., & Pandit, J. K. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.12.018 · Cited by 481 · see citing works
wei, Z., Hao, J., Yuan, S., Li, Y., Juan, W., Sha, X., & Fang, X. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.04.030 · Cited by 426 · see citing works
Nanoparticle Technologies for Cancer Therapy
Alexis, F., Pridgen, E. M., Langer, R., & Farokhzad, O. C. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-00477-3_2 · Cited by 372 · see citing works
pH-sensitive poly (histidine)-PEG/DSPE-PEG co-polymer micelles for cytosolic drug delivery
Wu, H., Zhu, L., & Torchilin, V. P. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2012.08.072 · Cited by 355 · see citing works
Modulation of membrane function by cholesterol
Yèagle, P. L. (1991) · Biochimie · doi:10.1016/0300-9084(91)90093-g · Cited by 354 · see citing works
Ruan, G., & Feng, S. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00419-8 · Cited by 348 · see citing works
Yokoyama, M. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00115-6 · Cited by 308 · see citing works
Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism
Hassaninasab, A., Hashimoto, Y., Tomita‐Yokotani, K., & Kobayashi, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016217108 · Cited by 302 · see citing works
Kim, T. H., Jiang, H. H., Youn, Y. S., Park, C. W., Tak, K. K., Lee, S., Kim, H., Jon, S., Chen, X. S., & Lee, K. C. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.10.041 · Cited by 293 · see citing works
Nanopreparations for organelle-specific delivery in cancer
Biswas, S., & Torchilin, V. P. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.11.004 · Cited by 292 · see citing works
Self-citationAggarwal, B. B., Deb, L., & Prasad, S. (2014) · Molecules · doi:10.3390/molecules20010185 · Cited by 270 · see citing works
Recent advances in PEG–PLA block copolymer nanoparticles
Zeng, Z. (2010) · International Journal of Nanomedicine · doi:10.2147/ijn.s14912 · Cited by 264 · see citing works
Wang, H., Zhao, P., Liang, X., Gong, X., Song, T., Niu, R., & Chang, J. K. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.089 · Cited by 251 · see citing works
Immunomodulatory and therapeutic activity of curcumin
Srivastava, R. M., Singh, S., Dubey, S. K., Misra, K., & Khar, A. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.08.014 · Cited by 216 · see citing works
Metabolism of Curcuminoids in Tissue Slices and Subcellular Fractions from Rat Liver
Hoehle, S. I., Pfeiffer, E., Sólyom, A. M., & Metzler, M. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf058146a · Cited by 192 · see citing works
Endres, T., Beck‐Broichsitter, M., Samsonova, O. V., Renette, T., & Kissel, T. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.06.064 · Cited by 175 · see citing works
Lee, A. L. Z., Venkataraman, S., Sirat, S. B. M., Gao, S., Hedrick, J. L., & Yang, Y. Y. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.11.032 · Cited by 160 · see citing works
Grießer, M., Pistis, V., Suzuki, T., Tejera, N., Pratt, D. A., & Schneider, C. G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.178806 · Cited by 154 · see citing works
Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate
Zhang, X., Li, Y., Chen, X., Wang, X., Xu, X., Liang, Q., Hu, J., & Jing, X. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.06.024 · Cited by 148 · see citing works
Preparation of Lipid Nanoemulsions Incorporating Curcumin for Cancer Therapy
Anuchapreeda, S., Fukumori, Y., Okonogi, S., & Ichikawa, H. (2011) · Journal of Nanotechnology · doi:10.1155/2012/270383 · Cited by 136 · see citing works
Self-microemulsifying drug delivery system improves curcumin dissolution and bioavailability
Wu, X., Xu, J., Huang, X., & Wen, C. (2010) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2010.489560 · Cited by 134 · see citing works
Li, Y., & Kwon, G. S. (2000) · Pharmaceutical Research · doi:10.1023/a:1007529218802 · Cited by 118 · see citing works
Development and optimization of solid lipid nanoparticles of amikacin by central composite design
Varshosaz, J., Ghaffari, S., Khoshayand, M. R., Atyabi, F., Azarmi, S., & Kobarfard, F. (2010) · Journal of Liposome Research · doi:10.3109/08982100903103904 · Cited by 107 · see citing works
Polymers Comprising Cholesterol: Synthesis, Self-Assembly, and Applications
Zhou, Y., Briand, V. A., Sharma, N., Ahn, S., & Kasi, R. M. (2009) · Materials · doi:10.3390/ma2020636 · Cited by 93 · see citing works
Liu, L., Li, C., Li, X., Yuan, Z., An, Y., & He, B. (2001) · Journal of Applied Polymer Science · doi:10.1002/app.1295 · Cited by 92 · see citing works
Chemopreventative effects of tetrahydrocurcumin on human diseases
Wu, J.-C., Tsai, M.-L., Lai, C., Wang, Y., Ho, C., & Pan, M. (2013) · Food & Function · doi:10.1039/c3fo60370a · Cited by 92 · see citing works
Chen, C.-J., Wang, J., Zhao, E.-Y., Gao, L., Feng, Q., Liu, X.-Y., Zhao, Z.-X., Ma, X., Hou, W., Zhang, L., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.03.056 · Cited by 88 · see citing works
Jain, A., Goyal, A. K., Gupta, P. N., Khatri, K., Mishra, N., Mehta, A., Mangal, S., & Vyas, S. P. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.02.010 · Cited by 87 · see citing works
Recent advances of curcumin and its analogues in breast cancer prevention and treatment
Mock, C. D., Jordan, B. C., & Selvam, C. (2015) · RSC Advances · doi:10.1039/c5ra14925h · Cited by 85 · see citing works
Song, L., Shen, Y., Hou, J., Lei, L., Guo, S., & Qian, C. (2011) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2011.08.031 · Cited by 82 · see citing works
Properties of ?-caprolactone/DL-lactide (?-CL/DL-LA) copolymers with a minor ?-CL content
Hiljanen-Vainio, M., Orava, P., & Sepp�l�, J. V. (1997) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199701)34:1 · Cited by 71 · see citing works
Curcumin Delivery by Poly(Lactide)-Based Co-Polymeric Micelles: An In Vitro Anticancer Study
Kumari, P., Muddineti, O. S., Nadipalli, S. K., Myneni, S., Ghosh, B., & Biswas, S. (2015) · Pharmaceutical Research · doi:10.1007/s11095-015-1830-z · Cited by 71 · see citing works
Self-citationDegradation of Curcuminoids by in Vitro Pure Culture Fermentation
Tan, S., Rupasinghe, T., Tull, D., Boughton, B. A., Oliver, C., McSweeney, C. S., Gras, S. L., & Augustin, M. A. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf5031168 · Cited by 60 · see citing works
Wang, D. K., Varanasi, S., Fredericks, P. M., Hill, D. J. T., Symons, A. L., Whittaker, A. K., & Rasoul, F. A. (2013) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.26930 · Cited by 55 · see citing works
Wichitnithad, W., Nimmannit, U., Callery, P. S., & Rojsitthisak, P. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22716 · Cited by 52 · see citing works
Ha, W., Wu, H., Wang, X., Peng, S., Ding, L., Zhang, S., & Li, B. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.04.083 · Cited by 38 · see citing works
Yao, X., Chen, L., Chen, X., He, C., Zheng, H., & Chen, X. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.05.032 · Cited by 38 · see citing works
Dutta, P., & Dey, J. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.10.011 · Cited by 33 · see citing works
Cheng, W., Kumar, J., Zhang, Y., & Liu, Y. (2013) · Macromolecular Bioscience · doi:10.1002/mabi.201300339 · Cited by 30 · see citing works
Ma, Q., Li, B., Yu, Y., Zhang, Y., Wu, Y., Ren, W., Zheng, Y., He, J. F., Xie, Y., Song, X., et al. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.01.046 · Cited by 14 · see citing works
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Senapati, S., Mahanta, A. K., Kumar, S., & Maiti, P. (2018) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-017-0004-3 · Cited by 2,167 · see citing works
Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645 · see citing works
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Vaiserman, A. M., Koliada, A. K., Zayachkivska, A., & Lushchak, O. V. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00447 · Cited by 208 · see citing works
Curcumin in combination with anti-cancer drugs: A nanomedicine review
Batra, H., Pawar, S., & Bahl, D. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.11.005 · Cited by 169 · see citing works
Poly(Ethylene Glycol)–Polylactide Micelles for Cancer Therapy
Wang, J., Li, S., Han, Y., Guan, J., Chung, S., Wang, C., & Li, D. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00202 · Cited by 155 · see citing works
Zhang, Q., Polyakov, N. E., Chistyachenko, Y. S., Khvostov, M. V., Фролова, Т. С., Толстикова, Т. Г., Dushkin, A. V., & Su, W. (2018) · Drug Delivery · doi:10.1080/10717544.2017.1422298 · Cited by 136 · see citing works
Curcumin nanoformulations: Beneficial nanomedicine against cancer
Dizaj, S. M., Alipour, M., Abdolahinia, E. D., Ahmadian, E., Eftekhari, A., Forouhandeh, H., Saadat, Y. R., Sharifi, S., & Vahed, S. Z. (2022) · Phytotherapy Research · doi:10.1002/ptr.7389 · Cited by 119 · see citing works
Guo, S., Shi, Y., Liang, Y., Liu, L., Sun, K., & Li, Y. (2021) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2020.12.002 · Cited by 83 · see citing works
Itoo, A. M., Paul, M., Ghosh, B., & Biswas, S. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119108 · Cited by 78 · see citing works
Self-citationRompicharla, S. V. K., Bhatt, H., Shah, A., Komanduri, N., Vijayasarathi, D., Ghosh, B., & Biswas, S. (2017) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2017.08.009 · Cited by 75 · see citing works
Self-citationYang, L., Zhang, Z., Hou, J., Jin, X., Ke, Z., Liu, D., Du, M., Jia, X., & Lv, H. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s144305 · Cited by 69 · see citing works
Nairi, V., Magnolia, S., Piludu, M., Nieddu, M., Caria, C. A., Sogos, V., Vallet‐Regí, M., Monduzzi, M., & Salis, A. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.02.019 · Cited by 66 · see citing works
Yang, D. H., Kim, H. J., Park, K., Kim, J. K., & Chun, H. J. (2018) · Drug Delivery · doi:10.1080/10717544.2018.1461957 · Cited by 66 · see citing works
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Kumbham, S., Paul, M., Itoo, A. M., Ghosh, B., & Biswas, S. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.121479 · Cited by 57 · see citing works
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Yıldırım, M., Sessevmez, M., Poyraz, S., & Düzgüneş, N. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15112566 · Cited by 48 · see citing works
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Self-citationAfsharzadeh, M., Abnous, K., Robati, R. Y., Attaranzadeh, A., Ramezani, M., & Hashemi, M. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27346 · Cited by 28 · see citing works
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Oliveira, A. L. C. D. S. L., Schomann, T., de Geus‐Oei, L., Kapiteijn, E., Cruz, L. J., & Júnior, R. F. D. A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081321 · Cited by 27 · see citing works
Kumbham, S., Ghosh, A., Ghosh, B., & Biswas, S. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.09.250 · Cited by 27 · see citing works
Self-citationSanthamoorthy, M., Ramkumar, V., Thirupathi, K., Gnanasekaran, L., Karuppannan, V., Phan, T. T. V., & Kim, S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061631 · Cited by 27 · see citing works
Praban, S., Piromjitpong, P., Balasanthiran, V., Jayaraj, S., Chisholm, M. H., Tantirungrotechai, J., & Phomphrai, K. (2019) · Dalton Transactions · doi:10.1039/c8dt04699a · Cited by 25 · see citing works
Liu, Y., Chen, F., Zhang, K., Wang, Q., Chen, Y., & Luo, X. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb00305c · Cited by 24 · see citing works
Praban, S., Yimthachote, S., Kiriratnikom, J., Chotchatchawankul, S., Tantirungrotechai, J., & Phomphrai, K. (2019) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.29479 · Cited by 24 · see citing works
Synthesis methods of nanoparticles and their key applications
Triphati, A., & Pirzadah, T. B. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91195-5.00001-5 · Cited by 23 · see citing works
Mahmoud, N. N., Sabbah, D. A., Abu‐Dahab, R., Abuarqoub, D. A., Abdallah, M., Ameerah, & Khalil, E. A. (2019) · RSC Advances · doi:10.1039/c9ra01041f · Cited by 21 · see citing works
A Review of Multifunction Smart Nanoparticle based Drug Delivery Systems
Fatima, H., Naz, M. Y., Shukrullah, S., Aslam, H., Ullah, S., & Assiri, M. A. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220422085702 · Cited by 20 · see citing works
Poly(lactide)-Based Materials Modified with Biomolecules: A Review
Świerczyńska, M., Kudzin, M. H., & Chruściel, J. J. (2024) · Materials · doi:10.3390/ma17215184 · Cited by 19 · see citing works
Zhang, Y., Li, W., Liu, D., Ge, Y., Zhao, M., Zhu, X., Li, W., Wang, L., Zheng, T., & Li, J. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b10368 · Cited by 18 · see citing works
Qin, Y., & Peng, X. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00090 · Cited by 18 · see citing works
Bobde, Y., Paul, M., Patel, T. K., Biswas, S., & Ghosh, B. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120866 · Cited by 17 · see citing works
Self-citationSuo, H., Liu, S., Liu, J., Zhang, Z., Qu, R., Gu, Y., & Qin, Y. (2023) · Polymer Chemistry · doi:10.1039/d3py00890h · Cited by 14 · see citing works
Theranostics Applications of Nanoparticles in Cancer Immunotherapy
Liu, Y., Wang, X., Hussain, M., Lv, M., Dong, X., Wang, T., Xu, X., & Liu, B. (2018) · Medical Sciences · doi:10.3390/medsci6040100 · Cited by 15 · see citing works
Muddineti, O. S., Asmitha, V., Rompicharla, S. V. K., Kumari, P., Ghosh, B., & Biswas, S. (2018) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2018.1435551 · Cited by 14 · see citing works
Self-citationPreparation of a novel lipid-core micelle using a low-energy emulsification method
Fritz, H. F., Ortiz, A. C., Velaga, S. P., & Morales, J. O. (2018) · Drug Delivery and Translational Research · doi:10.1007/s13346-018-0521-9 · Cited by 14 · see citing works
Chen, Y., Chang, C., Hsiue, G., & Chiang, Y. (2021) · Cancers · doi:10.3390/cancers13153816 · Cited by 13 · see citing works
Jafari, M., Abolmaali, S. S., Borandeh, S., Najafi, H., Zareshahrabadi, Z., Heidari, R., Azarpira, N., Zomorodian, K., & Tamaddon, A. M. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.212996 · Cited by 13 · see citing works
Fitzgerald, D. M., Zhang, H., Bordeianu, C., Colson, Y. L., & Grinstaff, M. W. (2023) · ACS Macro Letters · doi:10.1021/acsmacrolett.3c00275 · Cited by 12 · see citing works
The effect of protein BSA on the stability of lipophilic drug (docetaxel)-loaded polymeric micelles
Polat, H., Eren, M. Ç., & Polat, M. (2021) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2021.127712 · Cited by 12 · see citing works
Cicco, C. D., Vecchione, R., Quagliariello, V., Busato, A., Tufano, I., Bedini, E., Gerosa, M., Sbarbati, A., Boschi, F., Marzola, P., et al. (2022) · Journal of The Royal Society Interface · doi:10.1098/rsif.2021.0800 · Cited by 10 · see citing works
Chen, D., Gong, F., Han, X., Chi, L., Sun, J., & Shen, Y. (2019) · Journal of Polymer Research · doi:10.1007/s10965-019-1768-7 · Cited by 8 · see citing works
Polymeric nanoparticles for potential drug delivery applications in cancer
Fatima, S., Quadri, S. N., Parveen, S., Beg, S., Rahman, M., Ahmad, F. J., & Abdin, M. Z. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821095-6.00009-4 · Cited by 7 · see citing works
Guo, Q., Jian, L.-Y., Hu, Y.-H., & Wang, S. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156073 · Cited by 7 · see citing works
Romero, J. F., Herziger, S., Cherri, M., Dimde, M., Achazi, K., Mohammadifar, E., & Haag, R. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15102452 · Cited by 6 · see citing works
Recent Trends in the Application of Materials for Cancer Therapy and Diagnosis
Bakhshandeh, B., Jahanafrooz, Z., Haghighi, D. M., Rahmani-Kukia, N., Abbasi, A., & Pourramezanali, A. (2023) · Springer eBooks · doi:10.1007/978-981-99-2119-5_12 · Cited by 5 · see citing works
Shariare, M. H., Mannan, M., Khan, F., Sharmin, A., Attwa, M. W., Rahman, A. F. M. M., Rahman, M., Uddin, M. N., & Kazi, M. (2024) · Journal of Nanoparticle Research · doi:10.1007/s11051-023-05921-0 · Cited by 5 · see citing works
Allegri, P., Cimino, L., Davis, J. L., Tuğal-Tutkun, İ., & The Norflo Oro study group (2022) · Ocular Immunology and Inflammation · doi:10.1080/09273948.2022.2039210 · Cited by 4 · see citing works
Micelle-based curcumin delivery systems as cancer therapeutics
Rahiman, N., Alavizadeh, S. H., Simental‐Mendía, L. E., & Sahebkar, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15412-6.00020-9 · Cited by 4 · see citing works
Cholesterol-Functionalized Porous PLA Microparticles for Enhanced Drug Delivery
Mohammed-Sadhakathullah, A. H., Resina, L., Enshaei, H., Ivanova, K., Tzanov, T., Pérez‐Madrigal, M. M., Armelin, E. A., & Torras, J. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c00693 · Cited by 3 · see citing works
Tumor microenvironment-mediated targeted drug delivery to breast cancer cells
Haider, T., Kanwar, I. L., Pandey, V., Jain, P., & Soni, V. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824476-0.00015-2 · Cited by 4 · see citing works
Applications of Turmeric Starch and Curcumin
Kırboğa, K. K., Tekin, B., & DEMİR, M. (2023) · Bayburt Üniversitesi Fen Bilimleri Dergisi · doi:10.55117/bufbd.1161709 · Cited by 3 · see citing works
Emerging Nanomaterials in Drug Delivery and Therapy
Nargis, M. (2022) · Materials research foundations · doi:10.21741/9781644902172-6 · Cited by 2 · see citing works
Recent Advances in Chitosan-Based Systems for Delivery of Anticancer Drugs
Polat, M., & Polat, H. (2019) · Springer eBooks · doi:10.1007/978-981-15-0263-7_7 · Cited by 3 · see citing works
An Updated Insight into Phytomolecules and Novel Approaches used in the Management of Breast Cancer
Nooreen, Z., Tandon, S., Wal, A., & Rai, A. K. (2024) · Current Drug Targets · doi:10.2174/0113894501277556231221072938 · Cited by 2 · see citing works
Arakelova, E. R., Grigoryan, S. G., Khachatryan, A. M., Mirzoian, A. A., Farmazyan, Z. M., Grigoryan, S. L., Yeranosyan, M. A., Arsenyan, F. G., Muradyan, R. E., & Gasparyan, H. V. (2019) · Natural Science · doi:10.4236/ns.2019.113008 · Cited by 2 · see citing works
Nanocarreadores aplicados ao tratamento do câncer de mama
Pitta, M. G. D. R., Silva, R. P. D. S., Alves, G. V. S., Angelo, I. C. B. L., de Souza, J. M., Pessôa, J. R. C. P., de Carvalho, J. S., de Miranda, M. K. V., & de Souza, M. B. R. (2021) · Research Society and Development · doi:10.33448/rsd-v10i10.18966 · Cited by 2 · see citing works
Material and strategies used in oncology drug delivery
Verma, N., Thapa, K., & Dua, K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85503-7.00015-8 · Cited by 1 · see citing works
He, J., Li, S., & Liu, J. (2021) · Science of Advanced Materials · doi:10.1166/sam.2021.4049
Arakelova, E. R., Grigoryan, S. G., Khachatryan, A. M., Mirzoian, A. A., Farmazyan, Z. M., Grigoryan, S. L., Yeranosyan, M. A., Arsenyan, F. G., Muradyan, R. E., & Gasparyan, H. V. (2019) · Natural Science · doi:10.4236/ns.2019.103008
Self‐Assembled Micellar Aggregates From Star‐Shaped Copolymers Decorated With Cholesterol
Morelos‐Ramírez, I., & Cortez-Lemus, N. A. (2025) · Journal of Polymer Science · doi:10.1002/pol.20240898
Novel delivery systems for curcumin
Ahmed, M., & Basheer, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29196-8.00011-2
Krishna, A. B., Suvilal, A., Jayakrishnan, D., Vamadevan, R., & Babu, J. S. (2025) · Materials Chemistry and Physics · doi:10.1016/j.matchemphys.2025.131921
Uroomiye, S. S., Karami, K., Ahmadi, M., Derakhshandeh, K., & Ahmadabadi, A. N. (2026) · Research in Pharmaceutical Sciences · doi:10.4103/rps.rps_198_25
- Authors
- Kumari, P., Muddineti, O. S., Rompicharla, S. V. K., Ghanta, P., B B N, A. K., Ghosh, B., & Biswas, S.
- Affiliations
- Birla Institute of Technology and Science, Pilani (IN)
- Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Hyderabad, India
- Corresponding author
- Biswas, Swati
- ORCID
- Venue
- Drug Delivery
- Publisher
- Informa UK Limited
- Published
- 2017-01-01
- Volume
- 24
- Issue
- 1
- Pages
- 209-223
- ISSN
- 1071-7544 (ISSN-L)
- 1521-0464
- PMC
- PMC8253141
- OpenAlex
- W2583238555
- Cited by
- 79
- References
- 60
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 5 · 2023: 9 · 2022: 11 · 2021: 11 · 2020: 8 · 2019: 14 · 2018: 12 · 2017: 3
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Drug Delivery (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- polymeric micelles, curcumin delivery, nanocarriers, tumor targeting, encapsulation efficiency, drug loading, melanoma, breast cancer, tumor xenografts, hemocompatibility, critical micelle concentration, hydrodynamic diameter
- MeSH terms
- Animals, Antineoplastic Agents, Breast Neoplasms, Cholesterol, Curcumin, Drug Carriers, Female, Melanoma, Experimental, Mice, Inbred C57BL, Micelles, Particle Size, Polyesters, Polyethylene Glycols, Polymers, Cell Line, Tumor, Mice
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