Advancement of Electrospun Nerve Conduit for Peripheral Nerve Regeneration: A Systematic Review (2016–2021)
Open accessAbstract
Peripheral nerve injury (PNI) is a worldwide problem which hugely affects the quality of patients' life. Nerve conduits are now the alternative for treatment of PNI to mimic the gold standard, autologous nerve graft. In that case, with the advantages of electrospun micro- or nano-fibers nerve conduit, the peripheral nerve growth can be escalated, in a better way. In this systematic review, we focused on 39 preclinical studies of electrospun nerve conduit, which include the in vitro and in vivo evaluation from animal peripheral nerve defect models, to provide an update on the progress of the development of electrospun nerve conduit over the last 5 years (2016-2021). The physical characteristics, biocompatibility, functional and morphological outcomes of nerve conduits from different studies would be compared, to give a better strategy for treatment of PNI.
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Electrospinning technology is especially suitable for the design and preparation of biomaterials for vascular repair and peripheral nerve repair.
“The above advantages make electrospinning technology especially suitable for the design and preparation of biomaterials for vascular repair and peripheral nerve repair [79, 80].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [80]
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References 106 · Cited by 22
Research works printed but not linked: 2
- [4]Dodla MC. Peripheral Nerve Regeneration. Elsevier Inc.; 2011.
- [61]Usach V, Coronel F, Malet M, et al. Bone marrow-derived cells and peripheral nerve injury: translational implications for pain and regeneration treatments. Clin Pharmacol Transl Med. 2018; 2(2): 112– 124.
- Authors
- Lee, S. Y., Thow, S. Y., Abdullah, S., Ng, M. H., & Mohamed Haflah, N. H.
- Affiliations
- National University of Malaysia (MY)
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2022-12
- Volume
- Volume 17
- Pages
- 6723-6758
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- PMC
- PMC9805954
- OpenAlex
- W4313248453
- Cited by
- 22
- References
- 106
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 7 · 2023: 1
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Nanomedicine (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- Universiti Kebangsaan Malaysia
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- peripheral nerve regeneration, peripheral nerve injury, electrospun nanofibers, nerve conduits, biocompatibility
- MeSH terms
- Animals, Nerve Regeneration, Peripheral Nerves, Sciatic Nerve, Prostheses and Implants, Tissue Scaffolds
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