Correlation between aromatase expression in the eutopic endometrium of symptomatic patients and the presence of endometriosis
Open accessAbstract
OBJECTIVE: To investigate whether aromatase expression in the eutopic endometrium correlates with the presence and severity of endometriosis in patients with infertility and/or dysmenorrhea undergoing laparoscopy and hysteroscopy. PATIENTS: The study involved 106 patients of reproductive age with symptoms of dysmenorrhea and infertility. Sixteen endometriosis-free asymptomatic patients were used as a control group. METHODS: Concomitant laparoscopy and hysteroscopy was carried out in all cases. An endometrial biopsy was taken to determine aromatase p450 expression by immunohistochemistry. Endometriosis was staged according to the American Society of Reproductive Medicine classification. RESULTS: Endometriosis was diagnosed by laparoscopy in 92/106 symptomatic patients. In this group, aromatase expression was detected in the eutopic endometrium of 66/92 patients with endometriosis (72%) and in 13/14 (95%) patients in the symptomatic, endometriosis-free group (P = 0.09). Aromatase expression was not detected in any patients from the control group. In the endometriosis group, aromatase expression was detected in the eutopic endometrium of 28/45 patients (62%) with American Society of Reproductive Medicine classification stage 1 of the disease, in 11/14 patients (78%) with stage II, 14/20 patients (70%) with stage III, and in 12/13 patients (92%) with stage IV; however, the difference was only statistically significant between stages I and IV (P = 0.04). CONCLUSION: Aromatase expression in the endometrium was associated with the presence of dysmenorrhea and infertility irrespective of the presence of endometriosis. When endometriosis was present, however, there was a tendency for aromatase expression to be positively correlated with dysmenorrhea severity.
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Within affected women, aromatase expression positively predicts severity of dysmenorrhea.
“The eutopic endometrium of women with endometriosis demonstrates significantly elevated aromatase activity compared with unaffected women (Bukulmez et al., 2008), and within affected women, aromatase expression positively predicts severity of dysmenorrhea (Maia et al., 2012).”
From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Maia et al., 2012
The Abstract’s Conclusion reports a tendency toward a positive correlation between endometrial aromatase expression and dysmenorrhea severity when endometriosis was present. The claim’s unqualified “predicts” overstates that tentative association. No page number is available in our copy. (LLM, conf=0.88)
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Cites
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Inflammatory Status Influences Aromatase and Steroid Receptor Expression in Endometriosis
Bukulmez, O., Hardy, D. B., Carr, B. R., Word, R. A., & Mendelson, C. R. (2008) · Endocrinology · doi:10.1210/en.2007-0665 · Cited by 186 · cited 2× · see citing works
“The aggressiveness of endometriosis appears to correlate with the intensity of the expression of this enzyme in lesions, with the most aggressive occurring in red peritoneal lesions.(2) A correlation was also found between the severity of endometriosis and the intensity of Cox-2 expression in both lesions and the euto…”
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Research works printed but not linked: 15
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Structural and molecular features of the endomyometrium in endometriosis and adenomyosis
Benagiano, G., Brosens, I., & Habiba, M. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt052 · Cited by 246 · see citing works
Biomarkers in endometriosis: Challenges and opportunities
Ahn, S. H., Singh, V., & Tayade, C. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.01.009 · Cited by 242 · see citing works
Endometriosis and polycystic ovary syndrome are diametric disorders
Dinsdale, N. L., & Crespi, B. J. (2021) · Evolutionary Applications · doi:10.1111/eva.13244 · Cited by 90 · see citing works
“The eutopic endometrium of women with endometriosis demonstrates significantly elevated aromatase activity compared with unaffected women (Bukulmez et al., 2008), and within affected women, aromatase expression positively predicts severity of dysmenorrhea (Maia et al., 2012).”
BackgroundMercorio, A., Giampaolino, P., Romano, A., Dällenbach, P., & Pluchino, N. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.950866 · Cited by 16 · see citing works
“Eutopic endometrium often stained aromatase in endometriosis patients (18, 21), being detectable by IHC in 66/92 patients but also in the endometrium of 13/14 (95%) patients with severe dysmenorrhea but free from endometriosis.”
BackgroundAn Analysis of <i>ESR2</i> and <i>CYP19A1</i> Gene Expression Levels in Women With Endometriosis
SZAFLIK, T., SMOLARZ, B., MROCZKOWSKA, B., KULIG, B., SOJA, M., ROMANOWICZ, H., BRYŚ, M., FORMA, E., & SZYŁŁO, K. (2020) · In Vivo · doi:10.21873/invivo.11970 · Cited by 11 · see citing works
- Authors
- Maia Jr., H., Haddad, & Casoy
- Affiliations
- Centre for Population Ageing Research (AU)
- Venue
- International Journal of Women's Health
- Publisher
- Informa UK Limited
- Published
- 2012-02
- Volume
- 4
- Pages
- 61
- ISSN
- 1179-1411 (ISSN-L)
- PMC
- PMC3292405
- OpenAlex
- W2036895536
- Cited by
- 39
- References
- 2
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 4 · 2012: 3
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Women s Health (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- aromatase, eutopic endometrium, endometriosis, dysmenorrhea, infertility, endometriosis severity, endometriosis staging, aromatase P450, endometrial biopsy, immunohistochemistry
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