An Analysis of ESR2 and CYP19A1 Gene Expression Levels in Women With Endometriosis
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AIM: The analysis of oestrogen receptor (ESR2) and cytochrome P450 family 19 subfamily A member (CYP19A1) gene expression in the context of the risk for endometriosis development. MATERIALS AND METHODS: Tissue specimens, collected from patients with endometriosis (n=100) and from control patients (n=100) embedded into paraffin blocks, provided the material for genetic studies, oriented towards the expression of ESR2 and CYP19A1 genes. The gene expression was assessed by the reverse transcription-polymerase chain reaction technique. RESULTS: Higher expression levels of ESR2 gene were demonstrated in the patients with endometriosis in comparison with the healthy controls. The expression intensity of CYP19A1 gene was associated with endometriosis, manifested as abdominal wall nodules. A relationship was observed between CYP19A1 gene expression and the Revised American Society for Reproductive Medicine classification in the group with ovarian endometrioid cysts, as well as in the group with peritoneal endometriosis. CONCLUSION: This study suggests the significant role of ESR2 and CYP19A1 gene expression in the pathogenesis of endometriosis.
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Studies draw attention to the significant role of estrogen receptor genes, especially the ESR2 gene and the CYP19A1 gene, for the susceptibility and occurrence of endometriosis.
“Literature data indicate that studies draw attention to the significant role of estrogen receptor genes, especially the ESR2 gene and the CYP19A1 gene for the susceptibility and occurrence of endometriosis [199,200,201].”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [199]
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- Authors
- SZAFLIK, T., SMOLARZ, B., MROCZKOWSKA, B., KULIG, B., SOJA, M., ROMANOWICZ, H., BRYŚ, M., FORMA, E., & SZYŁŁO, K.
- Affiliations
- Polish Mother’s Memorial Hospital Research Institute (PL)
- University of Łódź (PL)
- Venue
- In Vivo
- Published
- 2020
- Volume
- 34
- Issue
- 4
- Pages
- 1765-1771
- ISSN
- 0258-851X (ISSN-L)
- 1791-7549
- PMC
- PMC7439897
- OpenAlex
- W3040298195
- Cited by
- 11
- References
- 21
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 3
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- In Vivo (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, ESR2, estrogen receptor beta, CYP19A1, aromatase, gene expression, endometriosis pathogenesis, peritoneal endometriosis, endometriosis classification
- MeSH terms
- Aromatase, Endometriosis, Endometrium, Female, Humans, Promoter Regions, Genetic, Gene Expression, Estrogen Receptor beta
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