CoChat
Sign Up
Cited by 129Wound Healing and TreatmentsElectrospun Nanofibers in Biomedical ApplicationsNanocomposite Films for Food Packaging

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Antimicrobial Double-Layer Wound Dressing Based on Chitosan/Polyvinyl Alcohol/Copper: In vitro and in vivo Assessment

Open access
Ghasemian Lemraski, Ensieh, Jahangirian, Hossein, Dashti, Maryam, Khajehali, Elaheh, Sharafinia, Mis. Soheila, Rafiee-Moghaddam, Roshanak, Webster, Thomas J·2021·International Journal of Nanomedicine
DOI 10.2147/ijn.s266692PMC PMC7810733
Open this paper in CoChat — free accountOpen PDF

Abstract

PURPOSE: Today, the development of wounds and their side effects has become a problematic issue in medical science research. Hydrogel-based dressings are some of the best candidates for this purpose due to their ability to keep the wound bed clean, as well as provide proper moisture, tissue compatibility and an antimicrobial effect for wound healing. On the other hand, copper and its compounds have been used experimentally for many years in studies as an antimicrobial substance. Various studies have been performed determining the antimicrobial properties of this element, during which significant effects on infection have been shown. METHODS: Chitosan/polyvinyl alcohol/copper nanofibers were successfully prepared by incorporating Cu onto a polymer electrospun using an electrospinning technique. A double-layer nanofiber composed of poly(vinyl alcohol) and chitosan incorporated with Cu nanoparticles as a protective layer and a second layer composed of polyvinylpyrrolidone (PVP) nanofibers which was adjacent to the damaged cells was prepared. The prepared nanofiber was characterized by TGA, FT-IR, TEM, SEM-EDS, and X-ray powder diffraction. The antimicrobial efficiency of the nanofibers was demonstrated through biological tests on some Gram-positive and Gram-negative bacteria. Finally, the prepared hydrogel formulations were prepared to evaluate their effect on the healing process of rat open wounds. RESULTS: In this study, data from SEM, TEM, EDS, and XRD confirmed the formation of uniform fibers with nanodiameters and the presence of Cu nanoparticles onto the electrospun nanofibers. The antibacterial activity of copper was observed against all of the selected bacteria, but the Gram-positive bacteria were more sensitive compared to Gram-negative bacteria. CONCLUSION: According to the obtained results, the hydrogel wound dressing prepared in this research can be effective in caring for open wounds in the early stages of wound healing and preventing the occurrence of prolonged open wounds.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.2147/ijn.s266692

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1 SEM images of the PVA/CS (A, B) and PVA/CS/CuNPs nanofibers (C, D).
Figure 1 SEM images of the PVA/CS (A, B) and PVA/CS/CuNPs nanofibers (C, D).CC BY-NC · PubMed Central
Figure 2 EDX spectra of the PVA/CS/CuNPs nanofibers.
Figure 2 EDX spectra of the PVA/CS/CuNPs nanofibers.CC BY-NC · PubMed Central
Figure 3 TEM images of the PVA/CS/CuNPs nanofibers.
Figure 3 TEM images of the PVA/CS/CuNPs nanofibers.CC BY-NC · PubMed Central
Figure 4 XRD pattern of the PVA/CS/Cu nanofibers.
Figure 4 XRD pattern of the PVA/CS/Cu nanofibers.CC BY-NC · PubMed Central
Figure 5 FT-IR spectra of the PVA, PVA/CS, and PVA/CS/CuNPs nanofibers.
Figure 5 FT-IR spectra of the PVA, PVA/CS, and PVA/CS/CuNPs nanofibers.CC BY-NC · PubMed Central
Figure 6 TGA curves of the PVA (gray solid line), PVA/CS (dashed line), and PVA/CS/Cu nanofiber (black solid line).
Figure 6 TGA curves of the PVA (gray solid line), PVA/CS (dashed line), and PVA/CS/Cu nanofiber (black solid line).CC BY-NC · PubMed Central
Figure 7 Cu release test as a function of time.
Figure 7 Cu release test as a function of time.CC BY-NC · PubMed Central
Figure 8 Antimicrobial susceptibility disk diffusion test. (A) Escherichia coli, (B) Bacillus cereus, (C) Staphylococcus aureus, and (D) Pseudomonas aeruginosa with 1) PVA, 2) PVA/CS, 3) PVA/CS/CuNPs and T) Tetracycline (Control).
Figure 8 Antimicrobial susceptibility disk diffusion test. (A) Escherichia coli, (B) Bacillus cereus, (C) Staphylococcus aureus, and (D) Pseudomonas aeruginosa with 1) PVA, 2) PVA/CS, 3) PVA/CS/CuNPs and T) Tetracycline (Control).CC BY-NC · PubMed Central
Figure 9 In vivo result of wounds in adult male albino rats. Images of the wound area of all five groups of rats on days 0, 3, 7, 11, and 15 and for the positive control, negative control, PVA, PVA/CS, and PVA/CS/CuNPs.
Figure 9 In vivo result of wounds in adult male albino rats. Images of the wound area of all five groups of rats on days 0, 3, 7, 11, and 15 and for the positive control, negative control, PVA, PVA/CS, and PVA/CS/CuNPs.CC BY-NC · PubMed Central
Figure 10 The percentage of wound closure for the positive control, negative control, PVA, PVA/CS, and PVA/CS/CuNPs.
Figure 10 The percentage of wound closure for the positive control, negative control, PVA, PVA/CS, and PVA/CS/CuNPs.CC BY-NC · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 37 references

Research works printed but not linked: 2

  1. 2012, Nano Antimicrobials
  2. Jahangirian, 2013, Dig J Nanomater Bios, 8, 1263

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Ghasemian Lemraski, E., Jahangirian, H., Dashti, M., Khajehali, E., Sharafinia, M. S., Rafiee-Moghaddam, R., & Webster, T. J.
Affiliations
  • Northeastern University (US)
  • Ilam University (IR)
  • Shahid Chamran University of Ahvaz (IR)
ORCID
Venue
International Journal of Nanomedicine
Publisher
Informa UK Limited
Published
2021-01
Volume
Volume 16
Pages
223-235
ISSN
  • 1176-9114 (ISSN-L)
  • 1178-2013
DOI
10.2147/ijn.s266692
PMC
PMC7810733
OpenAlex
W3120794207
Cited by
125
References
37
Citations by year
2026: 8 · 2025: 20 · 2024: 21 · 2023: 30 · 2022: 31 · 2021: 15
FWCI
12.73
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Nanomedicine (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Funders
Ilam University
Topics
  • Health Sciences › Medicine › Surgery › Wound Healing and Treatments
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Physical Sciences › Materials Science › Biomaterials › Nanocomposite Films for Food Packaging
Keywords
wound dressings, chitosan, polyvinyl alcohol, copper nanoparticles, electrospun nanofibers, polyvinylpyrrolidone, antibacterial activity, wound healing, open wounds, Gram-positive bacteria, Gram-negative bacteria
MeSH terms
Animals, Anti-Infective Agents, Anti-Bacterial Agents, Bacteria, Bandages, Copper, Ions, Male, Microbial Sensitivity Tests, Polyvinyl Alcohol, Spectrometry, X-Ray Emission, Thermogravimetry, Wound Healing, Wounds and Injuries, X-Ray Diffraction, Rats, Wistar, Spectroscopy, Fourier Transform Infrared, Chitosan, Rats, Nanofibers

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review