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Cited by 485

The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.

Nanomedicine in pulmonary delivery

Open access
Mansour, Heidi, Haemosu, Wu, Xiao·2009·International Journal of Nanomedicine

Abstract

Nanomedicine in pulmonary delivery Heidi M Mansour, Yun-Seok Rhee, Xiao WuUniversity of Kentucky, College of Pharmacy, Division of Pharmaceutical Sciences-Drug Development Division, Lexington, KY, USAAbstract: The lung is an attractive target for drug delivery due to noninvasive administration via inhalation aerosols, avoidance of first-pass metabolism, direct delivery to the site of action for the treatment of respiratory diseases, and the availability of a huge surface area for local drug action and systemic absorption of drug. Colloidal carriers (ie, nanocarrier systems) in pulmonary drug delivery offer many advantages such as the potential to achieve relatively uniform distribution of drug dose among the alveoli, achievement of improved solubility of the drug from its own aqueous solubility, a sustained drug release which consequently reduces dosing frequency, improves patient compliance, decreases incidence of side effects, and the potential of drug internalization by cells. This review focuses on the current status and explores the potential of colloidal carriers (ie, nanocarrier systems) in pulmonary drug delivery with special attention to their pharmaceutical aspects. Manufacturing processes, in vitro/in vivo evaluation methods, and regulatory/toxicity issues of nanomedicines in pulmonary delivery are also discussed.Keywords: pulmonary delivery, colloidal carriers, nanocarrier systems, liposome, polymeric nanoparticle, solid lipid nanoparticle, submicron emulsion, dendrimer

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Metadata

Authors
Mansour, H., Haemosu, & Wu, X.
Venue
International Journal of Nanomedicine
Published
2009-12
Volume
4
Pages
299
ISSN
  • 1176-9114 (ISSN-L)
  • 1178-2013
OpenAlex
W2098205520
Cited by
485
References
180
FWCI
18.04
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Nanomedicine in pulmonary delivery. https://app.cochat.ai/papers/10.2147/ijn.s4937
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Mansour, H., Haemosu, & Wu, X. (2009). Nanomedicine in pulmonary delivery. International Journal of Nanomedicine. https://doi.org/10.2147/ijn.s4937

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.