The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.
The Mechanisms of HBV-Induced Hepatocellular Carcinoma
Open accessAbstract
Hepatocellular carcinoma (HCC) is a common malignancy, and the hepatitis B virus (HBV) is its major pathogenic factor. Over the past decades, it has been confirmed that HBV infection could promote disease progression through a variety of mechanisms, ultimately leading to the malignant transformation of liver cells. Many factors have been identified in the pathogenesis of HBV-associated HCC (HBV-HCC), including HBV gene integration, genomic instability caused by mutation, and activation of cancer-promoting signaling pathways. As research in the progression of HBV-HCC progresses, the role of many new mechanisms, such as epigenetics, exosomes, autophagy, metabolic regulation, and immune suppression, is also being continuously explored. The occurrence of HBV-HCC is a complex process caused by interactions across multiple genes and multiple steps, where the synergistic effects of various cancer-promoting mechanisms accelerate the process of disease evolution from inflammation to tumorigenesis. In this review, we aim to provide a brief overview of the mechanisms involved in the occurrence and development of HBV-HCC, which may contribute to a better understanding of the role of HBV in the occurrence and development of HCC.
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“66 HBV can cause epigenetic remodeling by changing the methylation state of DNA and the post-translational modification of histones, which is an important pathogenesis mechanism of HBV-associated HCC. Bioinformatics analysis showed that the methylation levels of tumor tissues from patients with…”
Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma
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Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma
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The Incidence and Epidemiology of Hepatocellular Carcinoma: A Global and Regional Perspective
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Trans-ancestry mutational landscape of hepatocellular carcinoma genomes
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“In addition, it has also been confirmed that many genes, including TERT, ARID1A, ARID2, and NFE2L2, are mutated in HBV-associated HCC.(13,14) These genes have been shown to be closely related to the occurrence of a variety of malignant tumors, including HCC,”
Metadata
- Authors
- Jiang, Y., Han, Q., Zhao, H., & Zhang, J.
- Venue
- Journal of Hepatocellular Carcinoma
- Publisher
- Informa UK Limited
- Published
- 2021-05
- Volume
- Volume 8
- Pages
- 435-450
- ISSN
- 2253-5969 (ISSN-L)
- OpenAlex
- W3162819955
- Cited by
- 258
- References
- 137
- FWCI
- 25.43
- Type
- journal article
- Language
- en
- Open access
- gold
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- Jiang, Y., Han, Q., Zhao, H., & Zhang, J. (2021). The Mechanisms of HBV-Induced Hepatocellular Carcinoma. Journal of Hepatocellular Carcinoma. https://doi.org/10.2147/jhc.s307962
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
