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Cited by 1,140

The DOI matches its Crossref record.

Noninvasive Imaging of Quantum Dots in Mice

Open access
Ballou, Byron, Lagerholm, B. Christoffer, Ernst, Lauren A., Bruchez, Marcel P., Waggoner, Alan S.·2004·Bioconjugate Chemistry
DOI 10.1021/bc034153y
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Abstract

Quantum dots having four different surface coatings were tested for use in in vivo imaging. Localization was successfully monitored by fluorescence imaging of living animals, by necropsy, by frozen tissue sections for optical microscopy, and by electron microscopy, on scales ranging from centimeters to nanometers, using only quantum dots for detection. Circulating half-lives were found to be less than 12 min for amphiphilic poly(acrylic acid), short-chain (750 Da) methoxy-PEG or long-chain (3400 Da) carboxy-PEG quantum dots, but approximately 70 min for long-chain (5000 Da) methoxy-PEG quantum dots. Surface coatings also determined the in vivo localization of the quantum dots. Long-term experiments demonstrated that these quantum dots remain fluorescent after at least four months in vivo.

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Metadata

Authors
Ballou, B., Lagerholm, B. C., Ernst, L. A., Bruchez, M. P., & Waggoner, A. S.
Venue
Bioconjugate Chemistry
Publisher
American Chemical Society (ACS)
Published
2003-12-30
Volume
15
Issue
1
Pages
79-86
ISSN
  • 1043-1802 (ISSN-L)
  • 1520-4812
DOI
10.1021/bc034153y
OpenAlex
W2013557720
Cited by
1,140
References
0
FWCI
23.95
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Noninvasive Imaging of Quantum Dots in Mice. https://app.cochat.ai/papers/10.1021/bc034153y
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Ballou, B., Lagerholm, B. C., Ernst, L. A., Bruchez, M. P., & Waggoner, A. S. (2004). Noninvasive Imaging of Quantum Dots in Mice. Bioconjugate Chemistry. https://doi.org/10.1021/bc034153y

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.