Cited by 78Nanoparticles: synthesis and applicationsIron Metabolism and DisordersImmunotoxicology and immune responses

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Biodistribution, Clearance And Morphological Alterations Of Intravenously Administered Iron Oxide Nanoparticles In Male Wistar Rats

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Gaharwar, Usha Singh, Meena, Ramovatar, Rajamani, Paulraj·2019·International Journal of Nanomedicine

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Abstract

INTRODUCTION: Nanoparticles are used worldwide because of their unique properties, with large-scale application in various fields, such as medicine, cosmetics and industries. In view of their widespread use, the potential adverse effects of nanoparticles have become a significant cause for concern, in terms of not only human health and safety but also the environment. The present investigation focused on establishing the bioaccumulation patterns and ultrastructural changes induced by retained iron oxide nanoparticles (IONPs) in various target organs of rats. METHODS: Twenty-four male Wistar rats were randomly divided into four groups. Experimental animals were intravenously administered different doses of IONPs (7.5 mg/kg, 15 mg/kg and 30 mg/kg) once in a week for 4 weeks. Urine and feces samples were collected on a daily basis to assess nanoparticle clearance and analyzed via atomic absorption spectroscopy (AAS). At the end of the experiment, rats were euthanized and different organs, including spleen, liver, kidney, lung, heart, testis and brain, were dissected. Bioaccumulation of iron in organs and ultrastructural changes induced by IONPs were determined. RESULTS: The maximal concentration of iron was detected in spleen and minimal concentration in the brain. The level of iron accumulation in organs was as follows: spleen>blood>liver>kidney>lung>heart>testis>brain. The excretion profile in urine revealed maximum excretion on the day following administration that was maintained until day 28, whereas the iron content in feces remained high during the first three days after injection. A similar pattern was observed throughout the duration of the experiment. Ultrastructural alterations were detected in spleen, kidney, lung, heart, testis, brain and liver, indicative of cellular damage induced by accumulating nanoparticles in these organs. CONCLUSION: Intravenous administration of IONPs results in ultrastructural changes and dose-dependent bioaccumulation in different organs of rats.

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Authors: Gaharwar, U. S., Meena, R., & Rajamani, P.
Affiliations: Jawaharlal Nehru University (IN)
Corresponding author: Gaharwar, Usha Singh
Meena, Ramovatar
Rajamani, Paulraj
ORCID: Gaharwar, Usha Singh
Meena, Ramovatar
Rajamani, Paulraj
Venue: International Journal of Nanomedicine
Publisher: Informa UK Limited
Published: 2019-12
Volume: Volume 14
Pages: 9677-9692
ISSN: 1176-9114 (ISSN-L)
1178-2013
DOI: 10.2147/ijn.s223142
PMC: PMC6902883
OpenAlex: W2993868899
Cited by: 75
References: 57
Citations by year: 2026: 5 · 2025: 14 · 2024: 7 · 2023: 10 · 2022: 15 · 2021: 14 · 2020: 10
FWCI: 3.52
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/3.0/ (unspecified)
Locations: International Journal of Nanomedicine (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Jawaharlal Nehru University
Advanced Instrumentation Research Facility
Topics: Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords: iron oxide nanoparticles, tissue distribution, nanoparticle clearance, bioaccumulation, ultrastructural changes, intravenous administration, dose-dependent toxicity, nanoparticle excretion, spleen, kidney, liver, lung, testis, brain, heart
MeSH terms: Animals, Brain, Ferric Compounds, Heart, HeLa Cells, Humans, Iron, Kidney, Liver, Lung, Male, Spleen, Testis, Tissue Distribution, Rats, Wistar, Metal Nanoparticles, Administration, Intravenous

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Biodistribution, Clearance And Morphological Alterations Of Intravenously Administered Iron Oxide Nanoparticles In Male Wistar Rats

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