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Cited by 48Hydrogels: synthesis, properties, applicationsTissue Engineering and Regenerative Medicine3D Printing in Biomedical Research

Cell-Seeded Biomaterial Scaffolds: The Urgent Need for Unanswered Accelerated Angiogenesis

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Shokrani, Hanieh, Shokrani, Amirhossein, Sajadi, S Mohammad, Seidi, Farzad, Mashhadzadeh, Amin Hamed, Rabiee, Navid, Saeb, Mohammad Reza, Aminabhavi, Tejraj +1 more·2022·International Journal of Nanomedicine
DOI 10.2147/ijn.s353062PMC PMC8927652
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Abstract

One of the most arduous challenges in tissue engineering is neovascularization, without which there is a lack of nutrients delivered to a target tissue. Angiogenesis should be completed at an optimal density and within an appropriate period of time to prevent cell necrosis. Failure to meet this challenge brings about poor functionality for the tissue in comparison with the native tissue, extensively reducing cell viability. Prior studies devoted to angiogenesis have provided researchers with some biomaterial scaffolds and cell choices for angiogenesis. For example, while most current angiogenesis approaches require a variety of stimulatory factors ranging from biomechanical to biomolecular to cellular, some other promising stimulatory factors have been underdeveloped (such as electrical, topographical, and magnetic). When it comes to choosing biomaterial scaffolds in tissue engineering for angiogenesis, key traits rush to mind including biocompatibility, appropriate physical and mechanical properties (adhesion strength, shear stress, and malleability), as well as identifying the appropriate biomaterial in terms of stability and degradation profile, all of which may leave essential trace materials behind adversely influencing angiogenesis. Nevertheless, the selection of the best biomaterial and cells still remains an area of hot dispute as such previous studies have not sufficiently classified, integrated, or compared approaches. To address the aforementioned need, this review article summarizes a variety of natural and synthetic scaffolds including hydrogels that support angiogenesis. Furthermore, we review a variety of cell sources utilized for cell seeding and influential factors used for angiogenesis with a concentrated focus on biomechanical factors, with unique stimulatory factors. Lastly, we provide a bottom-to-up overview of angiogenic biomaterials and cell selection, highlighting parameters that need to be addressed in future studies.

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Authors
Shokrani, H., Shokrani, A., Sajadi, S. M., Seidi, F., Mashhadzadeh, A. H., Rabiee, N., Saeb, M. R., Aminabhavi, T., & Webster, T. J.
Affiliations
  • Sharif University of Technology (IR)
  • Cihan University-Erbil (IQ)
  • Nanjing Forestry University (CN)
  • Nazarbayev University (KZ)
  • Gdańsk University of Technology (PL)
  • Karnatak University (IN)
  • Hebei University (CN)
Corresponding author
Sajadi, S Mohammad
ORCID
Venue
International Journal of Nanomedicine
Publisher
Informa UK Limited
Published
2022-03
Volume
Volume 17
Pages
1035-1068
ISSN
  • 1176-9114 (ISSN-L)
  • 1178-2013
DOI
10.2147/ijn.s353062
PMC
PMC8927652
OpenAlex
W4221063411
Cited by
48
References
1
Citations by year
2026: 7 · 2025: 10 · 2024: 6 · 2023: 12 · 2022: 13
FWCI
0.75
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Nanomedicine (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Nazarbayev University Repository (Nazarbayev University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords
angiogenesis, cell-seeded scaffolds, neovascularization, biomaterial scaffolds, hydrogels, cell sources, biomechanical stimulation, electrical stimulation, topographical cues, magnetic stimulation, scaffold biocompatibility, scaffold degradation, tissue engineering
MeSH terms
Biocompatible Materials, Neovascularization, Physiologic, Hydrogels, Tissue Engineering, Tissue Scaffolds

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